Hepatitis caused by antidepressive therapy with maprotiline and opipramol.
Pharmacopsychiatry
; 31(4): 152-5, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9754852
ABSTRACT
There are few published reports of antidepressive therapy induced hepatotoxicity. In most cases antidepressants cause only slight elevation of liver enzymes without clinical relevance. However, our patient with recidivation of unipolar depressive disorder developed severe laboratory abnormalities and clinical symptoms during therapy with maprotiline (Ludiomil) and opipramol (Insidon). To our knowledge, this is the first case report of bioptically proven severe acute hepatitis caused by these antidepressants. After their withdrawal, the patient's fatigue symptoms, scleric jaundice, and marked increase of liver enzymes completely disappeared. Hepatic side effects should be considered during antidepressive therapy with maprotiline and opipramol especially when additional clinical symptoms emerge.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Opipramol
/
Antidepressivos de Segunda Geração
/
Doença Hepática Induzida por Substâncias e Drogas
/
Maprotilina
/
Antidepressivos Tricíclicos
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pharmacopsychiatry
Ano de publicação:
1998
Tipo de documento:
Article