Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics.
Curr Microbiol
; 37(6): 418-25, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9806981
ABSTRACT
Eleven structurally similar ketolide antibiotics were tested at a concentration of 1 microg/ml for their relative inhibitory effects on growth and ribosome activities in Staphylococcus aureus cells. Ten of the compounds examined had an inhibitory effect on protein synthesis at this concentration and eight of the 11 compounds were also effective inhibitors of the formation of the 50S ribosomal subunit. All of the drugs tested inhibited protein synthesis to a greater extent than they affected 50S subunit formation. The decline in growth rate and cell number was proportional to the effect on ribosome formation and function. The growth of an ermC erythromycin-resistant strain of S. aureus was also significantly inhibited by nine ketolide compounds, suggesting that they were not inducers of methylase gene expression. These inhibitory activities can be related to structural differences between these ketolide antibiotics.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Ribossômicas
/
Staphylococcus aureus
/
Biossíntese de Proteínas
/
Antibacterianos
Idioma:
En
Revista:
Curr Microbiol
Ano de publicação:
1998
Tipo de documento:
Article