[Study on sijunzi decoction in rectifying digestive disorder in mice].

ABSTRACT

OBJECTIVE: To observe the Sijunzi Decoction in rectifying the digestive disorder. METHODS: Sijunzi decoction (SJZD) was chosen to treat digestive dysfunction in mice. The model was induced by Xiaochengqi decoction and semi-starvation. The effects on the absorptive function of the small intestine, body weight, autonomous activity levels, oxidative phosphorylation of hepatic mitochondrion, respiratory control rate (RCR) and cells energy charge were observed in vivo. RESULTS: The group given Xiaochengqi decoction had lower absorption, decreased body weight, and lower autonomous activity levels, and their hepatic mitochondrion RCR and cell energy charge were also lower than those of the control group. The figures for the group given SJZD all showed improvement, especially the group given the larger dose of SJZD. CONCLUSION: SJZD could correct Deficiency of the Spleen and Stomach which to some extent is caused by digestive dysfunction. So it is considered that the Spleen's function of transportation and transformation includes two meanings external transportation and transformation--the digestive and absorptive function of the small intestine, and internal transportation and transformation--the liver's conversion of nutrients and generate energy (ATP).