Temperature transitions of protein properties in human red blood cells.
Biophys J
; 75(6): 3179-83, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9826638
ABSTRACT
Human red blood cells (RBC) undergo a sudden change from blocking to passing through 1.3 +/- 0.2-micrometer micropipettes at a transition temperature (Tc) of 36.4 degrees C. For resealed RBC ghosts this transition occurs at 28.3 degrees C (Tg). These findings are attributed to an elastomeric transition of hemoglobin from being gel-like to a fluid and to an elastomeric transition of membrane proteins such as spectrin. Spectrin shows a uniform distribution along the aspirated RBC tongue above Tg in contrast to the linear gradient below Tg.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Sanguíneas
/
Deformação Eritrocítica
/
Eritrócitos
Limite:
Humans
Idioma:
En
Revista:
Biophys J
Ano de publicação:
1998
Tipo de documento:
Article