Divergent effects of short-term, very-low-calorie diet on insulin-like growth factor-I and insulin-like growth factor binding protein-3 serum concentrations in premenopausal women with obesity.
Obes Res
; 6(6): 408-15, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9845230
ABSTRACT
OBJECTIVE:
Insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) serum concentrations provide a good measure of the biological effects of growth hormone. The aims of the present study were to (1) investigate the associations of IGF-I and IGFBP-3 with body fat mass and distribution, and (2) evaluate the effects of 3 weeks of very-low-calorie diet (VLCD) (318 kcal/day, with 40 g protein, 35 g carbohydrate, and 2 g fat) on IGF-I and IGFBP-3 serum concentrations. RESEARCH METHODS AND PROCEDURES The study was performed in 21 nondiabetic premenopausal women with obesity (body mass index >27.0 kg/m2; age ranging from 18 to 48 years). Body fat mass and distribution were measured by computed tomography.RESULTS:
Before dietary treatment, IGF-I and IGFBP-3 serum concentrations were inversely associated with visceral adipose tissue (VAT) area (p<0.005 and p<0.05, respectively), but not with either total body fat or subcutaneous adipose tissue area. VLCD produced a significant decrease of body mass index (p<0.001), total body fat (p<0.001), VAT (p<0.005), subcutaneous adipose tissue (p<0.001), IGF-I concentrations (p<0.05), and an increase of IGFBP-3 serum levels (p<0.001). The association of VAT with either IGF-I or IGFBP-3 serum concentrations was not maintained following VLCD.DISCUSSION:
Our study suggests that visceral adipose tissue, rather than adiposity per se, accounts for IGF-I and IGFBP-3 serum concentrations, and that rapid weight loss, possibly due to nutritional changes, results in lower IGF-I concentrations, higher IGFBP-3 concentrations, and abrogation of the inverse associations of VAT with IGF-I and IGFBP-3.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ingestão de Energia
/
Fator de Crescimento Insulin-Like I
/
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Dieta Redutora
/
Obesidade
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Obes Res
Ano de publicação:
1998
Tipo de documento:
Article