A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.
Bioorg Med Chem Lett
; 8(5): 453-8, 1998 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-9871597
ABSTRACT
The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Receptores de Leucotrienos
/
Antiasmáticos
/
Antagonistas de Leucotrienos
/
Proteínas de Membrana
/
Acetatos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
1998
Tipo de documento:
Article