N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.
Bioorg Med Chem Lett
; 8(2): 199-200, 1998 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-9871654
ABSTRACT
A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective antagonist of the NR1A/2B subtype.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cinamatos
/
Receptores de N-Metil-D-Aspartato
/
Antagonistas de Aminoácidos Excitatórios
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
1998
Tipo de documento:
Article