The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.
Bioorg Med Chem Lett
; 8(9): 1077-82, 1998 May 05.
Article
em En
| MEDLINE
| ID: mdl-9871711
ABSTRACT
Cyclic urea SD146, a potent HIV protease inhibitor bearing a flat resistance profile, possessed poor solubility and bioavailability, which precluded further development of the compound. In an effort to improve upon the pharmacokinetic profile of the compound, several analogs modified at the P1/P1' residues were prepared and evaluated. Several of those compounds displayed significant improvement of physical properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureia
/
Inibidores da Protease de HIV
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
1998
Tipo de documento:
Article