Role of apoptosis in testicular tissue damage caused by varicocele.
Arch Esp Urol
; 51(9): 947-50, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9887572
ABSTRACT
OBJECTIVE:
Histomorphological changes reported in patients with varicocele (so-called stress pattern) have some degree of resemblance to the ones observed during apoptosis of various cell types due to a variety of reasons. In order to further clarify a possible role of apoptosis in impaired spermatogenetic activity associated with varicocele, we have investigated the presence of this specific type of cell death in testicular tissue. MATERIAL ANDMETHODS:
Surgical specimens were obtained after the completion of ligation and division of the spermatic vein(s) in patients with varicocele associated with infertility and testicular tissue obtained by scrotal orchiectomy for hormonal ablation treatment in prostate cancer patients served as the control group. Terminal deoxynucleotidyl transferase end labeling (TUNEL) technique was utilized in paraffin-embedded tissue specimens to demonstrate the presence of apoptosis.RESULTS:
Data obtained from 29 samples (varicocele, 24 patients; control, 5 patients) revealed that apoptosis was quite rare in testicular tissue of control group. Mean percentage of apoptotic cells per high power field (x400 magnification) was 2% for the control group and 14.7% for varicocele patients.CONCLUSION:
In light of our data, it appears that apoptosis may have a significant role in spermatogenetic dysfunction associated with varicocele.
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Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Testículo
/
Varicocele
/
Apoptose
Limite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Esp Urol
Ano de publicação:
1998
Tipo de documento:
Article