Acquired skin fragility syndrome in a juvenile cat following a routine ovariohysterectomy

Background: Acquired skin fragility syndrome (ASFS) is a rare condition, which is characterized by spontaneous fragility of the skin and an absence of hyperextensibility. Even though the real pathogenesis of ASFS remains unknown that isreported generally with some iatrogenic causes and severe diseases. Thus, based on the clinical findings this is the firstreport of describes the case and treatment of feline acquired skin fragility syndrome following a routine ovariohysterectomy.Case: An 8-month-old domestic shorthair female cat was brought to the Siirt University Animal Health Application andResearch Center for ovariohysterectomy operation. Before the operation physical examination of the animal revealed bodytemperature, heart rate, respiratory rate, the color of mucosas, and lymph nodes were determined normally. Besides, thereis no hematological and biochemical problem detected. The cat had no previous history of several infections or systemicdisease. A routine ovariohysterectomy procedure was applied under general anesthesia and the cat was discharged onthe same day. Three days after that a spontaneously developed cutaneous laceration below the left scapular region wasdetermined by the cat owner. During the clinical examination, it was determined that the cat was sensitive to touch againstthe left scapular area. Multiple spontaneous skin tear was revealed over the left scapular region while shaving for betterinspection but did not obtain any problem with incision line. To identify the underlying cause of skin tearing, hematological and biochemical tests were done but the animal’s results were found within the normal references. Also, rapid bloodtests were performed for feline leukemia virus and immunodeficiency virus, and none of them were positive. Additionally,the skin was not hyperextensible. Although the clinicopathological abnormalities were...

Acquired skin fragility syndrome in a juvenile cat following a routine ovariohysterectomy

Background: Acquired skin fragility syndrome (ASFS) is a rare condition, which is characterized by spontaneous fragility of the skin and an absence of hyperextensibility. Even though the real pathogenesis of ASFS remains unknown that isreported generally with some iatrogenic causes and severe diseases. Thus, based on the clinical findings this is the firstreport of describes the case and treatment of feline acquired skin fragility syndrome following a routine ovariohysterectomy.Case: An 8-month-old domestic shorthair female cat was brought to the Siirt University Animal Health Application andResearch Center for ovariohysterectomy operation. Before the operation physical examination of the animal revealed bodytemperature, heart rate, respiratory rate, the color of mucosas, and lymph nodes were determined normally. Besides, thereis no hematological and biochemical problem detected. The cat had no previous history of several infections or systemicdisease. A routine ovariohysterectomy procedure was applied under general anesthesia and the cat was discharged onthe same day. Three days after that a spontaneously developed cutaneous laceration below the left scapular region wasdetermined by the cat owner. During the clinical examination, it was determined that the cat was sensitive to touch againstthe left scapular area. Multiple spontaneous skin tear was revealed over the left scapular region while shaving for betterinspection but did not obtain any problem with incision line. To identify the underlying cause of skin tearing, hematological and biochemical tests were done but the animals results were found within the normal references. Also, rapid bloodtests were performed for feline leukemia virus and immunodeficiency virus, and none of them were positive. Additionally,the skin was not hyperextensible. Although the clinicopathological abnormalities were...(AU)

Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model

Purpose: To evaluate the effect of a new cross-linked hyaluronan (NCHA) gel on healing of the staple line in an experimental sleeve gastrectomy.Methods: Eighteen rats were randomly divided into three groups. The control group (n = 6) received no medication. In the saline group (n = 6) and NCHA gel group (n = 6), saline and NCHA gel were respectively administered onto the staple line and intraperitoneally into the abdominal cavity after the standard stapling procedure.Results: The fibroblast activity and collagen deposition were significantly higher in the NCHA gel group than in the control group (p = 0.00, p = 0.017) and saline group (p = 0.004, p = 0.015). The tissue hydroxyproline protein level was significantly higher in the NCHA gel group than in the control group (p = 0.041). Adhesion formation was significantly lower in the NCHA gel group than in the control and saline groups (p = 0.015, p = 0.041).Conclusions: New cross-linked hyaluronan gel could be an effective approach to improve staple line wound healing and prevent potential leakage after sleeve gastrectomy. Moreover, NCHA gel helps to prevent adhesion formation without compromising healing of the staple line.(AU)

Effects of local alendronate administration on bone defect healing. Histomorphometric and radiological evaluation in a rabbit model

Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments: no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery. Results: Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups. Conclusion: The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.(AU)