Mielolipoma de adrenal funcional em um cão / Functional adrenal myelolipoma in a dog

Background: Myelolipomas are benign tumors composed of a mixture of fat and hematopoietic tissue similar to the bone marrow. They are rare tumors in humans and dogs, and occur generally in the spleen, liver, spinal canal and in the adrenal glands. When they develop in the adrenal glands they feature non-secretory and endocrinologically inactive characteristics, usually without clinical signs or other dysfunctions. Thus, they are often an incidental finding during necropsy. This paper aims to describe a case of functional adrenal gland myelolipoma and spleen myelolipoma in a female dog with clinical signs and laboratory tests compatible with hyperadrenocorticism.Case: A 12 year-old female dog, undefined breed, was treated at the Hospital Unit for Companion Animals of the Pontifical Catholic University of Paraná (PUCPR), São José dos Pinhais, Paraná, Brazil, with polyuria, polydipsia, polyphagia, cutaneous hypotonia and central obesity. Blood tests showed hypercholesterolemia and increased alkaline phosphatase; urinalysis identified isostenuria with proteinuria; and ultrasound and MRI of the abdomen indicated right adrenomegaly, with heterogeneous characteristics, without invasion of attached blood vessels and splenic nodules. The low dose dexamethasone suppression test was performed which confirmed hyperadrenocorticism. The animal was submitted to adrenalectomy and splenectomy, and tissue specimens were obtained for histopathological examination, which revealed mature adipocytes and hematopoietic elements in different phases of maturation, compatible with adrenal and spleen myelolipoma. After surgical treatment, there was a progressive improvement of the clinical manifestations and laboratory abnormalities of hypercortisolemia, without recurrence during one year.[...](AU)

Mielolipoma de adrenal funcional em um cão / Functional adrenal myelolipoma in a dog

Background: Myelolipomas are benign tumors composed of a mixture of fat and hematopoietic tissue similar to the bone marrow. They are rare tumors in humans and dogs, and occur generally in the spleen, liver, spinal canal and in the adrenal glands. When they develop in the adrenal glands they feature non-secretory and endocrinologically inactive characteristics, usually without clinical signs or other dysfunctions. Thus, they are often an incidental finding during necropsy. This paper aims to describe a case of functional adrenal gland myelolipoma and spleen myelolipoma in a female dog with clinical signs and laboratory tests compatible with hyperadrenocorticism.Case: A 12 year-old female dog, undefined breed, was treated at the Hospital Unit for Companion Animals of the Pontifical Catholic University of Paraná (PUCPR), São José dos Pinhais, Paraná, Brazil, with polyuria, polydipsia, polyphagia, cutaneous hypotonia and central obesity. Blood tests showed hypercholesterolemia and increased alkaline phosphatase; urinalysis identified isostenuria with proteinuria; and ultrasound and MRI of the abdomen indicated right adrenomegaly, with heterogeneous characteristics, without invasion of attached blood vessels and splenic nodules. The low dose dexamethasone suppression test was performed which confirmed hyperadrenocorticism. The animal was submitted to adrenalectomy and splenectomy, and tissue specimens were obtained for histopathological examination, which revealed mature adipocytes and hematopoietic elements in different phases of maturation, compatible with adrenal and spleen myelolipoma. After surgical treatment, there was a progressive improvement of the clinical manifestations and laboratory abnormalities of hypercortisolemia, without recurrence during one year.[...]

Vulvar lymphangiosarcoma in a bitch

Background: Lymphangiosarcoma (LSA) is a rare, highly malignant and infiltrative neoplasm of the lymphatic endothelium of dogs and cats. It is mostly reported in medium to large breed dogs, over 5-year-old, with no sexual predisposition. Affected animals present fluctuating and diffuse swelling, covering both dermis and subcutaneous tissue, spreading through lymphatic and haematic vessels. Histologically, LSA is characterized by connected channels devoid of conspicuous haematic elements. Treatment depends on location of the neoplasm, staging, and possibility of curative surgical excision. Chemotherapy and radiotherapy can increase survival time. In this report, we describe a rare case of vulvar LSA in a dog. This is the first Brazilian report of LSA in dogs so far.Case: A 3-year-old, female, mixed breed dog was presented for evaluation of vesicle-bullous lesions in the vulvar and perivulvar region with progressive growth along 6 month. Histopathology revealed neoplastic proliferation in the superficial dermis, advancing through the profound dermis. The histological lesion pattern was consistent with angiosarcoma, which united along with macroscopic pattern of the tumor, and the presence of multiple anastomosed vascular structures without erythrocytes within it at microscopy, was compatible with LSA. No evidence of metastasis or lymphadenopathy was found on survey radiography and ultrasound. We performed a surgical excision, and remaining wound was reconstructed with an advancement skin flap. Despite wide surgical resection, neoplastic cells could be found in surgical borders, as well as a metastatic inguinal lymph node. Postoperative chemotherapy based on doxorubicin as a single agent was administrated. Disease free interval (DFI) was one month after surgery, when small bullous lesions were observed near the surgical site, and histopathological exam confirmed LSA...

Vulvar lymphangiosarcoma in a bitch

Background: Lymphangiosarcoma (LSA) is a rare, highly malignant and infiltrative neoplasm of the lymphatic endothelium of dogs and cats. It is mostly reported in medium to large breed dogs, over 5-year-old, with no sexual predisposition. Affected animals present fluctuating and diffuse swelling, covering both dermis and subcutaneous tissue, spreading through lymphatic and haematic vessels. Histologically, LSA is characterized by connected channels devoid of conspicuous haematic elements. Treatment depends on location of the neoplasm, staging, and possibility of curative surgical excision. Chemotherapy and radiotherapy can increase survival time. In this report, we describe a rare case of vulvar LSA in a dog. This is the first Brazilian report of LSA in dogs so far.Case: A 3-year-old, female, mixed breed dog was presented for evaluation of vesicle-bullous lesions in the vulvar and perivulvar region with progressive growth along 6 month. Histopathology revealed neoplastic proliferation in the superficial dermis, advancing through the profound dermis. The histological lesion pattern was consistent with angiosarcoma, which united along with macroscopic pattern of the tumor, and the presence of multiple anastomosed vascular structures without erythrocytes within it at microscopy, was compatible with LSA. No evidence of metastasis or lymphadenopathy was found on survey radiography and ultrasound. We performed a surgical excision, and remaining wound was reconstructed with an advancement skin flap. Despite wide surgical resection, neoplastic cells could be found in surgical borders, as well as a metastatic inguinal lymph node. Postoperative chemotherapy based on doxorubicin as a single agent was administrated. Disease free interval (DFI) was one month after surgery, when small bullous lesions were observed near the surgical site, and histopathological exam confirmed LSA...(AU)

The epidemiological and clinical aspects of Demodex injai demodicosis in dogs: a report of eight cases / Aspectos epidemiológicos e clínicos da demodiciose por Demodex injai em cães: relato de oito casos

The mite Demodex injai causes demodicosis, an uncommon, chronic, and recurrent parasitic dermatopathy in dogs. Demodicosis is characterized by an excessive proliferation of the Demodex injai mite in the pilosebaceous unit. Typically, demodicosis occurs in adults, and is associated with an underlying disease or a specific host immunodeficiency. Here, we describe the epidemiological, clinical, dermatological, and therapeutic aspects of Demodex injai demodicosis in dogs (n=8) at the Hospital Unit for Companion Animals of the Pontifical Catholic University of Paraná in Brazil. The affected dogs were predominantly purebred, had a mean age of eight years, and showed no gender predisposition. The lesions were predominantly alopecic and erythematous-desquamatory, associated with follicular dyskeratosis and greasiness of the coat, and mainly affected the facial region, in addition to the back and limbs. The animals had a history of allergic, dyskeratotic, endocrine, neoplastic, and immunosuppressive comorbidities. The diagnosis of demodicosis was based on multiple skin scrapings, trichogram, and acetate tape impression of the lesion areas, macroscopic observation, and morphological characterization of the mite. Macrocyclic lactones were effectively used for treatment in most cases; however, improvement of the condition may be related to adjunctive treatment of the underlying disease.(AU)

Demodiciose provocada pelo ácaro Demodex injai é uma dermatopatia parasitária, crônica, recorrente, incomum em cães, caracterizada pela proliferação excessiva do ácaro na unidade pilossebácea. É frequentemente caracterizada como de surto adulto, generalizada e associada a uma doença de base ou a uma imunodeficiência específica inerente ao hospedeiro. O presente relato tem como objetivo descrever os aspectos epidemiológicos, clínico-dermatológicos e o tratamento da demodiciose por Demodex injai em cães (n=8) atendidos na Unidade Hospitalar para Animais de Companhia da Pontifícia Universidade Católica do Paraná, em São José dos Pinhais, Paraná, Brasil. Os animais acometidos apresentaram idade média de oito anos, predominantemente de raças puras e não houve predisposição sexual. As lesões tinham características predominantemente alopécicas e eritêmato-descamativas, associadas à disqueratose folicular e untuosidade da pelagem, acometendo principalmente a região da face, mas também o dorso e os membros. Os animais apresentavam histórico de comorbidades alérgicas, disqueratóticas, endócrinas, neoplásicas ou imunossupressivas de base. O diagnóstico da demodiciose foi estabelecido por múltiplos raspados de pele, tricograma e técnica de beliscamento por fita adesiva em áreas lesionais, seguindo à observação macroscópica e caracterização morfológica do ácaro. Instituiu-se tratamento com lactonas macrocíclicas, que se mostraram eficazes na maioria dos casos, entretanto, ainvolução do quadro pode estar relacionado ao tratamento adjunto das doenças de base.(AU)

Use of Staphylococcus aureus phage Lysate Staphage Lysate (SPL)® for the control of recurrent pyoderma eczema in dogs with atopic dermatitis

Background: Recurrent staphylococcal infections are frequent in dogs with atopic dermatitis (AD). Many factors seem to contribute to making bacterial pyoderma refractory to treatment. Short-term systemic antibiotic therapy is effective for the treatment of acute symptoms, and may, along with pulsatile therapy, contribute to the long-term control of the disease. However, microbial resistance has become a growing and alarming problem. The aim of this study was to evaluate whether the use of Staphylococcus aureus Phage Lysate Staphage Lysate (SPL)®, can minimize the symptoms of recurrent pyoderma and increase the interval between acute atopic manifestations in dogs. Materials, Methods & Results: Thirteen dogs with a history of Canine Atopic Dematitis (CAD) and recurrent bacterial pyoderma received SPL at increasing intervals for 23 weeks. The contents of an intact pustule of each dog was collected and submitted to microbiological analysis. Systemic antibiotic therapy was established for the first 4-6 weeks of SPL protocol, based on the antibiotic sensitivity tests. The animals included in the study underwent a therapeutic protocol receiving shots of 0.5 mL of SPL subcutaneously (SC) twice a week for the first 12 weeks; 1.0 mL of SPL (SC) once a week for four weeks; 1.0 mL of SPL (SC) once every 15 days; 1.0 mL of SPL (SC) after a three-week interval from the last dose on week [...](AU)

Use of Staphylococcus aureus phage Lysate Staphage Lysate (SPL)® for the control of recurrent pyoderma eczema in dogs with atopic dermatitis

Background: Recurrent staphylococcal infections are frequent in dogs with atopic dermatitis (AD). Many factors seem to contribute to making bacterial pyoderma refractory to treatment. Short-term systemic antibiotic therapy is effective for the treatment of acute symptoms, and may, along with pulsatile therapy, contribute to the long-term control of the disease. However, microbial resistance has become a growing and alarming problem. The aim of this study was to evaluate whether the use of Staphylococcus aureus Phage Lysate Staphage Lysate (SPL)®, can minimize the symptoms of recurrent pyoderma and increase the interval between acute atopic manifestations in dogs. Materials, Methods & Results: Thirteen dogs with a history of Canine Atopic Dematitis (CAD) and recurrent bacterial pyoderma received SPL at increasing intervals for 23 weeks. The contents of an intact pustule of each dog was collected and submitted to microbiological analysis. Systemic antibiotic therapy was established for the first 4-6 weeks of SPL protocol, based on the antibiotic sensitivity tests. The animals included in the study underwent a therapeutic protocol receiving shots of 0.5 mL of SPL subcutaneously (SC) twice a week for the first 12 weeks; 1.0 mL of SPL (SC) once a week for four weeks; 1.0 mL of SPL (SC) once every 15 days; 1.0 mL of SPL (SC) after a three-week interval from the last dose on week [...]

Idiopathic diffuse lipomatosis in dogs

Background: Idiopathic diffuse lipomatosis is a rare disease in veterinary medicine. It is characterized by excessive proliferation of adipocytes, which results in the formation of fatty tumours throughout the body. In humans, this disease is also known as Madelungs disease or multiple symmetric lipomatosis and is classified as type I and II. The aim of this study was to investigate two cases of dogs diagnosed with idiopathic diffuse lipomatosis and compare their characteristics with those found in humans. Cases: Case 1 - A 3-year-old standard poodle female was taken for veterinary evaluation for a slow-growing tumoural lesion over the neck and trunk. The tumours measured >30 cm in diameter that caused irregular and protruding folds resulting in a significant loss of body architecture. No clinical signs of adjacent systemic disease were observed. Elliptical excisions of the skin revealed diffuse mature adipocytes and hyperplastic and dysplastic lipoblast hypertrophy of the panniculus, which was associated with epidermodermal hypotrophy and skin appendages. The combination of these findings supported a diagnosis of idiopathic diffuse lipomatosis. The animal underwent surgical therapy. However, the clinical symptoms recurred within two months. Owing to the continuous recurrence of tumours and history of three other surgeries, it was decided to euthanize the animal. [...]

Idiopathic diffuse lipomatosis in dogs

Background: Idiopathic diffuse lipomatosis is a rare disease in veterinary medicine. It is characterized by excessive proliferation of adipocytes, which results in the formation of fatty tumours throughout the body. In humans, this disease is also known as Madelungs disease or multiple symmetric lipomatosis and is classified as type I and II. The aim of this study was to investigate two cases of dogs diagnosed with idiopathic diffuse lipomatosis and compare their characteristics with those found in humans. Cases: Case 1 - A 3-year-old standard poodle female was taken for veterinary evaluation for a slow-growing tumoural lesion over the neck and trunk. The tumours measured >30 cm in diameter that caused irregular and protruding folds resulting in a significant loss of body architecture. No clinical signs of adjacent systemic disease were observed. Elliptical excisions of the skin revealed diffuse mature adipocytes and hyperplastic and dysplastic lipoblast hypertrophy of the panniculus, which was associated with epidermodermal hypotrophy and skin appendages. The combination of these findings supported a diagnosis of idiopathic diffuse lipomatosis. The animal underwent surgical therapy. However, the clinical symptoms recurred within two months. Owing to the continuous recurrence of tumours and history of three other surgeries, it was decided to euthanize the animal. [...](AU)

Sebaceous adenitis in a cat

Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil.Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining...(AU)

Sebaceous adenitis in a cat

Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil. Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining pos...(AU)

Sebaceous adenitis in a cat

Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil. Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining pos...

Canine bone sporotrichosis: a case report / Esporotricose óssea canina: relato de caso

Sporotrichosis, a subcutaneous and zoonotic mycosis, is caused by dimorphic fungus Sporothrix schenckii. The infection occurs after a traumatic skin injury, while handling plant materials or animals. This disease commonly occurs in cats and is rarely reported in dogs. Herein we report a case of bone sporotrichosis in a dog that presented at the Hospital Unit for Pets (HUP) of the Pontifical Catholic University of Paraná (PUCPR). The animal had a 4-month history of lameness in its thoracic limbs. Haematological, radiological, mycological, and histopathological tests were conducted to confirm the diagnosis. The animal was treated for 2 months with a 10 mg kg-1 PO SID dose of itraconazole, but only partial improvement was observed. A 20% supersaturated potassium iodide solution i.e., a 40 mg kg-1 dose every 24 h was then included for regression and healing of the wounds.(AU)

A esporotricose é uma micose subcutânea e zoonótica, causada pelo fungo dimórfico Sporothrix schenckii. A infecção ocorre através de uma lesão traumática na pele associada ao meio ambiente ou animais. É uma doença incomum em cães, e está mais frequentemente associada aos felinos. Este artigo relata o caso de um canino atendido na Unidade Hospitalar de Animais de Companhia (UHAC) da Pontifícia Universidade Católica do Paraná (PUCPR) com diagnóstico de esporotricose óssea. O animal apresentava como sinal clínico claudicação em membros torácicos há quatro meses. Para confirmação do diagnóstico foram realizados exames hematológico, radiológico, micológico e histopatológico. O animal foi tratado durante dois meses com itraconazol na dose de 10 mg kg-1 SID, por via oral com melhora parcial, foi associado ao protocolo uma solução hipersaturada de iodeto de potássio a 20%, na dose de 40 mg kg-1, a cada 24 horas, obtendo-se regressão e cura das lesões.(AU)

Avaliação da eficácia da ração de soja hidrolisada no controle do prurido crônico em cães com dermatite atópica

O presente estudo tem como objetivo avaliar a eficácia da ração de soja hidrolisada no controle lesional e doprurido crônico em cães com dermatite atópica. Para isso 14 cães com dermatite atópica, baseados nos critérios de Favrot et. al (2010), foram alimentados exclusivamente com ração hidrolisada de soja, e avaliadosquinzenalmente, durante oito semanas, seus índices de prurido, pela escala de Rybnicek et al. (2009), e lesional,pelo índice de lesão para cães com dermatite atópica (CADLI). Após 60 dias os cães foram desafiadoscom alimento pregresso. A eficácia foi analisada através do teste não paramétrico de Kruskall-wallis, seguidodo teste de Mood`s, com (p<0,005). Houve minimização no prurido nos dias +30, +45 e +60 (p<0,001) ,edas lesões (p<0,05) nos dias +30, +45 e +60, com relação ao dia 0, em 78,5% doa animais estudados. (AU)

Avaliação da eficácia da ração de soja hidrolisada no controle do prurido crônico em cães com dermatite atópica

O presente estudo tem como objetivo avaliar a eficácia da ração de soja hidrolisada no controle lesional e doprurido crônico em cães com dermatite atópica. Para isso 14 cães com dermatite atópica, baseados nos critérios de Favrot et. al (2010), foram alimentados exclusivamente com ração hidrolisada de soja, e avaliadosquinzenalmente, durante oito semanas, seus índices de prurido, pela escala de Rybnicek et al. (2009), e lesional,pelo índice de lesão para cães com dermatite atópica (CADLI). Após 60 dias os cães foram desafiadoscom alimento pregresso. A eficácia foi analisada através do teste não paramétrico de Kruskall-wallis, seguidodo teste de Mood`s, com (p<0,005). Houve minimização no prurido nos dias +30, +45 e +60 (p<0,001) ,edas lesões (p<0,05) nos dias +30, +45 e +60, com relação ao dia 0, em 78,5% doa animais estudados.

Lúpus eritematoso cutâneo vesicular em um cão sem raça definida: relato de caso

O lúpus eritematoso cutâneo vesicular (LECV) descrito em cães possui etiologia e patogenia não muitobem esclarecidas. Esta forma de doença só havia sido descrita em animais da raça shetland sheepdog, collie e border collie. O propósito deste trabalho é relatar um caso de LECV em um cão sem raça definida (SRD) e discutir seus aspectos clínicos, dermatopatológicos e seu controle terapêutico (AU)

Estomatite vesico-bolhosa possivelmente causada por penfigóidemucomembranoso em um cão: relato de caso

O penfigóide mucomembranoso (PMM) é uma doença rara que acomete mucosa e junção mucocutânea, levando a vesículas, erosões e úceras em cavidade oral, perioral, plano nasal, olhos, conduto auditivo, anus e genitália. O objetivo deste trabalho é relatar o caso de cão, fêmea, 8 anos, ovariohisterectomizada, com histórico de úlceras e erosões em mucosa jugal, palatina, anal e vulvo-vaginal, disfagia, halitose e sialorréia mucopurulenta. O exame histopatológico revelou presença de fenda subepidermal extensacontendo discreta quantidade de restos celulares ou sangue. Pelos sinais clínicos e a análise histopatológica,suspeita se que a estomatite vesico-bolhosa era devido ao PMM. O controle parcial da doença foi obtido com uso de ciclosporina diário com corticosteroide intermitente. (AU)

Estomatite vesico-bolhosa possivelmente causada por penfigóidemucomembranoso em um cão: relato de caso

O penfigóide mucomembranoso (PMM) é uma doença rara que acomete mucosa e junção mucocutânea, levando a vesículas, erosões e úceras em cavidade oral, perioral, plano nasal, olhos, conduto auditivo, anus e genitália. O objetivo deste trabalho é relatar o caso de cão, fêmea, 8 anos, ovariohisterectomizada, com histórico de úlceras e erosões em mucosa jugal, palatina, anal e vulvo-vaginal, disfagia, halitose e sialorréia mucopurulenta. O exame histopatológico revelou presença de fenda subepidermal extensacontendo discreta quantidade de restos celulares ou sangue. Pelos sinais clínicos e a análise histopatológica,suspeita se que a estomatite vesico-bolhosa era devido ao PMM. O controle parcial da doença foi obtido com uso de ciclosporina diário com corticosteroide intermitente.

Lúpus eritematoso cutâneo vesicular em um cão sem raça definida: relato de caso

O lúpus eritematoso cutâneo vesicular (LECV) descrito em cães possui etiologia e patogenia não muitobem esclarecidas. Esta forma de doença só havia sido descrita em animais da raça shetland sheepdog, collie e border collie. O propósito deste trabalho é relatar um caso de LECV em um cão sem raça definida (SRD) e discutir seus aspectos clínicos, dermatopatológicos e seu controle terapêutico

Alopecia areata generalizada em um cão da raça Lhasa Apso - relato de caso / Generalized alopecia areata in a Lhasa Apso dog - case report

A alopecia areata é uma dermatopatia autoimune da unidade pilo-sebácea, de caráter benigno, incomumentedescrita em cães e rara em gatos. A patogênese da doença é incerta porém parece estar relacionada a imunidade celular mediada por linfócitos CD8, que atuam contra antígenos foliculares e alteram o ciclo de crescimento do pelo. Este trabalho tem como objetivo relatar um cão, lhasa apso, com alopecia areatageneralizada, e discutir seus aspectos clínicos, diagnósticos e terapêuticos de forma comparada. (AU)

Alopecia areata is an autoimmune skin disease of the pilosebaceous unit, benign, described uncommonlyin dogs and rare in cats. The pathogenesis is uncertain but may be related to cellular immunity mediatedby CD8 lymphocytes that act against follicular antigens and alter the cycle of hair growth. This paper aims to report a dog, Lhasa Apso, with widespread alopecia areata, and discuss its clinical, diagnostic and therapeutic aspects of a comparative basis. (AU)