Ações anti - inflamatória e antinociceptiva do extrato etanólico de Hymenaea courbaril L. em roedores / Anti - inflammatory and antinociceptive actions of etanolic extract from Hymenaea courbaril L. in rodents

The anti-inflammatory and antinociceptive actions of the Etanolic Extract from Hymenaea courbaril L. (EEHC) were evaluated for the first time in animal models. The extract was produced using the stem bark. The preparation was administered to rodents per oral. EEHC has efficiently reduced the abdominal contortions induced by acetic acid; time of paw licking in formalin test; paw edema induced by carrageenan and dextran; leukocyte migration after intraperitoneal injection of carrageenan and myeloperoxidase expression on peritoneal exsudate. EECH also improved the histophatologycal damages in the rat paw after carrageenan inflammation as well as reduced TNF-α expression in the same tissue. Doses varying from 1 to 400 mg/kg were tested. The dose of 100 mg/kg presented significant results in all experiments (p < 0.05). The data suggest intense anti-inflammatory and antinociceptive effects associated to extract from Hymenaea courbaril. Further studies must be carried out to elucidate all mechanisms involved.

Ações anti - inflamatória e antinociceptiva do extrato etanólico de Hymenaea courbaril L. em roedores / Anti - inflammatory and antinociceptive actions of etanolic extract from Hymenaea courbaril L. in rodents

The anti-inflammatory and antinociceptive actions of the Etanolic Extract from Hymenaea courbaril L. (EEHC) were evaluated for the first time in animal models. The extract was produced using the stem bark. The preparation was administered to rodents per oral. EEHC has efficiently reduced the abdominal contortions induced by acetic acid; time of paw licking in formalin test; paw edema induced by carrageenan and dextran; leukocyte migration after intraperitoneal injection of carrageenan and myeloperoxidase expression on peritoneal exsudate. EECH also improved the histophatologycal damages in the rat paw after carrageenan inflammation as well as reduced TNF-α expression in the same tissue. Doses varying from 1 to 400 mg/kg were tested. The dose of 100 mg/kg presented significant results in all experiments (p < 0.05). The data suggest intense anti-inflammatory and antinociceptive effects associated to extract from Hymenaea courbaril. Further studies must be carried out to elucidate all mechanisms involved. (AU)