General anesthesia in geriatric dogs with propofol-isoflurane, propofolsevoflurane, alphaxalone-isoflurane, alphaxalone-sevoflurane and their comparison of biochemical, hemodynamic and cardiopulmonary effects

Background: Geriatric is defined as the life-cycle in which the physical state, organ functions, sensory functions, mental function and immunity progressively regress. Aging causes progressive and irreversible changes in the functional capacities of organ systems, which in turn alter the response to stress and anesthetic drugs. Propofol is an anesthetic agent with sedative and hypnotic effects. Anesthesia induction with propofol is fast and smooth. Alphaxalone (3α-hydroxy-5α-pregnane11,20-dione) is a central nervous system depressant in the form of synthetic neuroactive steroids. This allows anesthesia and muscle relaxation by increasing the inhibition of gamma amino butyric acid type A (GABA) receptors. The aim of this study is to compare effects of propofol-isoflurane and propofol-sevoflurane with relatively a new anesthetic combination alphaxalone-isoflurane and alphaxalone-sevoflurane on hematological, biochemical and physiological parameters.Materials, Methods & Results: Dogs were randomly divided into 4 groups and anesthesia protocols were applied. After induction of anesthesia with 6 mg/kg propofol in groups 1 and 2, isoflurane anesthesia was continued in group 1 and sevoflurane in group 2. After induction of 3 mg/kg alphaxalone anesthesia in groups 3 and 4, isoflurane anesthesia was continued in group 3 whereas sevoflurane in group 4. Vena cephalica was catheterized for blood collection. At the preanesthetic period, 15, 30, 45, 60 min and 60 min after the anesthesia, complete blood counts were performed. Serum ALT, AST, urea, creatinine values were measured during preanesthesia, perianesthesia 15-30 min and 60 min after anesthesia. Cardiopulmonary parameters and reflexes were evaluated before anesthesia and recorded at perianesthetic 5, 10, 15, 30, 45, 60 min and 60 min after full recovery. Patients were monitored during anesthesia. The average age of the dogs in the study was 10.83.[...]

General anesthesia in geriatric dogs with propofol-isoflurane, propofolsevoflurane, alphaxalone-isoflurane, alphaxalone-sevoflurane and their comparison of biochemical, hemodynamic and cardiopulmonary effects

Background: Geriatric is defined as the life-cycle in which the physical state, organ functions, sensory functions, mental function and immunity progressively regress. Aging causes progressive and irreversible changes in the functional capacities of organ systems, which in turn alter the response to stress and anesthetic drugs. Propofol is an anesthetic agent with sedative and hypnotic effects. Anesthesia induction with propofol is fast and smooth. Alphaxalone (3α-hydroxy-5α-pregnane11,20-dione) is a central nervous system depressant in the form of synthetic neuroactive steroids. This allows anesthesia and muscle relaxation by increasing the inhibition of gamma amino butyric acid type A (GABA) receptors. The aim of this study is to compare effects of propofol-isoflurane and propofol-sevoflurane with relatively a new anesthetic combination alphaxalone-isoflurane and alphaxalone-sevoflurane on hematological, biochemical and physiological parameters.Materials, Methods & Results: Dogs were randomly divided into 4 groups and anesthesia protocols were applied. After induction of anesthesia with 6 mg/kg propofol in groups 1 and 2, isoflurane anesthesia was continued in group 1 and sevoflurane in group 2. After induction of 3 mg/kg alphaxalone anesthesia in groups 3 and 4, isoflurane anesthesia was continued in group 3 whereas sevoflurane in group 4. Vena cephalica was catheterized for blood collection. At the preanesthetic period, 15, 30, 45, 60 min and 60 min after the anesthesia, complete blood counts were performed. Serum ALT, AST, urea, creatinine values were measured during preanesthesia, perianesthesia 15-30 min and 60 min after anesthesia. Cardiopulmonary parameters and reflexes were evaluated before anesthesia and recorded at perianesthetic 5, 10, 15, 30, 45, 60 min and 60 min after full recovery. Patients were monitored during anesthesia. The average age of the dogs in the study was 10.83.[...](AU)

Comparison of clinical and hemodynamic effects of isoflurane and sevoflurane anesthesia in calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+ , Ca++, K+ , Mg++) and blood gases (pH, pCO2 , pO2 , HCO3-, TCO2 , O2 Sat, HCT) were evaluated from blood samples taken from both groups. The second derivation, durations and amplitudes of the P and T waves, the durations and amplitudes of the QRS complex, and the durations of PQ and QT intervals were evaluated on the ECGs recorded before anesthesia, after induction and during anesthesia. Following anesthesia termination, the extubation time and the time it took for straightening of the head and standing up were recorded. Decrease in heart rate and body temperature were found significant in two of the groups.[...]

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+, Ca++, K+, Mg++) and blood gases (pH, pCO2, pO2, HCO3-, TCO2, O2Sat, HCT) were evaluated from blood samples taken from both gr

Comparison of clinical and hemodynamic effects of isoflurane and sevoflurane anesthesia in calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+ , Ca++, K+ , Mg++) and blood gases (pH, pCO2 , pO2 , HCO3-, TCO2 , O2 Sat, HCT) were evaluated from blood samples taken from both groups. The second derivation, durations and amplitudes of the P and T waves, the durations and amplitudes of the QRS complex, and the durations of PQ and QT intervals were evaluated on the ECGs recorded before anesthesia, after induction and during anesthesia. Following anesthesia termination, the extubation time and the time it took for straightening of the head and standing up were recorded. Decrease in heart rate and body temperature were found significant in two of the groups.[...](AU)

Posttraumatic bacterial infections in extremities before and after osteosynthesis in dogs

Background: Posttraumatic osteomyelitis is one of the most serious complications after fracture treatment. Although haematogenous osteomyelitis is fairly common in man, it is rarely seen in small animal orthopedic surgery. Predisposing factors to osteomyelitis include bacterial contamination in combination with severe trauma, surgical intervention, the presence of dead bone, or metallic implants, especially if bone or implants are unstable. Posttraumatic osteomyelitis is nearly always infectious in etiology, caused by various pathogens. The purpose of this present study is to find out the type of aerobic bacteria, which plays an important role in the posttraumatic infection before and after fracture osteosynthesis. Materials, Methods & Results: Our study was performed on 15 patients with long bone fractures operated at the Department of Surgery, Small Animal Clinic, University of Adnan Menderes, Aydin. The patients without an antibiotic treatment 24 h prior to surgery were included in the study. Our study was performed on 15 patients who had undergone osteosynthesis in extremities at Department of Surgery, Small Animal Clinic, University of Adnan Menderes, Aydin. The patients without antimicrobial treatment 24 h before surgery were included in our study. The osteosynthesis procedures were performed by two experienced orthopaedists. Theywere returned to our clinic at 4-8 weeks after operation for follow-up orthopaedic and radiographic examinations. The next follow-ups were carried out at 4-6-week intervals, if needed. The implants for internal fracture were removed after clinical and radiological bone healing. All criteria were analyzed by using χ2 test and Fischer's exact test with P < 0.05 and P < 0.01 to evaluate the incidence bone infection in each group of patients. A high percentage of the bacterial isolates was coagulase-negative staphylococci resistent to cephalosporins. the highest sensitivity of all isolates (coagulase-negative Stapylococcus, Staphylococcus aureus, Bacillus spp., Corynebacterium spp., Serratia liquefaciens, Alcaligenes faecalis and Escherichia coli) was observed to ceftriaxone (100 %), as well as to danofloxacin (80.9%) and amoxicillin/clavulanic acid (57.1%). The highest resistant isolates was determined against to penicillin (66.6%) and ampicillin/sulbactam (57.1%). Although we use cephalosporins prophylactically in all patients undergoing orthopaedic surgery in our clinic, the incidence of postoperative infections was very low. Discussion: As the surgical site infection etiology is multi-factorial, the sterilization, preoperative patient preparation and operating theatre environments must be considered as the main sources of this bacterial contamination. Antiseptics used in our practice were theoretically supposed to be effective. Since povidone-iodine and chlorhexidine have a broad spectrum of antimicrobial activity against vegetative bacteria, fungi, viruses, protozoa, and yeasts, they are suitable for removing bacteria from the skin surface at preoperative surgical site. Additionally, povidone-iodine surgical scrub is also used extensively in veterinary practice for the pre-operative preparation of patients and surgeons. Therefore, it is obvious that the use of cephalosporins as preoperative prophylaxis is sufficient in most cases. In the patients at high risk of osteomyelitis development (polytraumatized or immunosuppressed patients, patients receiving prosthetic joint or large metallic implants), or in the patients where the infection is already present, it is important to know hospital-specific pathogens to select adequate complementary antibiotics (in this case we use cephalosporines together with quinolones such as danofloxacin). This emphasizes the need of epidemiologic studies, specific for each clinic.

Surgical treatment of rupture of the anterior cruciate ligament in a cat caused by dog bite

Background: Cranial cruciate ligament (CCL) ruptures in the cat is uncommon. Rupture of the feline cruciate ligament was generally described as or assumed to be of a traumatic etiology and its surgical repair was documented in individual cases. Traumatic cruciate ruptures commonly occur as a result of falls. While rupture of the CCL is common in those circumstances, it is almost always part of "polytrauma" to the stifle. To the authors's knowledge no description has been published of ruptur of CCL in cats caused by dog bite. This paper reports a first case of ruptur of CCL caused by dog attack in a Turkish Angora cat. Case: A 2 year-old intact female Turkish Angora cat was presented because of acute pain in the left hindquarters. The cat experienced difficulty in locomotion and weight-bearing on left hind limb. The owner reported that the cat was attacked from a Bull Terrier dog. Since then, the cat had lameness. Examination under general anesthesia revealed a pronounced cranial drawer sign in the left stifle joints. Radiographic examinations revealed distal displacement of the left popliteal sesamoid bones and cranial displacement of the tibia. Surgical exploration confirmed cranial cruciate rupture of the left stifle. Contusions were pronounced in the soft tissues surrounding the stifle joints suggesting a traumatic etiology. The involved stifle joints were stabilized with two strands of 0 non-absorbable suture materials using the lateral retinacular imbricaton technique. Two weeks post-operatively, the cat was using both hind legs somewhat gingerly. Discussion: In a survey of nine cases of degenerative feline cruciate ruptures, the cats averaged 8.5 years of age and had a mean weight of 6.5 kg. Significant differences in age or sex distribution could not be demonstrated. In a survey of 165 dogs with CCL rupture, conducted from 1983 to 1990, 78% were small breeds (under 15 kg), with a mean age of 8.7 years. Many of these dogs were overweight. In this study, a 2-year-old intact female cat weighing 2.3 kg was presented to the Veterinary Medical Teaching Hospital, Adnan Menderes. Diagnosis of feline CCL rupture is usually easily confirmed on physical examination. Drawer motion is pronounced in most affected cats. Radiographic signs are similar to those seen in the dog and may include joint effusion, degenerative joint disease, and distal displacement of one or both popliteal sesamoid bones. In this case, radiographic examinations revealed distal displacement of the left popliteal sesamoid bones and cranial displacement of the tibia. Treatment of CCL rupture in cats is not without controversy. Multiligamentous traumatic injuries can be stabilized by ligament reconstruction techniques or the placement of a transarticular pin. The "dogma" concerning degenerative CCL rupture in cats has favored conservative therapy, including confi nement and nonsteroidal anti-inflammatory medication. Published results of extracapsular surgical repair in cats, including those of this survey, indicate that results are at least as good as those achieved with conservative treatment, and that surgery provides quicker and more reliable return to function.

Surgical treatment of corneal large dermoid in a Simmental calf

Background: Ocular dermoid is a skin or skin-like appendage usually arising on the limbus, conjunctivae, and cornea. It can be unilateral or bilateral and may be associated with other ocular manifestation or with other malformations. Hair from the lesions is predominantly responsible for the associated irritation resulting in chronic inflammation of the conjunctivae and cornea and may cause visual impairment. Ocular dermoids are rare in cattle, with the prevalence estimated between 0.002% and 0. 4%. Case: A one-day-old Simmental calf presented for bilateral haired masses on the eyes and tumor-like growth since birth. The calf was admitted to the University of Adnan Menderes, Faculty of Veterinary Medicine 1 days after initial examination. The calf weighed 35 kg, was in good bodily condition and no further abnormalities were detected on physical examination, complete blood count and serum chemistries. General anesthesia was induced and maintained with an intravenous detomidine-ketamine-midazolam combination. The corneal dermoids extended slightly beyond the inferonasal limbus and then merged with a second mass of lightly haired tissue within the inferonasal bulbar conjunctiva of both eyes. The dermoids were excised by superficial lamellar keratectomy that was extended into the inferonasal conjunctiva. The nasal masses were excised by electrocautery. All excised tissue was submitted for histopathology. Histopathology of the excised tissue confirmed bilateral corneoconjunctival dermoids with bilateral nasal hyperplastic tissue. Topical 1% atropine sulfate ointment was applied twice daily to both eyes for 5 days and bacitracin-neomycin-polymixin ophthalmic ointment applied twice daily to both eyes for 2 weeks postoperatively. Ocular and nasal healing was uneventful, with prominent corneoconjunctival granulation tissue 6 days postoperatively, which largely resolved by the 6-week follow-up examination. Bilateral large dermoids with nasal hyperplastic tissue have not been documented previously in Simmental cattle in Turkey. Discussion: The precise developmental mechanisms involved in the pathogenesis of ocular dermoids are not known. Metaplasia of mesenchyme (of primarily neural crest origin), resulting in abnormal differentiation of the surface ectoderm, is considered the most likely mechanism. Ocular dermoids may be associated with other congenital ocular or multiorgan abnormalities. The medial and lateral nasal processes, optic vesicle and first and second branchial arches are in close relationship on the lateral side of the embryonic head and might all be adversely influenced by the same stimulus. Ectopic lacrimal tissue may appear in combination with an ocular dermoid as in this case report and previously reported in cattle, or alone as an epibulbar choristoma. The ectopic lacrimal tissue in this calf may have represented misplacement of the nictitans gland or additional lacrimal tissue development. Superficial keratectomy is required to surgically excise a corneal dermoid although the depth of the dermoid within the cornea cannot be ascertained by ophthalmic examination until surgery is undertaken. In the case of large corneal dermoids, surgical excision should be performed early in the life of the patient to achieve optical improvement and allow functional development of the eye.

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+, Ca++, K+, Mg++) and blood gases (pH, pCO2, pO2, HCO3-, TCO2, O2Sat, HCT) were evaluated from blood samples taken from both gr

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+, Ca++, K+, Mg++) and blood gases (pH, pCO2, pO2, HCO3-, TCO2, O2Sat, HCT) were evaluated from blood samples taken from both gr

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+, Ca++, K+, Mg++) and blood gases (pH, pCO2, pO2, HCO3-, TCO2, O2Sat, HCT) were evaluated from blood samples taken from both gr

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+, Ca++, K+, Mg++) and blood gases (pH, pCO2, pO2, HCO3-, TCO2, O2Sat, HCT) were evaluated from blood samples taken from both gr

Comparison of Clinical and Hemodynamic Effects of Isoflurane and Sevoflurane Anesthesia in Calves

Background: Inhalation anesthesia is the preferred method for use on many animal species, including ruminants, due to its superiority over the injectable anesthetics. The most commonly used inhalation anesthetics are isoflurane and sevoflurane The aim of the study was to investigate the effects of isoflurane and sevoflurane anesthesia on the cardiovascular system of calves.Materials, Methods & Results: A total of 20 calves (11 male, 9 female) between 1 and 6 months in age and 50 to 85 kg in body weight were used. The calves were divided randomly into two groups of 10 each, with one group being administered isoflurane and the other sevoflurane. An intramuscular dosage of 0.1 mg/kg of xylazine was administered to the calves as premedication. Induction was performed 10 min after calves were given an intramuscular dosage of 4 mg/kg of ketamine. Inhalation anesthesia was maintained with isoflurane or sevoflurane in 100% oxygen saturation. Before anesthesia, after induction and at intervals of 5, 10, 15, 20, 25, 30, 45, and 60 min of anesthesia, the body temperature, heart rate, and respiratory rate of the calves were recorded. Additionally, before anesthesia, after induction and at intervals of 15, 30, 45, and 60 min of anesthesia, serum electrolyte (Na+, Ca++, K+, Mg++) and blood gases (pH, pCO2, pO2, HCO3-, TCO2, O2Sat, HCT) were evaluated from blood samples taken from both gr