Perforated duodenal ulcer associated with nonsteroidal antiinflammatory drug administration in a dairy cow

A case report of perforated duodenal ulcer in a 4.5 year-old Holstein cow is presented. The cow was treated with an overdose of diclofenac sodium. Necropsy findings included diffuse fibrinous peritonitis and microscopically there was severe necrosis and acute inflammation of the duodenum at the margin of the ulcer. Although gastrointestinal ulcers are often associated with non-steroidal anti-inflammatory drugs in others species, it is rarely described in cattle.