Resumo
Background: The carotid artery transposition may be used in research when continuous measurements of arterial pressureor serial blood sampling are needed. In sheep, this procedure has usually been performed under inhalational or barbiturateanesthesia; however, these anesthetic techniques may cause cardiorespiratory depression and delayed recovery. Conversely,propofol is a general anesthetic that promotes rapid induction, smooth recovery, and hemodynamic stability. The aim ofthis study was to assess physiological and anesthetic effects of total intravenous anesthesia with propofol to establish itssafety and efficacy for performing permanent carotid transposition, in sheep.Materials, Methods & Results: Seven young healthy ewes, weighing 35.00 ± 4.43 kg and subjected to a new techniqueof permanent transposition of the carotid artery were used. Propofol was administered by constant rate infusion (0.5 mg/kg/min; IV) after anesthetic induction with this same drug. Heart rate (HR), cardiac rhythm, oxyhemoglobin saturation(SpO2), respiratory rate (f), rectal temperature (RT), systolic arterial pressure (SAP), and venous blood gas parameters(SvO2, PvO2, PvCO2, and HCO3-) were evaluated before induction and every 10 min up to 1 h of anesthesia. Recoveryperiod was also evaluated. Data were submitted to Shapiro-Wilk normality test followed by one-way repeated measuresanalysis of variance and Tukey-Kramer multiple comparisons test (P < 0.05) to analyze possible effects over time. Therewas no occurrence of apnea or regurgitation after anesthetic induction; however, all sheep presented hypersalivation. Inrelation to baseline, HR was greater at 10 min, whereas PvO2, PvCO2, and SvO2 increased at all evaluation points, andHCO3- was higher at 40 min and 60 min. There was a decrease in RT from 20 min to 60 min...(AU)
Assuntos
Animais , Ovinos , Anestesia Intravenosa/veterinária , Propofol , Artérias Carótidas/cirurgiaResumo
Background: The carotid artery transposition may be used in research when continuous measurements of arterial pressureor serial blood sampling are needed. In sheep, this procedure has usually been performed under inhalational or barbiturateanesthesia; however, these anesthetic techniques may cause cardiorespiratory depression and delayed recovery. Conversely,propofol is a general anesthetic that promotes rapid induction, smooth recovery, and hemodynamic stability. The aim ofthis study was to assess physiological and anesthetic effects of total intravenous anesthesia with propofol to establish itssafety and efficacy for performing permanent carotid transposition, in sheep.Materials, Methods & Results: Seven young healthy ewes, weighing 35.00 ± 4.43 kg and subjected to a new techniqueof permanent transposition of the carotid artery were used. Propofol was administered by constant rate infusion (0.5 mg/kg/min; IV) after anesthetic induction with this same drug. Heart rate (HR), cardiac rhythm, oxyhemoglobin saturation(SpO2), respiratory rate (f), rectal temperature (RT), systolic arterial pressure (SAP), and venous blood gas parameters(SvO2, PvO2, PvCO2, and HCO3-) were evaluated before induction and every 10 min up to 1 h of anesthesia. Recoveryperiod was also evaluated. Data were submitted to Shapiro-Wilk normality test followed by one-way repeated measuresanalysis of variance and Tukey-Kramer multiple comparisons test (P < 0.05) to analyze possible effects over time. Therewas no occurrence of apnea or regurgitation after anesthetic induction; however, all sheep presented hypersalivation. Inrelation to baseline, HR was greater at 10 min, whereas PvO2, PvCO2, and SvO2 increased at all evaluation points, andHCO3- was higher at 40 min and 60 min. There was a decrease in RT from 20 min to 60 min...
Assuntos
Animais , Anestesia Intravenosa/veterinária , Artérias Carótidas/cirurgia , Ovinos , PropofolResumo
O objetivo deste estudo foi realizar a avaliação anestésica e registrar os possíveis efeitos sobre as variáveis fisiológicas da administração intratecal de ropivacaína isolada ou associada à metadona, em ovinos saudáveis. Para tanto, foram utilizadas sete ovelhas, adultas, da raça Santa Inês, com peso corporal de 47,8 ± 4,65 kg, as quais foram alocadas em dois grupos de dez indivíduos. Os animais receberam, por via intratecal, 0,5 mg/kg de ropivacaína 0,75% (grupo R) ou 0,5 mg/kg deste fármaco associado a 0,1 mg/kg de metadona 1% (grupo RMet). Os volumes finais aplicados foram ajustados para 0,15 mL/kg nos dois grupos com solução fisiológica a 0,9% e as ovelhas foram reutilizadas após o intervalo de um mês. As variáveis fisiológicas frequência cardíaca (FC), frequência respiratória (f), temperatura retal (TR), movimento ruminal (MR), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), bem como alguns parâmetros hemogasométricos arteriais (PaO2, PaCO2, pH e HCO3-), foram avaliados a cada 10 minutos durante o período de duas horas (T0 a T120). Paralelamente, o período de latência (PL), a extensão do bloqueio (EB), o tempo de bloqueio sensitivo (BS), o tempo de bloqueio motor (BM) e o período hábil anestésico (PHA) também foram avaliados. Os dados obtidos, quando paramétricos, foram submetidos à análise de variância para medidas repetidas e teste de Tukey (P?0,05). Para os dados não paramétricos, empregou-se o teste Mann Whitney seguido do teste de Dunn (P<0,05). Não foram evidenciadas diferenças significativas relativas a avaliação anestésica, a qual revelou que nos dois grupos o PL foi imediato e os valores de BS e BM foram de aproximadamente 155 minutos. Além disso, pôde ser observada uma diminuição da FC e da MR nos dois grupos, enquanto que a TR aumentou apenas em RM. Na análise gasométrica, o grupo RMet apresentou maiores valores de PaCO2 e HCO3- no intervalo entre T50, T90 e nos momentos T50 e T90, respectivamente. A ropivacaína, isolada ou em associação à metadona, foi eficaz para a anestesia intratecal e não provocou efeitos prejudiciais nas variáveis fisiológicas avaliadas, podendo ser empregada com segurança na espécie ovina