Metastatic squamous cell carcinoma in a horse / Carcinoma de células escamosas metastático em um equino

Background: Squamous cell carcinoma is a relatively commum cutaneous neoplasia in a horse, originated mainly in external genitalia, periocular region, especially, eyelids and oral cavitity. Squamous cell carcinoma metastasis was considered rare. Depigmentation, ultraviolet light exposure and actinic acantosis were considered etiopathologic factors. The squamous cell carcinoma rarely metastasizing however causes severely local invasion. The diagnosis confirmation just was done for histopathological and citopathological exams. The following report outlines clinical and pathological findings of a case of a metastatic squamous cell carcinoma to multiple sites in a horse revealed after anatomopathological exam. Case: The case consisted of a 10-month old Appaloosa x Mangalarga horse whose owners main complaint was a multiple ulcerative tumor in the nasal region of the animal. The horse presented depigmented libs, narines, prepuce and peniane tegument. The lesion beginning at 12 months and the horse presented sneezing and intermittent epistaxis of the right narine and moderated sialorheia. During clinical evaluation, the animal presented discrete dispneia e severe emaciation. The tumor invaded into deep inner nasal cavity, causing partial stenosis of the nasal passage of the left nasal cavity. However, stenosis and bleeding is not allowed to specify the compromised extension...(AU)

Metastatic squamous cell carcinoma in a horse / Carcinoma de células escamosas metastático em um equino

Background: Squamous cell carcinoma is a relatively commum cutaneous neoplasia in a horse, originated mainly in external genitalia, periocular region, especially, eyelids and oral cavitity. Squamous cell carcinoma metastasis was considered rare. Depigmentation, ultraviolet light exposure and actinic acantosis were considered etiopathologic factors. The squamous cell carcinoma rarely metastasizing however causes severely local invasion. The diagnosis confirmation just was done for histopathological and citopathological exams. The following report outlines clinical and pathological findings of a case of a metastatic squamous cell carcinoma to multiple sites in a horse revealed after anatomopathological exam. Case: The case consisted of a 10-month old Appaloosa x Mangalarga horse whose owners main complaint was a multiple ulcerative tumor in the nasal region of the animal. The horse presented depigmented libs, narines, prepuce and peniane tegument. The lesion beginning at 12 months and the horse presented sneezing and intermittent epistaxis of the right narine and moderated sialorheia. During clinical evaluation, the animal presented discrete dispneia e severe emaciation. The tumor invaded into deep inner nasal cavity, causing partial stenosis of the nasal passage of the left nasal cavity. However, stenosis and bleeding is not allowed to specify the compromised extension...

Metástase múltipla de carcinoma de células escamosas ocular em bovino: dois casos / Multiple metastasis of eye squamous cell carcinoma in cattle: two cases

Dentre os diversos tumores que acometem bovinos, o carcinoma de células escamosas ocular é o mais frequente nessa espécie,determinando prejuízos consideráveis nos criatórios. São vários os fatores envolvidos na patogênese, porém a constante exposiçãoà luz ultravioleta e a quantidade reduzida de pigmentação em torno dos olhos estão relacionados com a maior prevalência. Aneoplasia ocorre principalmente na pálpebra inferior, membrana nictitante e a junção corneoescleral. São descritos dois casosincomuns de carcinoma de células escamosas oculares que resultaram em metástases múltiplas para linfonodo regional, glândulassalivares e pulmão em vacas criadas do Sudoeste de Goiás. Histopatologia de todos os casos revelou proliferação de blocoshipercelulares de queratinócitos neoplásicos. As células possuíam citoplasma amplo e eosinofílico, núcleo arredondado, centrale basofílico, com cromatina frouxa e um a dois nucléolos grandes e proeminentes. Havia anisocariose e anisocitose acentuadase sete a dez mitoses em dez campos de 400X. Exposição prolongada aos raios solares e despigmentação dos tecidos primáriosafetados foram considerados fatores predisponentes importantes.(AU)

Among the various tumor affecting cattle, ocular squamous cell carcinoma is the most common in this species, causing considerablelosses to farms. Several factors involved in the pathogenesis, but constant exposure to ultraviolet light and the reduced amountof pigmentation around the eyes are related to higher prevalence. The tumor occurs mainly in the lower eyelid, the nictitatingmembrane and corneoescleral junction. Two unusual cases of ocular squamous cell carcinoma that resulted in multiple metastasesto regional lymph node, salivary gland and lung in cows created in southwest Goiás. Histopathology exams of all cases revealedhypercellular proliferation of neoplastic keratinocytes blocks. Cells had broad and eosinophilic cytoplasm, rounded nuclei and centralbasophilic, with loose chromatin and one to two large and prominent nucleoli. There was marked anisocytosis and anisokaryosisseven to ten mitoses in ten 400X fields. Prolonged exposure to sunlight and depigmentation of the affected primary tissues wereconsidered important predisposing factors.(AU)