Gastrointestinal stromal tumor associated with hypertrophic osteopathy in a dog

Background: Gastrointestinal stromal tumor (GIST) is a malignant mesenchymal neoplasm rarely described in the veterinary routine. The aim of this study was to report a case of GIST accompanied by a periosteal reaction, suggestive ofhypertrophic osteopathy, in a dog.Case: An 11-year-old male dog had a history of progressive weight loss, difficulty in locomotion, and dyspnea. During clinical care, increased bone volume was observed. Blood samples were collected for a complete blood count and biochemicalanalysis. The dog also underwent thoracic radiography and abdominal ultrasonography. The test results revealed anemia,leukocytosis, hypocalcemia, hypoalbuminemia, and hypocholesterolemia. The radiographic images of the limbs showeda generalized periosteal reaction, and thoracic radiography indicated changes compatible with mild chronic lung disease.Ultrasonographic findings indicated a neoformation in the intestinal loop of the right mesogastric region and increasedvolume in the left testicle, both of which were indicative of neoplasia. Therefore, the dog was referred for surgery, whereinthe intestinal mass and both testes were removed; the intestinal mass and left testicle were subjected to histopathologicaldiagnosis. The results of the biopsies confirmed that the testicular neoplasm was a seminoma, whereas the intestinal nodulewas compatible with GIST, and immunohistochemical analysis was necessary to confirm the diagnosis. On the basis ofpositive labeling for the antibodies vimentin, desmin, S100, and c-kit, the diagnosis of GIST was confirmed. Therefore,the animal underwent metronomic chemotherapy with 12 mg/m2 cyclophosphamide every 24 h for 3 months, and thereafter every 48 h for 6 months. Moreover, the dog was periodically monitored via imaging (radiography of the anteriorand posterior limbs, abdominal ultrasonography, and computed tomography)...

Gastrointestinal stromal tumor associated with hypertrophic osteopathy in a dog

Background: Gastrointestinal stromal tumor (GIST) is a malignant mesenchymal neoplasm rarely described in the veterinary routine. The aim of this study was to report a case of GIST accompanied by a periosteal reaction, suggestive ofhypertrophic osteopathy, in a dog.Case: An 11-year-old male dog had a history of progressive weight loss, difficulty in locomotion, and dyspnea. During clinical care, increased bone volume was observed. Blood samples were collected for a complete blood count and biochemicalanalysis. The dog also underwent thoracic radiography and abdominal ultrasonography. The test results revealed anemia,leukocytosis, hypocalcemia, hypoalbuminemia, and hypocholesterolemia. The radiographic images of the limbs showeda generalized periosteal reaction, and thoracic radiography indicated changes compatible with mild chronic lung disease.Ultrasonographic findings indicated a neoformation in the intestinal loop of the right mesogastric region and increasedvolume in the left testicle, both of which were indicative of neoplasia. Therefore, the dog was referred for surgery, whereinthe intestinal mass and both testes were removed; the intestinal mass and left testicle were subjected to histopathologicaldiagnosis. The results of the biopsies confirmed that the testicular neoplasm was a seminoma, whereas the intestinal nodulewas compatible with GIST, and immunohistochemical analysis was necessary to confirm the diagnosis. On the basis ofpositive labeling for the antibodies vimentin, desmin, S100, and c-kit, the diagnosis of GIST was confirmed. Therefore,the animal underwent metronomic chemotherapy with 12 mg/m2 cyclophosphamide every 24 h for 3 months, and thereafter every 48 h for 6 months. Moreover, the dog was periodically monitored via imaging (radiography of the anteriorand posterior limbs, abdominal ultrasonography, and computed tomography)...(AU)

Hemangiossarcoma cardíaco primário em cão - relato de caso / Primary cardiac hemangiosarcoma in a dog - case report / Hemangiosarcoma cardiaco primario en perro - relato de caso

Tumores cardíacos são pouco frequentes em cães. De etiologia desconhecida, acredita-se que existam fatores genéticos que influenciem o aparecimento desse tipo de neoplasia. No estágio inicial, não provocam sinais clínicos relevantes, mas à medida que o tumor primário avança, haverá compromisso da função cardíaca. Esses tumores podem ser confundidos com quadros de insuficiência cardíaca congestiva. O hemangiossarcoma é uma das neoplasias cardíacas mais frequentes e pode ter diversas localizações, porém geralmente acomete o átrio direito. As neoplasias cardíacas não costumam provocar metástases, porém indicam mau prognóstico para os pacientes. As alternativas terapêuticas, quando possíveis, incluem a cirurgia e a quimioterapia. O objetivo do presente trabalho foi relatar um caso de hemangiossarcoma cardíaco primário numa cadela dachshund de pelo duro de oito anos, detalhando as alterações clínicas encontradas, os exames complementares realizados e a confirmação diagnóstica final por meio da necropsia e do exame histopatológico.

Cardiac tumors are uncommon in dogs. Their etiology is unknown, and it is believed that genetic factors may have an influence on the appearance of this type of neoplasia. At the initial stage, they do not cause relevant clinical signs, but as the primary tumor progresses, cardiac function is affected. These tumors may be confused with congestive heart failure. Hemangiosarcoma is one of the most frequent cardiac neoplasms and may have several locations, but it usually affects the right atrium. Cardiac neoplasms do not usually metastasize, but have poor prognosis for patients. Therapeutic alternatives, when possible, include surgery and chemotherapy. The objective of the present study was to report a case of primary cardiac hemangiosarcoma in an eight-year-old Dachshund bitch, presenting the clinical alterations found, the complementary exams performed and the final diagnostic confirmation through necropsy and histopathological examination.

Los tumores cardíacos son poco frecuentes en perros. Si bien su etiología es desconocida, se cree que existen factores genéticos relacionados con la presentación de este tipo de tumores. En estadios iniciales no suelen provocar signos clínicos relevantes, pero a medida que el tumor crece, habrá un compromiso de la función cardíaca. Este tipo de tumores pueden ser confundidos con cuadros de insuficiencia cardíaca congestiva. El hemangiosarcoma es una de las neoplasias cardíacas más frecuentes y, si bien puede tener diferentes localizaciones, suele afectar más el atrio derecho. Las neoplasias cardíacas no suelen dar metástasis; no obstante, estos pacientes tienen mal pronóstico. Las alternativas terapéuticas, cuando pueden ser realizadas, incluyen la cirugía y la quimioterapia. El objetivo del presente trabajo fue relatar el caso de una perra Dachshund pelo duro de ocho años que presentó un hemangiosarcoma cardíaco primario, detallándose las alteraciones clínicas encontradas, los exámenes complementarios realizados y su confirmación diagnóstica final por necropsia y examen histopatológico.

Hemangiossarcoma cardíaco primário em cão - relato de caso / Primary cardiac hemangiosarcoma in a dog - case report / Hemangiosarcoma cardiaco primario en perro - relato de caso

Tumores cardíacos são pouco frequentes em cães. De etiologia desconhecida, acredita-se que existam fatores genéticos que influenciem o aparecimento desse tipo de neoplasia. No estágio inicial, não provocam sinais clínicos relevantes, mas à medida que o tumor primário avança, haverá compromisso da função cardíaca. Esses tumores podem ser confundidos com quadros de insuficiência cardíaca congestiva. O hemangiossarcoma é uma das neoplasias cardíacas mais frequentes e pode ter diversas localizações, porém geralmente acomete o átrio direito. As neoplasias cardíacas não costumam provocar metástases, porém indicam mau prognóstico para os pacientes. As alternativas terapêuticas, quando possíveis, incluem a cirurgia e a quimioterapia. O objetivo do presente trabalho foi relatar um caso de hemangiossarcoma cardíaco primário numa cadela dachshund de pelo duro de oito anos, detalhando as alterações clínicas encontradas, os exames complementares realizados e a confirmação diagnóstica final por meio da necropsia e do exame histopatológico.(AU)

Cardiac tumors are uncommon in dogs. Their etiology is unknown, and it is believed that genetic factors may have an influence on the appearance of this type of neoplasia. At the initial stage, they do not cause relevant clinical signs, but as the primary tumor progresses, cardiac function is affected. These tumors may be confused with congestive heart failure. Hemangiosarcoma is one of the most frequent cardiac neoplasms and may have several locations, but it usually affects the right atrium. Cardiac neoplasms do not usually metastasize, but have poor prognosis for patients. Therapeutic alternatives, when possible, include surgery and chemotherapy. The objective of the present study was to report a case of primary cardiac hemangiosarcoma in an eight-year-old Dachshund bitch, presenting the clinical alterations found, the complementary exams performed and the final diagnostic confirmation through necropsy and histopathological examination.(AU)

Los tumores cardíacos son poco frecuentes en perros. Si bien su etiología es desconocida, se cree que existen factores genéticos relacionados con la presentación de este tipo de tumores. En estadios iniciales no suelen provocar signos clínicos relevantes, pero a medida que el tumor crece, habrá un compromiso de la función cardíaca. Este tipo de tumores pueden ser confundidos con cuadros de insuficiencia cardíaca congestiva. El hemangiosarcoma es una de las neoplasias cardíacas más frecuentes y, si bien puede tener diferentes localizaciones, suele afectar más el atrio derecho. Las neoplasias cardíacas no suelen dar metástasis; no obstante, estos pacientes tienen mal pronóstico. Las alternativas terapéuticas, cuando pueden ser realizadas, incluyen la cirugía y la quimioterapia. El objetivo del presente trabajo fue relatar el caso de una perra Dachshund pelo duro de ocho años que presentó un hemangiosarcoma cardíaco primario, detallándose las alteraciones clínicas encontradas, los exámenes complementarios realizados y su confirmación diagnóstica final por necropsia y examen histopatológico. (AU)