Evaluation of intraperitoneal and incisional bupivacaine or levobupivacaine for postoperative analgesia in ovariohysterectomized dogs

Background: Ovariohysterectomy (OHE) is the most commonly performed elective surgical procedure in companionanimals. OHE offers benefits of control of population and decreased risk of potentially life-threatening diseases such asmammarian tumours and pyometra. Traditional OHE intervention causes inflammation and pain due to trauma duringorgan manipulation. The purpose of this study was to compare the effect of intraperitoneal and incisional administrationof bupivacaine (BP) or levobupivacaine (LP) on postoperative analgesia in dogs undergoing the OHE procedure.Materials, Methods & Results: A total of 24 mix-breed bitches aged between 1 - 3 years and weighed 19 - 20 kg wereused in this study. The animals were divided into three groups as control (n = 8), BP (n = 8) and LP group (n = 8). Theanimals were kept under surveillance at the hospitalisation unit of the animal hospital for one day before the elective OHE.The dogs were fasted for 12 h before the surgery, with adlib water consumption. Atropine sulphate 0.045 mg/kg was administered subcutaneously approximately 30 min before general anaesthesia. Midazolam (0.3 mg/kg) was intravenouslyinjected into all dogs for pre-anaesthetic medication. After sedation, anaesthesia was induced with propofol (4 mg/kg, IV)and then the dogs were orotracheally intubated using cuffed endotracheal tubes. General anaesthesia was maintained byadministration of 2% isoflurane. The ventral abdomen was prepared aseptically for OHE following the general anaesthesia.All animals were operated on by the same surgeon. During surgery, sprayed bupivacaine 0.5% (4.4 mg/kg) with an equalvolume of saline in BP group, levobupivacaine 0.5% (4.4 mg/kg) with an equal volume of saline in LP were then appliedover the ovaries, uterine broad ligaments and cervix uteri. After removal of the uterine body, either LP or BP was sprayedto left and right, or cranial and caudal parts of the abdominal cavity...

Evaluation of intraperitoneal and incisional bupivacaine or levobupivacaine for postoperative analgesia in ovariohysterectomized dogs

Background: Ovariohysterectomy (OHE) is the most commonly performed elective surgical procedure in companionanimals. OHE offers benefits of control of population and decreased risk of potentially life-threatening diseases such asmammarian tumours and pyometra. Traditional OHE intervention causes inflammation and pain due to trauma duringorgan manipulation. The purpose of this study was to compare the effect of intraperitoneal and incisional administrationof bupivacaine (BP) or levobupivacaine (LP) on postoperative analgesia in dogs undergoing the OHE procedure.Materials, Methods & Results: A total of 24 mix-breed bitches aged between 1 - 3 years and weighed 19 - 20 kg wereused in this study. The animals were divided into three groups as control (n = 8), BP (n = 8) and LP group (n = 8). Theanimals were kept under surveillance at the hospitalisation unit of the animal hospital for one day before the elective OHE.The dogs were fasted for 12 h before the surgery, with adlib water consumption. Atropine sulphate 0.045 mg/kg was administered subcutaneously approximately 30 min before general anaesthesia. Midazolam (0.3 mg/kg) was intravenouslyinjected into all dogs for pre-anaesthetic medication. After sedation, anaesthesia was induced with propofol (4 mg/kg, IV)and then the dogs were orotracheally intubated using cuffed endotracheal tubes. General anaesthesia was maintained byadministration of 2% isoflurane. The ventral abdomen was prepared aseptically for OHE following the general anaesthesia.All animals were operated on by the same surgeon. During surgery, sprayed bupivacaine 0.5% (4.4 mg/kg) with an equalvolume of saline in BP group, levobupivacaine 0.5% (4.4 mg/kg) with an equal volume of saline in LP were then appliedover the ovaries, uterine broad ligaments and cervix uteri. After removal of the uterine body, either LP or BP was sprayedto left and right, or cranial and caudal parts of the abdominal cavity...(AU)

Effect of exogenous progesterone on success of Ovsynch protocol in dairy cows with ovarian cyst

Background: It has been suggested that unresponsiveness of the hypothalamus to increasing estradiol may be an underlying mechanism in the development of ovarian cysts which may be treated with progesterone. Therefore, this study was designed to compare the effectiveness of Ovsynch and Ovsynch modifi ed with progesterone releasing intravaginal device (PRID) for the treatment of ovarian cysts that cause important economic in Holstein dairy cows.Materials, Methods & Results: Cows with ovarian cysts (n = 33) were divided into randomly Ovsynch (Ov) (n = 9) and Modifi ed Ovsynch (MOv) (n = 9) groups for follicular cysts and Ov (n = 7) and MOv (n = 8) groups for luteal cyst. Ov group were treated with im GnRH on Day 0, im PGF2 on Day 7, im GnRH on Day 9 and then were time-inseminated 18 h later. MOv group were treated with Ov protocol combined with PRID from Day 0 to 7. Data obtained by transrectal ultrasonography on Day 0, 7, 10, 17, 31 and 45 and progesterone (P4) and 17-estradiole (E2) concentrations in blood samples collected on Day 0, 7, 10, 17 and 31 were evaluated. The treatments resulted in regression, increased diameter or no changes in ultrasonic appearance in OV group in 2 (22%), 5 (56%) and 2 (22%) cows with follicular cyst and in 4 (57%), 2 (29%) and 1 (14%) cows with luteal cyst, respectively. MOv group showed regression, increased diameter or no changes...(AU)

Effect of exogenous progesterone on success of Ovsynch protocol in dairy cows with ovarian cyst

Background: It has been suggested that unresponsiveness of the hypothalamus to increasing estradiol may be an underlying mechanism in the development of ovarian cysts which may be treated with progesterone. Therefore, this study was designed to compare the effectiveness of Ovsynch and Ovsynch modifi ed with progesterone releasing intravaginal device (PRID) for the treatment of ovarian cysts that cause important economic in Holstein dairy cows.Materials, Methods & Results: Cows with ovarian cysts (n = 33) were divided into randomly Ovsynch (Ov) (n = 9) and Modifi ed Ovsynch (MOv) (n = 9) groups for follicular cysts and Ov (n = 7) and MOv (n = 8) groups for luteal cyst. Ov group were treated with im GnRH on Day 0, im PGF2 on Day 7, im GnRH on Day 9 and then were time-inseminated 18 h later. MOv group were treated with Ov protocol combined with PRID from Day 0 to 7. Data obtained by transrectal ultrasonography on Day 0, 7, 10, 17, 31 and 45 and progesterone (P4) and 17-estradiole (E2) concentrations in blood samples collected on Day 0, 7, 10, 17 and 31 were evaluated. The treatments resulted in regression, increased diameter or no changes in ultrasonic appearance in OV group in 2 (22%), 5 (56%) and 2 (22%) cows with follicular cyst and in 4 (57%), 2 (29%) and 1 (14%) cows with luteal cyst, respectively. MOv group showed regression, increased diameter or no changes...