Administration of curcumin affects the anxiety behavior in Wistar rats after formaldehyde injected

The curcumin is part of the curcuminoids family. Present in the spice turmeric is a vegetable alkaloid obtained from Curcuma longa. Many studies have been carried out to describe the multiple biological actions of curcumin. The positive antidepressant and anti-anxiety effects of curcumin are most likely due to its ability to normalize specific physiological mechanisms, in addition to being a potent antioxidant and anti-inflammatory agent. Curcumin also protects the brain and simultaneously acts on several mechanisms related to depression. It is considered to be the most promising therapeutic target for treating depressive behaviors. Through this work, we will prove the protective effect of curcumin on the anxious behavior of Wistar rats and the complications induced by the administration of a toxic product that is formaldehyde. To this fact, 25 white rats of Wistar strains (250±50 g) were separated into five experimental batches: control batch (T; n = 5),vehicle control batch (CV; n = 5), Curcumin control batch (CC; n = 5), one batch formaldehyde vehicle (FV; n = 5) and one batch formaldehyde Curcumin (FC; n = 5). A single intraperitoneal injection carried out the formaldehyde administration diluted in distilled water at a dose of 10 mg/kg. Turmeric dissolved in olive oil was administered by gastric gavage at a dose of (60 mg/kg). Our results show the therapeutic benefits of curcumin against the deficits caused by formaldehyde reflected in a disturbance in rat behavior and degree of anxiety using the open-field test and the light and dark box test.(AU)

Administration of curcumin affects the anxiety behavior in Wistar rats after formaldehyde injected

The curcumin is part of the curcuminoids family. Present in the spice turmeric is a vegetable alkaloid obtained from Curcuma longa. Many studies have been carried out to describe the multiple biological actions of curcumin. The positive antidepressant and anti-anxiety effects of curcumin are most likely due to its ability to normalize specific physiological mechanisms, in addition to being a potent antioxidant and anti-inflammatory agent. Curcumin also protects the brain and simultaneously acts on several mechanisms related to depression. It is considered to be the most promising therapeutic target for treating depressive behaviors. Through this work, we will prove the protective effect of curcumin on the anxious behavior of Wistar rats and the complications induced by the administration of a toxic product that is formaldehyde. To this fact, 25 white rats of Wistar strains (250±50 g) were separated into five experimental batches: control batch (T; n = 5),vehicle control batch (CV; n = 5), Curcumin control batch (CC; n = 5), one batch formaldehyde vehicle (FV; n = 5) and one batch formaldehyde Curcumin (FC; n = 5). A single intraperitoneal injection carried out the formaldehyde administration diluted in distilled water at a dose of 10 mg/kg. Turmeric dissolved in olive oil was administered by gastric gavage at a dose of (60 mg/kg). Our results show the therapeutic benefits of curcumin against the deficits caused by formaldehyde reflected in a disturbance in rat behavior and degree of anxiety using the open-field test and the light and dark box test.

Activity and rest alternation: temporal distribution and influencing factors in nocturnal rodents

Lifestyle and heredity are two different terms but yet closely related components. An evaluation for the time invested in sleep and locomotion behaviors per second in the Wistar rats animal model was carried out. A total of six rats within the same cage were marked by color in a room supported by the days light (12h lighting/12h darkness). These animals were filmed for 18 h daily for ten days (9h lighting, 9h darkness) to estimate the time budget of sleep and locomotion behaviors and the temporal distribution taking into account the nature of this biological models activity. The results obtained reveal sleeping/locomotion cycles respecting the natural photoperiod except for a rat that shows dominance in nocturnal sleep compared to the rest of the rats. These advances support a change in photoperiodic behavior in response to an adaptation to the rhythm imposed by the manipulator. They invite studies on a larger sample to consolidate this behavior controlled by the environment.(AU)

Activity and rest alternation: temporal distribution and influencing factors in nocturnal rodents

Lifestyle and heredity are two different terms but yet closely related components. An evaluation for the time invested in sleep and locomotion behaviors per second in the Wistar rats animal model was carried out. A total of six rats within the same cage were marked by color in a room supported by the day’s light (12h lighting/12h darkness). These animals were filmed for 18 h daily for ten days (9h lighting, 9h darkness) to estimate the time budget of sleep and locomotion behaviors and the temporal distribution taking into account the nature of this biological model’s activity. The results obtained reveal sleeping/locomotion cycles respecting the natural photoperiod except for a rat that shows dominance in nocturnal sleep compared to the rest of the rats. These advances support a change in photoperiodic behavior in response to an adaptation to the rhythm imposed by the manipulator. They invite studies on a larger sample to consolidate this behavior controlled by the environment.