Avaliação parasitológica de fezes diarreicas e não diarreicas em leitões na fase pré-inicial / (Parasitological evaluation of non-diarrheal and diarrheal feces in piglets at pre-initial phase

Os helmintos gastrintestinais podem afetar o desempenho dos leitões e causar diarreias na fase de creche, um dos grandes desafios enfrentados na produção. Logo, o acompanhamento parasitológico é fundamental para que seja realizado o diagnóstico do grau de infecção animal para se tomar as medidas curativas e preventivas corretas. Portanto objetivou-se analisar as fezes de leitões com e sem diarreia na fase pré-inicial e sua relação com a presença de ovos de parasitas. As coletas foram realizadas em uma granja comercial de suínos, em que 40 animais foram escolhidos aleatoriamente e divididos igualmente em dois grupos, com e sem diarreia. As amostras foram analisadas pelo exame de direto das fezes e pelo método de flutuação. Das amostras analisadas, todas mostraram se negativas para o grupo sem diarreia. No entanto os animais com diarreia apresentaram prevalência de 10% e 5% quanto à presença de parasitoses gastrintestinais nos métodos direto e de flutuação respectivamente. Foram detectados: Ascaris sp., Strongyloides sp., Cystoisospora sp. e Eimeria spp. Dada a origem multifatorial das diarreias em leitões no pós-desmame, conclui-se que as diarreias de leitões na fase pré-inicial não estão somente relacionadas à presença de endoparasitos, dessa forma, outras possíveis causas devem ser estudadas para que haja um maior controle dos distúrbios entéricos nesta fase.

Gastrointestinal nematodes can affect piglet performance, causing diarrhea in the nursery phase, one of the major challenges faced in production. Therefore, parasitological monitoring is essential for the diagnosis of the degree of animal infection in order to take the right curative and preventive measures. Therefore, the objective was to analyze the feces of piglets with and without diarrhea in the pre-initial phase and their relationship with the presence of parasite eggs. The collections were carried out in a commercial pig farm, in which 40 animals were randomly chosen and divided equally into two groups, with and without diarrhea. The samples were analyzed by direct stool examination and the flotation method. Of the analyzed samples, all were negative for the group without diarrhea. However, animals with diarrhea had a prevalence of 10% and 5% regarding the presence of gastrointestinal parasites at direct and flotation method, respectively. Ascaris sp., Strongyloides sp., Cystoisosporasp. and Eimeria spp. were detected. Given the multifactorial origin of diarrhea in piglets in the post-weaning period, it is concluded that piglet diarrhea in the pre-initial phase is not only related to the presence of endoparasites, therefore, other possible causes must be studied so that there is a greater control of disorders enteric at this stage.

Avaliação parasitológica de fezes diarreicas e não diarreicas em leitões na fase pré-inicial / (Parasitological evaluation of non-diarrheal and diarrheal feces in piglets at pre-initial phase

Os helmintos gastrintestinais podem afetar o desempenho dos leitões e causar diarreias na fase de creche, um dos grandes desafios enfrentados na produção. Logo, o acompanhamento parasitológico é fundamental para que seja realizado o diagnóstico do grau de infecção animal para se tomar as medidas curativas e preventivas corretas. Portanto objetivou-se analisar as fezes de leitões com e sem diarreia na fase pré-inicial e sua relação com a presença de ovos de parasitas. As coletas foram realizadas em uma granja comercial de suínos, em que 40 animais foram escolhidos aleatoriamente e divididos igualmente em dois grupos, com e sem diarreia. As amostras foram analisadas pelo exame de direto das fezes e pelo método de flutuação. Das amostras analisadas, todas mostraram se negativas para o grupo sem diarreia. No entanto os animais com diarreia apresentaram prevalência de 10% e 5% quanto à presença de parasitoses gastrintestinais nos métodos direto e de flutuação respectivamente. Foram detectados: Ascaris sp., Strongyloides sp., Cystoisospora sp. e Eimeria spp. Dada a origem multifatorial das diarreias em leitões no pós-desmame, conclui-se que as diarreias de leitões na fase pré-inicial não estão somente relacionadas à presença de endoparasitos, dessa forma, outras possíveis causas devem ser estudadas para que haja um maior controle dos distúrbios entéricos nesta fase.(AU)

Gastrointestinal nematodes can affect piglet performance, causing diarrhea in the nursery phase, one of the major challenges faced in production. Therefore, parasitological monitoring is essential for the diagnosis of the degree of animal infection in order to take the right curative and preventive measures. Therefore, the objective was to analyze the feces of piglets with and without diarrhea in the pre-initial phase and their relationship with the presence of parasite eggs. The collections were carried out in a commercial pig farm, in which 40 animals were randomly chosen and divided equally into two groups, with and without diarrhea. The samples were analyzed by direct stool examination and the flotation method. Of the analyzed samples, all were negative for the group without diarrhea. However, animals with diarrhea had a prevalence of 10% and 5% regarding the presence of gastrointestinal parasites at direct and flotation method, respectively. Ascaris sp., Strongyloides sp., Cystoisosporasp. and Eimeria spp. were detected. Given the multifactorial origin of diarrhea in piglets in the post-weaning period, it is concluded that piglet diarrhea in the pre-initial phase is not only related to the presence of endoparasites, therefore, other possible causes must be studied so that there is a greater control of disorders enteric at this stage.(AU)

Impact of massage on goats on the human-animal relationship and parameters linked to physiological response / Impacto da massagem em cabras na relação homem-animal e parâmetros relacionados à resposta fisiológica

Considering the benefits that massage can promote, this research aimed to apply the stroking massage in five adult goats (G1-G5) assessed in group and individually for ten days. Parameters related to massage, immune system, physiology and behavior of goats were observed. There was only significant difference (P 0.05) regarding behavior expressed in the presence of the masseur in G4 and G5, between week 1 and 2. Most goats accepted massage, except G2, with greater demonstrations of positive than negative behavior towards the masseur. Therefore, stroking massage promoted positive interactions between the masseur and goats, and should be explored as an alternative method to those existing in improving the relationship between humans and farm animals.(AU)

Considerando os benefícios que a massagem pode promover, este trabalho teve como objetivo aplicar a massagem do tipo stroking em cinco cabras adultas (G1-G5) avaliadas em grupo e individualmente por dez dias. Parâmetros relacionados à massagem, sistema imunológico, fisiologia e comportamento das cabras foram observados. Houve apenas diferença significativa (P 0,05) em relação ao comportamento expresso na presença da massagista em G4 e G5, entre as semanas 1 e 2. A maioria das cabras aceitou a massagem, exceto G2, com maiores demonstrações de comportamentos positivos do que negativos direcionados à massagista. Portanto, a massagem do tipo stroking promoveu interações positivas entre a massagista e as cabras, devendo ser explorada como um método alternativo aos existentes na melhora da relação entre seres humanos e animais de produção.(AU)

Piodermite em uma cadela: um breve relato de caso

Piodermite é uma afecção da pele caracterizada por um processo inflamatório agudo ou até mesmo crônico. Ela é uma importante patologia na clínica veterinária e pode estar relacionada a presença de bactérias oportunistas e enfermidades de base. Objetivou-se relatar um caso de uma cadela com piodermite profunda. Uma cadela de 10 meses foi atendida em uma clínica particular apresentando prurido e um nódulo no focinho. Após o exame físico, foi solicitada uma citologia aspirativa. O resultado mostrou a presença de um grande número de neutrófilos, com raros linfócitos e macrófagos. Baseado nos sinais clínicos e os resultados da citologia, diagnosticou-se piodermite profunda no animal. Conclui-se, que o exame citológico foi essencial para se alcançar o diagnóstico de piodermite profunda. Essa enfermidade induziu alterações clínicas no animal que, se não tratada, poderia comprometer o seu bem-estar.(AU)

Pyoderma is a skin condition characterized by an acute or even chronic inflammatory process. It is an important pathology in the veterinary clinic and may be related to the presence of opportunistic bacteria and basic diseases. The objective of this study was to report a case of a dog with deep pyoderma. A 10-month bitch was seen in a private clinic with pruritus and a lump in the muzzle. After the physical examination, an aspiration cytology was requested. The result showed the presence of a large number of neutrophils, with rare lymphocytes and macrophages. Based on clinical signs and cytology results, deep pyoderma in the animal was diagnosed. It was concluded that the cytological examination was essential to reach the diagnosis of deep pyoderma. This disease induced clinical changes in the animal that, if untreated, could compromise its well-being.

Mupirocin pemphigus-like drug reaction in a dog

Background: Pharmacodermia is defined as adverse reaction in skin, mucosa and appendages, which generates morphofunctional alterations in cutaneous barrier, inducing autoimmune diseases, such as pemphigus foliaceous, which is known asthe most common autoimmune skin disease in dogs. This disease involves autoantibodies against desmoglein and desmocolinmolecules, being induced by the use of certain drugs. Mupirocin (pseudomonic acid A) is a broad-spectrum antibiotic withbacteriostatic activity, being effective against Gram-positive pathogens and used to control superficial bacterial folliculitis.Based on that, the aim of this study was to report a pemphigus-like lesions after topical use of mupirocin in dog.Case: An 1-year-old, uncastrated male, Poodle dog, weighing 13.8 kg was treated in a private clinic in Fortaleza. The maincomplaint was related to pruritus in abdominal and inguinal region, in addition of legs licking. Dermatological examination revealed melanic crusts, epidermal collars and diffuse pustules in inguinal, abdominal, perianal and thoraco-lumbarregions. The therapy was based on topical use of Mupirocin in form of 0.2% aquous spray. After drug administration, theanimal presented urticaria, diffuse epidermal collars, papulo-crusted and pustular lesions, which were more evident inabdominal and inguinal region. Nasal erythema, binocular blepharitis, apathy and fever were also observed. Cytologicalexamination and bacterial culture were performed, revealing inflammatory and acantholytic cells and no bacterial growth.Biopsy procedure revealed subcorneal pustule with presence of epithelial acantholytic cells and neutrophils, compatiblewith canine pemphigus foliaceous. The topical treatment of ocular lesions with 0.1% Tacrolimus associated with systemictreatment with high dose of prednisolone (1.2 mg kg-1)...

Mupirocin pemphigus-like drug reaction in a dog

Background: Pharmacodermia is defined as adverse reaction in skin, mucosa and appendages, which generates morphofunctional alterations in cutaneous barrier, inducing autoimmune diseases, such as pemphigus foliaceous, which is known asthe most common autoimmune skin disease in dogs. This disease involves autoantibodies against desmoglein and desmocolinmolecules, being induced by the use of certain drugs. Mupirocin (pseudomonic acid A) is a broad-spectrum antibiotic withbacteriostatic activity, being effective against Gram-positive pathogens and used to control superficial bacterial folliculitis.Based on that, the aim of this study was to report a pemphigus-like lesions after topical use of mupirocin in dog.Case: An 1-year-old, uncastrated male, Poodle dog, weighing 13.8 kg was treated in a private clinic in Fortaleza. The maincomplaint was related to pruritus in abdominal and inguinal region, in addition of legs licking. Dermatological examination revealed melanic crusts, epidermal collars and diffuse pustules in inguinal, abdominal, perianal and thoraco-lumbarregions. The therapy was based on topical use of Mupirocin in form of 0.2% aquous spray. After drug administration, theanimal presented urticaria, diffuse epidermal collars, papulo-crusted and pustular lesions, which were more evident inabdominal and inguinal region. Nasal erythema, binocular blepharitis, apathy and fever were also observed. Cytologicalexamination and bacterial culture were performed, revealing inflammatory and acantholytic cells and no bacterial growth.Biopsy procedure revealed subcorneal pustule with presence of epithelial acantholytic cells and neutrophils, compatiblewith canine pemphigus foliaceous. The topical treatment of ocular lesions with 0.1% Tacrolimus associated with systemictreatment with high dose of prednisolone (1.2 mg kg-1)...(AU)

Piodermite em uma cadela: um breve relato de caso

Piodermite é uma afecção da pele caracterizada por um processo inflamatório agudo ou até mesmo crônico. Ela é uma importante patologia na clínica veterinária e pode estar relacionada a presença de bactérias oportunistas e enfermidades de base. Objetivou-se relatar um caso de uma cadela com piodermite profunda. Uma cadela de 10 meses foi atendida em uma clínica particular apresentando prurido e um nódulo no focinho. Após o exame físico, foi solicitada uma citologia aspirativa. O resultado mostrou a presença de um grande número de neutrófilos, com raros linfócitos e macrófagos. Baseado nos sinais clínicos e os resultados da citologia, diagnosticou-se piodermite profunda no animal. Conclui-se, que o exame citológico foi essencial para se alcançar o diagnóstico de piodermite profunda. Essa enfermidade induziu alterações clínicas no animal que, se não tratada, poderia comprometer o seu bem-estar.

Pyoderma is a skin condition characterized by an acute or even chronic inflammatory process. It is an important pathology in the veterinary clinic and may be related to the presence of opportunistic bacteria and basic diseases. The objective of this study was to report a case of a dog with deep pyoderma. A 10-month bitch was seen in a private clinic with pruritus and a lump in the muzzle. After the physical examination, an aspiration cytology was requested. The result showed the presence of a large number of neutrophils, with rare lymphocytes and macrophages. Based on clinical signs and cytology results, deep pyoderma in the animal was diagnosed. It was concluded that the cytological examination was essential to reach the diagnosis of deep pyoderma. This disease induced clinical changes in the animal that, if untreated, could compromise its well-being.

Achados citopatológicos e ultrassonográficos de mastocitoma na bolsa escrotal em cão / Cytopathological and ultrasonographic findings of mastocytoma in a scrotal pouch in a dog

Mast cell tumors are the most common skin cancer in dogs. They are characterized by excessive proliferation of neoplastic mast cells. The areas of higher incidence are posterior region of the animal body, scrotum and flank. The diagnosis of mastocytoma is may have the aid of imaging tests such as ultrasonography, but it is essentially based on cytology. A dog was admitted to VETCLINIC for ultrasonographic and cytological examination of the scrotal region, because it was enlarged after orchiectomy procedure. Ultrasonographic examination revealed a heterogeneous echogenic image measuring 3.93 cm by 2.76 cm, showing regular and defined contours and with evident internal vascularity in Doppler mode suggestive of inflammatory process. In cytology, the sample of low cellularity consists of individualized round cells. Round to oval nucleus presenting coarse chromatin and sometimes evident nucleoli (1-2). Moderate to large cytoplasm with intense presence of granules of pink coloration. Intense anisocytosis and anisocariasis. Background of hemorrhagic blade with marked presence of granules, being the suggestive report, being the findings compatible with mastocytoma.

Achados citopatológicos e ultrassonográficos de mastocitoma na bolsa escrotal em cão / Cytopathological and ultrasonographic findings of mastocytoma in a scrotal pouch in a dog

Mast cell tumors are the most common skin cancer in dogs. They are characterized by excessive proliferation of neoplastic mast cells. The areas of higher incidence are posterior region of the animal body, scrotum and flank. The diagnosis of mastocytoma is may have the aid of imaging tests such as ultrasonography, but it is essentially based on cytology. A dog was admitted to VETCLINIC for ultrasonographic and cytological examination of the scrotal region, because it was enlarged after orchiectomy procedure. Ultrasonographic examination revealed a heterogeneous echogenic image measuring 3.93 cm by 2.76 cm, showing regular and defined contours and with evident internal vascularity in Doppler mode suggestive of inflammatory process. In cytology, the sample of low cellularity consists of individualized round cells. Round to oval nucleus presenting coarse chromatin and sometimes evident nucleoli (1-2). Moderate to large cytoplasm with intense presence of granules of pink coloration. Intense anisocytosis and anisocariasis. Background of hemorrhagic blade with marked presence of granules, being the suggestive report, being the findings compatible with mastocytoma.(AU)

Reação farmacodérmica após administração tópica de Mupirocina em cão / Cutaneous adverse drug reaction after topical administration of Mupirocin in dog

Pharmacodermia is defined as adverse reaction in skin, mucosa and appendages, capable of generating morpho-functional alterations in cutaneous barrier. The purpose of this study was to report a cutaneous adverse drug reaction after topical use of mupirocin in dog. The diagnosis was made through clinical-cytological analyzes. The therapy involved topical and systemic immunomodulatory drugs. Therefore, it is concluded that Mupirocin is capable of generating pharmacodermic reactions.

Reação farmacodérmica após administração tópica de Mupirocina em cão / Cutaneous adverse drug reaction after topical administration of Mupirocin in dog

Pharmacodermia is defined as adverse reaction in skin, mucosa and appendages, capable of generating morpho-functional alterations in cutaneous barrier. The purpose of this study was to report a cutaneous adverse drug reaction after topical use of mupirocin in dog. The diagnosis was made through clinical-cytological analyzes. The therapy involved topical and systemic immunomodulatory drugs. Therefore, it is concluded that Mupirocin is capable of generating pharmacodermic reactions.(AU)

Diferenciação hematológica e bioquímica de cães infectados por Leishmania infantum, Babesia spp., Dirofilaria spp. e vírus da Cinomose / Hematologic and biochemical differentiation of dogs infected with Leishmania infantum, Babesia spp., Dirofilaria spp. and Cinomosis virus

Patógenos virais, protozoários e helmintoícos podem ser transmitidos simultaneamente ao mesmo hospedeiro canino, através de vetores biológicos. A avaliação de parâmetros hematobioquímicos pode fornecer dados acerca da fisiopatologia das coinfecções. Nesse contexto, objetivou-se avaliar o papel da coinfecção natural sobre o perfil hematológico e bioquímico de cães, naturalmente infectados por Leishmania infantum. Para tanto, foram utilizados 31 cães, distribuídos entre grupo controle (Grupo A, n=10) e grupo infectado (Grupo B, n=21), que foi subdividido em cães mono-infectados com L. infantum (Grupo B1, n=14) e co-infectados com L. infantum e Babesia spp., Dirofilaria spp. ou vírus da cinomose canina (Grupo B2, n=7). Amostras de sangue e soro foram analisadas, respectivamente, para avaliação de parâmetros hematológicos e dosagens bioquímicas de AST, ALT, ureia, creatinina e proteína total. Previamente, os animais foram avaliados por métodos sorológicos e parasitológicos, para confirmar as coinfecções. O protocolo experimental foi aprovado pelo CEUA/UECE (4609061/2014). Os resultados foram expressos em média±desvio padrão e foram analisados pelo teste t-Student não-pareado com p≤0,05. Hemácias, hemoglobina, hematócrito, plaquetas, eosinófilos e linfócitos apresentaram valores reduzidos (p≤0,05) nos Grupos B e B2, quando comparados com o Grupo A; enquanto que os teores de AST foram maiores (p≤0,05), na mesma comparação. O valor de ureia foi maior (p≤0,05) no Grupo B e menor no Grupo B2, quando comparado com o Grupo A. Os valores de ALT foram maiores (p≤0,05) no Grupo B1, em relação ao B2. As co-infecções influenciam nos parâmetros hematológicos e os níveis séricos de ALT, AST e ureia são importantes na avaliação bioquímica de cães acometidos por Leishmania infantum, em relação aos animais infectados...

Virus, protozoa and helminths may be transmitted simultaneously to the same canine host through biological vectors. The evaluation of blood-biochemical parameters can provide data about the pathophysiology of coinfection. In this context, the objective was to evaluate the role of natural coinfection on hematological and biochemical profile of dogs naturally infected by Leishmania infantum. To this end, 31 dogs were randomly divided between control group (Group A, n=10) and infected group (group B, n=21), which was divided into dogs mono-infected with L. infantum (Group B1, n=14) and dogs co-infected with L. infantum and Dirofilaria spp, Babesia spp or canine distemper virus (B2 Group, n=7). Blood and serum samples were analyzed, respectively, for hematological and biochemical levels of AST, ALT, urea, creatinine, and total protein. Previously, animals were evaluated by serological and parasitological methods to confirm the co-infections. The experimental protocol was approved by CEUA / UECE (4609061/2014). Results were expressed as mean ± standard deviation and were analyzed by unpaired t-test with p≤0.05. Erythrocytes, hemoglobin, hematocrit and platelets showed reduced values (p≤0.05) in group B and B2 compared with group A, while AST levels were higher (p≤0.05) in the same comparison. The amount of urea was higher (p≤0.05) in Group B and lower in Group B2 when compared to Group A. ALT levels were higher (p≤0.05) in Group B1 relative to B2. It is concluded that coinfection influence on hematological parameters and serum levels of ALT, AST and urea are important in biochemical evaluation of affected dogs by L. infantum.

Diferenciação hematológica e bioquímica de cães infectados por Leishmania infantum, Babesia spp., Dirofilaria spp. e vírus da Cinomose / Hematologic and biochemical differentiation of dogs infected with Leishmania infantum, Babesia spp., Dirofilaria spp. and Cinomosis virus

Patógenos virais, protozoários e helmintoícos podem ser transmitidos simultaneamente ao mesmo hospedeiro canino, através de vetores biológicos. A avaliação de parâmetros hematobioquímicos pode fornecer dados acerca da fisiopatologia das coinfecções. Nesse contexto, objetivou-se avaliar o papel da coinfecção natural sobre o perfil hematológico e bioquímico de cães, naturalmente infectados por Leishmania infantum. Para tanto, foram utilizados 31 cães, distribuídos entre grupo controle (Grupo A, n=10) e grupo infectado (Grupo B, n=21), que foi subdividido em cães mono-infectados com L. infantum (Grupo B1, n=14) e co-infectados com L. infantum e Babesia spp., Dirofilaria spp. ou vírus da cinomose canina (Grupo B2, n=7). Amostras de sangue e soro foram analisadas, respectivamente, para avaliação de parâmetros hematológicos e dosagens bioquímicas de AST, ALT, ureia, creatinina e proteína total. Previamente, os animais foram avaliados por métodos sorológicos e parasitológicos, para confirmar as coinfecções. O protocolo experimental foi aprovado pelo CEUA/UECE (4609061/2014). Os resultados foram expressos em média±desvio padrão e foram analisados pelo teste t-Student não-pareado com p≤0,05. Hemácias, hemoglobina, hematócrito, plaquetas, eosinófilos e linfócitos apresentaram valores reduzidos (p≤0,05) nos Grupos B e B2, quando comparados com o Grupo A; enquanto que os teores de AST foram maiores (p≤0,05), na mesma comparação. O valor de ureia foi maior (p≤0,05) no Grupo B e menor no Grupo B2, quando comparado com o Grupo A. Os valores de ALT foram maiores (p≤0,05) no Grupo B1, em relação ao B2. As co-infecções influenciam nos parâmetros hematológicos e os níveis séricos de ALT, AST e ureia são importantes na avaliação bioquímica de cães acometidos por Leishmania infantum, em relação aos animais infectados...(AU)

Virus, protozoa and helminths may be transmitted simultaneously to the same canine host through biological vectors. The evaluation of blood-biochemical parameters can provide data about the pathophysiology of coinfection. In this context, the objective was to evaluate the role of natural coinfection on hematological and biochemical profile of dogs naturally infected by Leishmania infantum. To this end, 31 dogs were randomly divided between control group (Group A, n=10) and infected group (group B, n=21), which was divided into dogs mono-infected with L. infantum (Group B1, n=14) and dogs co-infected with L. infantum and Dirofilaria spp, Babesia spp or canine distemper virus (B2 Group, n=7). Blood and serum samples were analyzed, respectively, for hematological and biochemical levels of AST, ALT, urea, creatinine, and total protein. Previously, animals were evaluated by serological and parasitological methods to confirm the co-infections. The experimental protocol was approved by CEUA / UECE (4609061/2014). Results were expressed as mean ± standard deviation and were analyzed by unpaired t-test with p≤0.05. Erythrocytes, hemoglobin, hematocrit and platelets showed reduced values (p≤0.05) in group B and B2 compared with group A, while AST levels were higher (p≤0.05) in the same comparison. The amount of urea was higher (p≤0.05) in Group B and lower in Group B2 when compared to Group A. ALT levels were higher (p≤0.05) in Group B1 relative to B2. It is concluded that coinfection influence on hematological parameters and serum levels of ALT, AST and urea are important in biochemical evaluation of affected dogs by L. infantum.(AU)

Topical anti-inflammatory potential of pumpkin (Cucurbita pepo l) seed oil on acute and chronic skin inflammation in mice

Background: Inflammation is an adaptive response that is triggered by noxious stimuli and conditions, which involves interactions amongst many cell types and mediators, and underlies many pathological process. Unsaturated fatty acids (UFAs) can infl uence inflammation through a variety of mechanisms, and have been indicated as alternative anti-inflammatory agents to treat several inflammatory skin disorders. Pumpkin seed oil (PSO) is rich in UFAs, but its topical anti-inflammatory properties have not been investigated. Therefore, the aim of this paper was to evaluate the effects of PSO on acute and chronic cutaneous inflammation experimental models. Materials, Methods & Results: PSO was purchased commercially and analyzed phytochemically. The topical anti-inflammatory activity of PSO at different concentrations was evaluated on acute models (xylene- and 12-O-tetradecanoylphorbol acetate (TPA)-induced ear edema) and chronic model (multiple applications of oxazolone-induced dermatitis) in mice. Indomethacin and dexamethasone were used as reference drugs. The ear swelling was measured in both ear thickness (µm) and weight tissue (mg) at 1 and 4 h after xylene and TPA application, respectively. In the chronic model, the effectiveness of treatments was measured each 24 h post-challenge with oxazolone for 4 days. At the end of experiments, ear biopsies were assessed by histological analysis on hematoxylin-eosin- and toluidine blue-stained slides. Data were submitted to ANOVA followed Student Newman Keuls test (P < 0.05). PSO was characterized by a high content of unsaturated fatty acids (UFAs) (79.80%), including linoleic acid (ω-6, 55.83%) and oleic acid (ω-9, 23.47%). PSO caused a dose-dependent inhibition of xylene and TPA-induced ear edema in both skin thickness and weight when compared to respective positive controls (P < 0.05). This anti-inflammatory effects was maximum when PSO was applied in nature (inhibition of 69.9 ± 2.8% and 78.1 ± 7.7% for inflammation induced by xylene and TPA, respectively; P < 0.05), and was similar to, at least, one drug reference (P < 0.05). In addition, the topical treatment with PSO caused the inhibition of inflammation-induced by oxazolone in 60.9 ± 9.8% when compared to control positive (P < 0.05), which was similar to dexamethasone (68.7 ± 8.1%, P < 0.05). In histological analysis, PSO reduced the inflammatory parameters (edema, congestion, epidermal hyperplasia and cellular infiltration) in inflammation models studied. However, the number of mastocytes in cell infiltration was reduced (17.6 ± 4.0) when compared to positive control (39.4 ± 5.8 cells) in chronic model (P < 0.05), but no differences were observed in acute models. Discussion: Topical anti-inflammatory activity of plant-originated substances can be evaluated in several experimental models. In this study, we used as phlogistic agents: xylene, a promoter of neurogenic inflammation; TPA, a phorbol ester that activate protein kinase C, leading to production of lipid-derived mediators; and oxazolone, an inductor of contact delayed-type hypersensitivity. Our results suggest that PSO alter inflammatory response via modulation of cellular and molecular mediators involved in inflammatory pathways activated by theses phlogistic agents. In addition, this oil was able to resolve a persistent inflammatory lesion similar to dexamethasone, but we did not observe any cutaneous alterations caused by its topical use as related for corticosteroids. This is the first report on topical anti-inflammatory potential of PSO in acute and chronic skin inflammation. This activity may be attributed the proper balance of ω-6 and ω-9 UFAs present in PSO, suggesting this oil as alternative therapy for the treatment of inflammatory skin diseases. Further investigations are needed to support its application in clinical practice.