Clinical-dermatological, histological abnormalities and prevalence of Trypanosoma caninum and Leishmania infantum in dogs from Midwest region of Brazil / Anormalidades clínico-dermatológicas, histológicas e prevalência de Trypanosoma caninum e Leishmania infantum em cães da região Centro-Oeste do Brasil

Leishmania infantum is a trypanosomatid that causes parasitic dermatopathy in dogs. Trypanosoma caninum is another trypanosomatid, which infects the skin of dogs, although cutaneous abnormalities are absent. This study aimed to investigate the occurrence of T. caninum infection and its associated cutaneous and histological changes and compare it with the occurrence of L. infantum infection in dogs. The study included 150 dogs, of which T. caninum infection was identified in 3 (2%) and L. infantum infection in 15 (10%) of them, with no association (p>0.05) of these infections with the breed, gender, age, or cutaneous abnormalities. The cutaneous abnormalities were based on 1 (4.8%) and 12 (57.1%) dogs infected by T. caninum and L. infantum, respectively. The dermatohistopathological abnormalities in the dogs infected with T. caninum included mild perivascular lymphohistioplasmacytic infiltrates in the clinically asymptomatic ones, while in those with dermatological abnormalities, acanthosis, epidermal orthokeratotic hyperkeratosis, melanomacrophages, and co-infection with Microsporum sp. and Trichophyton sp. were observed. InL. infantum infected, the histopathological findings included chronic granulomatous inflammatory infiltrates and structures compatible with amastigotes. Despite the low frequency of T. caninum infection, our findings suggest that this trypanosomatid, unlike L. infantum, does not cause any macroscopic skin abnormalities.(AU)

Leishmania infantum é um tripanosomatídeo que causa dermatopatia parasitária em cães. Trypanosoma caninum é outro tripanosomatídeo, que infecta a pele de cães, embora anormalidades cutâneas sejam ausentes. Este estudo teve como objetivo investigar a ocorrência da infecção por T. caninum e suas alterações cutâneas e histológicas associadas e compará-las com a ocorrência da infecção por L. infantum em cães. O estudo incluiu 150 cães, dos quais a infecção por T. caninum foi identificada em 3 (2%) e a infecção por L. infantum em 15 (10%) deles, sem associação (p>0,05) dessas infecções com a raça, sexo, idade ou anormalidades cutâneas. As alterações cutâneas foram observadas em 1 (4,8%) e 12 (57,1%) cães infectados por T. caninum e L. infantum, respectivamente. As anormalidades dermato-histopatológicas nos cães infectados por T. caninum incluíram infiltrados linfo-histioplasmocitários perivasculares leves nos clinicamente assintomáticos, enquanto naqueles com anormalidades dermatológicas, foram observados acantose, hiperqueratose ortoqueratótica epidermal e melanomacrófagos e co-infecção por Microsporum sp. e Trichophyton sp. Nos cães infectados por L. infantum, os achados histopatológicos incluíram infiltrados inflamatórios granulomatosos crônicos e estruturas compatíveis com amastigotas. A despeito da baixa frequência da infecção por T. caninum, nossos achados sugerem que esse tripanosomatídeo, diferentemente de L. infantum, não causa anormalidades macroscópicas na pele.(AU)

Experimental poisoning by Niedenzuella stannea in cattle and corresponding detection of monofluoroacetate / Intoxicação experimental por Niedenzuella stannea em bovinos e correspondente detecção de monofluoroacetato

In Brazil sodium monofluoroacetate (MFA) containing plants are represented by 16 species that belong to three principle genera: Palicourea ( Rubiaceae ), Amorimia ( Malpighiaceae ), and Tanaecium ( Bignoniaceae ). These plants can cause acute cardiac failure often referred to as sudden death syndrome. The objective of this paper was to determine if N. stannea contains MFA and to report the clinical signs and pathology of cattle experimentally poisoned by this plant. MFA was detected in all N. stannea plant parts except mature leaves. Niedenzuella stannea was dosed to cattle at single doses of 15-30g kg-1 bw. Clinical signs and pathology observed were similar to those reported by other MFA-containing plants. Animals showed marked tachycardia, labored breathing, muscle tremors, loss of balance, ataxia, falling, recumbence, pedaling movements, and opisthotonous leading to death in few minutes. Gross lesions included engorgement of the large veins, severe lung edema, and petechiae , ecchymosis and suffusions in the pericardium, epicardium and pleura. Histologically, hydropic vacuolar degeneration and necrosis of epithelial cells of the kidney were observed. Cattle that received daily doses of 4g kg-1 body weight for 24 days showed no clinical signs. In summary, this is the first report that N. stannea contains monofluoroacetate and causes sudden death in cattle.

No Brasil as plantas que contêm monofluoroacetato de sódio (MFA) são representadas por 16 espécies e pertencem a três principais gêneros: Palicourea ( Rubiaceae ), Amorimia ( Malpighiaceae ) e Tanaecium ( Bignoniaceae ). Estas plantas podem causar falha cardíaca aguda que frequentemente é referida como síndrome da morte súbita. O objetivo deste trabalho é determinar se N. stannea contêm MFA e relatar os sinais clínicos e patológicos em bovinos associados à intoxicação experimental por esta planta. Monofluoroacetato foi detectado em todas as partes da N. stannea , exceto em folhas maduras. Niedenzuella stannea foi fornecida a bovinos em doses únicas de 15-30g kg-1 peso vivo. Os sinais clínicos e patológicos observados foram similares aos relatados pelas intoxicações por outras plantas que contêm monofluoroacetato. Os animais apresentaram taquicardia acentuada, respiração profunda, tremores musculares, perda de equilíbrio, ataxia, queda, decúbito, movimentos de pedalagem e opistótono, seguido de morte em poucos minutos. As lesões macroscópicas observadas foram ingurgitamento de grandes vasos, edema pulmonar acentuado, petéquias, equimoses e sufusões no pericárdio, epicárdio e pleura. Histologicamente foi observado degeneração hidrópica vacuolar e necrose de células do epitélio renal. Bovinos que receberam doses diárias de 4g kg-1 peso vivo por 24 dias seguidos não apresentaram sinais clínicos. Este é o primeiro relato que N. stannea contêm MFA e causa morte súbita em bovinos.

Experimental poisoning by Niedenzuella stannea in cattle and corresponding detection of monofluoroacetate / Intoxicação experimental por Niedenzuella stannea em bovinos e correspondente detecção de monofluoroacetato

In Brazil sodium monofluoroacetate (MFA) containing plants are represented by 16 species that belong to three principle genera: Palicourea ( Rubiaceae ), Amorimia ( Malpighiaceae ), and Tanaecium ( Bignoniaceae ). These plants can cause acute cardiac failure often referred to as sudden death syndrome. The objective of this paper was to determine if N. stannea contains MFA and to report the clinical signs and pathology of cattle experimentally poisoned by this plant. MFA was detected in all N. stannea plant parts except mature leaves. Niedenzuella stannea was dosed to cattle at single doses of 15-30g kg-1 bw. Clinical signs and pathology observed were similar to those reported by other MFA-containing plants. Animals showed marked tachycardia, labored breathing, muscle tremors, loss of balance, ataxia, falling, recumbence, pedaling movements, and opisthotonous leading to death in few minutes. Gross lesions included engorgement of the large veins, severe lung edema, and petechiae , ecchymosis and suffusions in the pericardium, epicardium and pleura. Histologically, hydropic vacuolar degeneration and necrosis of epithelial cells of the kidney were observed. Cattle that received daily doses of 4g kg-1 body weight for 24 days showed no clinical signs. In summary, this is the first report that N. stannea contains monofluoroacetate and causes sudden death in cattle. (AU)

No Brasil as plantas que contêm monofluoroacetato de sódio (MFA) são representadas por 16 espécies e pertencem a três principais gêneros: Palicourea ( Rubiaceae ), Amorimia ( Malpighiaceae ) e Tanaecium ( Bignoniaceae ). Estas plantas podem causar falha cardíaca aguda que frequentemente é referida como síndrome da morte súbita. O objetivo deste trabalho é determinar se N. stannea contêm MFA e relatar os sinais clínicos e patológicos em bovinos associados à intoxicação experimental por esta planta. Monofluoroacetato foi detectado em todas as partes da N. stannea , exceto em folhas maduras. Niedenzuella stannea foi fornecida a bovinos em doses únicas de 15-30g kg-1 peso vivo. Os sinais clínicos e patológicos observados foram similares aos relatados pelas intoxicações por outras plantas que contêm monofluoroacetato. Os animais apresentaram taquicardia acentuada, respiração profunda, tremores musculares, perda de equilíbrio, ataxia, queda, decúbito, movimentos de pedalagem e opistótono, seguido de morte em poucos minutos. As lesões macroscópicas observadas foram ingurgitamento de grandes vasos, edema pulmonar acentuado, petéquias, equimoses e sufusões no pericárdio, epicárdio e pleura. Histologicamente foi observado degeneração hidrópica vacuolar e necrose de células do epitélio renal. Bovinos que receberam doses diárias de 4g kg-1 peso vivo por 24 dias seguidos não apresentaram sinais clínicos. Este é o primeiro relato que N. stannea contêm MFA e causa morte súbita em bovinos. (AU)

Osteopatia hipertrófica associada à metástase intratorácica de tumor mamário canino: relato de dois casos / Hypertrophic osteopathy associated with intrathoracic metastasis of mammary tumor canine: two cases report / Osteopatía hipertrófica asociada con metástasis intratorácica canina de tumor de mama: dos casos de informe

A osteopatia hipertrófica é um distúrbio de osteoprodução generalizada do periósteo que acomete os ossos longos, sendo geralmente secundária a alguma doença intratorácica, como doença cardiopulmonar ou neoplasia. A maioria das lesões são bilaterais e simétricas, podendo ocorrer nos quatro membros. O presente trabalho tem como objetivo relatar dois casos de osteopatia hipertrófica associada à metástase pulmonar de carcinoma mamário e os achados clínico patológicos destes cães foram estudados.(AU)

Hypertrophic osteopathy is a generalized bone production disorder the periosteum that affects the long bones, usually secondary to some intrathoracic disease, such as cardiopulmonary disease or cancer. Most lesions are bilateral and symmetrical and can occur in all four limbs. This study aims to report two cases of hypertrophic osteopathy associated pulmonary metastasis of breast carcinoma and the clinical and pathological findings of these dogs were studied.(AU)

Osteopatía hipertrófica es un trastorno generalizado osteoproducción del periostio que afecta a los huesos largos, generalmente secundaria a alguna enfermedad intratorácica, como la enfermedad cardiopulmonar o cáncer. La mayoría de las lesiones son bilaterales y simétricas, que se producen en las cuatro extremidades. Este estudio tiene como objetivo reportar dos casos de la osteopatía hipertrófica asociada con se estudiaron las metástasis pulmonares de carcinoma de mama hallazgos clínicos y patológicos de estos perros.(AU)

Osteopatia hipertrófica associada à metástase intratorácica de tumor mamário canino: relato de dois casos / Hypertrophic osteopathy associated with intrathoracic metastasis of mammary tumor canine: two cases report / Osteopatía hipertrófica asociada con metástasis intratorácica canina de tumor de mama: dos casos de informe

A osteopatia hipertrófica é um distúrbio de osteoprodução generalizada do periósteo que acomete os ossos longos, sendo geralmente secundária a alguma doença intratorácica, como doença cardiopulmonar ou neoplasia. A maioria das lesões são bilaterais e simétricas, podendo ocorrer nos quatro membros. O presente trabalho tem como objetivo relatar dois casos de osteopatia hipertrófica associada à metástase pulmonar de carcinoma mamário e os achados clínico patológicos destes cães foram estudados.

Hypertrophic osteopathy is a generalized bone production disorder the periosteum that affects the long bones, usually secondary to some intrathoracic disease, such as cardiopulmonary disease or cancer. Most lesions are bilateral and symmetrical and can occur in all four limbs. This study aims to report two cases of hypertrophic osteopathy associated pulmonary metastasis of breast carcinoma and the clinical and pathological findings of these dogs were studied.

Osteopatía hipertrófica es un trastorno generalizado osteoproducción del periostio que afecta a los huesos largos, generalmente secundaria a alguna enfermedad intratorácica, como la enfermedad cardiopulmonar o cáncer. La mayoría de las lesiones son bilaterales y simétricas, que se producen en las cuatro extremidades. Este estudio tiene como objetivo reportar dos casos de la osteopatía hipertrófica asociada con se estudiaron las metástasis pulmonares de carcinoma de mama hallazgos clínicos y patológicos de estos perros.

Hemangiosarcoma in a free-living Rufous-bellied Thrush (Turdus rufiventris)

Background: Hemangiosarcoma is a malignant endothelial cell-derived neoplasm characterized by an intense cellular proliferation organized in a solid or cavernous pattern. Is characterized by intense cell proliferation, and organized in vascular slits, filled with blood, with fast grow and there is a high recurrence rate. This paper reports a case of multiple hemangiosarcoma in a Rufous-bellied Thrush (Turdus rufiventris). Case: A free-living Rufous-bellied Thrush (Turdus rufiventris), was attended at the veterinary hospital of the Federal University of Mato Grosso (UFMT) - Cuiabá, presenting prostration and three masses located in the following regions: left periorbital area, left lateral insertion of the beak and distal portion of the left tibia. The masses were blackened colored with an irregular aspect, and the cut surface was multiple cavity, filled with a blackened gelatinous material. The animal died during the surgical procedure and was sent to necropsy. Additionally, special immunohistochemistry staining was used in the tumors sections, with primary anti-S-100, anti-Von Willebrand Factor, anti-desmin, anti-actin, anti-cytokeratin and anti-vimentin. The three masses have rounded shape, multilobuled surface, deep red to blackened color, with skin adhered base, and, when cut, blackened color with multiple cavities filled with red to blackened gelatinous material and [...]

Partial unilateral radial hemimelia in feline / Hemimelia parcial unilateral de rádio em felino

Background: Hemimelia is a rare anomaly in which one of paired bone is congenital or partially absent. The etiology may be related to genetic and/or environmental factors. Clinically is observed the angulation of the affected limb, resulting in functional limitations as angular deformity, lameness and decreased range of motion. The diagnosis is based on clinical findings and radiographic examination that detects the complete or partial absence of the affected bone and angular deviations. We aim to report a case of a partial unilateral radial hemimelia in a feline diagnosed at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT). Case: We attended at the HOVET-UFMT a two years old, feline, female, domestic short hair, presenting as a complaint the presence of a friable mass in the oral cavity for a year and a deformity in the left forelimb since birth, showing swallowing difficulties, lameness and difficulty support. On clinical examination, we obeserved the left forelimb flexed and deviation in the medial direction, shortening of the limb, no crepitation during handling and evident lameness. Radiographic examination in the craniocaudal and mediolateral projections of the thoracic limbs revealed the partial absence of the radius with just a trace of the proximal radial epiphysis, shortening and a marked ulnar curvature, producing a significant deviation [...]

Hemangiosarcoma in a free-living Rufous-bellied Thrush (Turdus rufiventris)

Background: Hemangiosarcoma is a malignant endothelial cell-derived neoplasm characterized by an intense cellular proliferation organized in a solid or cavernous pattern. Is characterized by intense cell proliferation, and organized in vascular slits, filled with blood, with fast grow and there is a high recurrence rate. This paper reports a case of multiple hemangiosarcoma in a Rufous-bellied Thrush (Turdus rufiventris). Case: A free-living Rufous-bellied Thrush (Turdus rufiventris), was attended at the veterinary hospital of the Federal University of Mato Grosso (UFMT) - Cuiabá, presenting prostration and three masses located in the following regions: left periorbital area, left lateral insertion of the beak and distal portion of the left tibia. The masses were blackened colored with an irregular aspect, and the cut surface was multiple cavity, filled with a blackened gelatinous material. The animal died during the surgical procedure and was sent to necropsy. Additionally, special immunohistochemistry staining was used in the tumors sections, with primary anti-S-100, anti-Von Willebrand Factor, anti-desmin, anti-actin, anti-cytokeratin and anti-vimentin. The three masses have rounded shape, multilobuled surface, deep red to blackened color, with skin adhered base, and, when cut, blackened color with multiple cavities filled with red to blackened gelatinous material and [...](AU)

Partial unilateral radial hemimelia in feline / Hemimelia parcial unilateral de rádio em felino

Background: Hemimelia is a rare anomaly in which one of paired bone is congenital or partially absent. The etiology may be related to genetic and/or environmental factors. Clinically is observed the angulation of the affected limb, resulting in functional limitations as angular deformity, lameness and decreased range of motion. The diagnosis is based on clinical findings and radiographic examination that detects the complete or partial absence of the affected bone and angular deviations. We aim to report a case of a partial unilateral radial hemimelia in a feline diagnosed at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT). Case: We attended at the HOVET-UFMT a two years old, feline, female, domestic short hair, presenting as a complaint the presence of a friable mass in the oral cavity for a year and a deformity in the left forelimb since birth, showing swallowing difficulties, lameness and difficulty support. On clinical examination, we obeserved the left forelimb flexed and deviation in the medial direction, shortening of the limb, no crepitation during handling and evident lameness. Radiographic examination in the craniocaudal and mediolateral projections of the thoracic limbs revealed the partial absence of the radius with just a trace of the proximal radial epiphysis, shortening and a marked ulnar curvature, producing a significant deviation [...](AU)