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1.
Vet. Not. (Online) ; 28(1): 1-10, abr. 2022. tab
Artigo em Inglês | VETINDEX | ID: biblio-1395466

Resumo

Pheochromocytoma is a functional neoplasm that produces catecholamines, located in the medullary region of the adrenal glands. As it presents nonspeciÀ c signs, scarcity of diagnostic tools and is still associated with concomitant diseases, it may not be easily considered as a differential condition among veterinarians. This is an uncommon neoplasm that usually affects dogs, with medium to advanced age and without racial predilection, being very rare in cats. Clinical manifestations vary according to the effects of catecholamines and/or circulatory impairment due to the local invasion of the tumor into adjacent structures. In this way, systemic arterial hypertension and consequences in target organs such as the central nervous system and kidneys can be observed, in addition to ocular changes. The deÀ nitive diagnosis is given by the histopathological analysis of the excised adrenal gland. However, the increase in the serum concentration of catecholamine metabolites may contribute to the conÀ rmation of the disease. Adrenalectomy is the therapy of choice, but if this is not feasible, α and ß adrenergic blocking drugs should be used. The prognosis varies from reserved to favorable, based on surgical success and the presence of metastases.(AU)


Assuntos
Animais , Feocromocitoma/veterinária , Doenças do Gato/diagnóstico , Neoplasias das Glândulas Suprarrenais/diagnóstico , Doenças do Cão/diagnóstico , Gatos , Cães
2.
Acta sci. vet. (Impr.) ; 50(supl.1): Pub. 792, 2022. ilus, tab, graf
Artigo em Inglês | VETINDEX | ID: biblio-1401186

Resumo

Background: Juvenile panhypopituitarism is an endocrinopathy that affects young dogs and must be differentiated from other causes of height disorders, as one could have a deficiency of one or more adenohypophysis hormones, besides growth hormone. Diagnosis consists of excluding endocrine and non-endocrine causes. Treatment requires administration of heterologous porcine growth hormone or progestins, as well as supplementing other hormones that are deficient in the circulation. The prognosis for these patients tends to be unfavorable and they have a shorter life expectancy. The present case aimed to report the therapeutic challenges in a dog diagnosed with juvenile panhypopituitarism. Case: This study presents the case of a 6-month-old crossbred Labrador/Brazilian Fila dog, not neutered, 6.7 kg of body weight (body condition score 5/9), with a growth disorder and persistence of the puppy coat, when compared to other members of the same litter. During inspection, it was possible to observe an undersized dog and soft puppy coat, besides no bone irregularities or joint tenderness was noted. The other physical examination parameters were within the normal range for the species. No changes in complete blood count and only increases in urea, cholesterol and alkaline phosphatase activity were observed. Thyroid and abdominal ultrasound (US) examination did not reveal any remarkable changes. After serum dosage of insulin-like growth factor, thyroxine, thyrostimulating hormone, and cortisol, the patient was diagnosed with juvenile panhypopituitarism and underwent therapy with medroxyprogesterone and thyroid hormone supplementation. Monitoring was instituted at intervals of 3, 6, and 12 weeks, and currently every 3 or 4 months and the IGF-1 values normalized after 6 months with. After 8 months of therapy, the patient had good body growth and bone mineralization compared to the time of diagnosis. However, skeletal development was completed only 12 months after hormone replacement, accompanied by the presence of vertebral osteophytes and coxofemoral osteoarticular alterations. Considering chronic use of progestins, ovariosalpingohysterectomy (OSH) was recommended, but for personal reasons, the owners chose to do not submit her to surgery. After 18 months of treatment, the dog starts to exhibit prostration, selective appetite, and increased abdominal volume. After imaging exam, she was forwarded for OSH, due to consistent findings of pyometra. Subsequently, even the supervision of possible comorbidities involved in the chronic use of progestins was maintained at half-yearly intervals, the bitch returned to the service with skin thickening, increased limb volume, and macroglossia after 60 months of therapy. At this point IGF-1 values were higher when compared to the previous measurements and the application of medroxyprogesterone was suspended. Its supplementation was reintroduced only after 8 months when IGF-1 was significantly reduced. To date, the patient is close to 6 years of age and with a good quality of life. Discussion: The greatest therapeutic challenge for these patients involves dealing with the adverse effects of progestins, mainly related to reproductive disorders and alopecia at the application site, as well as maintaining adequate hormone replacement in order to avoid hypersomatotropism. Although longevity is lower in these individuals, the patient in this report has achieved 6 years of age and has had an excellent quality of life so far.


Assuntos
Animais , Cães , Glândula Tireoide/diagnóstico por imagem , Hormônio do Crescimento/uso terapêutico , Nanismo Hipofisário/veterinária , Hipopituitarismo/veterinária , Medroxiprogesterona/administração & dosagem , Adeno-Hipófise/anormalidades , Doenças do Sistema Endócrino/veterinária
3.
Acta sci. vet. (Impr.) ; 50: Pub.1859-2022. ilus, tab
Artigo em Inglês | VETINDEX | ID: biblio-1458534

Resumo

Background: Biofilms have been reported as important virulent markers associated with drug resistance in urinary tractinfections (UTIs) in humans and dogs. However, in veterinary medicine, researches involving biofilm formation, treatments and preventions have been limited; yet, it is still possible to find few studies demonstrating biofilm-forming bacteriaassociated with different comorbidities such as otitis, wound infections, UTIs, and endometritis. These studies generallyselect dogs with chronic and recurrent infections, which could be an important factor in antibiotic resistance. We aimed toevaluate biofilms in sporadic cystitis regarding prevalence and drug resistance.Materials, Methods & Results: Urine samples were collected by cystocentesis from 36 client-owned dogs under clinicaland laboratory suspicion of non-recurrent urinary bladder infection (cystitis). Urine was aseptically plated onto bloodagar, MacConkey, and CLED, followed by incubation for 24 to 48 h. Definitive identification of a potential pathogen wasmade by subculture collected from an isolated colony to obtain a pure culture. The gram staining method and specificbiochemical tests (phenol red fermentation, lysine, phenylalanine, citrate, sulfide-indole-motility, and urease) were usedto distinguish and classify the bacteria. After identification, the bacteria were tested for antimicrobial susceptibility by astandard disk diffusion method, using the following antimicrobials: amoxicillin with clavulanic acid, ampicillin, ceftriaxone, ciprofloxacin, clindamycin, cefazolin, cephalothin, erythromycin, gentamicin, norfloxacin, and sulfamethoxazoletrimethoprim. The biofilm-forming ability was determined based on a culture...


Assuntos
Animais , Cães , Biofilmes , Cistite/veterinária , Sistema Urinário/virologia , Farmacorresistência Viral
4.
Acta Vet. Brasilica ; 15(1): 9-14, 2021. tab
Artigo em Inglês | VETINDEX | ID: biblio-1453250

Resumo

Hematuria is a relatively common manifestation in dogs and cats when secondary with urinary tract disorders, such as bacterial cystitis and urolithiasis, your treatment is limited to treatment of the primary cause. However, when the hematuria is persistent or capable of causing significant haematological disorders, other causes less common should to be investigated. A 12-year-old, male pit bull dog, was admitted presenting intense hematuria for the last 10 days. Laboratory tests showed intense normocytic and normochromic anemia, hypoalbuminemia and albuminuria associated with intense hematuria. The ultrasound images reveled presence of structures compatible with blood clots and increased wall thickness and irregularity of urinary bladder. The bladder wash cytology suggested chronic cystitis. Due to results of de laboratory tests and bladder US images, started treatment which antibiotic therapy associated with blood transfusions were maintained until histopathology results. During the biopsy surgery it was observed The bladder wall was thicker and richly vascularized, with normal elasticity and absence of masses or polyps on the inner and outer wall. Histopathological examination revealed thickening of the muscular layer, hemorrhage and diffuse hyperemia between muscle fibers and lamina propria, intact and ruptured capillaries filled with red blood cells, and a discrete multifoc


A hematúria é uma manifestação relativamente comum em cães e gatos quando secundária a distúrbios do trato urinário, tais como cistite bacteriana e urolitíase, sendo seu tratamento limitado à eliminação da causa primária. Entretanto, quando a hematúria é persistente ou capaz de causar distúrbios hematológicos significativos, outras causas menos comuns devem ser investigadas. Um cão, pit bull, macho de 12 anos de idade deu entrada no Hospital Veterinário da xxx com queixa principal de acentuado sangramento urinário há 10 dias. Os exames laboratoriais mostraram anemia normocítica e normo-crômica e hipoalbuminemia, associadas à proteinúria e hematúria intensa. As imagens ultrassonográficas revelaram à presença de estruturas compatíveis com coágulos sanguíneos e aumento da espessura e irregularidade da parede da bexiga, e a citologia do lavado vesical sugeriu cistite crônica. Com os resultados dos exames laboratoriais e de imagem, iniciaram-se os tratamentos com antibioticoterapia associados às transfusões sanguíneas, e o animal foi encaminhado para a biopsia de bexiga. Durante o procedimento cirúrgico, observou-se que a parede vesical apresentava-se espessa e ricamente vascularizada, com elasticidade normal e ausência de massas ou pólipos nas faces interna e externa. O exame histopatológico revelou tratar-se de cistite hemor-rágica linfoplasmocitária, uma doença rara e muito agressiva, a qual apresenta descrições semelhantes em seres humanos, mas ainda não descrita em cães.


Assuntos
Animais , Cães , Cistite/microbiologia , Cães , Hematúria/microbiologia , Inflamação
5.
Acta Vet. bras. ; 15(1): 9-14, 2021. tab
Artigo em Inglês | VETINDEX | ID: vti-30662

Resumo

Hematuria is a relatively common manifestation in dogs and cats when secondary with urinary tract disorders, such as bacterial cystitis and urolithiasis, your treatment is limited to treatment of the primary cause. However, when the hematuria is persistent or capable of causing significant haematological disorders, other causes less common should to be investigated. A 12-year-old, male pit bull dog, was admitted presenting intense hematuria for the last 10 days. Laboratory tests showed intense normocytic and normochromic anemia, hypoalbuminemia and albuminuria associated with intense hematuria. The ultrasound images reveled presence of structures compatible with blood clots and increased wall thickness and irregularity of urinary bladder. The bladder wash cytology suggested chronic cystitis. Due to results of de laboratory tests and bladder US images, started treatment which antibiotic therapy associated with blood transfusions were maintained until histopathology results. During the biopsy surgery it was observed The bladder wall was thicker and richly vascularized, with normal elasticity and absence of masses or polyps on the inner and outer wall. Histopathological examination revealed thickening of the muscular layer, hemorrhage and diffuse hyperemia between muscle fibers and lamina propria, intact and ruptured capillaries filled with red blood cells, and a discrete multifoc


A hematúria é uma manifestação relativamente comum em cães e gatos quando secundária a distúrbios do trato urinário, tais como cistite bacteriana e urolitíase, sendo seu tratamento limitado à eliminação da causa primária. Entretanto, quando a hematúria é persistente ou capaz de causar distúrbios hematológicos significativos, outras causas menos comuns devem ser investigadas. Um cão, pit bull, macho de 12 anos de idade deu entrada no Hospital Veterinário da xxx com queixa principal de acentuado sangramento urinário há 10 dias. Os exames laboratoriais mostraram anemia normocítica e normo-crômica e hipoalbuminemia, associadas à proteinúria e hematúria intensa. As imagens ultrassonográficas revelaram à presença de estruturas compatíveis com coágulos sanguíneos e aumento da espessura e irregularidade da parede da bexiga, e a citologia do lavado vesical sugeriu cistite crônica. Com os resultados dos exames laboratoriais e de imagem, iniciaram-se os tratamentos com antibioticoterapia associados às transfusões sanguíneas, e o animal foi encaminhado para a biopsia de bexiga. Durante o procedimento cirúrgico, observou-se que a parede vesical apresentava-se espessa e ricamente vascularizada, com elasticidade normal e ausência de massas ou pólipos nas faces interna e externa. O exame histopatológico revelou tratar-se de cistite hemor-rágica linfoplasmocitária, uma doença rara e muito agressiva, a qual apresenta descrições semelhantes em seres humanos, mas ainda não descrita em cães.(AU)


Assuntos
Animais , Cães , Cães , Hematúria/microbiologia , Cistite/microbiologia , Inflamação
6.
Acta sci. vet. (Online) ; 47(suppl.1): Pub. 367, 2019. ilus
Artigo em Inglês | VETINDEX | ID: vti-19499

Resumo

Background: Chylothorax is the accumulation of lymphatic fluid associated with molecules coming from digestion process(chyle) in the thorax. In this case report, we describe a canine patient with chylothorax that presented with an unusualclinical presentation: subcutaneous swelling due to chylous fluid leakage through the thoracic inlet.Case: A 4-year-old spayed female canine, Giant Schnauzer, presented to the Ontario Veterinary College Health SciencesCentre for evaluation and treatment of bilateral subcutaneous masses and edema on the ventral thorax. The patient wasoriginally evaluated by the primary care veterinarian and aspiration and cytology of the masses resulted in a large volumeof fluid with low cellularity, lightly basophilic. Due to the appearance of the fluid, triglyceride levels were performed andwas 7.95 mmol/L while the peripheral level was 0.5 mmol/L (ref: 0.2-1.3 mmol/L). Based on the cytology and triglyceridelevels, chylous fluid was suspected to be the cause of the swelling and edema. Over the following 10 months, the swellingprogressed to bilateral tumors of approximately 15 cm in the lateral thorax and surrounding edematous tissues on the ventralthorax. The patient was referred for evaluation. On presentation the patient was normal aside from the described thoracicswellings and decreased lung sounds on auscultation. Thoracic ultrasound revealed bilateral pleural effusion. Thoracentesisresulted in approximately 1,200 mL of chylous fluid. Thoracic computed tomography (CT) and lymphangiography throughpopliteal injection revealed bilaterally in the soft tissues of the axillary regions, and extending along the right thoracic wall,a moderate amount of fluid dense material. The lymphangiogram revealed two sites of rupture of lymphatic vessels, inthe caudal thorax (right sided), and in the cranial mediastinum/right thoracic inlet. Based on the findings, a video-assistedthoracic duct ligation and cisterna chyli ablation were...(AU)


Assuntos
Animais , Feminino , Cães , Quilotórax/veterinária , Celulite/complicações , Celulite/veterinária , Quilo , Tórax/diagnóstico por imagem , Tomografia Computadorizada por Raios X/veterinária , Linfografia/veterinária
7.
Braz. j. vet. pathol ; 12(3): 106-110, Nov. 2019. ilus, tab
Artigo em Inglês | VETINDEX | ID: biblio-1469738

Resumo

A six-year-old female Dachshund presented intense abdominal distension caused by hemorrhagic effusion. Cytological examination of the fluid was performed and suggested a carcinoma. The animal was submitted to exploratory laparotomy and histological examination of the substantially altered spleen revealed epithelioid mesothelioma. Owing to a poor prognosis, poor response to chemotherapy, and development of thoracic effusions that required daily drainages, the owners decided for euthanasia. At necropsy, besides a 600 mL of sera‐hemorrhagic abdominal fluid, no abnormal gross finding was identified in the abdominal cavity. The thoracic cavity was also filled with approximately 200 mL of effusion with same features as those detected in the abdominal fluid. A few firm white-to-gray nodules, with sizes ranging from 0.1 to 0.3 cm, were found in the lungs and diaphragm. Samples of the nodules were stained for routine histopathology and submitted to immunohistochemistry (IHC) assays using the antibodies vimentin, PAN Cytokeratin, calretinin, and TTF-1. Histopathology and IHC findings confirmed the diagnosis of metastatic papillary mesothelioma.


Assuntos
Feminino , Animais , Cães , Carcinoma Papilar/patologia , Carcinoma Papilar/veterinária , Mesotelioma/patologia , Mesotelioma/veterinária , Imuno-Histoquímica/veterinária
8.
Acta sci. vet. (Impr.) ; 47(suppl.1): Pub.367-2019. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1458131

Resumo

Background: Chylothorax is the accumulation of lymphatic fluid associated with molecules coming from digestion process(chyle) in the thorax. In this case report, we describe a canine patient with chylothorax that presented with an unusualclinical presentation: subcutaneous swelling due to chylous fluid leakage through the thoracic inlet.Case: A 4-year-old spayed female canine, Giant Schnauzer, presented to the Ontario Veterinary College Health SciencesCentre for evaluation and treatment of bilateral subcutaneous masses and edema on the ventral thorax. The patient wasoriginally evaluated by the primary care veterinarian and aspiration and cytology of the masses resulted in a large volumeof fluid with low cellularity, lightly basophilic. Due to the appearance of the fluid, triglyceride levels were performed andwas 7.95 mmol/L while the peripheral level was 0.5 mmol/L (ref: 0.2-1.3 mmol/L). Based on the cytology and triglyceridelevels, chylous fluid was suspected to be the cause of the swelling and edema. Over the following 10 months, the swellingprogressed to bilateral tumors of approximately 15 cm in the lateral thorax and surrounding edematous tissues on the ventralthorax. The patient was referred for evaluation. On presentation the patient was normal aside from the described thoracicswellings and decreased lung sounds on auscultation. Thoracic ultrasound revealed bilateral pleural effusion. Thoracentesisresulted in approximately 1,200 mL of chylous fluid. Thoracic computed tomography (CT) and lymphangiography throughpopliteal injection revealed bilaterally in the soft tissues of the axillary regions, and extending along the right thoracic wall,a moderate amount of fluid dense material. The lymphangiogram revealed two sites of rupture of lymphatic vessels, inthe caudal thorax (right sided), and in the cranial mediastinum/right thoracic inlet. Based on the findings, a video-assistedthoracic duct ligation and cisterna chyli ablation were...


Assuntos
Feminino , Animais , Cães , Celulite/complicações , Celulite/veterinária , Quilo , Quilotórax/veterinária , Tórax/diagnóstico por imagem , Linfografia/veterinária , Tomografia Computadorizada por Raios X/veterinária
9.
Braz. J. Vet. Pathol. ; 12(3): 106-110, Nov. 2019. ilus, tab
Artigo em Inglês | VETINDEX | ID: vti-24437

Resumo

A six-year-old female Dachshund presented intense abdominal distension caused by hemorrhagic effusion. Cytological examination of the fluid was performed and suggested a carcinoma. The animal was submitted to exploratory laparotomy and histological examination of the substantially altered spleen revealed epithelioid mesothelioma. Owing to a poor prognosis, poor response to chemotherapy, and development of thoracic effusions that required daily drainages, the owners decided for euthanasia. At necropsy, besides a 600 mL of sera‐hemorrhagic abdominal fluid, no abnormal gross finding was identified in the abdominal cavity. The thoracic cavity was also filled with approximately 200 mL of effusion with same features as those detected in the abdominal fluid. A few firm white-to-gray nodules, with sizes ranging from 0.1 to 0.3 cm, were found in the lungs and diaphragm. Samples of the nodules were stained for routine histopathology and submitted to immunohistochemistry (IHC) assays using the antibodies vimentin, PAN Cytokeratin, calretinin, and TTF-1. Histopathology and IHC findings confirmed the diagnosis of metastatic papillary mesothelioma.(AU)


Assuntos
Animais , Feminino , Cães , Mesotelioma/patologia , Mesotelioma/veterinária , Carcinoma Papilar/patologia , Carcinoma Papilar/veterinária , Imuno-Histoquímica/veterinária
10.
Pesqui. vet. bras ; 38(10): 1949-1954, out. 2018. tab
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-976372

Resumo

In view of the fact that cancer is considered a chronic disease that can interfere with hormonal homeostasis by means of cytokines, we hypothesized that, even at early stages, mammary carcinoma is able to alter the balance of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes. To test this hypothesis, the serum concentrations of basal cortisol, thyroxine (T4), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were evaluated in 20 unspayed bitches that had a histopathological diagnosis of grade 1 mammary carcinoma at clinical stage I according to the World Health Organization (WHO) classification (T1N0M0). The control animals comprised 10 unspayed bitches in perfect health conditions that were matched with those with mammary carcinoma by age. No significant differences regarding the concentrations of basal cortisol, TSH, t4, and fT4 were found between the bitches carrying early stage mammary carcinoma when compared to the control group. This suggests that, even if malignant, early-stage mammary carcinomas do not exhibit the ability to alter the concentrations of hormones produced by the hypothalamic-pituitary-adrenal or hypothalamic-pituitary-thyroid axes.(AU)


Em vista do fato de neoplasias serem consideradas doenças crônicas que por meio de citocinas podem interferir na homeostase hormonal, hipotetizou-se que o carcinoma mamário, mesmo nos seus estádios iniciais, fosse capaz de alterar o equilíbrio dos eixos hipotalâmico-hipofisário-tireóideo e hipotalâmico-hipofisário-adrenal. Para tal, foram avaliadas as concentrações séricas de cortisol basal, tiroxina (T4), tiroxina livre (fT4) e tireotrofina (TSH) de 20 fêmeas caninas, inteiras, com diagnóstico histopatológico de carcinoma mamário grau 1 e estadiamento clínico I segundo a classificação da Organização Mundial da Saúde - OMS (T1N0M0). Os animais controle constituíram-se por 10 fêmeas caninas inteiras, em perfeitas condições de higidez, as quais foram pareadas, por idade, com aquelas portadoras de carcinoma mamário. Não foram encontradas diferenças significativas nas concentrações de cortisol basal, TSH, T4 e fT4 das cadelas portadoras de carcinoma mamário em estádio inicial quando comparadas às controles sugerindo que, mesmo considerados malignos, ainda não apresentam a capacidade de alterar as concentrações dos hormônios produzidos pelos eixos hipotalâmico-hipofisário-adrenal e tireóideo.(AU)


Assuntos
Animais , Cães , Sistema Hipófise-Suprarrenal , Neoplasias Mamárias Animais/diagnóstico , Cães/sangue , Sistema Hipotálamo-Hipofisário
11.
Pesqui. vet. bras ; 38(10): 1949-1954, out. 2018. tab
Artigo em Inglês | VETINDEX | ID: vti-19732

Resumo

In view of the fact that cancer is considered a chronic disease that can interfere with hormonal homeostasis by means of cytokines, we hypothesized that, even at early stages, mammary carcinoma is able to alter the balance of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes. To test this hypothesis, the serum concentrations of basal cortisol, thyroxine (T4), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were evaluated in 20 unspayed bitches that had a histopathological diagnosis of grade 1 mammary carcinoma at clinical stage I according to the World Health Organization (WHO) classification (T1N0M0). The control animals comprised 10 unspayed bitches in perfect health conditions that were matched with those with mammary carcinoma by age. No significant differences regarding the concentrations of basal cortisol, TSH, t4, and fT4 were found between the bitches carrying early stage mammary carcinoma when compared to the control group. This suggests that, even if malignant, early-stage mammary carcinomas do not exhibit the ability to alter the concentrations of hormones produced by the hypothalamic-pituitary-adrenal or hypothalamic-pituitary-thyroid axes.(AU)


Em vista do fato de neoplasias serem consideradas doenças crônicas que por meio de citocinas podem interferir na homeostase hormonal, hipotetizou-se que o carcinoma mamário, mesmo nos seus estádios iniciais, fosse capaz de alterar o equilíbrio dos eixos hipotalâmico-hipofisário-tireóideo e hipotalâmico-hipofisário-adrenal. Para tal, foram avaliadas as concentrações séricas de cortisol basal, tiroxina (T4), tiroxina livre (fT4) e tireotrofina (TSH) de 20 fêmeas caninas, inteiras, com diagnóstico histopatológico de carcinoma mamário grau 1 e estadiamento clínico I segundo a classificação da Organização Mundial da Saúde - OMS (T1N0M0). Os animais controle constituíram-se por 10 fêmeas caninas inteiras, em perfeitas condições de higidez, as quais foram pareadas, por idade, com aquelas portadoras de carcinoma mamário. Não foram encontradas diferenças significativas nas concentrações de cortisol basal, TSH, T4 e fT4 das cadelas portadoras de carcinoma mamário em estádio inicial quando comparadas às controles sugerindo que, mesmo considerados malignos, ainda não apresentam a capacidade de alterar as concentrações dos hormônios produzidos pelos eixos hipotalâmico-hipofisário-adrenal e tireóideo.(AU)


Assuntos
Animais , Cães , Sistema Hipófise-Suprarrenal , Neoplasias Mamárias Animais/diagnóstico , Cães/sangue , Sistema Hipotálamo-Hipofisário
13.
Acta sci. vet. (Online) ; 42(suppl.1): Pub. 60, Aug. 15, 2014. ilus
Artigo em Português | VETINDEX | ID: vti-30912

Resumo

Background: Primary tongue tumors rarely affect dogs and correspond to 4% of tumors involving the oropharynx. Until now, primary tongue lymphoma had not been reported. However, lymphoma involvement in the skeletal muscle, although quite unusual, was described in the literature in four cases. Cutaneous lymphoma is another rare extranodal manifestation. The objective of this report is to describe a case of T immunophenotype lymphoma occurrence, whose manifestation is atypical, not only because it is situated in the tongue muscle but also because of the subsequent involvement of the striated musculature of the left forelimb and the skin, which showed unfavorable evolution. Case: A female seven-year-old mongrel was seen showing a regular lump in the base of the tongue, 3 cm in diameter, not ulcerated and of firm consistency, with halitosis as the only clinical sign of the disease. Incisional biopsy of the lump was performed and histopathology verified that it was large cell lymphoma. The material was sent for immunohistochemical evaluation and was characterized as T immunophenotype lymphoma by positive CD3 and negative CD79a marking. The CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy protocol was established as treatment and after the first chemotherapy session there was partial remission of the mass, measuring 2 cm in diameter. The lump, however...(AU)


Assuntos
Animais , Cães , Linfoma de Células T/complicações , Linfoma de Células T/veterinária , Neoplasias da Língua/veterinária , Músculo Esquelético/patologia
14.
Acta sci. vet. (Impr.) ; 42(suppl.1): Pub.60-30 jul. 2014. ilus
Artigo em Português | VETINDEX | ID: biblio-1457247

Resumo

Background: Primary tongue tumors rarely affect dogs and correspond to 4% of tumors involving the oropharynx. Until now, primary tongue lymphoma had not been reported. However, lymphoma involvement in the skeletal muscle, although quite unusual, was described in the literature in four cases. Cutaneous lymphoma is another rare extranodal manifestation. The objective of this report is to describe a case of T immunophenotype lymphoma occurrence, whose manifestation is atypical, not only because it is situated in the tongue muscle but also because of the subsequent involvement of the striated musculature of the left forelimb and the skin, which showed unfavorable evolution. Case: A female seven-year-old mongrel was seen showing a regular lump in the base of the tongue, 3 cm in diameter, not ulcerated and of firm consistency, with halitosis as the only clinical sign of the disease. Incisional biopsy of the lump was performed and histopathology verified that it was large cell lymphoma. The material was sent for immunohistochemical evaluation and was characterized as T immunophenotype lymphoma by positive CD3 and negative CD79a marking. The CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy protocol was established as treatment and after the first chemotherapy session there was partial remission of the mass, measuring 2 cm in diameter. The lump, however...


Assuntos
Animais , Cães , Linfoma de Células T/complicações , Linfoma de Células T/veterinária , Neoplasias da Língua/veterinária , Músculo Esquelético/patologia
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