Linfoma intravascular canino - aspectos clínicos, patológicos e imunohistoquímicos / Intravascular lymphoma in canine - clinical, pathological and immunohistochemical aspects

Background: Intravascular lymphoma (IL) is a rare disease characterized by presence of neoplastic lymphocytes in thelumen of blood vessels. Any tissue can be affected; however, the most frequently compromised areas of the body are theskin and the central nervous system (CNS). The clinical signs and macroscopic alterations caused by IL are nonspecific andare usually secondary to a continuous proliferative disorder, which leads to occlusion of the blood vessels with consequentthrombosis, hemorrhage and infarction. The objective of this work is to report a case of IL in a dog.Case: An 8-year-old male Rottweiler dog was referred to the Veterinary Hospital of the Federal University of Paraná witha history of cerebellar ataxia that had not improved after treatment. At the neurological examination, cerebellar ataxia anddeficit of nasal reflex were detected. A complete blood count showed presence of slight anemia (4.8 million red bloodcells/mm3; normal ranges= 5.5-8.5 million/mm3) and thrombocytopenia (176.000/mm3; normal ranges= 250.000-500.000/mm3). Biochemical tests revealed a small increase in alanine aminotransferase (42 IU/L; normal ranges= 14-38 IU/L) and aslight decrease in alkaline phosphatase (49 IU/L; normal ranges= 90-170 IU/L). The cerebrospinal fluid (CSF) exhibited anincreased protein concentration (147.3 mg/dL; normal ranges= 18-44 mg/dL) and pleocytosis (8 cells/µL; normal ranges=up to 5 cells/µL). No alterations were observed at radiographic and ultrasonographic exams. A clinical treatment was prescribed; however, in view of the worsening of the clinical signs, euthanasia was performed, and the body was submittedto a Laboratory of Pathology. At necropsy, moderate multifocal ulcers were observed in the oral cavity and ventral side ofthe tongue; moderately infarcted areas were detected in the spleen. Additional alterations such as fatty liver degeneration...

Linfoma intravascular canino - aspectos clínicos, patológicos e imunohistoquímicos / Intravascular lymphoma in canine - clinical, pathological and immunohistochemical aspects

Background: Intravascular lymphoma (IL) is a rare disease characterized by presence of neoplastic lymphocytes in thelumen of blood vessels. Any tissue can be affected; however, the most frequently compromised areas of the body are theskin and the central nervous system (CNS). The clinical signs and macroscopic alterations caused by IL are nonspecific andare usually secondary to a continuous proliferative disorder, which leads to occlusion of the blood vessels with consequentthrombosis, hemorrhage and infarction. The objective of this work is to report a case of IL in a dog.Case: An 8-year-old male Rottweiler dog was referred to the Veterinary Hospital of the Federal University of Paraná witha history of cerebellar ataxia that had not improved after treatment. At the neurological examination, cerebellar ataxia anddeficit of nasal reflex were detected. A complete blood count showed presence of slight anemia (4.8 million red bloodcells/mm3; normal ranges= 5.5-8.5 million/mm3) and thrombocytopenia (176.000/mm3; normal ranges= 250.000-500.000/mm3). Biochemical tests revealed a small increase in alanine aminotransferase (42 IU/L; normal ranges= 14-38 IU/L) and aslight decrease in alkaline phosphatase (49 IU/L; normal ranges= 90-170 IU/L). The cerebrospinal fluid (CSF) exhibited anincreased protein concentration (147.3 mg/dL; normal ranges= 18-44 mg/dL) and pleocytosis (8 cells/µL; normal ranges=up to 5 cells/µL). No alterations were observed at radiographic and ultrasonographic exams. A clinical treatment was prescribed; however, in view of the worsening of the clinical signs, euthanasia was performed, and the body was submittedto a Laboratory of Pathology. At necropsy, moderate multifocal ulcers were observed in the oral cavity and ventral side ofthe tongue; moderately infarcted areas were detected in the spleen. Additional alterations such as fatty liver degeneration...(AU)

Ameloblastic fibro-odontoma in a bovine

Background: Ameloblastic fibro-odontoma is a benign tumor derived from odontogenic epithelium and mesenchymaltissue, which forms enamel and dentin. It is a rare neoplasm in all species. One of the most common sites for their occurrence is the anterior mandibules. The prevalence of this odontogenic tumor is higher in young animals and only few casesare described in cattle. The purpose of this article is describe the clinical, surgical and the histopathological characteristicof a fibro-odontoma case in a Jersey Cow.Case: A 3-year-old Jersey cow was presented with a progressively growing mass in the anterior mandible displacing theincisor teeth. The mass measured approximately 12 cm diameter and there was a focal area of myiasis. The owner reportedweight loss and eating difficulties. The animal was treated with antibiotics for a few weeks but the conservative treatment failed, and the heifer underwent surgical removal of the lesion. The tumor was sent for histopathological evaluationat UFPR-Palotina Pathology laboratory. Microscopically, the excised mass was poorly delimited, and was composed oftumor cells of mesenchymal and epithelial origin which infiltrated and compressed surrounding tissues. Neoplastic cellswere arranged in bundles which multifocally formed dental sacs (dental follicles) of various sizes. These dental sacswere formed by neoplastic ameloblasts, and were surrounded by abundant fibrous connective tissue. The central zone ofthe tumor consisted of a loose, vacuolated neoplastic stellate reticulum. Mitotic figures were rare, and there was moderate anisokaryosis. In some areas, neoplastic ameloblasts surrounded the stellate reticulum. The presence of a sparse,well-organized basophilic extracellular matrix produced presumably by the tumor cells and interpreted as dentin. Thesemicroscopic characteristics led to the diagnosis of an...

Ameloblastic fibro-odontoma in a bovine

Background: Ameloblastic fibro-odontoma is a benign tumor derived from odontogenic epithelium and mesenchymaltissue, which forms enamel and dentin. It is a rare neoplasm in all species. One of the most common sites for their occurrence is the anterior mandibules. The prevalence of this odontogenic tumor is higher in young animals and only few casesare described in cattle. The purpose of this article is describe the clinical, surgical and the histopathological characteristicof a fibro-odontoma case in a Jersey Cow.Case: A 3-year-old Jersey cow was presented with a progressively growing mass in the anterior mandible displacing theincisor teeth. The mass measured approximately 12 cm diameter and there was a focal area of myiasis. The owner reportedweight loss and eating difficulties. The animal was treated with antibiotics for a few weeks but the conservative treatment failed, and the heifer underwent surgical removal of the lesion. The tumor was sent for histopathological evaluationat UFPR-Palotina Pathology laboratory. Microscopically, the excised mass was poorly delimited, and was composed oftumor cells of mesenchymal and epithelial origin which infiltrated and compressed surrounding tissues. Neoplastic cellswere arranged in bundles which multifocally formed dental sacs (dental follicles) of various sizes. These dental sacswere formed by neoplastic ameloblasts, and were surrounded by abundant fibrous connective tissue. The central zone ofthe tumor consisted of a loose, vacuolated neoplastic stellate reticulum. Mitotic figures were rare, and there was moderate anisokaryosis. In some areas, neoplastic ameloblasts surrounded the stellate reticulum. The presence of a sparse,well-organized basophilic extracellular matrix produced presumably by the tumor cells and interpreted as dentin. Thesemicroscopic characteristics led to the diagnosis of an...(AU)