Resumo
Background: Sodium monensin is a molecule of the group of ionophores antibiotics (IAs) of the polyether carboxylic typeproduced from the fermentation of Streptomyces cinnamonensis. Cases of IA poisoning in animals usually occur accidentally. Fatal poisoning in horses, a non-target species and with particular sensitivity usually occurs by the consumption ofthese products from the toxic dose of 2-3 mg/kg. This report aims to describe the epidemiological and clinical-pathologicalaspects of an outbreak of ionophore antibiotic poisoning in horses due to the consumption of mineral supplementationindicated for ruminants based on sugarcane molasses.Case: Two horses were necropsied. During necropsy, fragments of various organs were collected and fixed in 10% bufferedformalin, routinely processed for histology and stained with hematoxylin and eosin. The information obtained from the animaltrainer was that 19 horses received approximately 25 kg of low moisture mixture based on sugarcane molasses, enriched withmacro and micro minerals, vitamins and additives containing 1000 mg of monensin/kg in the trough. One day after receivingthe product, five horses began to develop ataxia, reluctance to move, difficulty of accompanying the herd and arising. Out ofthe five, three died after three days of evolution, one after six days (equine 1) and another after 15 days (equine 2) [morbidity 26.31%]. At necropsy, diffuse pallor was observed in the gluteus medius, quadriceps femoris, semimembranosus, bicepsbrachii and deep pectoral muscles. Microscopically the muscle fibers were tumefied with hypereosinophilic sarcoplasmof homogeneous appearance and with loss of striations, pynotic or absent nuclei (necrosis). Multifocal areas of fibers withsarcoplasmic fragmentation were observed, with clusters of irregular eosinophilic debris, flake (floct necrosis) or granule(granular necrosis)...
Assuntos
Animais , Cavalos , Doenças Musculares/veterinária , Melaço/análise , Minerais na Dieta , Monensin/toxicidade , Suplementos Nutricionais/análise , Brasil , Intoxicação/diagnóstico , Intoxicação/veterináriaResumo
Background: Sodium monensin is a molecule of the group of ionophores antibiotics (IAs) of the polyether carboxylic typeproduced from the fermentation of Streptomyces cinnamonensis. Cases of IA poisoning in animals usually occur accidentally. Fatal poisoning in horses, a non-target species and with particular sensitivity usually occurs by the consumption ofthese products from the toxic dose of 2-3 mg/kg. This report aims to describe the epidemiological and clinical-pathologicalaspects of an outbreak of ionophore antibiotic poisoning in horses due to the consumption of mineral supplementationindicated for ruminants based on sugarcane molasses.Case: Two horses were necropsied. During necropsy, fragments of various organs were collected and fixed in 10% bufferedformalin, routinely processed for histology and stained with hematoxylin and eosin. The information obtained from the animaltrainer was that 19 horses received approximately 25 kg of low moisture mixture based on sugarcane molasses, enriched withmacro and micro minerals, vitamins and additives containing 1000 mg of monensin/kg in the trough. One day after receivingthe product, five horses began to develop ataxia, reluctance to move, difficulty of accompanying the herd and arising. Out ofthe five, three died after three days of evolution, one after six days (equine 1) and another after 15 days (equine 2) [morbidity 26.31%]. At necropsy, diffuse pallor was observed in the gluteus medius, quadriceps femoris, semimembranosus, bicepsbrachii and deep pectoral muscles. Microscopically the muscle fibers were tumefied with hypereosinophilic sarcoplasmof homogeneous appearance and with loss of striations, pynotic or absent nuclei (necrosis). Multifocal areas of fibers withsarcoplasmic fragmentation were observed, with clusters of irregular eosinophilic debris, flake (floct necrosis) or granule(granular necrosis)... (AU)
Assuntos
Animais , Monensin/toxicidade , Cavalos , Minerais na Dieta , Suplementos Nutricionais/análise , Melaço/análise , Doenças Musculares/veterinária , Brasil , Intoxicação/diagnóstico , Intoxicação/veterináriaResumo
Background: Squamous cell carcinoma is a relatively commum cutaneous neoplasia in a horse, originated mainly in external genitalia, periocular region, especially, eyelids and oral cavitity. Squamous cell carcinoma metastasis was considered rare. Depigmentation, ultraviolet light exposure and actinic acantosis were considered etiopathologic factors. The squamous cell carcinoma rarely metastasizing however causes severely local invasion. The diagnosis confirmation just was done for histopathological and citopathological exams. The following report outlines clinical and pathological findings of a case of a metastatic squamous cell carcinoma to multiple sites in a horse revealed after anatomopathological exam. Case: The case consisted of a 10-month old Appaloosa x Mangalarga horse whose owners main complaint was a multiple ulcerative tumor in the nasal region of the animal. The horse presented depigmented libs, narines, prepuce and peniane tegument. The lesion beginning at 12 months and the horse presented sneezing and intermittent epistaxis of the right narine and moderated sialorheia. During clinical evaluation, the animal presented discrete dispneia e severe emaciation. The tumor invaded into deep inner nasal cavity, causing partial stenosis of the nasal passage of the left nasal cavity. However, stenosis and bleeding is not allowed to specify the compromised extension...(AU)
Assuntos
Animais , Cavalos , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/veterinária , Metástase Neoplásica , Neoplasias Cutâneas/veterináriaResumo
Background: Squamous cell carcinoma is a relatively commum cutaneous neoplasia in a horse, originated mainly in external genitalia, periocular region, especially, eyelids and oral cavitity. Squamous cell carcinoma metastasis was considered rare. Depigmentation, ultraviolet light exposure and actinic acantosis were considered etiopathologic factors. The squamous cell carcinoma rarely metastasizing however causes severely local invasion. The diagnosis confirmation just was done for histopathological and citopathological exams. The following report outlines clinical and pathological findings of a case of a metastatic squamous cell carcinoma to multiple sites in a horse revealed after anatomopathological exam. Case: The case consisted of a 10-month old Appaloosa x Mangalarga horse whose owners main complaint was a multiple ulcerative tumor in the nasal region of the animal. The horse presented depigmented libs, narines, prepuce and peniane tegument. The lesion beginning at 12 months and the horse presented sneezing and intermittent epistaxis of the right narine and moderated sialorheia. During clinical evaluation, the animal presented discrete dispneia e severe emaciation. The tumor invaded into deep inner nasal cavity, causing partial stenosis of the nasal passage of the left nasal cavity. However, stenosis and bleeding is not allowed to specify the compromised extension...