Pathomorphological and immunohistochemical evaluation of unilateral progressive Mooren’s ulcer in a cat

Background: Mooren’s ulcer is a chronic and painful ulceration of the cornea. It begins progressively in the periphery and spread centrally in cornea. In human, it is seen uniaterally in most of cases. Mooren ulcer has not been reported in any kind of animals up to now. Although its aetiology is not completely enlighted, it has been suspected of the inflammatory reaction against injuries-microbiological and immun mediated effects. Immun response in presence of accumulation of immune complexes into the limbal vessels.As a result of the deficit in the regulatory mechanism because the number of suppressor cells control over B and T lymphocytes, These situations can result in a progressive tendancy to inflammation because the production of autoantibodies and/or lymphokine from cytotoxic T-lymhocytes creates an immune-mediated vasculitis. Numerous immigrant inflammatory cells and proteins are evaded from vessels. After triggering inflammatory cells and releasing of meditors, corneal vascularization, scar tissue and re-epithelization develop. This regenerative-reperative process plays an important role during post-inflammatory process.Case: In this case, it was aimed to detect pathomorphological structure and immunologic relations in progressive Mooren’s ulcer (MU). A 1 year-old mix breed cat was submitted to clinic with complaints of progressive painful and eyesight loss in left eye. There were 1 cm-ulceration, opacification and old haemorrhagic areas at peripheral cornea. Histopathologically, there was wide ulceration including all layers of corneal epithelium and particularly vacuolar degeneration at suprabasal cells. In corneal stroma, numerous neutrophiles and mononuclear cells were infiltrated. Neovascularisation and fibrosis beginning from limbus were also present. This fibrotic progress was confirmed by Masson’s trichrome staining method.[...]

Clinicopathological evaluation of clear cell hidradenoma (acrospiroma) within multiple tumor complex in a dog

Background: Clear cell hidradenoma (acrospiroma) is adnexal tumors that arise from the distal excretory duct of eccrine sweat glands. It is generally defined in humanbeings. It presents solitary structure in firmness nodule. Most frequently are encountered in head, face, and upper extremities in humans. Hidradenomas are called generally by definition benign. Their malignant transformations and metastasis are seen very rarely. In veterinary literature database, the malignant form of tumor has been defined as an unique report in four dogs. They are extremely rare tumors in dogs. It is not documented within multiple tumor complex up to now.Case: In the case, three tumors were detected in a 9-year-old neutered female German shepherd dog. After clinical examination, a complete surgical resection of all masses was performed and masses were sent to Pathology for diagnosis. A mass on the right last rib was a 8x6 cm in diameters with severe ulceration. The mass had a hard texture, immobility and irregular borders. Other masses were localized on the back and left caudo-abdominal mammary lobe. Tumors on the back and the mammary lobe did not invade muscle layer, but the tumor on the last rib aggressively invaded surrounding tissue and were very difficult to remove surgically After macroscopy, all the masses were stained with hematoxylin-eosin (H&E), Mayer’s mucicarmine and Periodic Acid Shiff (PAS) stainings. In the first mass, there were multilobular epithelial islands between prominent fibrous septa from the upper to deep of dermis. The neoplastic cells were generally round or polyhedral in shape. Some of cytoplasms were eosinophilic at different degree. But cytoplasms were generally finely granular and vesicular or clear in appearance. Some cells had possible glycogen deposits. Nucleus was oval to round and had fine reticular chromatin and a distinct nucleolus.[...]

Pathomorphological and immunohistochemical evaluation of unilateral progressive Moorens ulcer in a cat

Background: Moorens ulcer is a chronic and painful ulceration of the cornea. It begins progressively in the periphery and spread centrally in cornea. In human, it is seen uniaterally in most of cases. Mooren ulcer has not been reported in any kind of animals up to now. Although its aetiology is not completely enlighted, it has been suspected of the inflammatory reaction against injuries-microbiological and immun mediated effects. Immun response in presence of accumulation of immune complexes into the limbal vessels.As a result of the deficit in the regulatory mechanism because the number of suppressor cells control over B and T lymphocytes, These situations can result in a progressive tendancy to inflammation because the production of autoantibodies and/or lymphokine from cytotoxic T-lymhocytes creates an immune-mediated vasculitis. Numerous immigrant inflammatory cells and proteins are evaded from vessels. After triggering inflammatory cells and releasing of meditors, corneal vascularization, scar tissue and re-epithelization develop. This regenerative-reperative process plays an important role during post-inflammatory process.Case: In this case, it was aimed to detect pathomorphological structure and immunologic relations in progressive Moorens ulcer (MU). A 1 year-old mix breed cat was submitted to clinic with complaints of progressive painful and eyesight loss in left eye. There were 1 cm-ulceration, opacification and old haemorrhagic areas at peripheral cornea. Histopathologically, there was wide ulceration including all layers of corneal epithelium and particularly vacuolar degeneration at suprabasal cells. In corneal stroma, numerous neutrophiles and mononuclear cells were infiltrated. Neovascularisation and fibrosis beginning from limbus were also present. This fibrotic progress was confirmed by Massons trichrome staining method.[...](AU)

Clinicopathological evaluation of clear cell hidradenoma (acrospiroma) within multiple tumor complex in a dog

Background: Clear cell hidradenoma (acrospiroma) is adnexal tumors that arise from the distal excretory duct of eccrine sweat glands. It is generally defined in humanbeings. It presents solitary structure in firmness nodule. Most frequently are encountered in head, face, and upper extremities in humans. Hidradenomas are called generally by definition benign. Their malignant transformations and metastasis are seen very rarely. In veterinary literature database, the malignant form of tumor has been defined as an unique report in four dogs. They are extremely rare tumors in dogs. It is not documented within multiple tumor complex up to now.Case: In the case, three tumors were detected in a 9-year-old neutered female German shepherd dog. After clinical examination, a complete surgical resection of all masses was performed and masses were sent to Pathology for diagnosis. A mass on the right last rib was a 8x6 cm in diameters with severe ulceration. The mass had a hard texture, immobility and irregular borders. Other masses were localized on the back and left caudo-abdominal mammary lobe. Tumors on the back and the mammary lobe did not invade muscle layer, but the tumor on the last rib aggressively invaded surrounding tissue and were very difficult to remove surgically After macroscopy, all the masses were stained with hematoxylin-eosin (H&E), Mayers mucicarmine and Periodic Acid Shiff (PAS) stainings. In the first mass, there were multilobular epithelial islands between prominent fibrous septa from the upper to deep of dermis. The neoplastic cells were generally round or polyhedral in shape. Some of cytoplasms were eosinophilic at different degree. But cytoplasms were generally finely granular and vesicular or clear in appearance. Some cells had possible glycogen deposits. Nucleus was oval to round and had fine reticular chromatin and a distinct nucleolus.[...](AU)

Medical and surgical approach to gangrenous mastitis related to galactostasis in a cat

Background: Feline mastitis is an uncommon inflammation of mammary gland that is caused by bacterial infection of lactating gland or during pseudopregnancy. Milk accumulation may cause acute septic mastitis due to congestion of milk. It is believed that the microorganisms gain entrance via fissures in the nipples and adjacent skin or spread by way of both the ducts and the lymphatics. The staphylococci that are a persistent pathogen may cause gangrene within a few days. In cases of mastitis that does not respond medical treatment, radical treatment is mastectomy. Case: A 1-year-old, which had given a birth for a week, primiparous, unused exogenous hormone, mixed breed cat was brought to the clinic with complaint of anorexia, dehydration and fatigue for 3 days. Cat had fi ve healthy kittens on the 73rd day of pregnancy. The owner mentioned that there were home renovations, so the cat was scared from the noise and hid. The cats body temperature and respiratory rate increased. The right caudo-abdominal mammary gland was asymmetric, enlarged, hyperemic, warm, edematous and painful, also gland veins were dilated. A viscous, yellow colored milk came from the nipple and Staphylococcus aureus was isolated. Whereas blood biochemical parameters were within normal limits, complete blood cell count were observed to be deviating significantly. The combination of amoxicillin and clavulanic...(AU)

Medical and surgical approach to gangrenous mastitis related to galactostasis in a cat

Background: Feline mastitis is an uncommon inflammation of mammary gland that is caused by bacterial infection of lactating gland or during pseudopregnancy. Milk accumulation may cause acute septic mastitis due to congestion of milk. It is believed that the microorganisms gain entrance via fissures in the nipples and adjacent skin or spread by way of both the ducts and the lymphatics. The staphylococci that are a persistent pathogen may cause gangrene within a few days. In cases of mastitis that does not respond medical treatment, radical treatment is mastectomy. Case: A 1-year-old, which had given a birth for a week, primiparous, unused exogenous hormone, mixed breed cat was brought to the clinic with complaint of anorexia, dehydration and fatigue for 3 days. Cat had fi ve healthy kittens on the 73rd day of pregnancy. The owner mentioned that there were home renovations, so the cat was scared from the noise and hid. The cats body temperature and respiratory rate increased. The right caudo-abdominal mammary gland was asymmetric, enlarged, hyperemic, warm, edematous and painful, also gland veins were dilated. A viscous, yellow colored milk came from the nipple and Staphylococcus aureus was isolated. Whereas blood biochemical parameters were within normal limits, complete blood cell count were observed to be deviating significantly. The combination of amoxicillin and clavulanic...