Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 27
Filtrar
Mais filtros

Intervalo de ano de publicação
1.
Acta sci. vet. (Impr.) ; 50(suppl.1): Pub.760-4 jan. 2022. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1458568

Resumo

Background: Primary pituitary carcinoma is rarely reported in dogs and only few reports describe its malignancy. In veterinary literature, primary pituitary carcinomas correspond up to 2.4% to 3.4% of intracranial neoplasms found in dogs andinformation regarding its biological behavior is quite limited. In humans, primary pituitary carcinomas represent less than1.0% of all tumors found in the pituitary gland. The proposed classification for pituitary carcinoma in humans and dogsdetermines that the tumor must have its origin in adenohypophyseal region and disseminated metastasis by cerebrospinalfluid or systemically to other organs must be observed. In dogs, a few reports have described primary pituitary carcinoma.The goal of this report was to describe clinical, tomographic, histopathological and immunohistochemistry features of abitch with primary pituitary carcinoma with adjacent invasion.Case: A 7-year-old female spayed Golden Retriever dog was assessed by general practice due progressive weight loss,muscular atrophy, lethargy, blindness, head pressing, and hyporexia for 21 days. Computed tomography (CT) showeda cerebral parenchyma with expansive extra-axial base formation, originating from sella turcica topography, measuringabout 2.0 cm dorsally, displacing the third ventricle, suggesting the diagnosis of pituitary neoplasia. The hormones thyroidstimulating hormone (TSH) and total thyroxine (T4) as well as stimulation ACTH test were unremarkable. After 7 days,neurological clinical signs progressed and unfortunately the patient died ten days later after hospitalization. A necropsyexam revealed pituitary gland with increased dimensions (2.5 x 2.0 cm). Histopathological fi ndings revealed tumor proliferation in pituitary gland. The neoplasm showed invasion to the nervous parenchyma and metastatic foci between the brainlobes. Immunohistochemistry was positive for keratin and neuron-specifi c enolase...


Assuntos
Feminino , Animais , Cães , Carcinoma/veterinária , Hormônio Adrenocorticotrópico , Neoplasias Hipofisárias/diagnóstico por imagem , Neoplasias Hipofisárias/veterinária , Imuno-Histoquímica/veterinária
2.
Acta cir. bras ; 36(10): e361003, 2021. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1349865

Resumo

ABSTRACT Purpose: To evaluate the low-level laser therapy (LLLT) on the membrane induced by the Masquelet technique in rabbits. Methods: Twelve Norfolk rabbits at approximately 3 months of age were used. A 1-cm segmental defect was induced in both radii, which were filled with polymethylmethacrylate cylinder. LLLT was used postoperatively in the bone defect of one of the forelimbs every 48 hours for 15 days. Six rabbits were euthanatized on third and sixth postoperative weeks. Results: In both forelimbs, radiographs showed new bone growth from radius cut ends on the third postoperative week and more advanced stage on the sixth postoperative week. Ultrasound showed induced membrane one week after the surgery. Histologically, there were no significant differences in the semi-quantitative score of inflammation intensity, total number of blood vessels, bone metaplasia, and collagen. The average thicknesses were 2,050.17 and 1,451.96 μm for control membranes and 2,724.26 and 2,081.03 μm for irradiated membranes, respectively, on third and sixth postoperative weeks. Vascular endothelial growth factor A (VEGF-A) and platelet derived growth factor (PDGF) expression were present in the induced membranes of control and irradiated forelimbs, but there was no significant difference. Conclusions: Based on assessment methods, it was not possible to demonstrate the effect of LLLT on the induced membrane.


Assuntos
Animais , Terapia com Luz de Baixa Intensidade , Fator A de Crescimento do Endotélio Vascular , Coelhos , Osso e Ossos , Colágeno
3.
Semina ciênc. agrar ; 41(3): 907-914, May-June 2020. tab
Artigo em Inglês | VETINDEX | ID: biblio-1501794

Resumo

Bovine viral diarrhoea (BVD) is an infectious and contagious disease affecting cattle that is responsible for causing a wide range of clinical manifestations ranging from inapparent or subclinical infections to an acute and sometimes fatal disease known as mucosal disease. The agent that causes BVD is an RNA virus of the genus Pestivirus and family Flaviridae. BVD is transmitted in two different ways: horizontal, by secretions, and vertically in pregnant cows, where the cow transmits the virus to the foetus. The clinical signs depend on the affected animal, its immunological capacity, and in the case of pregnant females, the gestation phase. A gestational infection can result in several changes, such as congenital anomalies, abortion, or even the birth of so-called persistently infected (PI) animals, which are difficult to detect and have a very important epidemiological role within the herd. The southwest region of Paraná has the largest dairy basin in the state of Paraná and is predominantly composed of family farmers, many of whom adopt measures that increase the health risk of their herd. The objective of this study was to delineate the serological prevalence of non-vaccinated dairy cattle in the municipality of Royalty-PR in relation to the BVD-1 virus, as well as to evaluate the odds ratios, relative risk and risk attributable to the independent variables of breed, age and the community under study. To that end, 317 blood serum samples from non-vaccinated cows from 18 different farms, with various breeds and ages, were evaluated by virus neutralization for the detection of antibodies specific to BVD-1. The results showed that 17.03% of the animals (54/317) had positive BVD-1 serology, and 82.33% (15/18) of the farms had at least one positive animal. Animals of the Jersey breed and the Barra do Sarandi Line community had the highest epidemiological risks, with a strong association with BVD-1 infection.


A Diarreia Viral Bovina (BVD) é uma doença infectocontagiosa que acomete bovinos, responsável por causar uma ampla gama de manifestações clínicas, que variam desde infecções inaparentes ou subclínicas até uma doença aguda e, por vezes, fatal conhecida como Doença das Mucosas. O agente causal da BVD é um RNA vírus do gênero Pestivirus, e da família Flaviridae. A BVD é transmitida de duas formas distintas: horizontal, por secreções, e de forma vertical em vacas prenhes, ocorrendo transmissão da vaca para o feto. Os sinais clínicos dependem do animal acometido, de sua capacidade imunológica, e no caso de fêmeas prenhes, da fase de gestação que a mesma se encontra. Uma infecção no período gestacional pode resultar em várias alterações como: anomalias congênitas, aborto, ou até mesmo no nascimento dos chamados animais persistentemente infectados (PI), que são fontes de difícil detecção e que tem papel epidemiológico muito importante dentro do rebanho bovino. A região Sudoeste do Paraná possui a maior bacia leiteira do estado do Paraná, sendo composta, predominantemente, por pequenos produtores, sendo que muitos destes, adotam medidas que aumentam o risco sanitário do seu rebanho. Objetivou-se com este estudo, delinear a prevalência sorológica de bovinos leiteiros não vacinados do município de Realeza-PR, perante o vírus da BVD-1, bem como, avaliar odds ratio, risco relativo e atribuído as variáveis independentes: raça, idade e comunidade em estudo. Para tal, 317 amostras de soro sanguíneo provenientes de fêmeas não vacinadas, de 18 diferentes propriedades, raças e idades foram avaliadas por meio de vírus neutralização para a detecção de anticorpos específicos a BVD-1. Os resultados demonstram que 17, 03% dos animais (54/317) foram positivos a sorologia de BVD-1, sendo que em 82,33 % (15/18) das propriedades havia ao menos um animal positivo. Animais da raça Jersey e da comunidade de linha Barra do Sarandi...


Assuntos
Animais , Bovinos , Doenças dos Bovinos , Testes Sorológicos/estatística & dados numéricos , Testes Sorológicos/veterinária , Vacinação/veterinária , Vírus da Diarreia Viral Bovina Tipo 1
4.
Semina Ci. agr. ; 41(3): 907-914, May-June 2020. tab
Artigo em Inglês | VETINDEX | ID: vti-746032

Resumo

Bovine viral diarrhoea (BVD) is an infectious and contagious disease affecting cattle that is responsible for causing a wide range of clinical manifestations ranging from inapparent or subclinical infections to an acute and sometimes fatal disease known as mucosal disease. The agent that causes BVD is an RNA virus of the genus Pestivirus and family Flaviridae. BVD is transmitted in two different ways: horizontal, by secretions, and vertically in pregnant cows, where the cow transmits the virus to the foetus. The clinical signs depend on the affected animal, its immunological capacity, and in the case of pregnant females, the gestation phase. A gestational infection can result in several changes, such as congenital anomalies, abortion, or even the birth of so-called persistently infected (PI) animals, which are difficult to detect and have a very important epidemiological role within the herd. The southwest region of Paraná has the largest dairy basin in the state of Paraná and is predominantly composed of family farmers, many of whom adopt measures that increase the health risk of their herd. The objective of this study was to delineate the serological prevalence of non-vaccinated dairy cattle in the municipality of Royalty-PR in relation to the BVD-1 virus, as well as to evaluate the odds ratios, relative risk and risk attributable to the independent variables of breed, age and the community under study. To that end, 317 blood serum samples from non-vaccinated cows from 18 different farms, with various breeds and ages, were evaluated by virus neutralization for the detection of antibodies specific to BVD-1. The results showed that 17.03% of the animals (54/317) had positive BVD-1 serology, and 82.33% (15/18) of the farms had at least one positive animal. Animals of the Jersey breed and the Barra do Sarandi Line community had the highest epidemiological risks, with a strong association with BVD-1 infection.(AU)


A Diarreia Viral Bovina (BVD) é uma doença infectocontagiosa que acomete bovinos, responsável por causar uma ampla gama de manifestações clínicas, que variam desde infecções inaparentes ou subclínicas até uma doença aguda e, por vezes, fatal conhecida como Doença das Mucosas. O agente causal da BVD é um RNA vírus do gênero Pestivirus, e da família Flaviridae. A BVD é transmitida de duas formas distintas: horizontal, por secreções, e de forma vertical em vacas prenhes, ocorrendo transmissão da vaca para o feto. Os sinais clínicos dependem do animal acometido, de sua capacidade imunológica, e no caso de fêmeas prenhes, da fase de gestação que a mesma se encontra. Uma infecção no período gestacional pode resultar em várias alterações como: anomalias congênitas, aborto, ou até mesmo no nascimento dos chamados animais persistentemente infectados (PI), que são fontes de difícil detecção e que tem papel epidemiológico muito importante dentro do rebanho bovino. A região Sudoeste do Paraná possui a maior bacia leiteira do estado do Paraná, sendo composta, predominantemente, por pequenos produtores, sendo que muitos destes, adotam medidas que aumentam o risco sanitário do seu rebanho. Objetivou-se com este estudo, delinear a prevalência sorológica de bovinos leiteiros não vacinados do município de Realeza-PR, perante o vírus da BVD-1, bem como, avaliar odds ratio, risco relativo e atribuído as variáveis independentes: raça, idade e comunidade em estudo. Para tal, 317 amostras de soro sanguíneo provenientes de fêmeas não vacinadas, de 18 diferentes propriedades, raças e idades foram avaliadas por meio de vírus neutralização para a detecção de anticorpos específicos a BVD-1. Os resultados demonstram que 17, 03% dos animais (54/317) foram positivos a sorologia de BVD-1, sendo que em 82,33 % (15/18) das propriedades havia ao menos um animal positivo. Animais da raça Jersey e da comunidade de linha Barra do Sarandi...(AU)


Assuntos
Animais , Bovinos , Testes Sorológicos/estatística & dados numéricos , Testes Sorológicos/veterinária , Vírus da Diarreia Viral Bovina Tipo 1 , Doenças dos Bovinos , Vacinação/veterinária
5.
Acta sci. vet. (Impr.) ; 47(suppl.1): Pub.435-2019. ilus, tab
Artigo em Inglês | VETINDEX | ID: biblio-1458199

Resumo

Background: Calcium electroporation (CaEP) is a novel therapeutic treatment that has been studied for cancer due to itsselective killing cancer cells by necrosis and danger signals. Besides that, electrochemotherapy (ECT) is an effective local treatment that involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to thetumor. The combination with ECT and CaEP has been reported in literature suggesting that additional response of immunesystem could have been enhanced by electroporation with calcium. This case, report on the successful treatment with CaEPcombined with ECT for treatment of a regional metastasis in a feline model of malignant melanoma.Case: A 9-year-old, mixed breed cat was referred to the veterinary clinic with a 2-month history of cutaneous peripalpebralplaque lesion (0.19 cm³) and a submandibular lymph node enlargement (0.5 cm³). Incisional biopsy of the cutaneous lesionand fine-needle aspiration of submandibular lymph node confirmed a cutaneous melanoma with submandibular lymph nodemetastasis. Tumor staging was set in T1N1M0 according to WHO staging criteria. ECT for the primary lesion and lymphnode metastasis was proposed. For the ECT, bleomycin (15,000 UI/m²) application was performed intravenous followedby electroporation (8 pulses of 100 μs at 1000 V/cm, and 1 Hz) using a needle array electrode consisted of two parallelrows with six needles in each row. At 28-day post-ECT complete remission of the primary tumor and metastatic foci wasachieved. However, 120 days after ECT, recurrence was observed in submandibular and retropharyngeal...


Assuntos
Animais , Gatos , Eletroquimioterapia/veterinária , Gluconato de Cálcio/uso terapêutico , Melanoma/terapia , Melanoma/veterinária , Metástase Neoplásica/terapia , Eletroporação/veterinária
6.
Acta sci. vet. (Online) ; 47(suppl.1): Pub. 435, Oct. 30, 2019. ilus, tab
Artigo em Inglês | VETINDEX | ID: vti-25726

Resumo

Background: Calcium electroporation (CaEP) is a novel therapeutic treatment that has been studied for cancer due to itsselective killing cancer cells by necrosis and danger signals. Besides that, electrochemotherapy (ECT) is an effective local treatment that involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to thetumor. The combination with ECT and CaEP has been reported in literature suggesting that additional response of immunesystem could have been enhanced by electroporation with calcium. This case, report on the successful treatment with CaEPcombined with ECT for treatment of a regional metastasis in a feline model of malignant melanoma.Case: A 9-year-old, mixed breed cat was referred to the veterinary clinic with a 2-month history of cutaneous peripalpebralplaque lesion (0.19 cm³) and a submandibular lymph node enlargement (0.5 cm³). Incisional biopsy of the cutaneous lesionand fine-needle aspiration of submandibular lymph node confirmed a cutaneous melanoma with submandibular lymph nodemetastasis. Tumor staging was set in T1N1M0 according to WHO staging criteria. ECT for the primary lesion and lymphnode metastasis was proposed. For the ECT, bleomycin (15,000 UI/m²) application was performed intravenous followedby electroporation (8 pulses of 100 μs at 1000 V/cm, and 1 Hz) using a needle array electrode consisted of two parallelrows with six needles in each row. At 28-day post-ECT complete remission of the primary tumor and metastatic foci wasachieved. However, 120 days after ECT, recurrence was observed in submandibular and retropharyngeal...(AU)


Assuntos
Animais , Gatos , Eletroquimioterapia/veterinária , Melanoma/terapia , Melanoma/veterinária , Metástase Neoplásica/terapia , Gluconato de Cálcio/uso terapêutico , Eletroporação/veterinária
7.
Acta sci. vet. (Impr.) ; 46: Pub.1616-2018. tab, graf
Artigo em Inglês | VETINDEX | ID: biblio-1457906

Resumo

Background: Hemostatic alterations are commonly detected in canine cancer patients. However, few studies have described hemostatic dysfunction in dogs with different tumor subtypes. In Veterinary Medicine, the state of hypercoagulability is hardly diagnosed alive, since laboratory exams for evaluate hemostatic function are not always requested. Due to importance of homeostatic disorders in cancer patients, this study aimed to evaluate hemostatic alterations such as platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT) and fibrinogen in tumor-bearing dogs.Materials, Methods & Results: From the 55 dogs evaluated, 30 had mammary carcinoma, 6 visceral hemangiosarcoma, 9 high-grade cutaneous mast cell tumor and 10 multicentric lymphoma. The results were compared to a control group composed by 10 Beagle dogs. Thrombocytosis was observed in 26.6% (8/30) of mammary carcinoma group and thrombocytopenia in 10% (3/30). The patients with hemangiosarcoma and mast cell tumor did not reveal thrombocytosis, however, thrombocytopenia was present in 16.6% (1/6) and 33% (3/9), respectively. Three dogs with multicentric lymphoma showed thrombocytopenia and other three showed thrombocytosis. From patients with thrombocytosis, one was classified as severe thrombocytosis (1077 x 10³/µL). Therefore, there were no statistically significant associations between neoplasia group with control group (P > 0.05). Regarding the aPTT and PT evaluation, mammary carcinoma (P = 0.0005), hemangiosarcoma (P = 0.033) and mast cell tumor (P = 0.012) patients showed statistical difference for aPTT, while the evaluation for PT was not significant (P > 0.05). We grouped all patients as a “tumor group” and compared to the control group. It was possible to observe increased aPTT and PT in 89% (49/55) and 50.90% (28/55) respectively, in tumor group compared to normal.[...]


Assuntos
Animais , Cães , Neoplasias/sangue , Neoplasias/veterinária , Transtornos Hemostáticos/diagnóstico , Transtornos Hemostáticos/veterinária , Contagem de Plaquetas/veterinária , Fibrinogênio/análise , Tempo de Protrombina/veterinária , Tempo de Tromboplastina Parcial/veterinária
8.
Acta sci. vet. (Online) ; 46: Pub. 1616, 2018. tab, graf
Artigo em Inglês | VETINDEX | ID: vti-738787

Resumo

Background: Hemostatic alterations are commonly detected in canine cancer patients. However, few studies have described hemostatic dysfunction in dogs with different tumor subtypes. In Veterinary Medicine, the state of hypercoagulability is hardly diagnosed alive, since laboratory exams for evaluate hemostatic function are not always requested. Due to importance of homeostatic disorders in cancer patients, this study aimed to evaluate hemostatic alterations such as platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT) and fibrinogen in tumor-bearing dogs.Materials, Methods & Results: From the 55 dogs evaluated, 30 had mammary carcinoma, 6 visceral hemangiosarcoma, 9 high-grade cutaneous mast cell tumor and 10 multicentric lymphoma. The results were compared to a control group composed by 10 Beagle dogs. Thrombocytosis was observed in 26.6% (8/30) of mammary carcinoma group and thrombocytopenia in 10% (3/30). The patients with hemangiosarcoma and mast cell tumor did not reveal thrombocytosis, however, thrombocytopenia was present in 16.6% (1/6) and 33% (3/9), respectively. Three dogs with multicentric lymphoma showed thrombocytopenia and other three showed thrombocytosis. From patients with thrombocytosis, one was classified as severe thrombocytosis (1077 x 10³/µL). Therefore, there were no statistically significant associations between neoplasia group with control group (P > 0.05). Regarding the aPTT and PT evaluation, mammary carcinoma (P = 0.0005), hemangiosarcoma (P = 0.033) and mast cell tumor (P = 0.012) patients showed statistical difference for aPTT, while the evaluation for PT was not significant (P > 0.05). We grouped all patients as a “tumor group” and compared to the control group. It was possible to observe increased aPTT and PT in 89% (49/55) and 50.90% (28/55) respectively, in tumor group compared to normal.[...](AU)


Assuntos
Animais , Cães , Transtornos Hemostáticos/diagnóstico , Transtornos Hemostáticos/veterinária , Neoplasias/sangue , Neoplasias/veterinária , Tempo de Tromboplastina Parcial/veterinária , Tempo de Protrombina/veterinária , Contagem de Plaquetas/veterinária , Fibrinogênio/análise
9.
Vet. Zoot. ; 24(1): 49-59, mar. 2017.
Artigo em Português | VETINDEX | ID: vti-688150

Resumo

La especie canina presenta semejanza con la especie humana con relación a las lesiones prostáticas. Es la única especie en presentar tumores espontáneos con frecuencia, de esta manera representa un importante modelo para estudio comparativo de afecciones de la glándula. El desarrollo de las neoplasia prostáticas es una enfermedad con causas multifactoriales, entre estas, alteraciones genéticas y epigenéticas están involucradas. Por lo tanto, el perro puede ser un modelo natural y espontaneo para el estudio de lesiones preneoplásicas e neoplásicas de próstata canina. En el futuro, podrá ser utilizado como modelo en pruebas pre-clínicas de medicamentos, como ya fue realizado para osteosarcoma, por ejemplo. Una de las vías importantes para el desarrollo de los carcinomas prostáticos es la WNT canónica dependiente de la proteína Beta-catenina. En esta revisión abordaremos el papel de esta vía y su participación en la carcinogénesis prostática, importante en humanos y perros, además de algunas proteínas involucradas en la regulación de la misma.(AU)


Prostate of dogs have similar lesions to that observed in human and is the only species other than man which frequently displays spontaneous prostatic tumors. In this way, the dog represent an important model of studying different prostatic affections. The prostate cancer development is multifactorial and among them, genetic and epigenetic alterations are involved. The dog can be a natural and spontaneous model to study preneoplastic and neoplastic lesions, with potential future studies as models for pre-clinical tests. One of important pathway to prostate carcinogenesis is beta catenin dependent canonical WNT pathway. In this paper, we review the role of this pathway in prostate carcinogenesis, important in humans and dogs, besides some regulatory proteins involved in this pathway.(AU)


A espécie canina apresenta semelhanças com a espécie humana com relação às lesões prostáticas, sendo a única espécie a apresentar tumores espontâneos e com frequência, desse modo representa um importante modelo para estudo comparativo de afecções desta glândula. O desenvolvimento das neoplasias prostáticas é multifatorial e dentre eles, alterações genéticas e epigenéticas estão envolvidas, portanto o cão pode ser um modelo natural e espontâneo para o estudo das lesões pré neoplásicas e neoplásicas da próstata, com futuro alto potencial de ser utilizado como modelo em testes pré-clínicos de medicamentos. Uma das vias importantes para o desenvolvimento dos carcinomas prostáticos é a WNT canônica, dependente da proteína Beta-catenina. Nesta revisão, abordaremos o papel desta via e sua participação na carcinogênese prostática, importante em humanos e cães, além de algumas proteínas envolvidas na regulação da mesma.(AU)


Assuntos
Animais , Masculino , Cães , Carcinogênese , Próstata/fisiopatologia , Proteínas Wnt/análise , Carcinoma/etiologia , Carcinoma/veterinária , Estudos de Casos e Controles
10.
Vet. zootec ; 24(1): 49-59, mar. 2017.
Artigo em Português | VETINDEX | ID: biblio-1503396

Resumo

La especie canina presenta semejanza con la especie humana con relación a las lesiones prostáticas. Es la única especie en presentar tumores espontáneos con frecuencia, de esta manera representa un importante modelo para estudio comparativo de afecciones de la glándula. El desarrollo de las neoplasia prostáticas es una enfermedad con causas multifactoriales, entre estas, alteraciones genéticas y epigenéticas están involucradas. Por lo tanto, el perro puede ser un modelo natural y espontaneo para el estudio de lesiones preneoplásicas e neoplásicas de próstata canina. En el futuro, podrá ser utilizado como modelo en pruebas pre-clínicas de medicamentos, como ya fue realizado para osteosarcoma, por ejemplo. Una de las vías importantes para el desarrollo de los carcinomas prostáticos es la WNT canónica dependiente de la proteína Beta-catenina. En esta revisión abordaremos el papel de esta vía y su participación en la carcinogénesis prostática, importante en humanos y perros, además de algunas proteínas involucradas en la regulación de la misma.


Prostate of dogs have similar lesions to that observed in human and is the only species other than man which frequently displays spontaneous prostatic tumors. In this way, the dog represent an important model of studying different prostatic affections. The prostate cancer development is multifactorial and among them, genetic and epigenetic alterations are involved. The dog can be a natural and spontaneous model to study preneoplastic and neoplastic lesions, with potential future studies as models for pre-clinical tests. One of important pathway to prostate carcinogenesis is beta catenin dependent canonical WNT pathway. In this paper, we review the role of this pathway in prostate carcinogenesis, important in humans and dogs, besides some regulatory proteins involved in this pathway.


A espécie canina apresenta semelhanças com a espécie humana com relação às lesões prostáticas, sendo a única espécie a apresentar tumores espontâneos e com frequência, desse modo representa um importante modelo para estudo comparativo de afecções desta glândula. O desenvolvimento das neoplasias prostáticas é multifatorial e dentre eles, alterações genéticas e epigenéticas estão envolvidas, portanto o cão pode ser um modelo natural e espontâneo para o estudo das lesões pré neoplásicas e neoplásicas da próstata, com futuro alto potencial de ser utilizado como modelo em testes pré-clínicos de medicamentos. Uma das vias importantes para o desenvolvimento dos carcinomas prostáticos é a WNT canônica, dependente da proteína Beta-catenina. Nesta revisão, abordaremos o papel desta via e sua participação na carcinogênese prostática, importante em humanos e cães, além de algumas proteínas envolvidas na regulação da mesma.


Assuntos
Masculino , Animais , Cães , Carcinogênese , Carcinoma/etiologia , Carcinoma/veterinária , Proteínas Wnt/análise , Próstata/fisiopatologia , Estudos de Casos e Controles
11.
Acta sci. vet. (Impr.) ; 45(suppl.1): Pub.242-2017. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1457779

Resumo

Background: Canine lymphoma is the most common hematopoietic neoplasm in dogs and reveals divergent biological behaviors correlated to histopathological subtype, the immunophenotypic (T or B) and tumor stage. The multi-centric form is the most common presentation for canine lymphoma, followed by gastrointestinal and cutaneous forms. Miscellaneous forms of canine lymphoma (nasal, osseous, central nervous system and muscle) represent less than 1% of all cases. This report describes the clinical, macroscopic, histopathological and immunohistochemical findings detected in a dog with a primary muscular lymphoma. Case: The subject was referred to the Emergency and Critical Care Service at the Veterinary Hospital with a history of claudication in the left pelvic limb, severe dehydration, hypovolemia, vomiting and diarrhea caused by gastroenteritis associated with the use of phenylbutazone. After death, the post-mortem examination revealed ulcerative gastritis in the gastrointestinal tract (GIT). Histopathological examination of the GIT specimens, mesenteric lymph nodes, and the left popliteal lymph node revealed no neoplastic alterations. Histological examination of semitendinosus muscle revealed proliferation of cells with round or oval nucleus, an evident pleomorphic nucleolus and scanty, eosinophilic cytoplasm. There were five to six mitosis per each 400x field. These cells infiltrated through the muscle fibers. The muscle fibers displayed marked eosinophilic sarcoplasm, loss of striations and fragmentation (degeneration). Immunohistochemical staining revealed negative reaction for CD79a and positive for CD45 and CD3. Discussion: The primary muscle lymphoma it is very rare disease and patients commonly have clinical signs related with muscle location...


Assuntos
Animais , Cães , Linfoma/veterinária , Linfócitos T/patologia , Músculo Esquelético , Imuno-Histoquímica/veterinária
12.
Acta sci. vet. (Online) ; 45(suppl.1): Pub. 242, 2017. ilus
Artigo em Inglês | VETINDEX | ID: vti-20097

Resumo

Background: Canine lymphoma is the most common hematopoietic neoplasm in dogs and reveals divergent biological behaviors correlated to histopathological subtype, the immunophenotypic (T or B) and tumor stage. The multi-centric form is the most common presentation for canine lymphoma, followed by gastrointestinal and cutaneous forms. Miscellaneous forms of canine lymphoma (nasal, osseous, central nervous system and muscle) represent less than 1% of all cases. This report describes the clinical, macroscopic, histopathological and immunohistochemical findings detected in a dog with a primary muscular lymphoma. Case: The subject was referred to the Emergency and Critical Care Service at the Veterinary Hospital with a history of claudication in the left pelvic limb, severe dehydration, hypovolemia, vomiting and diarrhea caused by gastroenteritis associated with the use of phenylbutazone. After death, the post-mortem examination revealed ulcerative gastritis in the gastrointestinal tract (GIT). Histopathological examination of the GIT specimens, mesenteric lymph nodes, and the left popliteal lymph node revealed no neoplastic alterations. Histological examination of semitendinosus muscle revealed proliferation of cells with round or oval nucleus, an evident pleomorphic nucleolus and scanty, eosinophilic cytoplasm. There were five to six mitosis per each 400x field. These cells infiltrated through the muscle fibers. The muscle fibers displayed marked eosinophilic sarcoplasm, loss of striations and fragmentation (degeneration). Immunohistochemical staining revealed negative reaction for CD79a and positive for CD45 and CD3. Discussion: The primary muscle lymphoma it is very rare disease and patients commonly have clinical signs related with muscle location...(AU)


Assuntos
Animais , Cães , Linfócitos T/patologia , Linfoma/veterinária , Complexo CD3 , Antígenos CD79 , Músculo Esquelético , Imuno-Histoquímica/veterinária
13.
Acta sci. vet. (Impr.) ; 44(supl): 01-06, 2016. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1457534

Resumo

Background: Hemangiosarcoma (HSA) is a malignant tumor that arises from the vascular endothelium affecting more often dogs than other species as cats, cows and horses. It comprises approximately 2% of all tumors in dogs. The most common primary site for the HSA in dogs is the spleen, and other locations include the right atrium, pericardium, liver and prostate. Other authors have reported this tumor in lungs, kidney, oral cavity, muscle, bone, urinary bladder, left ventricle, tongue and retroperitoneum. Due to the importance of the HSA in canine species, the aim of this study was to describe the clinical and pathological findings, besides therapeutic protocol in an unusual case of HSA. Case: A six-year-old male pinscher was referred to the veterinary hospital with a history of cyanosis and choking. The animal was submitted to radiographic examination in lateral cervical view, which identified the presence of a mass of 1.2 cm in diameter near the pharynx. In order to evaluate the oral cavity, general anesthesia was performed, and it was possible to see a soft, rosy, circumscribed and vascularized lump in pharyngeal region. Due to suspicion of neoplasm, excisional biopsy without surgical margin was performed. The histopathological exam diagnosed hemangiosarcoma. Immunohistochemistry against vimentin, factor VIII, VEGF and Ki67 was performed and confirmed diagnosis of low grade [...]


Assuntos
Animais , Cães , Baço/patologia , Cianose/veterinária , Hemangiossarcoma/veterinária , Neoplasias/veterinária , Imuno-Histoquímica/veterinária
14.
Acta sci. vet. (Online) ; 44(supl): 01-06, 2016. ilus
Artigo em Inglês | VETINDEX | ID: vti-482953

Resumo

Background: Hemangiosarcoma (HSA) is a malignant tumor that arises from the vascular endothelium affecting more often dogs than other species as cats, cows and horses. It comprises approximately 2% of all tumors in dogs. The most common primary site for the HSA in dogs is the spleen, and other locations include the right atrium, pericardium, liver and prostate. Other authors have reported this tumor in lungs, kidney, oral cavity, muscle, bone, urinary bladder, left ventricle, tongue and retroperitoneum. Due to the importance of the HSA in canine species, the aim of this study was to describe the clinical and pathological findings, besides therapeutic protocol in an unusual case of HSA. Case: A six-year-old male pinscher was referred to the veterinary hospital with a history of cyanosis and choking. The animal was submitted to radiographic examination in lateral cervical view, which identified the presence of a mass of 1.2 cm in diameter near the pharynx. In order to evaluate the oral cavity, general anesthesia was performed, and it was possible to see a soft, rosy, circumscribed and vascularized lump in pharyngeal region. Due to suspicion of neoplasm, excisional biopsy without surgical margin was performed. The histopathological exam diagnosed hemangiosarcoma. Immunohistochemistry against vimentin, factor VIII, VEGF and Ki67 was performed and confirmed diagnosis of low grade [...](AU)


Assuntos
Animais , Cães , Hemangiossarcoma/veterinária , Neoplasias/veterinária , Cianose/veterinária , Baço/patologia , Imuno-Histoquímica/veterinária , /veterinária
15.
Arq. ciênc. vet. zool. UNIPAR ; 19(3): 187-194, jul.-set. 2016. ilus
Artigo em Português | VETINDEX | ID: vti-691064

Resumo

O Carcinoma Inflamatório de Mama (CIM) é um neoplasma maligno de rápida evolução que apresenta baixa ocorrência tanto em cadelas quanto em mulheres. É pouco relatado pelos médicos veterinários no Brasil, fato que pode ser relacionado à falta de conhecimento da doença associado à necessidade da relação dos achados clínicos com exame histopatológico para o diagnóstico definitivo. Esse neoplasma também acomete a glândula mamária de mulheres, nas quais demonstra características clássicas de inflamação como dor, turgor de pele e aumento de temperatura local. Para diagnóstico definitivo é considerado a presença de êmbolos de células tumorais em canais linfáticos da derme associados aos sinais clínicos de inflamação. Devido ao grau de infiltração local, os sinais de inflamação e a presença de êmbolos em linfáticos, o paciente humano e veterinário apresentam prognóstico desfavorável. O CIM é pouco responsivo à quimioterapia e devido às características de inflamação, não apresenta indicação cirúrgica na maioria dos casos. Devido à agressividade do CIM em mulheres e nas cadelas, do prognóstico desfavorável e das restritas opções terapêuticas essa revisão objetiva descrever os avanços das opções terapêuticas além do tratamento paliativo na literatura atual além de apresentar uma abordagem comparada, considerando a cadela um modelo de estudo para a doença na mulher.(AU)


The Inflammatory Mammary Carcinoma (IMC) is a low-occurrence malignant neoplasm with rapid evolution that affects dogs and women. There are few reports of this disease in the Brazilian veterinary literature, which may be related to the lack of knowledge of the disease associated with the need of relating clinical findings to histopathology exams for definitive diagnosis. This neoplasm also affects the mammary glands in women, which demonstrates classical signs of inflammation such as pain, skin turgor and increased local temperature. The diagnosis considers the presence of tumor cell emboli in the lymph vessels in the dermis associated with clinical signs of inflammation. Due to the degree of local infiltration, signs of inflammation and the presence of lymph emboli, both human and veterinary patients have unfavorable prognosis. The IMC is poorly responsive to chemotherapy and due to its inflammation characteristics, in most cases, surgical removal is not recommended. Due to the aggressiveness of the IMC on women and bitches, poor prognosis and limited therapeutic options, this paper aims to describe the advances of therapeutic options beyond palliative care in current literature, as well as presenting a comparative approach considering the bitch as a study model for treating the disease in women.(AU)


El carcinoma inflamatorio de mama (CIM) es una neoplasia maligna de evolución rápida que tiene una baja incidencia tanto en perras como en mujeres. Es poco relatado por médicos veterinarios en Brasil, hecho que puede estar relacionado a la falta de conocimiento de la enfermedad, asociada a la necesidad de la relación de los hallazgos clínicos con examen histopatológico para el diagnóstico definitivo. Esta neoplasia también afecta a las glándulas mamarias de mujeres, lo que demuestra características clásicas de inflamación, como dolor, la turgencia de la piel y el aumento de la temperatura local. Para el diagnóstico definitivo se considera la presencia de émbolos de células tumorales en los canales dermis ganglios, asociados con los signos clínicos de inflamación. Debido al grado de infiltración local, los signos de inflamación y la presencia de embolias en el linfático, el paciente humano y veterinario presentan pronóstico desfavorable. El CIM es poco sensible a la quimioterapia y debido a las características de inflamación no presenta indicación quirúrgica en la mayoría de los casos. Debido a la agresividad del CIM en mujeres y perras, del pronóstico desfavorable y de las restrictas opciones terapéuticas, esa investigación tuvo como objetivo revisar el progreso de las opciones terapéuticas además del tratamiento paliativo en la literatura actual, allende presentar un enfoque comparativo, teniendo en cuenta que la perra es un modelo de estudios para la enfermedad en mujeres.(AU)


Assuntos
Animais , Carcinoma/veterinária , Carcinoma , Carcinoma/diagnóstico
16.
Arq. ciênc. vet. zool. UNIPAR ; 19(3): 187-194, jul.-set. 2016. ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-833160

Resumo

O Carcinoma Inflamatório de Mama (CIM) é um neoplasma maligno de rápida evolução que apresenta baixa ocorrência tanto em cadelas quanto em mulheres. É pouco relatado pelos médicos veterinários no Brasil, fato que pode ser relacionado à falta de conhecimento da doença associado à necessidade da relação dos achados clínicos com exame histopatológico para o diagnóstico definitivo. Esse neoplasma também acomete a glândula mamária de mulheres, nas quais demonstra características clássicas de inflamação como dor, turgor de pele e aumento de temperatura local. Para diagnóstico definitivo é considerado a presença de êmbolos de células tumorais em canais linfáticos da derme associados aos sinais clínicos de inflamação. Devido ao grau de infiltração local, os sinais de inflamação e a presença de êmbolos em linfáticos, o paciente humano e veterinário apresentam prognóstico desfavorável. O CIM é pouco responsivo à quimioterapia e devido às características de inflamação, não apresenta indicação cirúrgica na maioria dos casos. Devido à agressividade do CIM em mulheres e nas cadelas, do prognóstico desfavorável e das restritas opções terapêuticas essa revisão objetiva descrever os avanços das opções terapêuticas além do tratamento paliativo na literatura atual além de apresentar uma abordagem comparada, considerando a cadela um modelo de estudo para a doença na mulher.


The Inflammatory Mammary Carcinoma (IMC) is a low-occurrence malignant neoplasm with rapid evolution that affects dogs and women. There are few reports of this disease in the Brazilian veterinary literature, which may be related to the lack of knowledge of the disease associated with the need of relating clinical findings to histopathology exams for definitive diagnosis. This neoplasm also affects the mammary glands in women, which demonstrates classical signs of inflammation such as pain, skin turgor and increased local temperature. The diagnosis considers the presence of tumor cell emboli in the lymph vessels in the dermis associated with clinical signs of inflammation. Due to the degree of local infiltration, signs of inflammation and the presence of lymph emboli, both human and veterinary patients have unfavorable prognosis. The IMC is poorly responsive to chemotherapy and due to its inflammation characteristics, in most cases, surgical removal is not recommended. Due to the aggressiveness of the IMC on women and bitches, poor prognosis and limited therapeutic options, this paper aims to describe the advances of therapeutic options beyond palliative care in current literature, as well as presenting a comparative approach considering the bitch as a study model for treating the disease in women.


El carcinoma inflamatorio de mama (CIM) es una neoplasia maligna de evolución rápida que tiene una baja incidencia tanto en perras como en mujeres. Es poco relatado por médicos veterinarios en Brasil, hecho que puede estar relacionado a la falta de conocimiento de la enfermedad, asociada a la necesidad de la relación de los hallazgos clínicos con examen histopatológico para el diagnóstico definitivo. Esta neoplasia también afecta a las glándulas mamarias de mujeres, lo que demuestra características clásicas de inflamación, como dolor, la turgencia de la piel y el aumento de la temperatura local. Para el diagnóstico definitivo se considera la presencia de émbolos de células tumorales en los canales dermis ganglios, asociados con los signos clínicos de inflamación. Debido al grado de infiltración local, los signos de inflamación y la presencia de embolias en el linfático, el paciente humano y veterinario presentan pronóstico desfavorable. El CIM es poco sensible a la quimioterapia y debido a las características de inflamación no presenta indicación quirúrgica en la mayoría de los casos. Debido a la agresividad del CIM en mujeres y perras, del pronóstico desfavorable y de las restrictas opciones terapéuticas, esa investigación tuvo como objetivo revisar el progreso de las opciones terapéuticas además del tratamiento paliativo en la literatura actual, allende presentar un enfoque comparativo, teniendo en cuenta que la perra es un modelo de estudios para la enfermedad en mujeres.


Assuntos
Animais , Cães , Carcinoma/diagnóstico , Carcinoma/epidemiologia , Carcinoma/veterinária
17.
Acta sci. vet. (Online) ; 44(supl): 01-05, 2016. ilus
Artigo em Inglês | VETINDEX | ID: vti-993

Resumo

Background: Spirocercosis is considered to be an emerging pathological condition within veterinary medicine. The disease has worldwide distribution, although the greatest prevalence has been described in tropical and subtropical regions. The infection rate is affected by the interrelationships between the density of the dog population and intermediate hosts. The aim of this study was report the morphological and histopathological characteristics of natural infection by Spirocerca lupi in dogs from Distrito Federal, Brazil. Cases: Records were obtained from 10 dogs diagnosed with spirocercosis at the Pathology Sector, School of Veterinary Medicine, União Pioneira de Integração Social (UPIS), in Brasília, Federal District. For six animals, the diagnosis was confirmed through necropsy. Two dogs presented aortic rupture, thus resulting in hemothorax and consequent hypovolemic shock. Another animal presented gastric nodules, erratic migration to the lungs and renal and splenic infarction due to aortic thromboembolism. One dog presented neoplastic transformation of the esophageal granuloma to osteosarcoma. The age of the dogs ranged from one to eight years and the weight ranged from 15 to 40 kg. The clinical histories were similar: regurgitation (10/10), emesis (5/10), dysphagia (7/10), weight loss (10/10), weakness (3/10) and dyspnea (4/10). Esophageal nodules measured 1 to 5 cm in [...](AU)


Assuntos
Animais , Cães , Thelazioidea/parasitologia , Hemotórax/veterinária , Hipovolemia/veterinária , Tromboembolia/veterinária , Omã , Doenças Parasitárias/economia
18.
Acta sci. vet. (Impr.) ; 44(supl): 01-05, 2016. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1457522

Resumo

Background: Spirocercosis is considered to be an emerging pathological condition within veterinary medicine. The disease has worldwide distribution, although the greatest prevalence has been described in tropical and subtropical regions. The infection rate is affected by the interrelationships between the density of the dog population and intermediate hosts. The aim of this study was report the morphological and histopathological characteristics of natural infection by Spirocerca lupi in dogs from Distrito Federal, Brazil. Cases: Records were obtained from 10 dogs diagnosed with spirocercosis at the Pathology Sector, School of Veterinary Medicine, União Pioneira de Integração Social (UPIS), in Brasília, Federal District. For six animals, the diagnosis was confirmed through necropsy. Two dogs presented aortic rupture, thus resulting in hemothorax and consequent hypovolemic shock. Another animal presented gastric nodules, erratic migration to the lungs and renal and splenic infarction due to aortic thromboembolism. One dog presented neoplastic transformation of the esophageal granuloma to osteosarcoma. The age of the dogs ranged from one to eight years and the weight ranged from 15 to 40 kg. The clinical histories were similar: regurgitation (10/10), emesis (5/10), dysphagia (7/10), weight loss (10/10), weakness (3/10) and dyspnea (4/10). Esophageal nodules measured 1 to 5 cm in [...]


Assuntos
Animais , Cães , Hemotórax/veterinária , Hipovolemia/veterinária , Omã , Thelazioidea/parasitologia , Tromboembolia/veterinária , Doenças Parasitárias/economia
19.
Acta Vet. Brasilica ; 9(3): 279-283, 2015. ilus
Artigo em Português | VETINDEX | ID: biblio-1453582

Resumo

Inúmeras etiologias são descritas como causadoras de úlceras gástricas em pequenos animais,dentre elas, destaca-se a administração indiscriminada de anti-inflamatórios não esteroides (AINEs). É umaafecção de curso clínico assintomático, de difícil diagnóstico e com consequências graves à saúde do paciente.No presente trabalho foi realizada a necropsia de três felinos apresentando alterações gastrointestinais. Duranteexame necroscópico, observaram-se perfurações na região de piloro estomacal com bordos brancos earredondados, além de grande quantidade de líquido na cavidade abdominal, hiperemia, presença de fibrina nostrês pacientes. Apesar de poucos relatos descreverem a ocorrência de úlceras gastrointestinais em felinos, infereseque estas tenham sido provocadas pelo efeito da administração prolongada e em doses inadequadas de AINEs.Embora bem documentada em cães, há poucas descrições da gastrite ulcerativa em gatos devido ao uso deAINEs. Devido à importância dos AINEs na rotina clínica de pequenos animais, este trabalho visa relatar amorte de três gatos em consequência de gastrite ulcerativa associada a peritonite secundária


Stomach ulcers are commun in small animal practice and occurs commonly in dogs dueadministration of nonsteroidal anti-inflammatory drugs (NSAIDs). It is an often silent disease, difficult todiagnose and with serious consequences to health of the animal. Although well documented in dogs, there arefew reports of ulcers associated with the use of NSAIDs in cats. This paper describes the death of three cats as aresult of perforated ulcer and secondary peritonitis associated with NSAIDs administration. There were holes inthe stomach pyloric region with white and rounded edges, and large amount of fluid in the abdominal cavity,hyperemia, the presence of fibrin. Although not commonly reported the occurrence of gastrointestinal ulcers incats, it appears that these have been caused by the effect of prolonged administration and inadequate doses ofNSAIDs


Assuntos
Animais , Gatos , Gastrite/patologia , Gastrite/veterinária , Úlcera Gástrica/veterinária , Anti-Inflamatórios não Esteroides , Peritonite/veterinária
20.
Ci. Rural ; 45(9): 1644-1647, Sept. 2015. ilus
Artigo em Inglês | VETINDEX | ID: vti-27643

Resumo

Oesophageal leiomyosarcoma is a malignant neoplasm of smooth muscle fibres that is infrequently reported in the literature. Because of the importance of definitive diagnosis and the low incidence of this tumour in dogs, it was reported a case of oesophageal leiomyosarcoma in a dog. A 13-year-old intact male Rottweiler presented regurgitation, hyporexia, and chronic weight loss. After an imaging examination, tumour in the thoracic oesophagus was suspected and a biopsy was sugested for definitive diagnosis. However, the owner did not permit the procedure. Six months after the clinical diagnosis, the patient was brought for evaluation of anorexia, apathy, and severe dyspnoea. Because of the patient's clinical signs and lack of response to emergency treatment, he was euthanized. Upon necropsy, it was identified the neoplastic formation, previously identified in the radiographic examination in the thoracic oesophagus, near the diaphragm. Histopathology revealed a proliferation of mesenchymal cells, and the diagnosis of leiomyosarcoma was confirmed by immunohistochemical examination. Despite the low incidence of oesophageal leiomyosarcoma, it should be included as a differential diagnosis for animals with chronic regurgitation.(AU)


O leiomiossarcoma esofágico é um neoplasma maligno das fibras musculares lisas pouco descrito na literatura e, devido à importância do seu diagnóstico definitivo e à baixa frequência desta neoplasia em cães, relata-se um caso de leiomiossarcoma em localização esofágica. Foi atendido um cão, 13 anos, Rottweiler, com histórico de regurgitação, hiporexia e perda de peso crônica. Após exames complementares de imagem, suspeitou-se de neoplasma localizado em esôfago torácico, no entanto, o proprietário optou por não realizar nenhum exame para o diagnóstico definitivo. Após seis meses do atendimento inicial, o animal retornou com anorexia, apatia e dispneia severa. Devido aos sinais clínicos apresentados e ausência de resposta ao tratamento emergencial instituído, optou-se pela eutanásia. Foi realizada a necropsia e, no esôfago torácico, próximo à região diafragmática, foi possível identificar a formação neoplásica anteriormente visualizada no exame radiográfico. O exame histopatológico revelou proliferação de células mesenquimais, sugestiva de leiomiossarcoma. O diagnóstico foi confirmado pelo exame imuno-histoquímico. Apesar da baixa frequência do leiomiossarcoma esofágico, animais que apresentam regurgitação crônica devem ser investigados quanto à possibilidade desse diagnóstico.(AU)


Assuntos
Animais , Cães , Leiomiossarcoma/veterinária , Leiomiossarcoma/diagnóstico , Doenças do Cão , Neoplasias Esofágicas/veterinária
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA