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1.
Acta sci. vet. (Impr.) ; 48: Pub.1739-Jan. 30, 2020. tab, graf
Artigo em Inglês | VETINDEX | ID: biblio-1458262

Resumo

Background: Mast cell tumors (MCT) are among the most common malignant cutaneous neoplasm in dogs with variable biologic behavior and remain a therapeutic challenge in high-grade cases. Surgery remains the primary treatment for canine MCT; however, chemotherapy and radiation therapy are commonly used to treat aggressive cases. The combination of vinblastine (VBL) at a dose of 2 mg/m² and prednisone is the classically described protocol for MCT treatment. Studies have shown the safety of higher VBL doses for dogs with MCT, but there is a lack of information regarding dose intensity and outcome as a goal after chemotherapy. This study aimed to evaluate the impact of a higher dose of VBL on MCT treatment outcome. Materials, Methods & Results: This was an observational and comparative study conducted in two different Veterinary Teaching Hospitals. Client-owned dogs with histopathological diagnosis of grade II or III MCT were selected and underwent at least four chemotherapy sessions with VBL and prednisone. The experimental group (EG) consisted of 18 dogs that received a dose of 3 mg/m² VBL treated in one institution. The control group (CG) included 31 dogs that received a dose of 2 mg/m² VBL treated at the other institution. All dogs treated in both groups had a clinical and complete blood count (CBC) evaluation performed previous the start of chemotherapy (T0) and before each weekly treatment (T1, T2, T3, and T4). After treatment, dogs in both groups were followed-up for the recurrence rate and overall survival time after diagnosis. There was no significant difference in clinical variables between EG and CG. During treatment, dogs of EG showed a significant reduction in erythrocyte, hemoglobin, and hematocrit values between T0 and T1, T2, T3, and T4 (P < 0.001). Comparatively, the CG showed significant reduction in hemoglobin (P = 0.02) and total leucocytes (P = 0.001) values in the same period. Despite these findings, these hematological...


Assuntos
Animais , Cães , Mastocitoma Cutâneo/tratamento farmacológico , Mastocitoma Cutâneo/veterinária , Prednisona/administração & dosagem , Vimblastina/administração & dosagem , Vimblastina/uso terapêutico , Contagem de Células Sanguíneas/veterinária
2.
MEDVEP Derm. ; 3(9): 198-203, abr.-jun. 2014. ilus
Artigo em Português | VETINDEX | ID: vti-11263

Resumo

A demodiciose felina é uma dermatopatia parasitária rara, causada principalmente por dois ácaros, oDemodex cati e o Demodex gatoi. O D. cati é comensal da pele dos gatos, causa lesões alopécicas não pruriginosase, eventualmente, generalizadas, e pode ser associado a doenças imunodepressoras como a FIV eFeLV. O D. gatoi, por outro lado, é infeccioso, causa lesões pruriginosas que podem mimetizar dermatopatiasalérgicas ou psicogênicas e acomete gatos anteriormente saudáveis. (AU)


The feline demodicosis is a rare parasitic skin disease, mainly caused by two mites, Demodex cati and Demodexgatoi. D. cati is found on healthy hair follicles but it may cause generalized non pruritic alopecic lesions on hostsand it is associated with immunosuppressive diseases like FIV and FeLV, meanwhile. D. gatoi is infectious, causes pruritic lesions that may mimic allergic or psychogenic injuries and may affect otherwise healthy cats. (AU)


Assuntos
Animais , Gatos , Gatos , Prurido , Infestações por Ácaros/veterinária
3.
Medvep Derm ; 3(9): 198-203, abr.-jun. 2014. ilus
Artigo em Português | VETINDEX | ID: biblio-1485578

Resumo

A demodiciose felina é uma dermatopatia parasitária rara, causada principalmente por dois ácaros, oDemodex cati e o Demodex gatoi. O D. cati é comensal da pele dos gatos, causa lesões alopécicas não pruriginosase, eventualmente, generalizadas, e pode ser associado a doenças imunodepressoras como a FIV eFeLV. O D. gatoi, por outro lado, é infeccioso, causa lesões pruriginosas que podem mimetizar dermatopatiasalérgicas ou psicogênicas e acomete gatos anteriormente saudáveis.


The feline demodicosis is a rare parasitic skin disease, mainly caused by two mites, Demodex cati and Demodexgatoi. D. cati is found on healthy hair follicles but it may cause generalized non pruritic alopecic lesions on hostsand it is associated with immunosuppressive diseases like FIV and FeLV, meanwhile. D. gatoi is infectious, causes pruritic lesions that may mimic allergic or psychogenic injuries and may affect otherwise healthy cats.


Assuntos
Animais , Gatos , Gatos , Prurido , Infestações por Ácaros/veterinária
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