Biliary cystadenoma in a lion (Panthera leo)

Animals in human care often exceed the life expectancy of animals in the wild when they have veterinarian follow-ups, no competition for space or food, and continuous care. Advanced age favors the development of mutations that often trigger cancer, which sometimes causes death. There are reports in the literature on neoplasms in lions in the liver, which are one of the main organs affected. A 20-year-old lion specimen was received for necropsy at the Federal University of Paraná, Curitiba, Brazil. Multiple cystic dilations were observed in the liver. Histologically, they were internally covered by a simple cuboidal epithelium, similar to that observed in the bile ducts, without cellular atypia. The adjacent liver parenchyma presented with mild disorganization of the hepatocyte cords. Biliary cystadenomas are benign growths formed by a thin opaque capsule filled with a slightly yellowish translucent fluid compressing the adjacent liver parenchyma, as highlighted in this case. The epithelium of the cysts was positive for anti-cytokeratin (CK) (EIA/A3E) and anti-CK7, confirming histogenesis in the bile ducts. This study reports a case of biliary cystadenoma in a Panthera leo specimen.(AU)

Megaesôfago em muar / Megaesophagus in mule

Background: Megaesophagus is a chronic dilation of the esophagus rarely found in horses. It’s a non-specific disease that is associated with several causes, and esophageal hypomotility is the dysfunction that most commonly results in organ dilation. In the literature, there are few reports of megaesophagus in horses and, to date, no cases in mule have been reported. The objective of this work is to describe a case of a donkey with thoracic megaesophagus. Case: A 16 year-old donkey, castrated male, mixed breed weighing 195 kg, was referred for clinical care with a history of 5 days of anorexia. On physical examination, apathy, cachexia, 8% dehydration, moderate enophthalmos, ptialism, bilateral nasal discharge, dry and bristling hair were observed. Due to the poor general condition, a nasogastric tube was chosen to perform enteral nutrition, however, it was not possible to progress the tube to the stomach. In order to confirm the suspicion of a possible esophageal obstruction, gastroscopy was performed, where it was possible to observe an esophageal dilation filled with bulky food located in the thoracic portion of the esophagus. In an attempt to stimulate esophageal motility, in order to promote the progression of the material present in the region of dilation, intramuscular metoclopramide was administered (two applications every 6 h), however the treatment had no effect. Due to the unfavorable prognosis and financial limitations of the owner, euthanasia was performed, which was followed by autopsy and histopathological examination. At necropsy, a marked dilation of the esophagus was observed in the thoracic portion, which was filled with approximately 500 grams of bulky food (grass). In the mucosa of this area...

Megaesôfago em muar / Megaesophagus in mule

Background: Megaesophagus is a chronic dilation of the esophagus rarely found in horses. Its a non-specific disease that is associated with several causes, and esophageal hypomotility is the dysfunction that most commonly results in organ dilation. In the literature, there are few reports of megaesophagus in horses and, to date, no cases in mule have been reported. The objective of this work is to describe a case of a donkey with thoracic megaesophagus. Case: A 16 year-old donkey, castrated male, mixed breed weighing 195 kg, was referred for clinical care with a history of 5 days of anorexia. On physical examination, apathy, cachexia, 8% dehydration, moderate enophthalmos, ptialism, bilateral nasal discharge, dry and bristling hair were observed. Due to the poor general condition, a nasogastric tube was chosen to perform enteral nutrition, however, it was not possible to progress the tube to the stomach. In order to confirm the suspicion of a possible esophageal obstruction, gastroscopy was performed, where it was possible to observe an esophageal dilation filled with bulky food located in the thoracic portion of the esophagus. In an attempt to stimulate esophageal motility, in order to promote the progression of the material present in the region of dilation, intramuscular metoclopramide was administered (two applications every 6 h), however the treatment had no effect. Due to the unfavorable prognosis and financial limitations of the owner, euthanasia was performed, which was followed by autopsy and histopathological examination. At necropsy, a marked dilation of the esophagus was observed in the thoracic portion, which was filled with approximately 500 grams of bulky food (grass). In the mucosa of this area...(AU)