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Acta cir. bras. ; 30(9): 639-645, Sep. 2015. tab, ilus
Artigo em Inglês | VETINDEX | ID: vti-334064

Resumo

To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in healthy, tobacco-exposed and diabetic rats. Ninety male Wistar rats (250-300g) were randomly divided into six groups: control+saline (C1), control+BoNTA (C2), tobacco-exposed+saline (T1), tobacco-exposed+BoNTA (T2) diabetes+saline (D1) and diabetes+BoNTA (D2). A dorsal cutaneous flap (3×10cm) was performed. Survival area and total area of the flaps were measured. Lumen diameter, external arterial diameter and lumen/wall thickness ratio were recorded. Survival area increased in control group with BoNTA injection compared with control animals injected with saline (C2 x C1; 0.9±0.1 vs0.67±0.15, p= 0.001). A similar result was found in diabetes group injected with BontA (D2 x D1; 0.97±0.2 vs0.61±0.24, p=0.018). No difference was observed in skin flap viability in tobacco-exposed groups (T2 x T1; 0.74±0.24 vs 0.64±0.21, p=0.871). Lumen diameter (p= 0.004), external arterial diameter (p = 0.0046,) and lumen/wall thickness ratio (p= 0.003) were increased in diabetes+BoNTA-treated animals. This effect was not observed in control or in tobacco-exposed groups. Botulinum toxin A increased skin flap viability in control and diabetic rats on the seventh post-operative day. Increased lumen diameter, external arterial diameter, and lumen/wall thickness ratio were observed in the diabetes+BoNTA group. BoNTA had no effect in the tobacco-exposed group on the seventh postoperative day.(AU)


Assuntos
Humanos , Animais , Masculino , Toxinas Botulínicas Tipo A/farmacologia , Diabetes Mellitus Experimental/complicações , Fármacos Neuromusculares/farmacologia , Pele , Retalhos Cirúrgicos , Poluição por Fumaça de Tabaco/efeitos adversos , Sobrevivência de Enxerto , Necrose , Distribuição Aleatória , Ratos Wistar , Reprodutibilidade dos Testes , Pele/patologia , Estreptozocina , Retalhos Cirúrgicos/patologia , Fatores de Tempo
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