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1.
Acta sci. vet. (Impr.) ; 45: 1-8, 2017. tab, ilus, graf
Artigo em Inglês | VETINDEX | ID: biblio-1457653

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned skin from nasal planum were biopsied to histopathologic and DIF evaluation. The kappa (k) coefficient was used to determine the degree of agreement and reliability of the results of both tests. A P-value < 5% was considered to be statistically significant. In Group I, all animals were normal across both the physical and laboratorial evaluation. A diagnosis of canine CCLE was established in 81.8% (9/11) of the animals based on histopathology analysis.[...]


Assuntos
Animais , Cães , Lúpus Eritematoso Discoide/diagnóstico , Lúpus Eritematoso Discoide/veterinária , Técnica Direta de Fluorescência para Anticorpo/veterinária
2.
Artigo em Inglês | LILACS-Express | VETINDEX | ID: biblio-1457729

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned sk

3.
Acta sci. vet. (Online) ; 45: 1-8, 2017. tab, ilus, graf
Artigo em Inglês | VETINDEX | ID: vti-20220

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned skin from nasal planum were biopsied to histopathologic and DIF evaluation. The kappa (k) coefficient was used to determine the degree of agreement and reliability of the results of both tests. A P-value < 5% was considered to be statistically significant. In Group I, all animals were normal across both the physical and laboratorial evaluation. A diagnosis of canine CCLE was established in 81.8% (9/11) of the animals based on histopathology analysis.[...](AU)


Assuntos
Animais , Cães , Lúpus Eritematoso Discoide/diagnóstico , Lúpus Eritematoso Discoide/veterinária , Técnica Direta de Fluorescência para Anticorpo/veterinária
4.
Acta sci. vet. (Impr.) ; 41: Pub. 1112, 2013. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1372524

Resumo

Background: Cases of sporotrichosis in male and female cats and dogs of different ages with cutaneous sporotrichosis that were treated at the dermatology service of a teaching veterinary hospital and orally administered itraconazole (ITC) were retrospectively characterized by reviewing the clinical records corresponding to a 19-year period (1993-2011). The aim of the present study was to analyze regarding clinical cure, side effects, length of treatment and relapse using ITC in the treatment of cutaneous sporotrichosis in cats and dogs. Materials, Methods & Results: From the assessed case series, 20 animals were selected, of which 17 (85.0%) were cats and three (15.0%) were dogs; the animals were mostly males (80.0%) and of ill-defined breeds (75.0%). Cases of sporotrichosis in male and female cats and dogs of different ages that were treated at the dermatology service of a teaching veterinary hospital and orally administered ITC (10 mg/kg) once a day. The percentage of full remission of the treated cases, regardless of their clinical form, was 100%, and no systemic or tegumentary side effects were found in the assessed animals. The average duration of treatment was 3.4 months in cats and 11.3 months in dogs, whereas the maximum duration of treatment required to resolve the clinical condition in the assessed case series of cats and dogs was 16 months, regardless of the animal species. Relapses occurred in 15.0% (one cat and two dogs) of the cases treated with the investigated antifungal agent. Discussion: The remarkable difference in the average duration of therapy required to achieve clinical cure between cats and dogs might be related to the fact that most of the cases of feline sporotrichosis were of the localized cutaneous form (82.3%). Conversely, the three cases of canine sporotrichosis were of the disseminated cutaneous form, which may have delayed the success of treatment. Clinically manifested systemic or tegumentary side effects were not reported by the pet owners or were detected by clinical examination of the animals that were subjected to treatment with ITC in the present study, which agrees with previous reports. However, given the retrospective character of this research complementary laboratory exams are lacking and thus it cannot be asserted that alterations do not exist. Therapeutic failure was not observed with the use of ITC in the investigated cases of canine and feline sporotrichosis. Clinical relapse occurred in two dogs and one cat, all of which exhibited the disseminated cutaneous form, which might have predisposed them to clinical recrudescence. In addition, the evident difference in the percentage of relapse between the two species might be correlated with the higher prevalence of the disseminated cutaneous form among the investigated dogs (100%) compared with the cats (40%). Of the animals that exhibited relapse, one dog had been treated with topical corticoids for the previous three months. According to the literature, glucocorticoids and other immunosuppressants are contraindicated in dogs and cats with sporotrichosis. The cat, in turn, exhibited respiratory disease complex in addition to sporotrichosis, which might be related to the clinical relapse. In conclusion, ITC is efficacious in the treatment of sporotrichosis in cats and dogs and does not induce apparent side effects.


Assuntos
Animais , Gatos , Cães , Esporotricose/veterinária , Doenças do Gato/tratamento farmacológico , Itraconazol/administração & dosagem , Itraconazol/efeitos adversos , Doenças do Cão/tratamento farmacológico
5.
Acta sci. vet. (Impr.) ; 41: 01-05, 2013.
Artigo em Inglês | LILACS-Express | VETINDEX | ID: biblio-1457131

Resumo

Background: Cases of sporotrichosis in male and female cats and dogs of different ages with cutaneous sporotrichosis that were treated at the dermatology service of a teaching veterinary hospital and orally administered itraconazole (ITC) were retrospectively characterized by reviewing the clinical records corresponding to a 19-year period (1993-2011). The aim of the present study was to analyze regarding clinical cure, side effects, length of treatment and relapse using ITC in the treatment of cutaneous sporotrichosis in cats and dogs. Materials, Methods & Results: From the assessed case series, 20 animals were selected, of which 17 (85.0%) were cats and three (15.0%) were dogs; the animals were mostly males (80.0%) and of ill-defined breeds (75.0%). Cases of sporotrichosis in male and female cats and dogs of different ages that were treated at the dermatology service of a teaching veterinary hospital and orally administered ITC (10 mg/kg) once a day. The percentage of full remission of the treated cases, regardless of their clinical form, was 100%, and no systemic or tegumentary side effects were found in the assessed animals. The average duration of treatment was 3.4 months in cats and 11.3 months in dogs, whereas the maximum duration of treatment required to resolve the clinical condition in the assessed case series of cats and dogs was 16 months, regardless of the anim


Background: Cases of sporotrichosis in male and female cats and dogs of different ages with cutaneous sporotrichosis that were treated at the dermatology service of a teaching veterinary hospital and orally administered itraconazole (ITC) were retrospectively characterized by reviewing the clinical records corresponding to a 19-year period (1993-2011). The aim of the present study was to analyze regarding clinical cure, side effects, length of treatment and relapse using ITC in the treatment of cutaneous sporotrichosis in cats and dogs. Materials, Methods & Results: From the assessed case series, 20 animals were selected, of which 17 (85.0%) were cats and three (15.0%) were dogs; the animals were mostly males (80.0%) and of ill-defined breeds (75.0%). Cases of sporotrichosis in male and female cats and dogs of different ages that were treated at the dermatology service of a teaching veterinary hospital and orally administered ITC (10 mg/kg) once a day. The percentage of full remission of the treated cases, regardless of their clinical form, was 100%, and no systemic or tegumentary side effects were found in the assessed animals. The average duration of treatment was 3.4 months in cats and 11.3 months in dogs, whereas the maximum duration of treatment required to resolve the clinical condition in the assessed case series of cats and dogs was 16 months, regardless of the anim

6.
Semina ciênc. agrar ; 34(6): 3889-3896, 2013.
Artigo em Inglês | LILACS-Express | VETINDEX | ID: biblio-1499384

Resumo

O presente estudo caracterizou retrospectivamente a esporotricose canina e feline em machos e fêmeas de distintas idades. Os pacientes foram atendidos no Serviço de Dermatologia de um hospitalveterinário escola e o diagnostic foi confirmado pelo isolamento e identificação de Sporothrix spp em meio de cultura. Foram obtidas e analizadas as fichas clínicas de um período de 19 anos (1993-2011). Da casuística avaliada, 37 animais foram considerados para o estudo, incluindo 8 (21,6%) cães e 29 (78,4%) gatos. Os pacientes foram na sua maioria machos (30/37-86,5%) com media de idade de 79,5 meses entre os caninos e 36,3 meses dentre os felinos, sendo a maioria dos pacientes sem precisa definição racial (25/37-67,6%). A forma tegumentar localizada da enfermidade foi a mais prevalente (25/37-67,6%), sendo que na totalidade dos casos o diagnóstico histopatológico apresentou-se positivo. Em relação aos gatos esporotricóticos, observou-se infecção em animais e/ou humanos que com eles coabitavam em 17/37 (45,9%) dos casos. Já dentre os cães, nenhum pareceu disseminar a infecção, uma vez que não foram observados sinais clinicos compatíveis com a enfermidade nos seus contactantes. A esporotricose foi mais prevalente em felinos machos, sem precisa definição racial e, na sua maioria, com apresentação clínica compatível com a forma cutânea localizada da doença. Na amostra estudada, os gatos cons


The present study retrospectively characterized canine and feline sporotrichosis in male and female individuals of various ages. The patients had been attended at the Dermatology Service of a university veterinary hospital and the diagnosis had been confirmed by isolation and identification of Sporothrix spp in culture media. The study obtained and analyzed medical records from a period of 19 years (1993- 2011). From the evaluated sample, 37 animals were considered for the study, including eight (21.6%) dogs and 29 (78.4%) cats. The patients were mostly male (30/37-86.5%) and had mean ages of 79.5 months for dogs and 36.3 months for cats. Most of the patients had no defined breed (25/37-67.6%). The localized cutaneous form of the disease was most prevalent (25/37-67.6%), and all cases presented positive histopathological diagnoses. Among the cats with sporotrichosis, infection was also observed in animals and/or humans that lived with these cats in 17/37 (45.9%) cases. However, none of the affected dogs appeared to spread the infection, as there were no clinical signs that were consistent with the disease. Sporotrichosis was most prevalent among male mixed-breed cats, most of which had a clinical presentation that was consistent with the localized cutaneous form of the disease. In the studied sample, cats constituted an important source of infection for animals and humans livi

7.
Acta sci. vet. (Online) ; 41: 01-05, 2013.
Artigo em Inglês | VETINDEX | ID: vti-480159

Resumo

Background: Cases of sporotrichosis in male and female cats and dogs of different ages with cutaneous sporotrichosis that were treated at the dermatology service of a teaching veterinary hospital and orally administered itraconazole (ITC) were retrospectively characterized by reviewing the clinical records corresponding to a 19-year period (1993-2011). The aim of the present study was to analyze regarding clinical cure, side effects, length of treatment and relapse using ITC in the treatment of cutaneous sporotrichosis in cats and dogs. Materials, Methods & Results: From the assessed case series, 20 animals were selected, of which 17 (85.0%) were cats and three (15.0%) were dogs; the animals were mostly males (80.0%) and of ill-defined breeds (75.0%). Cases of sporotrichosis in male and female cats and dogs of different ages that were treated at the dermatology service of a teaching veterinary hospital and orally administered ITC (10 mg/kg) once a day. The percentage of full remission of the treated cases, regardless of their clinical form, was 100%, and no systemic or tegumentary side effects were found in the assessed animals. The average duration of treatment was 3.4 months in cats and 11.3 months in dogs, whereas the maximum duration of treatment required to resolve the clinical condition in the assessed case series of cats and dogs was 16 months, regardless of the anim


Background: Cases of sporotrichosis in male and female cats and dogs of different ages with cutaneous sporotrichosis that were treated at the dermatology service of a teaching veterinary hospital and orally administered itraconazole (ITC) were retrospectively characterized by reviewing the clinical records corresponding to a 19-year period (1993-2011). The aim of the present study was to analyze regarding clinical cure, side effects, length of treatment and relapse using ITC in the treatment of cutaneous sporotrichosis in cats and dogs. Materials, Methods & Results: From the assessed case series, 20 animals were selected, of which 17 (85.0%) were cats and three (15.0%) were dogs; the animals were mostly males (80.0%) and of ill-defined breeds (75.0%). Cases of sporotrichosis in male and female cats and dogs of different ages that were treated at the dermatology service of a teaching veterinary hospital and orally administered ITC (10 mg/kg) once a day. The percentage of full remission of the treated cases, regardless of their clinical form, was 100%, and no systemic or tegumentary side effects were found in the assessed animals. The average duration of treatment was 3.4 months in cats and 11.3 months in dogs, whereas the maximum duration of treatment required to resolve the clinical condition in the assessed case series of cats and dogs was 16 months, regardless of the anim

8.
Semina Ci. agr. ; 34(6): 3889-3896, 2013.
Artigo em Inglês | VETINDEX | ID: vti-471344

Resumo

O presente estudo caracterizou retrospectivamente a esporotricose canina e feline em machos e fêmeas de distintas idades. Os pacientes foram atendidos no Serviço de Dermatologia de um hospitalveterinário escola e o diagnostic foi confirmado pelo isolamento e identificação de Sporothrix spp em meio de cultura. Foram obtidas e analizadas as fichas clínicas de um período de 19 anos (1993-2011). Da casuística avaliada, 37 animais foram considerados para o estudo, incluindo 8 (21,6%) cães e 29 (78,4%) gatos. Os pacientes foram na sua maioria machos (30/37-86,5%) com media de idade de 79,5 meses entre os caninos e 36,3 meses dentre os felinos, sendo a maioria dos pacientes sem precisa definição racial (25/37-67,6%). A forma tegumentar localizada da enfermidade foi a mais prevalente (25/37-67,6%), sendo que na totalidade dos casos o diagnóstico histopatológico apresentou-se positivo. Em relação aos gatos esporotricóticos, observou-se infecção em animais e/ou humanos que com eles coabitavam em 17/37 (45,9%) dos casos. Já dentre os cães, nenhum pareceu disseminar a infecção, uma vez que não foram observados sinais clinicos compatíveis com a enfermidade nos seus contactantes. A esporotricose foi mais prevalente em felinos machos, sem precisa definição racial e, na sua maioria, com apresentação clínica compatível com a forma cutânea localizada da doença. Na amostra estudada, os gatos cons


 The present study retrospectively characterized canine and feline sporotrichosis in male and female individuals of various ages. The patients had been attended at the Dermatology Service of a university veterinary hospital and the diagnosis had been confirmed by isolation and identification of Sporothrix spp in culture media. The study obtained and analyzed medical records from a period of 19 years (1993- 2011). From the evaluated sample, 37 animals were considered for the study, including eight (21.6%) dogs and 29 (78.4%) cats. The patients were mostly male (30/37-86.5%) and had mean ages of 79.5 months for dogs and 36.3 months for cats. Most of the patients had no defined breed (25/37-67.6%). The localized cutaneous form of the disease was most prevalent (25/37-67.6%), and all cases presented positive histopathological diagnoses. Among the cats with sporotrichosis, infection was also observed in animals and/or humans that lived with these cats in 17/37 (45.9%) cases. However, none of the affected dogs appeared to spread the infection, as there were no clinical signs that were consistent with the disease. Sporotrichosis was most prevalent among male mixed-breed cats, most of which had a clinical presentation that was consistent with the localized cutaneous form of the disease. In the studied sample, cats constituted an important source of infection for animals and humans livi

9.
Vet. Zoot. ; 19(3)2012.
Artigo em Português | VETINDEX | ID: vti-699284

Resumo

Dermatomiosite canina familiarsímile é afecção caracterizada pelo comprometimento da pele, musculatura estriada e vasos sanguineos, sem envolvimento genético. O presente relato descreve o diagnóstico clínico e histopatológico, e avalia a eficácia do tratamento com pentoxifilina e prednisona em um cão acometido por tal enfermidade.Palavras-chave: isquemia, pentoxifilina, cães

10.
Vet. zootec ; 19(3)2012.
Artigo em Português | LILACS-Express | VETINDEX | ID: biblio-1503160

Resumo

Dermatomiosite canina familiarsímile é afecção caracterizada pelo comprometimento da pele, musculatura estriada e vasos sanguineos, sem envolvimento genético. O presente relato descreve o diagnóstico clínico e histopatológico, e avalia a eficácia do tratamento com pentoxifilina e prednisona em um cão acometido por tal enfermidade.Palavras-chave: isquemia, pentoxifilina, cães

11.
Artigo em Inglês | VETINDEX | ID: vti-732983

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned sk

12.
Artigo em Inglês | VETINDEX | ID: vti-731852

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned sk

13.
Artigo em Inglês | VETINDEX | ID: vti-731524

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned sk

14.
Artigo em Inglês | VETINDEX | ID: vti-730756

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned sk

15.
Artigo em Inglês | VETINDEX | ID: vti-730471

Resumo

Background: Localized chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus, is one of the most prevalent canine autoimmune skin diseases. Histopathology is considered the gold standard for the diagnosis of CCLE and the accuracy of which can be increased by use of direct immunofluorescence (DIF). This study aimed to investigate the fluorescence pattern revealed by DIF in cases of canine localized CCLE and to establish and compare its effectiveness with that obtained from histopathology.Materials, Methods & Results: Eleven dogs suspicious to localized CCLE, i.e., those animals that presented mucocutaneous lesions as erythema, leucoderma, erosive-ulcerative lesions, and loss of nasal planum architecture and its transition to the haired skin underwent medical physical and laboratory examinations (blood count, platelet count, determination of alanine transaminase, alkaline phosphatase, total protein, serum albumin, urea, creatinine). Only those animals that proved to be normal across both the physical and laboratorial evaluation were included in Group I. Animals belonging to this group were submitted to general anesthesia to biopsy two samples of lesioned skin from nasal planum to histopathologic examination and DIF test. Five dogs with no skin lesions were included in Group II as negative control to the DIF assay. Two samples of no lesioned sk

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