Concomitant occurrence of multicentric hemangiosarcoma and histiocytic sarcoma in a dog

Histiocytic sarcoma (HS) is uncommon malignant neoplasia of round cells with marked predilection in Rottweiler and Bernese Mountain. The disseminated form, which mainly affects the spleen, lungs, lymph nodes, bone marrow, skin, and subcutis, presents a quick and aggressive clinical behavior. Hemangiosarcoma (HAS) is a malignant neoplasm of endothelial vessel cells commonly reported to affect the right atrium of dogs' hearts. A male Rottweiler, five years old, presented flaccid paraplegia and progressive muscular atrophy in the temporal, masseter, and limbs muscles; Due to the clinical stage of the animal, euthanasia was conducted. During the necroscopic examination, it was noticed that several masses presented different sizes; some were whitish, and others were reddish and spread in multiple organs (lungs, heart, spleen, stomach, kidneys, brain, medulla, skeletal muscle, and pre-scapular lymph node). Microscopically, in some organs such as the stomach, right ventricle, lungs, and medulla, it was noticed a proliferation of myeloid cells, highly cellular, with poor demarcation, no encapsulation, and with the infiltrative growth pattern of cells with high pleomorphism. Numerous tumoral emboli were observed in the spleen, brain, skeletal muscle, and lymph node. These cells were submitted for immunohistochemistry and were positive for CD18 (HS antibody). In the right atrium, liver, and kidney it was observed malignant and infiltrative endothelial proliferation (HSA) and emboli in the medulla. Therefore, we conclude that both neoplasms (HS and HSA) cause the animal's paraplegia due to their embolism and metastasis to the spinal cord and skeletal muscle.(AU)

Topografia e morfometria do timo em aves (Gallus gallus domesticus) da linhagem Ross 308 AP (AP95) / Topography and morphometry of timo in fowl (Gallus domesticus) from Ross 308 AP LINEAGE (AP95)

Objetivou-se descrever a topografia e morfometria do timo em 30 aves domésticas da linhagem Ross 308 AP (AP95), 15 machos e 15 fêmeas, com idade de 14 a 16 semanas e massa corporal média de 2,1 kg e 1,7 kg, respectivamente nos machos e fêmeas. Após a fixação em solução aquosa de formol a 10%, as peças foram dissecadas. Os lobos tímicos localizavam-se desde o terço cranial do pescoço até os ossos claviculares, de forma linear, longitudinal e lateralmente no pescoço, paralelos ao nervo vago, veia jugular externa e artéria comum do nervo vago. Os lobos apresentaram formatos ovalados e triangulares e o número foi de quatro a oito. Agrupando os lobos de acordo com a localização no pescoço, nos terços cranial, médio e caudal, as médias de comprimento x largura x espessura variaram, nessa ordem, de 1,93 a 52,1 mm, 0,98 a 23,15 mm e 0,32 a 8,52 mm. O timo das aves AP95 apresentou características topográficas e morfológicas similares àquelas de outras linhagens, porém, quanto à morfometria, foram observadas características singulares.

The objective of this study was to describe the topography and morphometry of the thymus in 30 domestic fowl of the Ross 308 AP (AP95) lineage, 15 males and 15 females, with an approximate age of 15 weeks and a mean weight of 2.1 kg for males and 1.7 for females. After fixation in 10 % formalin aqueous solution, the specimens were dissected. The thymic lobes were located from the cranial third of neck to clavicular bones, linearly, longitudinally and laterally in neck, parallel to the vagus nerve, external jugular vein and common vagus nerve artery. The lobes presented oval and triangular shapes and the number varies from four to eight. Grouping the thymic lobes according to the location in neck in cranial, middle or caudal thirds, the averages of length x widths x thickness varied from 1.93 to 52.1 mm, 0.98 to 23.15 mm and 0.32 to 8.52 mm. The thymus of AP95 chicken presented topographic and morphological characteristics similar to those of other strains, but, regarding morphometry, unique characteristics were observed.

Topografia e morfometria do timo em aves (Gallus gallus domesticus) da linhagem Ross 308 AP (AP95) / Topography and morphometry of timo in fowl (Gallus domesticus) from Ross 308 AP LINEAGE (AP95)

Objetivou-se descrever a topografia e morfometria do timo em 30 aves domésticas da linhagem Ross 308 AP (AP95), 15 machos e 15 fêmeas, com idade de 14 a 16 semanas e massa corporal média de 2,1 kg e 1,7 kg, respectivamente nos machos e fêmeas. Após a fixação em solução aquosa de formol a 10%, as peças foram dissecadas. Os lobos tímicos localizavam-se desde o terço cranial do pescoço até os ossos claviculares, de forma linear, longitudinal e lateralmente no pescoço, paralelos ao nervo vago, veia jugular externa e artéria comum do nervo vago. Os lobos apresentaram formatos ovalados e triangulares e o número foi de quatro a oito. Agrupando os lobos de acordo com a localização no pescoço, nos terços cranial, médio e caudal, as médias de comprimento x largura x espessura variaram, nessa ordem, de 1,93 a 52,1 mm, 0,98 a 23,15 mm e 0,32 a 8,52 mm. O timo das aves AP95 apresentou características topográficas e morfológicas similares àquelas de outras linhagens, porém, quanto à morfometria, foram observadas características singulares.(AU)

The objective of this study was to describe the topography and morphometry of the thymus in 30 domestic fowl of the Ross 308 AP (AP95) lineage, 15 males and 15 females, with an approximate age of 15 weeks and a mean weight of 2.1 kg for males and 1.7 for females. After fixation in 10 % formalin aqueous solution, the specimens were dissected. The thymic lobes were located from the cranial third of neck to clavicular bones, linearly, longitudinally and laterally in neck, parallel to the vagus nerve, external jugular vein and common vagus nerve artery. The lobes presented oval and triangular shapes and the number varies from four to eight. Grouping the thymic lobes according to the location in neck in cranial, middle or caudal thirds, the averages of length x widths x thickness varied from 1.93 to 52.1 mm, 0.98 to 23.15 mm and 0.32 to 8.52 mm. The thymus of AP95 chicken presented topographic and morphological characteristics similar to those of other strains, but, regarding morphometry, unique characteristics were observed.(AU)