Salivary gland adenocarcinoma in an orange-spined hairy dwarf porcupine (Sphiggurus villosus)

The goal of this case report is to describe a salivary gland adenocarcinoma in a free ranging Sphiggurus villosus. A orange-spined hairy dwarf porcupine (S. villosus) was referred to the Wildlife Medicine Service at the Veterinarian Hospital of the Universidade Estadual Paulista (Jaboticabal, São Paulo, Brazil), with a mass in the lateral region of the face. Radiographs highlighted swelling in the soft tissues, measuring 7 cm x 9 cm, without bone involvement. The physical examination and radiographs were consistent with a neoplastic process. The animal was submitted to surgical excision of the mass. Microscopically, the tumor was composed of a highly cellular proliferation of epithelial cells arranged predominantly in tubular pattern, associated with moderated fibrous stroma, poorly demarcated, non-encapsulated and with infiltrative growth. These findings were consistent with salivary gland adenocarcinoma. To the authors" knowledge, this is the first report of a salivary gland adenocarcinoma in a wild life orange-spined hairy dwarf porcupine.

Salivary gland adenocarcinoma in an orange-spined hairy dwarf porcupine (Sphiggurus villosus)

The goal of this case report is to describe a salivary gland adenocarcinoma in a free ranging Sphiggurus villosus. A orange-spined hairy dwarf porcupine (S. villosus) was referred to the Wildlife Medicine Service at the Veterinarian Hospital of the Universidade Estadual Paulista (Jaboticabal, São Paulo, Brazil), with a mass in the lateral region of the face. Radiographs highlighted swelling in the soft tissues, measuring 7 cm x 9 cm, without bone involvement. The physical examination and radiographs were consistent with a neoplastic process. The animal was submitted to surgical excision of the mass. Microscopically, the tumor was composed of a highly cellular proliferation of epithelial cells arranged predominantly in tubular pattern, associated with moderated fibrous stroma, poorly demarcated, non-encapsulated and with infiltrative growth. These findings were consistent with salivary gland adenocarcinoma. To the authors" knowledge, this is the first report of a salivary gland adenocarcinoma in a wild life orange-spined hairy dwarf porcupine.(AU)

Avaliação da imunomarcação de células-tronco tumorais em carcinossarcomas mamários e carcinomas em tumores mistos em cadelas / Evaluation of immunostaining of tumor stem cells in mammary carcinosarcomas and carcinomas in mixed tumors in bitches

As células-tronco tumorais (CTTs) pertencem a uma pequena população de células dentro do tumor com propriedades de autorrenovação e diferenciação em outros tipos celulares. Neste estudo avaliou-se o comportamento tanto das porções mesenquimais quanto das epiteliais de seis carcinossarcomas (CSs), 11 carcinomas em tumores mistos (CTMs) grau I, 11 grau II e 10 grau III. Nas porções epiteliais dos CS e CTM foram observadas imunomarcações para os anticorpos CD44, CD24, Oct-4 e ALDH-1. Nas porções mesenquimais dos CS, nas porções epiteliais dos CTMs graus II e III não houve imunomarcação para o ALDH-1. Concluiu-se que as CTTs são expressas em proporções iguais tanto nas porções mesenquimais quanto nas epiteliais dos CSs e ausentes nas porções mesenquimais bem diferenciadas de CTMs.(AU)

Cancer stem cells belong to a small population of cells within the tumor with properties of self-renewal and differentiation into other cell types. In this study, the behavior of both portions, mesenchymal and epithelial, was evaluated. Six carcinosarcomas (CSs), 11 carcinomas within mixed tumors (CWMTs) grade I, 11 grade II, and 10 grade III were evaluated. In the epithelial portions of the CS and CWMTs was observed immunostaining for antibodies CD44, CD24, Oct-4 and ALDH-1. In the mesenchymal portions of the CS, in the epithelial portions of CMTs grades II and III no immunostaining for ALDH-1 was found. It was concluded that the tumor stem cells are expressed in equal proportions in the epithelial and mesenchymal portions of the CS. No immunostaining in the mesenchymal portions of well-differentiated CWMTs was seen.(AU)