Tumor Venéreo Transmissível (TVT) nasal com metástase óssea em um cão / Nasal transmissible venereal tumor (TVT) with bone metastasis in a dog

Background: Transmissible venereal tumor (TVT) is a highly contagious round cell neoplasm that affects dogs, and itis usually transmitted through coitus. The tumor is mainly located in the genital area; however, the neoplasm can also beextragenital, affecting the nose, mouth, and eyes, as well as the skin and superficial lymph nodes. Cytological examinationis the most commonly used method for definitive diagnosis due to its low cost and fast execution. Chemotherapy, radiotherapy, surgical resection, and other procedures such as cryosurgery are the possible treatment options. The objective ofthis report was to describe a case of extragenital TVT with nasal primary site and metastasis in the bone tissue in a dogtreated at a private veterinary hospital in the city of Belém, Pará, Brazil.Case: A 6-year-old male domiciliary Labrador Retriever dog, weighing 24.2 kg, received oncologic treatment in a privateveterinary hospital in the city of Belém, Pará, Brazil. The animal had a history of neoplastic disease, and he had undergoneTVT resection associated with chemotherapy treatment more than 3 years ago. The clinical examination revealed a volumeincrease in the periorbital region, left lateral ocular displacement, left nostril excessive epistaxis, recurrent sneezing, cough,and pain signs, and tumor metastasis was suspected. Complementary exams of oncological cytology, computed tomography(CT), hemogram, and serum biochemistry were requested for diagnosis and staging of the condition, and supportive therapywas prescribed. The cytological report showed a dense population of neoplastic round cells with characteristics of TVT. CTindicated the presence of a heterogeneous hypodense mass with irregular contours and partially defined limits, with slightuptake of the intravenously injected contrast medium that obliterated the nasal cavity, maxillary recess, nasopharyngealmeatus, frontal sinus, and sphenoid sinus on the left side...

Tumor Venéreo Transmissível (TVT) nasal com metástase óssea em um cão / Nasal transmissible venereal tumor (TVT) with bone metastasis in a dog

Background: Transmissible venereal tumor (TVT) is a highly contagious round cell neoplasm that affects dogs, and itis usually transmitted through coitus. The tumor is mainly located in the genital area; however, the neoplasm can also beextragenital, affecting the nose, mouth, and eyes, as well as the skin and superficial lymph nodes. Cytological examinationis the most commonly used method for definitive diagnosis due to its low cost and fast execution. Chemotherapy, radiotherapy, surgical resection, and other procedures such as cryosurgery are the possible treatment options. The objective ofthis report was to describe a case of extragenital TVT with nasal primary site and metastasis in the bone tissue in a dogtreated at a private veterinary hospital in the city of Belém, Pará, Brazil.Case: A 6-year-old male domiciliary Labrador Retriever dog, weighing 24.2 kg, received oncologic treatment in a privateveterinary hospital in the city of Belém, Pará, Brazil. The animal had a history of neoplastic disease, and he had undergoneTVT resection associated with chemotherapy treatment more than 3 years ago. The clinical examination revealed a volumeincrease in the periorbital region, left lateral ocular displacement, left nostril excessive epistaxis, recurrent sneezing, cough,and pain signs, and tumor metastasis was suspected. Complementary exams of oncological cytology, computed tomography(CT), hemogram, and serum biochemistry were requested for diagnosis and staging of the condition, and supportive therapywas prescribed. The cytological report showed a dense population of neoplastic round cells with characteristics of TVT. CTindicated the presence of a heterogeneous hypodense mass with irregular contours and partially defined limits, with slightuptake of the intravenously injected contrast medium that obliterated the nasal cavity, maxillary recess, nasopharyngealmeatus, frontal sinus, and sphenoid sinus on the left side...(AU)

Tumor venéreo transmissível canino em laringe com metástase pulmonar / Canine transmissible venereal tumor in the larynx with pulmonary metastasis

Background: Canine transmissible venereal tumor (TVT) is one of the most common canine neoplasms in Brazil. Lesions develop mainly in the genital tissue and less frequently in other areas, in the extragenital form. Metastasis is rare, and the disease progression depends on the patient’s immune status. The treatment of choice is chemotherapy with vincristine sulfate, considered an effective and safe modality. The present work describes the first case of extragenital TVT in the larynx with pulmonary metastasis at the time of diagnosis. Case: An approximately 4-month-old mixed-breed bitch was attended manifesting acute clinical respiratory signs. The patient had been rescued from the street 2 months beforehand. Physical examination revealed pale mucous membranes and crackling pulmonary auscultation. Thoracic radiography was performed in 3 projections, showing multiple nodules in the lung parenchyma, followed by cytopathological examination using fine needle puncture guided by thoracic ultrasound, confirming the diagnosis of TVT. Considering the cytological finding and the absence of primary tumor lesions in the genital, oral, cutaneous or nasal regions, endoscopy was performed in order to locate a possible primary focus. The exam revealed a small erythematous tumor with smooth and regular surface, measuring approximately 2.5 cm, located in the larynx, between the arytenoid cartilages. Chemotherapy was performed with vincristine sulfate with radiographic follow-up throughout the treatment. Full remission of the pulmonary and laryngeal nodules was achieved at the end of the protocol. The animal remained in complete remission for a period of 2 years. Discussion: TVT is more frequently observed in animals of active reproductive age, and rarely in animals under 1 year of age, as in the case...

Primary ocular transmissible venereal tumor in a prepubescent female dog

Background: Canine transmissible venereal tumor (CTVT) is a peculiar neoplasm resulting from the transmission of hostcancerous cells to another canid by implantation. Transmission occurs among reproductive age dogs, especially thosewith unrestricted sexual activity. It usually occurs on the external genitalia of dogs and other areas are unusual. However,implants have been described in injured mucosa, as well as metastases in lymph nodes, spleen, skin, anus and perianalspace, oral mucosa, nasal mucosa, eyeball and brain. The purpose of this report is to describe the first case of exclusivelyextragenital ocular CTVT in a prepubescent female dog.Case: A 6-month-old mixed-breed, non-spayed and prepubescent female dog, showing a fast-growing reddish-coloredmass in the right eye (RE), was examined. Blepharospasm, mild serosanguineous secretion, chemosis and a smooth surfacereddish mass with 2.5 cm in length occupying the orbital area were observed during physical examination, impairing thevisualization of the right eyeball. For ocular ultrasonography examination of the affected eye, acepromazine was used (0.03mg/kg) associated with methadone (0.3 mg/kg) intramuscularly, and propofol (4 mg/kg) for induction and 0.2 mg/kg formaintenance, intravenously. Ultrasonography examination evidenced an amorphous hyperechogenic structure, medial tothe RE, with homogeneous echotexture, punctiform vascularization to amplitude Doppler (Power Doppler), measuring 2.8cm in length and 1.4 cm in diameter, causing eyeball distortion and rejection. Based on ultrasonography results and withthe patient still anesthetized, an incisional biopsy of the peribulbar mass was performed with a 5 mm disposable punch.The final CTVT diagnosis was possible after histopathological analysis. No more CTVT nodules were found, especiallyin the vulva, which had a prepubescent appearance, consistent with age. Treatment...

Primary ocular transmissible venereal tumor in a prepubescent female dog

Background: Canine transmissible venereal tumor (CTVT) is a peculiar neoplasm resulting from the transmission of hostcancerous cells to another canid by implantation. Transmission occurs among reproductive age dogs, especially thosewith unrestricted sexual activity. It usually occurs on the external genitalia of dogs and other areas are unusual. However,implants have been described in injured mucosa, as well as metastases in lymph nodes, spleen, skin, anus and perianalspace, oral mucosa, nasal mucosa, eyeball and brain. The purpose of this report is to describe the first case of exclusivelyextragenital ocular CTVT in a prepubescent female dog.Case: A 6-month-old mixed-breed, non-spayed and prepubescent female dog, showing a fast-growing reddish-coloredmass in the right eye (RE), was examined. Blepharospasm, mild serosanguineous secretion, chemosis and a smooth surfacereddish mass with 2.5 cm in length occupying the orbital area were observed during physical examination, impairing thevisualization of the right eyeball. For ocular ultrasonography examination of the affected eye, acepromazine was used (0.03mg/kg) associated with methadone (0.3 mg/kg) intramuscularly, and propofol (4 mg/kg) for induction and 0.2 mg/kg formaintenance, intravenously. Ultrasonography examination evidenced an amorphous hyperechogenic structure, medial tothe RE, with homogeneous echotexture, punctiform vascularization to amplitude Doppler (Power Doppler), measuring 2.8cm in length and 1.4 cm in diameter, causing eyeball distortion and rejection. Based on ultrasonography results and withthe patient still anesthetized, an incisional biopsy of the peribulbar mass was performed with a 5 mm disposable punch.The final CTVT diagnosis was possible after histopathological analysis. No more CTVT nodules were found, especiallyin the vulva, which had a prepubescent appearance, consistent with age. Treatment...(AU)

Tumor venéreo transmissível cutâneo sem envolvimento genital em cão macho / Transmissible cutaneous venereal tumor without genital involvement in a male dog / Cutánea tumor venéreo transmisible sin la participación genital en perro macho

O tumor venéreo transmissível (TVT) trata-se de uma neoplasia de células redondas, transmitida a partir do transplante de células neoplásicas, altamente contagiosa, que afeta principalmente a genitália externa de caninos e também regiões extragenitais. A forma cutânea geralmente acomete a região de face e membros, secundária a um foco genital primário de forma simultânea. Relata-se um caso de TVT cutâneo sem envolvimento genital em um cão macho sem padrão de raça definida (SPRD), quatro anos de idade, semidomiciliado, com queixa principal de aparecimento de lesão única, de caráter nodular, friável, ulcerada com exsudação sanguinolenta na região cervical lateral. Foi realizada punção aspirativa com agulha fina para avaliação citológica, que demostrou predomínio de células redondas monomórficas, com vacuolização citoplasmática, citoplasma basofílico e escasso, além de núcleos ovais e centralizados, citologia esta compatível com TVT. Adotou-se o protocolo de tratamento quimioterápico com sulfato de vincristina 0,025 mg/kg a cada sete dias, com regressão completa do tumor após seis semanas. O envolvimento do tecido cutâneo sem acometimento venéreo é raro, e diante disso o TVT pode ser incluído como diagnóstico diferencial de lesões nodulares ou tumorais isoladas.(AU)

The transmissible venereal tumor (TVT) is a round cells tumor, transmitted from the highly contagious neoplastic cell transplantation, which mainly affects the external genitalia of dogs and also extragenital regions. The cutaneous form usually affects the region of the face and limbs, secondary to a primary genital focus simultaneously. A case of cutaneous TVT without genital involvement is reported in a four-year-old male, without racial standard set, half-domiciled, with a major complaint of a nodular, friable and ulcerated lesion with bloody exudation in the lateral cervical region. Fine needle aspiration was performed for cytological evaluation, and presented a monomorphic round cell population, with cytoplasmic vacuolization, basophilic and scarce cytoplasm, oval and centralized nuclei. The cytology evaluation was compatible with TVT. The chemotherapy protocol was adopted with vincristine sulphate at 0.025 mg/kg every 7 days. Complete regression of the tumor mass was observed after six weeks. Involvement of the cutaneous tissue without venereal involvement is uncommon, and there after the TVT is included as a differential diagnosis of isolated nodular cutaneous lesions.(AU)

El tumor venéreo transmisible (TVT) se trata de una neoplasia de células redondas, transmitida a partir del transplante de células neoplásicas, altamente contagiosa, que afecta principalmente a los genitales externos de los caninos y también a las regiones extragenitales. La forma cutánea generalmente acomete la región de cara y miembros, secundaria a un foco genital primario de forma simultánea. Se relata un caso de TVT cutáneo sin implicación genital en un perro macho, cuatro años de edad, semidomiciliado, con queja principal de aparición de lesión única, de carácter nodular, friable, ulcerada con exudación sanguinolenta en la región cervical lateral. Se realizó una punción aspirativa con aguja fina para evaluación citológica, y obtuvo como resultado el predominio de células redondas monomórficas, con vacuolización citoplasmática, citoplasma basofílico y escaso, además de núcleos ovalados y centralizados, citología esta compatible con TVT. Se adoptó el protocolo de tratamiento quimioterápico con sulfato de vincristina 0,025 mg / kg cada siete días, regresión completa del tumor después de seis semanas. La participación del tejido cutáneo sin afectación venérea es rara, y ante todo el TVT se incluye como diagnóstico diferencial de lesiones nodulares o tumorales aisladas.(AU)

Tumor venéreo transmissível cutâneo sem envolvimento genital em cão macho / Transmissible cutaneous venereal tumor without genital involvement in a male dog / Cutánea tumor venéreo transmisible sin la participación genital en perro macho

O tumor venéreo transmissível (TVT) trata-se de uma neoplasia de células redondas, transmitida a partir do transplante de células neoplásicas, altamente contagiosa, que afeta principalmente a genitália externa de caninos e também regiões extragenitais. A forma cutânea geralmente acomete a região de face e membros, secundária a um foco genital primário de forma simultânea. Relata-se um caso de TVT cutâneo sem envolvimento genital em um cão macho sem padrão de raça definida (SPRD), quatro anos de idade, semidomiciliado, com queixa principal de aparecimento de lesão única, de caráter nodular, friável, ulcerada com exsudação sanguinolenta na região cervical lateral. Foi realizada punção aspirativa com agulha fina para avaliação citológica, que demostrou predomínio de células redondas monomórficas, com vacuolização citoplasmática, citoplasma basofílico e escasso, além de núcleos ovais e centralizados, citologia esta compatível com TVT. Adotou-se o protocolo de tratamento quimioterápico com sulfato de vincristina 0,025 mg/kg a cada sete dias, com regressão completa do tumor após seis semanas. O envolvimento do tecido cutâneo sem acometimento venéreo é raro, e diante disso o TVT pode ser incluído como diagnóstico diferencial de lesões nodulares ou tumorais isoladas.

The transmissible venereal tumor (TVT) is a round cells tumor, transmitted from the highly contagious neoplastic cell transplantation, which mainly affects the external genitalia of dogs and also extragenital regions. The cutaneous form usually affects the region of the face and limbs, secondary to a primary genital focus simultaneously. A case of cutaneous TVT without genital involvement is reported in a four-year-old male, without racial standard set, half-domiciled, with a major complaint of a nodular, friable and ulcerated lesion with bloody exudation in the lateral cervical region. Fine needle aspiration was performed for cytological evaluation, and presented a monomorphic round cell population, with cytoplasmic vacuolization, basophilic and scarce cytoplasm, oval and centralized nuclei. The cytology evaluation was compatible with TVT. The chemotherapy protocol was adopted with vincristine sulphate at 0.025 mg/kg every 7 days. Complete regression of the tumor mass was observed after six weeks. Involvement of the cutaneous tissue without venereal involvement is uncommon, and there after the TVT is included as a differential diagnosis of isolated nodular cutaneous lesions.

El tumor venéreo transmisible (TVT) se trata de una neoplasia de células redondas, transmitida a partir del transplante de células neoplásicas, altamente contagiosa, que afecta principalmente a los genitales externos de los caninos y también a las regiones extragenitales. La forma cutánea generalmente acomete la región de cara y miembros, secundaria a un foco genital primario de forma simultánea. Se relata un caso de TVT cutáneo sin implicación genital en un perro macho, cuatro años de edad, semidomiciliado, con queja principal de aparición de lesión única, de carácter nodular, friable, ulcerada con exudación sanguinolenta en la región cervical lateral. Se realizó una punción aspirativa con aguja fina para evaluación citológica, y obtuvo como resultado el predominio de células redondas monomórficas, con vacuolización citoplasmática, citoplasma basofílico y escaso, además de núcleos ovalados y centralizados, citología esta compatible con TVT. Se adoptó el protocolo de tratamiento quimioterápico con sulfato de vincristina 0,025 mg / kg cada siete días, regresión completa del tumor después de seis semanas. La participación del tejido cutáneo sin afectación venérea es rara, y ante todo el TVT se incluye como diagnóstico diferencial de lesiones nodulares o tumorales aisladas.

Tumor venéreo transmisible canino: análisis de casos de 2008- 2014 en el Hospital Veterinario de Botucatu / Canine transmissible venereal tumor: casuistic analisis of 2008- 2014 at the Veterinary Hospital of Botucatu / Tumor venéreo transmissível canino: análise da casuística 2008- 2014 no Hospital Veterinário de Botucatu

El Tumor Venéreo Transmisible (TVT) es un tumor de células redondas de origen incierta, su diseminación ocurre principalmente por el contacto sexual o por el trasplante directo de células neoplásicas. Con el objetivo de establecer parámetros según la predisposición sexual, racial, etaria y la localización extragenital de mayor incidencia de ese tumor en perros atendidos en el Hospital Veterinario de Botucatu, fue realizado un estudio retrospectivo con 260 casos de ocurrencia natural de TVT durante el periodo de 6 años. Los machos, sin raza definida (SRD) y con edad superior a 7 años fueron los más afectados. La región más afectada fue la genital, seguida por la región nasal, este último aspecto, lleva al TVT a un nuevo nivel en la lista de diagnósticos diferenciales cuando consideramos los signos clínicos de epistaxis uni y/o bilaterar, dispnea compensatoria, secreción mucopurulenta a serosanguinolenta y obstrucción nasal.(AU)

The Transmissible Venereal Tumor (TVT) is a round cell tumor with uncertain origin, which is spread by sexual contact or by direct transplantation of neoplastic cells. In order to establish parameters according to sexual, racial, age predisposition and mainly to the extragenital location with the highest incidence of this tumor in dogs, a retrospective study of 260 cases of naturally occurring TVT was performed during the period of 6 years. The most affected dogs were male, with mixed breed and over the age of 7 years. The most frequent involvement region is the genitalia, followed by the nasal region, a fact that leads the TVT to a new level in differential diagnosis considering the clinical signs of uni and/or bilateral epistaxis, compensatory dyspnea, sanguinopurulent or mucopurulent discharge and nasal obstruction.(AU)

O Tumor Venéreo Transmissível (TVT) é um tumor de células redondas de origem incerta, cuja disseminação ocorre principalmente por contato sexual ou por transplante direto de célula neoplásica. Com o objetivo de estabelecerem-se parâmetros segundo a predisposição sexual, racial, etária e principalmente quanto à localização extragenital de maior incidência desse tumor em cães, foi realizado um estudo retrospectivo de 260 casos de ocorrência natural de TVT no período de 6 anos. Os cães mais acometidos foram os machos, sem raça definida (SRD) e com idade acima de 7 anos. A região de acometimento mais frequente é a genitália, seguida pela região nasal, fato esse que leva o TVT a um novo patamar na lista de diagnósticos diferenciais quando consideramos os sinais clínicos de epistaxe uni e/ou bilateral, dispneia compensatória, secreção mucopurulenta a serosanguinolenta e obstrução nasal.(AU)

Tumor venéreo transmisible canino: análisis de casos de 2008- 2014 en el Hospital Veterinario de Botucatu / Canine transmissible venereal tumor: casuistic analisis of 2008- 2014 at the Veterinary Hospital of Botucatu / Tumor venéreo transmissível canino: análise da casuística 2008- 2014 no Hospital Veterinário de Botucatu

El Tumor Venéreo Transmisible (TVT) es un tumor de células redondas de origen incierta, su diseminación ocurre principalmente por el contacto sexual o por el trasplante directo de células neoplásicas. Con el objetivo de establecer parámetros según la predisposición sexual, racial, etaria y la localización extragenital de mayor incidencia de ese tumor en perros atendidos en el Hospital Veterinario de Botucatu, fue realizado un estudio retrospectivo con 260 casos de ocurrencia natural de TVT durante el periodo de 6 años. Los machos, sin raza definida (SRD) y con edad superior a 7 años fueron los más afectados. La región más afectada fue la genital, seguida por la región nasal, este último aspecto, lleva al TVT a un nuevo nivel en la lista de diagnósticos diferenciales cuando consideramos los signos clínicos de epistaxis uni y/o bilaterar, dispnea compensatoria, secreción mucopurulenta a serosanguinolenta y obstrucción nasal.

The Transmissible Venereal Tumor (TVT) is a round cell tumor with uncertain origin, which is spread by sexual contact or by direct transplantation of neoplastic cells. In order to establish parameters according to sexual, racial, age predisposition and mainly to the extragenital location with the highest incidence of this tumor in dogs, a retrospective study of 260 cases of naturally occurring TVT was performed during the period of 6 years. The most affected dogs were male, with mixed breed and over the age of 7 years. The most frequent involvement region is the genitalia, followed by the nasal region, a fact that leads the TVT to a new level in differential diagnosis considering the clinical signs of uni and/or bilateral epistaxis, compensatory dyspnea, sanguinopurulent or mucopurulent discharge and nasal obstruction.

O Tumor Venéreo Transmissível (TVT) é um tumor de células redondas de origem incerta, cuja disseminação ocorre principalmente por contato sexual ou por transplante direto de célula neoplásica. Com o objetivo de estabelecerem-se parâmetros segundo a predisposição sexual, racial, etária e principalmente quanto à localização extragenital de maior incidência desse tumor em cães, foi realizado um estudo retrospectivo de 260 casos de ocorrência natural de TVT no período de 6 anos. Os cães mais acometidos foram os machos, sem raça definida (SRD) e com idade acima de 7 anos. A região de acometimento mais frequente é a genitália, seguida pela região nasal, fato esse que leva o TVT a um novo patamar na lista de diagnósticos diferenciais quando consideramos os sinais clínicos de epistaxe uni e/ou bilateral, dispneia compensatória, secreção mucopurulenta a serosanguinolenta e obstrução nasal.

Tumor venéreo transmissível subcutâneo – relato de caso / Subcutaneous transmissible venereal tumor – case report / Tumor venéreo transmisible subcutáneo – relato de un caso

O tumor venéreo transmissível (TVT) é neoplasia específica de caninos, de apresentação frequente em genitais. As metástases se dão por via hematógena ou linfática, e o acometimento extragenital é raro. A forma cutânea é relatada como lesão proliferativa verrucosa, de superfície ulcerada e friável, em geral concomitante à forma genital da doença. Para contribuir com dados clínicos, citopatológicos, prognóstico e devido à apresentação incomum, relata-se um caso de TVT subcutâneo em cadela adulta, sem raça definida, castrada, disseminado em forma de nódulos na face interna dos membros posteriores. O exame citopatológico revelou muitas células redondas com núcleo em geral excêntrico, cromatina frouxa e citoplasma amplo, muito vacuolizado, típicos de TVT plasmocitóide. Quatro sessões de quimioterapia com sulfato de vincristina levaram à remissão completa do tumor. É incomum ocorrer TVT apenas no subcutâneo, ainda mais quando não há lesões genitais a sugerir metástase.

Transmissible venereal tumor (TVT) is a specific cancer of the canine species that usually affects the genital region. Metastases occur by hematogenous or lymphatic routes. The extragenital form is rare and the cutaneous form is reported to be a warty proliferative lesion of ulcerated and friable surface, which usually presents itself concomitantly to the genital form of the disease. We hereby report a case of subcutaneous TVT in a mixed-breed neutered female, in order to contribute clinical and cytopathological data, as well as prognosis, due to unusual presentation of this neoplasm. The formation was disseminated as multiple nodules located on the inner face of the hind limbs. Diagnosis was achieved by cytological examination, which revealed the presence of round cells with predominantly eccentric nuclei, loose chromatin and large and intensely vacuolated cytoplasm, features of plasmacytoid TVT. Four courses of chemotherapy with vincristine sulfate were conducted, yielding complete remission of the tumor. The subcutaneous appearance of TVT is unusual, especially when no genital lesions that might suggest metastasis are found.

El tumor venéreo transmisible (TVT) es una neoplasia específica de los perros que se presenta con mayor frecuencia en región genital. Las metástasis pueden ocurrir por vía hematógena o linfática; es rara la presentación de tumores extragenitales. La forma cutánea se caracteriza como una lesión verrugosa proliferativa, de superficie ulcerada y friable, generalmente concomitante con la forma genital de la enfermedad. Con el objetivo de contribuir con datos clínicos, citopatológicos y de pronóstico, y dada su presentación tan poco frecuente, se relata un caso de TVT subcutáneo en una perra adulta, mestiza, castrada, que se diseminó en forma de nódulos en la cara interna de los miembros posteriores. El examen citopatológico mostró un gran número de células redondas con núcleo generalmente excéntrico, cromatina laxa y citoplasma amplio, muy vacuolizado, típicos de TVT plasmocitoide. Cuatro sesiones de quimioterapia con sulfato de vincristina llevaron a la remisión completa del tumor. Es poco común la presentación de un TVT exclusivamente subcutáneo, mas aún sin lesiones genitales que sugieran una metástasis.

Tumor venéreo transmissível subcutâneo relato de caso / Subcutaneous transmissible venereal tumor case report / Tumor venéreo transmisible subcutáneo relato de un caso

O tumor venéreo transmissível (TVT) é neoplasia específica de caninos, de apresentação frequente em genitais. As metástases se dão por via hematógena ou linfática, e o acometimento extragenital é raro. A forma cutânea é relatada como lesão proliferativa verrucosa, de superfície ulcerada e friável, em geral concomitante à forma genital da doença. Para contribuir com dados clínicos, citopatológicos, prognóstico e devido à apresentação incomum, relata-se um caso de TVT subcutâneo em cadela adulta, sem raça definida, castrada, disseminado em forma de nódulos na face interna dos membros posteriores. O exame citopatológico revelou muitas células redondas com núcleo em geral excêntrico, cromatina frouxa e citoplasma amplo, muito vacuolizado, típicos de TVT plasmocitóide. Quatro sessões de quimioterapia com sulfato de vincristina levaram à remissão completa do tumor. É incomum ocorrer TVT apenas no subcutâneo, ainda mais quando não há lesões genitais a sugerir metástase.(AU)

Transmissible venereal tumor (TVT) is a specific cancer of the canine species that usually affects the genital region. Metastases occur by hematogenous or lymphatic routes. The extragenital form is rare and the cutaneous form is reported to be a warty proliferative lesion of ulcerated and friable surface, which usually presents itself concomitantly to the genital form of the disease. We hereby report a case of subcutaneous TVT in a mixed-breed neutered female, in order to contribute clinical and cytopathological data, as well as prognosis, due to unusual presentation of this neoplasm. The formation was disseminated as multiple nodules located on the inner face of the hind limbs. Diagnosis was achieved by cytological examination, which revealed the presence of round cells with predominantly eccentric nuclei, loose chromatin and large and intensely vacuolated cytoplasm, features of plasmacytoid TVT. Four courses of chemotherapy with vincristine sulfate were conducted, yielding complete remission of the tumor. The subcutaneous appearance of TVT is unusual, especially when no genital lesions that might suggest metastasis are found.(AU)

El tumor venéreo transmisible (TVT) es una neoplasia específica de los perros que se presenta con mayor frecuencia en región genital. Las metástasis pueden ocurrir por vía hematógena o linfática; es rara la presentación de tumores extragenitales. La forma cutánea se caracteriza como una lesión verrugosa proliferativa, de superficie ulcerada y friable, generalmente concomitante con la forma genital de la enfermedad. Con el objetivo de contribuir con datos clínicos, citopatológicos y de pronóstico, y dada su presentación tan poco frecuente, se relata un caso de TVT subcutáneo en una perra adulta, mestiza, castrada, que se diseminó en forma de nódulos en la cara interna de los miembros posteriores. El examen citopatológico mostró un gran número de células redondas con núcleo generalmente excéntrico, cromatina laxa y citoplasma amplio, muy vacuolizado, típicos de TVT plasmocitoide. Cuatro sesiones de quimioterapia con sulfato de vincristina llevaron a la remisión completa del tumor. Es poco común la presentación de un TVT exclusivamente subcutáneo, mas aún sin lesiones genitales que sugieran una metástasis.(AU)