Relato de caso de carcinoma epitelial de saco escrotal em canino / Case report of canine scrotum epithelial carcinoma in canine

The skin lesions are responsible for significant number of clinical veterinarian, with the increase in thenumber of pets, especially in large cities, there is also an increase in concern on the part of owner stoward theirpets. The carcinoma is a tumor of keratinocytes. Observed under an optical microscope, the thickening of thedermis, forming is lands, trabeculae of neoplastic epithelial cells. The treatment is done surgically by removingthe neoplastic mass. Were port the case of adograce Labrador Retriever 3 years old, who had a neoplastic massin the region of preputial ulcers and bleeding. The treatment by surgical removal. Oriented by veterinaryclinical diagnosis aimed at the welfare and the animal future health, beyond cytology, that served as an aid inthe owner's decision to animals for realization of procedure. And after healing oft hesurgical wound was givenhigh for the animal. The objective of this study was to report a case of carcinoma involving the foreskin of a dogand describe the evolution of the patient after the diagnosis and of cirurgical management.(AU)

Caracterização de colágenos tipos I e III no estroma do carcinoma de células escamosas cutâneo em cães / Characterization of types I and III collagen in the stroma of cutaneous squamous cell carcinoma in dogs

O carcinoma de células escamosas (CCE) é uma neoplasia epitelial maligna que acomete cães e diversas outras espécies, incluindo a humana. O CCE afeta vários sítios anatômicos e pode desenvolver metástase. O objetivo deste estudo foi a caracterização das fibras de colágenos tipos I e III no estroma do CCE cutâneo de cães. Para este trabalho, utilizaram-se 44 amostras de pele incluídas em parafina e que tiveram prévio diagnóstico de CCE. As amostras foram processadas histologicamente e coradas com hematoxilina/eosina para confirmação do diagnóstico e classificação do grau de diferenciação tumoral e com a coloração histoquímica de picrosirius para observação dos colágenos tipos I e III. O colágeno tipo III mostrou maior expressão nos CCEs cutâneos bem diferenciados. O papel do colágeno do tipo III nas neoplasias não está bem esclarecido, e outros fatores além do grau de diferenciação celular podem estar envolvidos em sua expressão e determinar sua importância na biologia tumoral.(AU)

Squamous cell carcinoma (SCC) is a malignant epithelial tumor that affects dogs and several other species, including humans. The SCC occurs in various anatomical sites and can develop metastasis. The aim of this study was to characterize types I and III collagen fibers in the stroma of cutaneous SCC in dogs. For this work 44 paraffin-embedded samples with previous diagnostic of SCC were used. Samples were processed and evaluated histologically with hematoxylin/eosin to confirm the diagnosis and classification of cell differentiation degree and with Picrosirius for observation of types I and III collagen. Type III collagen expression was higher in well-differentiated SCC. The role of type III collagen in cancer is not very clear and factors other than cell differentiation degree may be involved in its expression and determine its importance in tumor biology.(AU)

Relato de caso de carcinoma epitelial de saco escrotal em canino / Case report of canine scrotum epithelial carcinoma in canine

The skin lesions are responsible for significant number of clinical veterinarian, with the increase in thenumber of pets, especially in large cities, there is also an increase in concern on the part of owner stoward theirpets. The carcinoma is a tumor of keratinocytes. Observed under an optical microscope, the thickening of thedermis, forming is lands, trabeculae of neoplastic epithelial cells. The treatment is done surgically by removingthe neoplastic mass. Were port the case of adograce Labrador Retriever 3 years old, who had a neoplastic massin the region of preputial ulcers and bleeding. The treatment by surgical removal. Oriented by veterinaryclinical diagnosis aimed at the welfare and the animal future health, beyond cytology, that served as an aid inthe owner's decision to animals for realization of procedure. And after healing oft hesurgical wound was givenhigh for the animal. The objective of this study was to report a case of carcinoma involving the foreskin of a dogand describe the evolution of the patient after the diagnosis and of cirurgical management.

Transitional cell carcinoma of urinary bladder with metastasis in lumbar vertebrae and spinal cord compression in an ocelot(Leopardus pardalis) / Carcinoma de células de transição de bexiga urinária com metástase em vértebras lombares e compressão de medula espinhal em uma jaguatirica (Leopardus pardalis)

This paper reports a case of nonpapillary and infiltrative transitional cell carcinoma (TCC) of the urinary bladder with metastasis of lumbar vertebrae and spinal cord compression in an adult female ocelot (Leopardus pardalis), from the Mato Grosso state, Brazil. The ocelot had pelvic limb paralysis and skin ulcers in the posterior region of the body and was submitted to euthanasia procedure. At necropsy was observed a multilobulated and irregular shaped, yellowish to white nodule in the urinary bladder. The nodule had a soft consistency and arised from the mucosa of the urinary bladder extending throughout the muscular layers and the serosa. Nodules of similar appearance infiltrating the vertebral column the at L6 and L7 vertebrae with corresponding spinal canal invasion were also observed. The histological evaluation showed epithelial neoplastic proliferation in the urinary bladder with characteristics of nonpapillary and infiltrative TCC, with positive immunohistochemical staining for pancytokeratin, and strong immunostaining for cytokeratin of low molecular weight, and weak or absent labeling for high molecular weight cytokeratin. This is the first report of TCC of urinary bladder in ocelot in Brazil.(AU)

O presente trabalho relata um caso de carcinoma de células de transição (TCC) da bexiga urinária com metástase em vértebras lombares e compressão da medula espinhal em uma jaguatirica fêmea adulta (Leopardus pardalis), no estado do Mato Grosso. A jaguatirica manifestava paralisia de membros pélvicos e úlceras de decúbito na região posterior do corpo e foi submetida a eutanásia. Na necropsia observou-se um nódulo multilobulado e irregular, brancoamarelado na bexiga urinária, de consistência macia com origem na mucosa vesical e que se estendia às camadas musculares e à serosa. Nódulos de aspecto semelhante infiltrando as vértebras L6 e L7 e invasão do canal vertebral correspondente. No exame histológico foi observada proliferação neoplásica na bexiga urinária com com características de TCC não papilar e infiltrativo, com marcação imuno-histoquímica positiva para pancitoqueratina, forte marcação para citoqueratina de baixo peso molecular e fraca ou inexistente para citoqueratina de alto peso molecular. Este é o primeiro relato de TCC em bexiga urinária de jaguatirica no Brasil.(AU)