Utilization of enbucrylate adhesive in the treatment of a corneal ulcer in a horse

Background: Ulcerative keratitis is a common condition in horses, and may leading to vision loss. The high incidence of corneal ulceration in horses is a consequence of several factors, including the large, prominent, laterally positioned eyes, naturally aggressive physical activity, and ubiquitous exposure to bacterial and fungal pathogens. Many surgical techniques have been proposed for the repair of corneal perforation, including conjunctival flaps, keratoplastic procedures, xenografts and biological grafts. In addition, cyanoacrylate adhesives may be used for the treatment of corneal ulcers up to 3 mm in diameter. Cyanoacrylate adhesives have been used to treat small partial corneal lacerations, descemetoceles, deep stromal corneal ulcers, and recurrent corneal erosions, in both human and veterinary ophthalmology. These adhesives allow not only corneal re-epithelialization, with complete sloughing of the glue, but also negative fluorescein retention. In this report, we describe a case of a deep corneal ulcer in a horse that was treated successfully with cyanoacrylate tissue adhesive. Case: A two-month-old female Quarter Horse was referred to the Ophthalmology Section of the Veterinary Clinics Hospital of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, presenting a deep corneal ulcer. The ophthalmic examination revealed ocular discomfort, epiphora, conjunctival hyperemia and a corneal ulcer measuring 3 mm in the left eye of the animal. Surgical repair was performed using an n-butyl-2-cyanoacrylate tissue adhesive. The patient allowed the procedure to be carried out under topical anesthesia alone. The postoperative treatment involved broadspectrum antibiotic (ciprofl oxacin chloridrate 0.35%) and a non-steroidal anti-inflammatory solution (sodium diclofenac 0.1%), administered six times a day for two weeks. In addition, atropine sulphate 1% was applied once a day for five days to induce pupillary dilation. After three weeks of follow-up, the cyanoacrylate adhesive became dislodged from the corneal bed. A fluorescein test was carried out to evaluate the presence of the corneal defect and there was no evidence of the ulcer. The time required for total resolution of the vascularization, which typically leaves a small leukoma, was six weeks. Discussion: The objectives of the treatment included prevention of structural loss, which would compromise globe integrity, resolution of any underlying causes and contributory infectious diseases, improving the patient's comfort by minimizing the development of scar tissue, and maximizing corneal clarity. Although many corneal ulcers are superficial and may heal quickly, a progressive or deep ulcer requires more aggressive therapy. In general, corneal ulcers that involve one-half to two-thirds of the depth of the corneal stroma should be repaired surgically because of the risk of perforation. However, the application of cyanoacrylate adhesives aids corneal healing, by establishing an artificial barrier against polymorphonuclear leucocytes and their enzymes, decreasing stromal melting, and having a bacteriostatic effect on Gram-positive organisms. The choice of surgical method was based on the fact that the adhesive can be applied with topical anesthesia, in its indication for deep ulcers up to 3 mm in diameter, and its advantages in the re-epithelization of the cornea in humans and other animals. In the present case, the use of n-2-butyl-cyanioacrylate offered an effective alternative for the management of a deep corneal defect.

Utilization of Enbucrylate adhesive in the treatment of a corneal ulcer in a horse / Utilization of Enbucrylate adhesive in the treatment of a corneal ulcer in a horse

Background: Ulcerative keratitis is a common condition in horses, and may leading to vision loss. The high incidence of corneal ulceration in horses is a consequence of several factors, including the large, prominent, laterally positioned eyes, naturally aggressive physical activity, and ubiquitous exposure to bacterial and fungal pathogens. Many surgical techniques have been proposed for the repair of corneal perforation, including conjunctival fl aps, keratoplastic procedures, xenografts and biological grafts. In addition, cyanoacrylate adhesives may be used for the treatment of corneal ulcers up to 3 mm in diameter. Cyanoacrylate adhesives have been used to treat small partial corneal lacerations, descemetoceles, deep stromal corneal ulcers, and recurrent corneal erosions, in both human and veterinary ophthalmology. These adhesives allow not only corneal re-epithelialization, with complete sloughing of the glue, but also negative fluorescein retention. In this report, we describe a case of a deep corneal ulcer in a horse that was treated successfully with cyanoacrylate tissue adhesive.Case: A two-month-old female Quarter Horse was referred to the Ophthalmology Section of the Veterinary Clinics Hospital of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, presenting a deep corneal ulcer. The ophthalmic examination revealed ocular discomfort, epiph

Background: Ulcerative keratitis is a common condition in horses, and may leading to vision loss. The high incidence of corneal ulceration in horses is a consequence of several factors, including the large, prominent, laterally positioned eyes, naturally aggressive physical activity, and ubiquitous exposure to bacterial and fungal pathogens. Many surgical techniques have been proposed for the repair of corneal perforation, including conjunctival fl aps, keratoplastic procedures, xenografts and biological grafts. In addition, cyanoacrylate adhesives may be used for the treatment of corneal ulcers up to 3 mm in diameter. Cyanoacrylate adhesives have been used to treat small partial corneal lacerations, descemetoceles, deep stromal corneal ulcers, and recurrent corneal erosions, in both human and veterinary ophthalmology. These adhesives allow not only corneal re-epithelialization, with complete sloughing of the glue, but also negative fluorescein retention. In this report, we describe a case of a deep corneal ulcer in a horse that was treated successfully with cyanoacrylate tissue adhesive.Case: A two-month-old female Quarter Horse was referred to the Ophthalmology Section of the Veterinary Clinics Hospital of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, presenting a deep corneal ulcer. The ophthalmic examination revealed ocular discomfort, epiph

Utilization of Enbucrylate adhesive in the treatment of a corneal ulcer in a horse / Utilization of Enbucrylate adhesive in the treatment of a corneal ulcer in a horse

Background: Ulcerative keratitis is a common condition in horses, and may leading to vision loss. The high incidence of corneal ulceration in horses is a consequence of several factors, including the large, prominent, laterally positioned eyes, naturally aggressive physical activity, and ubiquitous exposure to bacterial and fungal pathogens. Many surgical techniques have been proposed for the repair of corneal perforation, including conjunctival fl aps, keratoplastic procedures, xenografts and biological grafts. In addition, cyanoacrylate adhesives may be used for the treatment of corneal ulcers up to 3 mm in diameter. Cyanoacrylate adhesives have been used to treat small partial corneal lacerations, descemetoceles, deep stromal corneal ulcers, and recurrent corneal erosions, in both human and veterinary ophthalmology. These adhesives allow not only corneal re-epithelialization, with complete sloughing of the glue, but also negative fluorescein retention. In this report, we describe a case of a deep corneal ulcer in a horse that was treated successfully with cyanoacrylate tissue adhesive.Case: A two-month-old female Quarter Horse was referred to the Ophthalmology Section of the Veterinary Clinics Hospital of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, presenting a deep corneal ulcer. The ophthalmic examination revealed ocular discomfort, epiph

Background: Ulcerative keratitis is a common condition in horses, and may leading to vision loss. The high incidence of corneal ulceration in horses is a consequence of several factors, including the large, prominent, laterally positioned eyes, naturally aggressive physical activity, and ubiquitous exposure to bacterial and fungal pathogens. Many surgical techniques have been proposed for the repair of corneal perforation, including conjunctival fl aps, keratoplastic procedures, xenografts and biological grafts. In addition, cyanoacrylate adhesives may be used for the treatment of corneal ulcers up to 3 mm in diameter. Cyanoacrylate adhesives have been used to treat small partial corneal lacerations, descemetoceles, deep stromal corneal ulcers, and recurrent corneal erosions, in both human and veterinary ophthalmology. These adhesives allow not only corneal re-epithelialization, with complete sloughing of the glue, but also negative fluorescein retention. In this report, we describe a case of a deep corneal ulcer in a horse that was treated successfully with cyanoacrylate tissue adhesive.Case: A two-month-old female Quarter Horse was referred to the Ophthalmology Section of the Veterinary Clinics Hospital of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil, presenting a deep corneal ulcer. The ophthalmic examination revealed ocular discomfort, epiph