Diagnostic significance of mitotic index and AgNOR count in canine mammary tumours

The present study was designed to investigate the significance of mitotic index and AgNOR count in canine mammary tumours. Samples from 74 grossly suspected cases of bitches for mammary tumour were collected from different veterinary hospitals in 10% buffered formalin, of which 65 were confirmed as tumours on histopathological examination. Among them, 11 (16.92%) were benign and 54 (83.08%) were malignant tumours. Benign tumours included benign mixed mammary tumour (36.36%), fibroadenoma (27.27%), duct papilloma (18.18%) and simple adenoma (18.18%). The malignant mammary tumours comprised of papillary adenocarcinoma (27.78%), malignant mixed mammary tumour (25.92%), solid carcinoma (18.52%), squamous cell carcinoma (5.56%), fibrosarcoma (5.56%), infiltrative adenocarcinoma (3.7%), mucinous carcinoma (3.7%) and each (1.54%) of osteochondrosarcoma, carcinosarcoma, myxosarcoma, intraductal carcinoma and spindle cell carcinoma (malignant myoepithelioma). Mitotic index and AgNOR counts were significantly (P<0.05) differ for benign and malignant mammary tumours. Among malignant mammary tumours mitotic index ranged from 1.08 to 4.19 with solid carcinoma showing the highest index (4.197±1.570) and osteochondrosarcoma the lowest (1.08±0.0) while in benign mammary tumours, it ranged from 0.63 t0 0.9. AgNOR counts were significantly lower (2.57± 0.68) in benign mammary tumours than malignant (3.38±1.01). From this study it was concluded that mitotic index and AgNOR count was a good indicator of transformation of tumours towards the malignancy

Diagnostic significance of mitotic index and AgNOR count in canine mammary tumours

The present study was designed to investigate the significance of mitotic index and AgNOR count in canine mammary tumours. Samples from 74 grossly suspected cases of bitches for mammary tumour were collected from different veterinary hospitals in 10% buffered formalin, of which 65 were confirmed as tumours on histopathological examination. Among them, 11 (16.92%) were benign and 54 (83.08%) were malignant tumours. Benign tumours included benign mixed mammary tumour (36.36%), fibroadenoma (27.27%), duct papilloma (18.18%) and simple adenoma (18.18%). The malignant mammary tumours comprised of papillary adenocarcinoma (27.78%), malignant mixed mammary tumour (25.92%), solid carcinoma (18.52%), squamous cell carcinoma (5.56%), fibrosarcoma (5.56%), infiltrative adenocarcinoma (3.7%), mucinous carcinoma (3.7%) and each (1.54%) of osteochondrosarcoma, carcinosarcoma, myxosarcoma, intraductal carcinoma and spindle cell carcinoma (malignant myoepithelioma). Mitotic index and AgNOR counts were significantly (P<0.05) differ for benign and malignant mammary tumours. Among malignant mammary tumours mitotic index ranged from 1.08 to 4.19 with solid carcinoma showing the highest index (4.197±1.570) and osteochondrosarcoma the lowest (1.08±0.0) while in benign mammary tumours, it ranged from 0.63 t0 0.9. AgNOR counts were significantly lower (2.57± 0.68) in benign mammary tumours than malignant (3.38±1.01). From this study it was concluded that mitotic index and AgNOR count was a good indicator of transformation of tumours towards the malignancy (AU)

Adenoma hipofisário em pônei: relato de caso / Pituitary Adenoma on pony: report case / Adenoma Hipofisario en poni: reporte de un caso

A disfunção adeno hipofisária (DAH) é a mais comum endocrinopatia dos equídeos idosos. A presença de adenomas em região correspondente a hipófise pode ser associada a esta disfunção. Apesar de várias descrições desta afecção como doença clínica bem definida, suas características fisiopatológicas impõem a ela inúmeras possíveis interferências ao diagnóstico presuntivo. Relata-se neste artigo um caso de DAH por adenoma hipofisário em pônei idoso que apresentava diversos sinais associados a infecções secundárias, comumente predispostas pela endocrinopatia, definindo condição clínica diferenciada. Em função de sua senilidade e de seu estado geral debilitado não houve tempo hábil para diagnóstico in vivo sendo sua condição esclarecida somente em exame post-mortem.

The Adenohypophyseal dysfunction (AHD) is the most common endocrine disease of older horses.The presence of adenomas in pituitary corresponding region can be commonly associated with this disorder. Despite several descriptions of this condition as well-defined clinical disease, its pathophysiological characteristics impose numerous possible interference to the presumptive diagnosis. It's reported in this paper a case of AHD for pituitary adenomas in older pony that showed several signs associated with secondary infections, commonly . predisposed by endocrinopathy, defining distinct clinical condition. Because of their senility and its weakenedgeneral condition there wasn't enough time for in vivo diagnosis and their condition was only clarified in post mortem exam.

La disfunción adenohipofisarias (DAH) es Ia enfermedad endocrina más común de los caballos másviejos. La presencia de adenomas en Ia región correspondiente de hipófisis pueden ser comúnmente asociadoscon este trastorno. A pesar de varias descripciones de esta condición como uma enfermedad clínica bien definida,su características fisiopatológicas imponen numerosas posibles interferencias en diagnóstico presuntivo. Se informaen este trabajo un caso de DAH debido a adenomas hipofisarios en poni ancianos que mostraban varios signos asociados a infecciones secundarias, comúnmente predispuestos por endo crinopatía, que definen una condición clínica distinta. Debido a su senilidad y su estado general de debilidad no hubo tiempo suficiente para el diagnóstico in vivo y su condición aclaró sólo en examen post- mortem.

Adenoma hipofisário em pônei: relato de caso / Pituitary Adenoma on pony: report case / Adenoma Hipofisario en poni: reporte de un caso

A disfunção adeno hipofisária (DAH) é a mais comum endocrinopatia dos equídeos idosos. A presença de adenomas em região correspondente a hipófise pode ser associada a esta disfunção. Apesar de várias descrições desta afecção como doença clínica bem definida, suas características fisiopatológicas impõem a ela inúmeras possíveis interferências ao diagnóstico presuntivo. Relata-se neste artigo um caso de DAH por adenoma hipofisário em pônei idoso que apresentava diversos sinais associados a infecções secundárias, comumente predispostas pela endocrinopatia, definindo condição clínica diferenciada. Em função de sua senilidade e de seu estado geral debilitado não houve tempo hábil para diagnóstico in vivo sendo sua condição esclarecida somente em exame post-mortem.(AU)

The Adenohypophyseal dysfunction (AHD) is the most common endocrine disease of older horses.The presence of adenomas in pituitary corresponding region can be commonly associated with this disorder. Despite several descriptions of this condition as well-defined clinical disease, its pathophysiological characteristics impose numerous possible interference to the presumptive diagnosis. It's reported in this paper a case of AHD for pituitary adenomas in older pony that showed several signs associated with secondary infections, commonly . predisposed by endocrinopathy, defining distinct clinical condition. Because of their senility and its weakenedgeneral condition there wasn't enough time for in vivo diagnosis and their condition was only clarified in post mortem exam.(AU)

La disfunción adenohipofisarias (DAH) es Ia enfermedad endocrina más común de los caballos másviejos. La presencia de adenomas en Ia región correspondiente de hipófisis pueden ser comúnmente asociadoscon este trastorno. A pesar de varias descripciones de esta condición como uma enfermedad clínica bien definida,su características fisiopatológicas imponen numerosas posibles interferencias en diagnóstico presuntivo. Se informaen este trabajo un caso de DAH debido a adenomas hipofisarios en poni ancianos que mostraban varios signos asociados a infecciones secundarias, comúnmente predispuestos por endo crinopatía, que definen una condición clínica distinta. Debido a su senilidad y su estado general de debilidad no hubo tiempo suficiente para el diagnóstico in vivo y su condición aclaró sólo en examen post- mortem. (AU)