Cyclosporine reduces the spleen dimensions in rabbits

Purpose To assess the influence of prolonged cyclosporine use on the macro- and microscopic morphology of the spleen. Methods 16 adult rabbits were divided into two groups (n = 8): group 1 a placebo group, which was followed-up over a period of nine months; group 2 which had taken an oral dose of cyclosporine (10 mg·kg1·day1) over nine months. At the end of this period, the splenic histoarchitecture of all animals was evaluated and the splenic corpuscles were measured. Results The spleens of the first group presented normal characteristics and dimensions. The second group, however, had a reduction in all dimensions and its tissue texture had become soft. The white pulp and the perivascular sheath had become reduced in size and the number of lymphoid follicles had also fallen (p = 0.002), manifesting less splenic corpuscles (p = 0.0012) and lymphocyte nuclear pigments (p = 0.03). Conclusions Prolonged use of cyclosporine reduces the spleen size, transforming it into a soft organ associated with a decrease in white pulp, perivascular sheath, lymphoid follicles and nuclear pigments in rabbits.(AU)

Uso de ciclosporina em cão com dermatite atópica– relato de caso / Cyclosporine use in dog with atopic dermatitis – case report

Atopic dermatitis is caused by a genetic alteration in the skin barrier, making the animal more prone to develop allergies, inducing exacerbated pruritus, eritemosa skin, alopecia, recurrent ear infections and secondary infections. For the diagnosis should be excluded allergic reactions provoked by flea and tike bite and food allergy. In animals that have frequent crises the use of cyclosporine is recommended due to therapeutic success and side effects opposite to glucocorticoids.

Uso de ciclosporina em cão com dermatite atópicarelato de caso / Cyclosporine use in dog with atopic dermatitis case report

Atopic dermatitis is caused by a genetic alteration in the skin barrier, making the animal more prone to develop allergies, inducing exacerbated pruritus, eritemosa skin, alopecia, recurrent ear infections and secondary infections. For the diagnosis should be excluded allergic reactions provoked by flea and tike bite and food allergy. In animals that have frequent crises the use of cyclosporine is recommended due to therapeutic success and side effects opposite to glucocorticoids.(AU)