Rapid on-site cytopathological examination (ROSE) performed by endosonagraphers and its improvement in the diagnosis of pancreatic solid lesions

PURPOSE: To evaluate the diagnosis improvement of EUS-FNA when using ROSE performed by the endosonographer. METHODS: A retrospective study was conducted. A total of 48 pancreatic solid masses EUS-FNA were divided into two groups according to the availability of on-site cytology (ROSE) - the first 24 patients (group A-without ROSE) and the latter 24 cases (group B-with ROSE). Sensitivity, specificity, positive predictive value, negative predictive value, accuracy, complications and inadequacy rate of EUS-FNA were determined and compared. RESULTS: Among the 48 EUS-FNA, the overall performance was: sensitivity 82%; specificity 100%; positive predictive value (PPV) 100%; negative predictive value (NPV) 70% and accuracy 87%. The sensitivity of the Group A was 71%, versus 94% in-group B (p=0.61). Moreover, the negative predictive value was 58% versus 87% (p=0.72). The accuracy rate increased from 79% to 96% (p=0.67) in the ROSE group. The number of punctures was similar between the groups. No major complications were reported. CONCLUSION: Rapid on-site cytopathological examination, even when performed by the endosonographer, may improve the diagnostic performance in the diagnosis of solid pancreatic lesions, regardless of the slight increase in the number of punctures.(AU)

Histopathologic patterns of pancreatic lesions induced by Eurytrema coelomaticum in cattle from the central-west region of the State of Paraná, Southern Brazil

Bovine eurytrematosis in Brazil is induced by Eurytrema coelomaticum and is endemic in some Brazilian States. The pathology of the disease is not fully understood and there are few descriptions of the histopathological associated lesions. This study analyzed the histopathological patterns of 117 bovine pancreatic samples obtained randomly. Samples were collected during one year from the municipal slaughterhouse of Campo Mourão, Paraná, Brazil, during routine meat inspection; this location is endemic for bovine eurytrematosis. Five predefined histopathological patterns were analyzed. Differences between the types of lesions were analyzed statistically. The pancreas of 11.97% (14/117) animals normal; 31.62% (37/117) demonstrated initial proliferative periductal lesions; 17% (21/117) revealed severe proliferative periductal lesions; 21.37% (25/117) were characterized as chronic multifocal interstitial pancreatitis; while 17.09% (20/117) demonstrated chronic diffused interstitial pancreatitis. Statistically cases classified as initial proliferative interductal and chronic multifocal interstitial pancreatitis were the most frequently occurring lesions. The pathogenesis of lesions associated with this disease s also discussed.