Sporotrichosis outburst after cancer chemotherapy in a dog

Background: Sporotrichosis is a dermatozoonosis that affects mammals in general, with the domestic feline (Felis catus)being the most epidemiologically important species. However, diagnosis of this disease in dogs is important consideringthe proximity with people and with other communicants. The epidemiology of sporotrichosis is already known in somestates of Brazil, especially in the southeast region, but to the best of our knowledge there are no reports of sporotrichosisin non-human species in the state of Espírito Santo. This paper aimed at describing the first case of canine sporotrichosisin Espírito Santo, Brazil.Case: A 10 year-old Bull Terrier male dog was presented with nodular non-ulcerated lesions on the head and nodularulcerated lesion on the nasal planum. The dog had a previous diagnosis of a low-grade mast cell tumour and palpebralmelanoma. Mast cell tumour was treated with scrotum ablation (and orchiectomy) and bilateral inguinal lymph node removal, followed by chemotherapy with twelve intravenous infusion of vinblastine, along with prednisolone. Cutaneouslesions in the head and nasal planum appeared two months after finishing chemotherapy. At further anamnesis, the pet´sresponsible reported that the dog had the habit of hunting cats that entered the residence, which raised the hypothesis ofsporotrichosis. An undiagnostic cytology was performed, followed by a fungal culture, positive for Sporothrix schenckii.Treatment was then initiated with itraconazol (Oficial generic drug), at a dose of 10mg/kg/SID, until clinical remission,obtained after 60 days, maintaining it for 60 more days. Patient showed completed recovery, with no further complatintsafter a follow-up of more than 220 days.Discussion: Sporotrichosis is considered a rare disease in dogs, with isolated cases in the literature...

Sporotrichosis outburst after cancer chemotherapy in a dog

Background: Sporotrichosis is a dermatozoonosis that affects mammals in general, with the domestic feline (Felis catus)being the most epidemiologically important species. However, diagnosis of this disease in dogs is important consideringthe proximity with people and with other communicants. The epidemiology of sporotrichosis is already known in somestates of Brazil, especially in the southeast region, but to the best of our knowledge there are no reports of sporotrichosisin non-human species in the state of Espírito Santo. This paper aimed at describing the first case of canine sporotrichosisin Espírito Santo, Brazil.Case: A 10 year-old Bull Terrier male dog was presented with nodular non-ulcerated lesions on the head and nodularulcerated lesion on the nasal planum. The dog had a previous diagnosis of a low-grade mast cell tumour and palpebralmelanoma. Mast cell tumour was treated with scrotum ablation (and orchiectomy) and bilateral inguinal lymph node removal, followed by chemotherapy with twelve intravenous infusion of vinblastine, along with prednisolone. Cutaneouslesions in the head and nasal planum appeared two months after finishing chemotherapy. At further anamnesis, the pet´sresponsible reported that the dog had the habit of hunting cats that entered the residence, which raised the hypothesis ofsporotrichosis. An undiagnostic cytology was performed, followed by a fungal culture, positive for Sporothrix schenckii.Treatment was then initiated with itraconazol (Oficial generic drug), at a dose of 10mg/kg/SID, until clinical remission,obtained after 60 days, maintaining it for 60 more days. Patient showed completed recovery, with no further complatintsafter a follow-up of more than 220 days.Discussion: Sporotrichosis is considered a rare disease in dogs, with isolated cases in the literature...(AU)

Retalho de padrão axial angular da boca para reconstrução de ferida em região temporal em cão: relato de caso / The axial pattern flap of the angular artery of the mouthcorrection of wound in the temporal region in dog: case report / Colgagio de tipo axial de la artéria angular de la boca para la reconstrucción de la herida em la región temporal: relato de caso

O retalho de padrão axial da artéria angular da boca foi a técnica de escolha para fechamento de uma ferida cirúrgica, criada após a ressecção de um tumor cutâneo localizado na região temporal direita de um cão. O retalho foi transposto ao leito receptor com redução de espaço morto em padrão simples contínuo com poliglecaprone 25, e dermorrafia em padrão simples interrompido com nylon 3-0. No pós-operatório imediato foi observado algumas áreas com hematoma, após 12 dias do procedimento cirúrgico apresentou deiscência em dois pontos, sendo tratado pela segunda intenção com sulfadiazina de prata 1% e, alta após 5 dias com fechamento completo da ferida. O laudo histopatológico confirmou mastocitoma canino grau 2 (Patnaik) ou alto grau (Kiupel), foi indicada quimioterapia, porém proprietário não aderiu continuidade ao tratamento. Em conclusão, a utilização do retalho de padrão axial da artéria angular da boca revelou-se eficiente para correção de falhas cutâneas em região temporal.(AU)

The axial pattern flap of the angular artery of the mouth was the technique of choice for surgical wound closure after resection of a cutaneous tumor located in the right temporal region of a dog. The flap was transposed to the receptor bed with reduction of dead space in a continuous simple pattern with polyiglecapone 25, and the dermorrhaphy was performed with a simple pattern interrupted with 3-0 nylon. In the immediate postoperative period, it was observed some areas with hematoma, after 12 days of the surgical procedure, dehiscence was observed in two points, being treated by second intention with 1% sulfadiazine. The patient was discharged after 5 days with complete closure of the wound. The histopathological report confirmed canine mastocytoma grade 2 (Patnaik) or high grade (Kiupel), thus, chemotherapy was indicated, but the owner did not adhere to the treatment. In conclusion, the use of the axial pattern flap of the angular artery of the mouth was efficient for the correction of skin defects in the temporal region.(AU)

Un colgajo de tipo axial de la arteria angular de la boca fue la técnica escogida para cerrar una herida cutánea aguda ocasionada por escisión de un tumor localizado en la región temporal derecha de un perro. Tras realizar la tranposición del colgajo sobre el lecho receptor, el espacio muerto fue reducido con patrón de sutura simple continuo, subcutáneo, utilizando poliglecaprone 25, y la aposición de las bordes cutáneos fue con nylon 3-0 en patrón simple discontinuo. En el pós-operatorio inmediato fue observado hematoma en algunas áreas. Después de doce días hubo dehiscencia en dos puntos, la herida fue cicatrizando por segunda intención con administración de sulfadiazina de plata 1%. Después de cinco días la herida cicatrizó por completo y fue dada el alta. El resultado del histopatológico confirmó mastocitoma canino grado 2 (Patniak) o alto grado (Kiupel), fue recomendado quimioterapia, sin embargo el propietario no accedió al tratamiento. En conclusión, el colgajo de tipo axial de la arteria angular de la boca fue eficiente para corregir el defecto cutáneo en la región temporal.(AU)

Retalho de padrão axial angular da boca para reconstrução de ferida em região temporal em cão: relato de caso / The axial pattern flap of the angular artery of the mouthcorrection of wound in the temporal region in dog: case report / Colgagio de tipo axial de la artéria angular de la boca para la reconstrucción de la herida em la región temporal: relato de caso

O retalho de padrão axial da artéria angular da boca foi a técnica de escolha para fechamento de uma ferida cirúrgica, criada após a ressecção de um tumor cutâneo localizado na região temporal direita de um cão. O retalho foi transposto ao leito receptor com redução de espaço morto em padrão simples contínuo com poliglecaprone 25, e dermorrafia em padrão simples interrompido com nylon 3-0. No pós-operatório imediato foi observado algumas áreas com hematoma, após 12 dias do procedimento cirúrgico apresentou deiscência em dois pontos, sendo tratado pela segunda intenção com sulfadiazina de prata 1% e, alta após 5 dias com fechamento completo da ferida. O laudo histopatológico confirmou mastocitoma canino grau 2 (Patnaik) ou alto grau (Kiupel), foi indicada quimioterapia, porém proprietário não aderiu continuidade ao tratamento. Em conclusão, a utilização do retalho de padrão axial da artéria angular da boca revelou-se eficiente para correção de falhas cutâneas em região temporal.

The axial pattern flap of the angular artery of the mouth was the technique of choice for surgical wound closure after resection of a cutaneous tumor located in the right temporal region of a dog. The flap was transposed to the receptor bed with reduction of dead space in a continuous simple pattern with polyiglecapone 25, and the dermorrhaphy was performed with a simple pattern interrupted with 3-0 nylon. In the immediate postoperative period, it was observed some areas with hematoma, after 12 days of the surgical procedure, dehiscence was observed in two points, being treated by second intention with 1% sulfadiazine. The patient was discharged after 5 days with complete closure of the wound. The histopathological report confirmed canine mastocytoma grade 2 (Patnaik) or high grade (Kiupel), thus, chemotherapy was indicated, but the owner did not adhere to the treatment. In conclusion, the use of the axial pattern flap of the angular artery of the mouth was efficient for the correction of skin defects in the temporal region.

Un colgajo de tipo axial de la arteria angular de la boca fue la técnica escogida para cerrar una herida cutánea aguda ocasionada por escisión de un tumor localizado en la región temporal derecha de un perro. Tras realizar la tranposición del colgajo sobre el lecho receptor, el espacio muerto fue reducido con patrón de sutura simple continuo, subcutáneo, utilizando poliglecaprone 25, y la aposición de las bordes cutáneos fue con nylon 3-0 en patrón simple discontinuo. En el pós-operatorio inmediato fue observado hematoma en algunas áreas. Después de doce días hubo dehiscencia en dos puntos, la herida fue cicatrizando por segunda intención con administración de sulfadiazina de plata 1%. Después de cinco días la herida cicatrizó por completo y fue dada el alta. El resultado del histopatológico confirmó mastocitoma canino grado 2 (Patniak) o alto grado (Kiupel), fue recomendado quimioterapia, sin embargo el propietario no accedió al tratamiento. En conclusión, el colgajo de tipo axial de la arteria angular de la boca fue eficiente para corregir el defecto cutáneo en la región temporal.

Avaliação da proliferação celular como indicador prognóstico para mastocitomas cutâneos caninos / Evaluation of cellular proliferation as prognostic indicator for canine cutaneous mast cell tumors

Este estudo teve como objetivo avaliar o valor prognóstico de marcadores de proliferação celular em casos de mastocitomas cutâneos caninos. Vinte e três casos foram analisados quanto à expressão imuno-histoquímica de Ki67 e do Antígeno Nuclear de Proliferação Celular (PCNA), sendo subsequentemente acompanhados clinicamente. Observou-se que a expressão de Ki67 mantém relação negativa com a tradicional graduação histopatológica (p= 0,0418; p<0,05 entre os graus I e III), sendo um indicador confiável para o tempo de sobrevida pós-cirúrgica (p=0,0089). A imunoexpressão de PCNA, apesar de estar correlacionada à marcação por Ki67, não apresentou valores estatisticamente significantes na predição da mortalidade em função da doença e do tempo de sobrevida pós-cirúrgico. Os resultados obtidos confirmam que informações sobre a atividade proliferativa tumoral pela detecção imuno-histoquímica de Ki67 podem incrementar a classificação de mastocitomas cutâneos caninos quanto à malignidade.(AU)

This study evaluated the prognostic value of cell proliferation markers for canine cutaneous mast cell tumor cases. Twenty-three cases were analyzed with regard to immuno-histochemical expression of Ki67 and Proliferating Cell Nuclear Antigen (PCNA), and were clinically followed up. Ki67 expression was related to the traditional histopathological grading (p= 0.0418; p<0.05 between grades I and III), and was a reliable indicator of post-surgical survival (p=0.0089). PCNA immunoexpression did not show statistically significant values in the prediction of disease-related mortality and survival, although it is correlated to Ki67 expression. These results confirm that information about tumoral proliferative activity through Ki67 immunohistochemical detection can improve canine cutaneous mast cell tumor grading with regard to malignancy.(AU)