Resumo
Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups: A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p <0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p < 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.
Os metais tóxicos do soro têm sido implicados no desenvolvimento de muitas doenças. Este estudo investigou a associação entre os níveis sanguíneos de chumbo e cádmio com densidade mineral óssea anormal (DMO) e incidência de osteoporose. Sessenta adultos sauditas do sexo masculino com idades iguais foram divididos em dois grupos: um grupo de controle saudável (n = 30) e pacientes com osteoporose diagnosticados de acordo com o T-score (n = 30). Cálcio sérico, vitamina D, osteocalcina, chumbo, cádmio foram medidos. O grupo osteoporótico apresentou elevação altamente significativa dos níveis de chumbo e cádmio no sangue em comparação ao grupo controle (p < 0,001). A DMO foi negativamente correlacionada com o nível de osteocalcina sérica em comparação com o controle. Houve correlação negativa significativa entre os níveis de cádmio e chumbo (r = -0,465 ep = 0,01) e cálcio (p < 0,004). Nossos achados sugeriram que cádmio e chumbo elevados foram correlacionados negativamente à DMO e aumentaram o fator de risco para osteoporose.
Assuntos
Masculino , Humanos , Adulto , Chumbo/toxicidade , Cádmio/toxicidade , Osteocalcina/análise , Osteoporose/sangue , Vitamina D/análiseResumo
Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups: A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p <0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p < 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.(AU)
Os metais tóxicos do soro têm sido implicados no desenvolvimento de muitas doenças. Este estudo investigou a associação entre os níveis sanguíneos de chumbo e cádmio com densidade mineral óssea anormal (DMO) e incidência de osteoporose. Sessenta adultos sauditas do sexo masculino com idades iguais foram divididos em dois grupos: um grupo de controle saudável (n = 30) e pacientes com osteoporose diagnosticados de acordo com o T-score (n = 30). Cálcio sérico, vitamina D, osteocalcina, chumbo, cádmio foram medidos. O grupo osteoporótico apresentou elevação altamente significativa dos níveis de chumbo e cádmio no sangue em comparação ao grupo controle (p < 0,001). A DMO foi negativamente correlacionada com o nível de osteocalcina sérica em comparação com o controle. Houve correlação negativa significativa entre os níveis de cádmio e chumbo (r = -0,465 ep = 0,01) e cálcio (p < 0,004). Nossos achados sugeriram que cádmio e chumbo elevados foram correlacionados negativamente à DMO e aumentaram o fator de risco para osteoporose.(AU)
Assuntos
Humanos , Masculino , Adulto , Osteoporose/sangue , Chumbo/toxicidade , Cádmio/toxicidade , Vitamina D/análise , Osteocalcina/análiseResumo
Vitamin D is added to broiler diets to supply its physiological requirement for bone formation. The fast growth rate of modern broilers is often associated with poor bone formation. Increasing vitamin D supplementation levels and the use of more available sources have applied to try to prevent leg problems, to increase carcass yield, and to improve the performance of broilers. The present study evaluated three vitamin D supplementation levels (1) 3,500 IU (control); (2) control + 1,954 IU of 25-hydroxycholecalciferol; and (3) control + 3,500 IU of vitamin D in broiler diets supplied up to 21 days of age. The objective was to investigate if the vitamin D levels above the recommendations could reduce leg problems in broilers. In this experiment, a total of 1,296 one-day-old male and female Cobb(r) 500 broilers were used. A 2 x 3 factorial arrangement was applied, consisting of two sexes and three vitamin D levels. No difference was found between the levels of vitamin D (p > 0.05), the performance of males or females, the gait score, the valgus and varus incidence, the tibial dyschondroplasia incidence, the occurance of femoral degeneration, the bone colorimetric, and the carcass yield. Parts yield differences were found (p > 0.05), except for liver and intestine yields. We concluded that the lowest tested vitamin D level (3,500 IU per kilogram of feed) added to the diet was the best choice in terms of cost/benefit to help minimizing leg problems in broilers.(AU)
Assuntos
Animais , Galinhas/classificação , Galinhas/metabolismo , Vitamina D/administração & dosagem , Vitamina D/análise , Vitamina D/classificaçãoResumo
Vitamin D is added to broiler diets to supply its physiological requirement for bone formation. The fast growth rate of modern broilers is often associated with poor bone formation. Increasing vitamin D supplementation levels and the use of more available sources have applied to try to prevent leg problems, to increase carcass yield, and to improve the performance of broilers. The present study evaluated three vitamin D supplementation levels (1) 3,500 IU (control); (2) control + 1,954 IU of 25-hydroxycholecalciferol; and (3) control + 3,500 IU of vitamin D in broiler diets supplied up to 21 days of age. The objective was to investigate if the vitamin D levels above the recommendations could reduce leg problems in broilers. In this experiment, a total of 1,296 one-day-old male and female Cobb(r) 500 broilers were used. A 2 x 3 factorial arrangement was applied, consisting of two sexes and three vitamin D levels. No difference was found between the levels of vitamin D (p > 0.05), the performance of males or females, the gait score, the valgus and varus incidence, the tibial dyschondroplasia incidence, the occurance of femoral degeneration, the bone colorimetric, and the carcass yield. Parts yield differences were found (p > 0.05), except for liver and intestine yields. We concluded that the lowest tested vitamin D level (3,500 IU per kilogram of feed) added to the diet was the best choice in terms of cost/benefit to help minimizing leg problems in broilers.
Assuntos
Animais , Galinhas/classificação , Galinhas/metabolismo , Vitamina D/administração & dosagem , Vitamina D/análise , Vitamina D/classificaçãoResumo
This study evaluated the effects of dietary non-phytate phosphorus (NPP) and 1a-hydroxycholecalciferol (1a-OH-D3) on the growth performance, bone mineralization, and carcass traits of 1- to 21-day-old broiler chickens. On the day of hatch, 600 male Ross 308 chicks were weighed and randomly assigned to 12 treatments, with five cages of 10 birds each. A 6 × 2 factorial arrangement was applied, consisting of 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.45% NPP and 0 or 5 g/kg of 1a-OH-D3. The basal diet contained 0.52% calcium (Ca) and was not supplemented with vitamin D3. Dietary NPP levels significantly affected growth performance and tibia mineralization (except width) of broilers; by contrast, meat yield and organ relative weight were not influenced by NPP. The inclusion of 1a-OH-D3 improved growth performance, tibia mineralization, and carcass and breast yield, whereas it decreased the relative weights of the liver, heart, and kidney. A significant interaction between NPP and 1a-OH-D3 was observed for body weight gain (BWG), feed efficiency (FE), mortality, serum Ca and P levels, tibia breaking-strength, ash weight, and Ca content, as well as breast yield and heart relative weight. These results suggest that broilers fed with 5 g of 1a-OH-D3 per kg of diet obtain optimal growth performance and tibia mineralization when dietary NPP level was 0.30% and the analyzed Ca to NPP ratio was 1.97.
Assuntos
Animais , Aves Domésticas/crescimento & desenvolvimento , Carne/análise , Carne/efeitos adversos , Vitamina D/análise , Vitamina D/análogos & derivados , Vitamina D/efeitos adversosResumo
This study evaluated the effects of dietary non-phytate phosphorus (NPP) and 1a-hydroxycholecalciferol (1a-OH-D3) on the growth performance, bone mineralization, and carcass traits of 1- to 21-day-old broiler chickens. On the day of hatch, 600 male Ross 308 chicks were weighed and randomly assigned to 12 treatments, with five cages of 10 birds each. A 6 × 2 factorial arrangement was applied, consisting of 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, or 0.45% NPP and 0 or 5 g/kg of 1a-OH-D3. The basal diet contained 0.52% calcium (Ca) and was not supplemented with vitamin D3. Dietary NPP levels significantly affected growth performance and tibia mineralization (except width) of broilers; by contrast, meat yield and organ relative weight were not influenced by NPP. The inclusion of 1a-OH-D3 improved growth performance, tibia mineralization, and carcass and breast yield, whereas it decreased the relative weights of the liver, heart, and kidney. A significant interaction between NPP and 1a-OH-D3 was observed for body weight gain (BWG), feed efficiency (FE), mortality, serum Ca and P levels, tibia breaking-strength, ash weight, and Ca content, as well as breast yield and heart relative weight. These results suggest that broilers fed with 5 g of 1a-OH-D3 per kg of diet obtain optimal growth performance and tibia mineralization when dietary NPP level was 0.30% and the analyzed Ca to NPP ratio was 1.97.(AU)
Assuntos
Animais , Aves Domésticas/crescimento & desenvolvimento , Carne/efeitos adversos , Carne/análise , Vitamina D/análogos & derivados , Vitamina D/efeitos adversos , Vitamina D/análiseResumo
This study evaluated the effects of different sources of vitamin D and calcium levels on performance, egg quality and bone strength of hens in the second production cycle. A total of 384 Hy-Line W36 birds with 80 weeks of age were used, alloted into 3 x 4 factorial design (sources of vitamin D: cholecalciferol; 25(OH)D3 and 1.25(OH)2D3 x calcium levels: 2.85, 3.65; 4.45 and 5.25%) with four replicates and eight birds each. The performance was evaluated for three cycles of 28 days each, egg quality was evaluated in the last four days of each cycle and bone strength on the last day of the experimental period. There was no interaction (p > 0.05) between the different sources of vitamin D and calcium levels in all parameters evaluated. There was a quadratic effect (p 0.05) in the egg weight and Haugh unit, but there was a linear increase (p < 0.05) in the percentage and eggshell thickness, in specific gravity and bone strength. The different sources of vitamin D influenced (p < 0.05) the egg production rate, feed conversion, egg weight and Haugh unit. Thus, the results of this study suggest that the recommended calcium level for laying on second cycle is between 4.09% and 4.14% and that the metabolites cholecalciferol and 25(OH)D3 improved the performance and egg quality. Regarding bone strength was improved as the calcium levels were increased in diets.
Assuntos
Animais , Cálcio da Dieta/análise , Galinhas/crescimento & desenvolvimento , Vitamina D/análise , Vitaminas na Dieta/análise , Ração Animal/análiseResumo
This study evaluated the effects of different sources of vitamin D and calcium levels on performance, egg quality and bone strength of hens in the second production cycle. A total of 384 Hy-Line W36 birds with 80 weeks of age were used, alloted into 3 x 4 factorial design (sources of vitamin D: cholecalciferol; 25(OH)D3 and 1.25(OH)2D3 x calcium levels: 2.85, 3.65; 4.45 and 5.25%) with four replicates and eight birds each. The performance was evaluated for three cycles of 28 days each, egg quality was evaluated in the last four days of each cycle and bone strength on the last day of the experimental period. There was no interaction (p > 0.05) between the different sources of vitamin D and calcium levels in all parameters evaluated. There was a quadratic effect (p < 0.05) of calcium levels in egg production and feed conversion (kg/kg and kg/dz), with better results at levels of 4.12%, 4.09% and 4.14%, respectively. Calcium levels had no effect (p > 0.05) in the egg weight and Haugh unit, but there was a linear increase (p < 0.05) in the percentage and eggshell thickness, in specific gravity and bone strength. The different sources of vitamin D influenced (p < 0.05) the egg production rate, feed conversion, egg weight and Haugh unit. Thus, the results of this study suggest that the recommended calcium level for laying on second cycle is between 4.09% and 4.14% and that the metabolites cholecalciferol and 25(OH)D3 improved the performance and egg quality. Regarding bone strength was improved as the calcium levels were increased in diets.(AU)
Assuntos
Animais , Vitamina D/análise , Cálcio da Dieta/análise , Vitaminas na Dieta/análise , Galinhas/crescimento & desenvolvimento , Ração Animal/análiseResumo
Avaliaram-se o desempenho e o rendimento de carcaça e cortes nobres de frangos de corte machos com suplemento nas rações de 1,25 dihidroxicolecalciferol e redução de cálcio e fósforo disponível. Foi utilizado um delineamento em blocos ao acaso, com seis tratamentos: 0,0; 1,0; 2,0; 3,0; 4,0 e 5,0µg de vitamina D3 ativa/kg de ração, e seis repetições com 17 aves cada. Aos 8 e 42 dias de idade cada unidade experimental foi pesada para avaliação do desempenho. Posteriormente, quatro aves/repetição foram retiradas e abatidas para mensuração do rendimento de carcaça e de cortes nobres. A inclusão da vitamina D3 ativa influenciou positivamente (P<0,05) o ganho de peso e a conversão alimentar com as suplementações de 1,0 e 2,0µg/kg. O consumo de ração não apresentou diferença significativa para os níveis estudados. O rendimento de carcaça e de cortes nobres de frangos de corte machos aos 42 dias não foram influenciados pelo suplemento de 1,25 dihidroxicolecalciferol e redução de cálcio e fósforo disponível nas rações. Recomenda-se o fornecimento suplementar de 1,0 a 2,0µg/kg de vitamina D3 ativa nas rações para frangos de corte machos de 8 a 42 dias de idade.(AU)
There were evaluated the performance, the carcass yield and noble cuts yield of broilers with supplement of 1,25-dihydroxycholecalciferol and reduction of calcium and available phosphorus. It was used a randomized block design, with six treatments: 0.0; 1.0; 2.0; 3.0; 4.0 and 5.0µg of active vitamin D3/kg of ration, and six repetitions with 17 birds each. At 8 and 42 days of age each experimental unit was weighted in order to evaluated the performance. Later, four broilers/repetition were removed and slaughtered in order to measure the carcass and noble cuts yield. The inclusion of active vitamin D3 influenced positively (P<0.05) the weight gain and the feed conversion at the supplementations of 1.0 and 2.0µg/kg. The feed intake wasn't significative among the studied levels. The carcass and noble cuts of male broilers at 42 days were not influenced by supplement of 1,25-dihydroxycholecalciferol and reduction of calcium and available phosphorus in rations. It is recommended to provide additional of 1.0 up to 2.0µg/kg of active vitamin D3 in rations for male broilers from 8 to 42 days of age.(AU)
Assuntos
Animais , Suplementos Nutricionais/análise , Aves Domésticas/métodos , Vitamina D/análise , Ração Animal , Galinhas/fisiologia , CalcitriolResumo
Este trabalho teve como objetivo avaliar o desenvolvimento da discondroplasia tibial (DT) em frangos de corte de 1 ae fontes de vitamina D (1250UI D3/kg sem 25-(OH)D3; 1250UI D3/kg com 69mg 25-(OH)D3/ton e 3000UI D3/kg com 69mg 25-(OH)D3/ton) e dois tratamentos controles com níveis de cálcio e fósforo com 3000UI D3/kg sem 25-(OH)D3 e 3000UI D3/kg com 69mg 25-(OH)D3/ton de ração. Foram avaliadas características ósseas. No período de 1 a 21 dias, os resultados indicaram que as concentrações de cálcio e fósforo nas tíbias não foram influenciadas pelos tratamentos e que o consumo de ração foi superior para os tratamentos que compõem o fatorial. A resistência óssea também não foi influenciada pelos tratamentos e a análise histológica não evidenciou lesões características de DT. Conclui-se que, nas condições experimentais da presente pesquisa, o desenvolvimento de DT não foi observado.
This research was carried out to evaluate the development of tibial dyschondroplasia (TD) in broilers from 1 to 21 days. Four hundred forty day-old male chickens, from broiler breeders aged 60-62 weeks, were randomly distributed in a 3x3+2 factorial arrangement, resulting in 11 treatments with four replicates of 10 birds each. The factors evaluated were: bird strains (Ross 308, Cobb 500, and Hybro), levels and sources of vitamin D (1250UI D3/kg without 25-(OH)D3; 1250UI D3/kg with 69mg 25-(OH)D3/ton, and 3000UI D3/kg with 69mg 25-(OH)D3/ton), and two control treatments containing calcium and phosphorus levels with 3000UI D3/kg without 25-(OH)D3 and 3000UI D3/kg with 69mg 25- (OH)D3/ton of feed. Bone characteristics were evaluated. From 1 to 21 days, the results showed that bone calcium and phosphorus concentrations were not influenced by the treatments, however, feed intake was higher for factorial than control treatments. Bone breaking resistance was not influenced by the treatments and there were no typical lesions of TD. In conclusion, it was not observed TD development in broilers from 1 to 21 days according to experimental procedures of this research.(AU)