Antimicrobial activity of essential oils against Pasteurella spp isolated from the oral cavity of domestic cats / Avaliação da atividade antimicrobiana de óleos essenciais frente a isolados de Pasteurella spp oriundos da cavidade bucal de gatos domésticos

Pasteurella spp. have been identified predominantly in the oral microbiota of domestic cats. However, Pasteurella spp. was significantly more prevalent in cats with inflammatory oral disease; and consequently, it was considered as part of the etiology in this disease. In addition, in animals, Pasteurella spp. have become increasingly resistant to a large number of antimicrobials. Natural products, especially essential oils, could contribute to minimizing this issue. This study determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of six essential oils against Pasteurella spp. isolates from the oral cavity of domestic cats. Our results showed that essential oils with better antimicrobial effectiveness against most of the Pasteurella isolates were lemongrass, tea tree and clove, with inhibition values between 50 to 800 µg mL-¹. All essential oils showed bacteriostatic activity against the species of Pasteurella isolated from the domestic cats. These results suggested that lemongrass, tea tree and clove oils have potential to be used in products for oral hygiene and treatment of oral infections in domestic cats.

O gênero Pasteurella spp., considerado um comensal da cavidade bucal de gatos domésticos, vem sendo, nos últimos anos, apontado como possível agente etiológico de quadros inflamatórios crônicos bucais em felinos. Ademais, em animais, as espécies de Pasteurella têm apresentado cada vez mais resistência a um grande número de antimicrobianos de uso rotineiro. Nesse contexto, os produtos naturais, como óleos essenciais com potencial antimicrobiano tem sido alvo de estudos e apontados como alternativa terapêutica. Neste estudo, objetivou-se determinar a Concentração Mínima Inibitória (CMI) e da Concentração Bactericida Mínima (CBM) de seis óleos essenciais frente a isolados de Pasteurella spp. oriundos da cavidade bucal de gatos domésticos. Dos óleos essenciais testados, o capim-limão, tea tree, cravo e a camomila romana apresentaram ação bacteriostática frente aos isolados de Pasteurella spp. Contudo, os óleos de capim-limão, tea-tree e cravo apresentaram os melhores resultados, com valores de inibitórios entre 50 a 800 µg mL-¹. Esses resultados sugerem que os óleos de capim-limão, tea tree e cravo têm potencial para serem utilizados como produtos para higiene bucal e para o tratamento de infecções da cavidade bucal de gatos domésticos.

Eritema multiforme limitado à cavidade oral em um cão: relato de caso / Multiforme erythema limited to the oral cavity in a dog: case report

O eritema multiforme é uma doença incomum em cães, que afeta pele e mucosas, cuja etiologia ainda não foi completamente elucidada. Contudo, o envolvimento exclusivo da cavidade oral é considerado raro, tendo sido descrito poucas vezes até o presente momento. O objetivo deste trabalho é descrever um caso de eritema multiforme limitado à cavidade oral em um canino. Um cão, fêmea, Akita, com sete anos de idade, apresentou histórico de ulcerações na cavidade oral e nas laterais da língua, sem alterações cutâneas ou sistêmicas. O diagnóstico definitivo foi realizado por meio do exame histopatológico da mucosa oral, e a terapia imunossupressora empregada mostrou-se eficaz. Embora o eritema multiforme seja considerado incomum na espécie canina, este relato de caso apresenta a forma mais rara da doença, com poucos casos descritos em medicina veterinária.(AU)

Multiforme erythema is an uncommon disease in dogs that affects the skin and mucous membranes, the etiology of which has not yet been fully elucidated. However, the exclusive involvement of the oral cavity is considered rare, having been described few times until the present moment. The aim of this work is to describe a case of multiforme erythema limited to the oral cavity in a canine. A seven-year-old female dog, akita, presented a history of ulcerations in the oral cavity and on the sides of the tongue, with no cutaneous or systemic changes. The definitive diagnosis was made through the histopathological examination of the oral mucosa and the immunosuppressive therapy used proved to be effective. Although multiforme erythema is considered uncommon in the canine species, this case report presents the rarest form of the disease, with few cases described in veterinary medicine.(AU)

Eritema multiforme limitado à cavidade oral em um cão: relato de caso / Multiforme erythema limited to the oral cavity in a dog: case report

O eritema multiforme é uma doença incomum em cães, que afeta pele e mucosas, cuja etiologia ainda não foi completamente elucidada. Contudo, o envolvimento exclusivo da cavidade oral é considerado raro, tendo sido descrito poucas vezes até o presente momento. O objetivo deste trabalho é descrever um caso de eritema multiforme limitado à cavidade oral em um canino. Um cão, fêmea, Akita, com sete anos de idade, apresentou histórico de ulcerações na cavidade oral e nas laterais da língua, sem alterações cutâneas ou sistêmicas. O diagnóstico definitivo foi realizado por meio do exame histopatológico da mucosa oral, e a terapia imunossupressora empregada mostrou-se eficaz. Embora o eritema multiforme seja considerado incomum na espécie canina, este relato de caso apresenta a forma mais rara da doença, com poucos casos descritos em medicina veterinária.(AU)

Multiforme erythema is an uncommon disease in dogs that affects the skin and mucous membranes, the etiology of which has not yet been fully elucidated. However, the exclusive involvement of the oral cavity is considered rare, having been described few times until the present moment. The aim of this work is to describe a case of multiforme erythema limited to the oral cavity in a canine. A seven-year-old female dog, akita, presented a history of ulcerations in the oral cavity and on the sides of the tongue, with no cutaneous or systemic changes. The definitive diagnosis was made through the histopathological examination of the oral mucosa and the immunosuppressive therapy used proved to be effective. Although multiforme erythema is considered uncommon in the canine species, this case report presents the rarest form of the disease, with few cases described in veterinary medicine.(AU)

Peripheral T-cell lymphoma in the oral cavity of a cow

Background: Squamous cell carcinomas and lymphomas are the most prevalent neoplasms in cattle, the latter usually being attributed to infection by bovine leukemia virus (BLV). Neoplasms of the oral cavity are sporadic in cattle, with but asingle case of lymphoma involving this anatomic site in a bovine reported to date. This paper reports a case of lymphomainvolving the oral cavity of a dairy cow. The clinical and pathological aspects of the tumor are described and discussed.Case: A 39-month-old Holstein-Friesian cow was presented with weight loss and a tumorous growth in the left masseterregion, tearing in the left eye, and mild ipsilateral exophthalmos. Treatment with antibiotics was unsuccessful. The tumorgrowth was 16 x 11 cm, with a soft center and firm periphery, multilobulated, with white intercalated with black and friableareas from which a fetid odor emanated. The cut surface was predominantly white-yellow. A cross-section of the head,caudal to the second molar, revealed a mass infiltrating and almost completely obliterating the left nasal cavity, destroyingthe frontal sinus, the ventral conchae, and the middle and ventral meatus, and compressing the common meatus. The tracheobronchial, mediastinal, and internal iliac lymph nodes were enlarged and masses with similar characteristics to thosein the oral cavity replace their parenchyma. Microscopically, the mass consisted of large neoplastic lymphocytes arrangedin a non-encapsulated and infiltrative mantle and supported by scarce fibrovascular tissue. The cytoplasm of neoplasticcells was scarce and had distinct boundaries; the nuclei were round or oval, the chromatin was finely granulated, and theprominent nucleolus had occasionally multiplied. Nuclear pleomorphism was marked and there were, on average, five mitotic figures per microscopic field of 400x. Similar neoplastic cells obliterated the normal...

Peripheral T-cell lymphoma in the oral cavity of a cow

Background: Squamous cell carcinomas and lymphomas are the most prevalent neoplasms in cattle, the latter usually being attributed to infection by bovine leukemia virus (BLV). Neoplasms of the oral cavity are sporadic in cattle, with but asingle case of lymphoma involving this anatomic site in a bovine reported to date. This paper reports a case of lymphomainvolving the oral cavity of a dairy cow. The clinical and pathological aspects of the tumor are described and discussed.Case: A 39-month-old Holstein-Friesian cow was presented with weight loss and a tumorous growth in the left masseterregion, tearing in the left eye, and mild ipsilateral exophthalmos. Treatment with antibiotics was unsuccessful. The tumorgrowth was 16 x 11 cm, with a soft center and firm periphery, multilobulated, with white intercalated with black and friableareas from which a fetid odor emanated. The cut surface was predominantly white-yellow. A cross-section of the head,caudal to the second molar, revealed a mass infiltrating and almost completely obliterating the left nasal cavity, destroyingthe frontal sinus, the ventral conchae, and the middle and ventral meatus, and compressing the common meatus. The tracheobronchial, mediastinal, and internal iliac lymph nodes were enlarged and masses with similar characteristics to thosein the oral cavity replace their parenchyma. Microscopically, the mass consisted of large neoplastic lymphocytes arrangedin a non-encapsulated and infiltrative mantle and supported by scarce fibrovascular tissue. The cytoplasm of neoplasticcells was scarce and had distinct boundaries; the nuclei were round or oval, the chromatin was finely granulated, and theprominent nucleolus had occasionally multiplied. Nuclear pleomorphism was marked and there were, on average, five mitotic figures per microscopic field of 400x. Similar neoplastic cells obliterated the normal...(AU)

Feline lymphoplasmacytic gingivostomatitis: clinical and anatomopathological aspects

Background: Feline lymphoplasmacytic gingivostomatitis (FLPG) is an idiopathic, multifactorial and highly challengingcondition, since the results of the available treatments are partial and transitory. A set of lesions triggered by inflammatoryreaction is observed, sometimes with ulcerations in the oral mucosa, leading to algia and discomfort. Histopathologicalexamination figures as the definitive diagnostic tool, presenting distinct cellular elements. The present study aims to reportthree cases of FLPG, firstly addressing the anatomopathological findings, as well as the therapeutic approach used andthe results obtained in each case.Cases: Case 1- Occurred in a feline Siamese male 15-year-old, weighing 3.8 kg, which was admitted at a local clinic, underthe complaint of prostration, dysphagia, and weight loss, signs that were noticed approximately 5 days before. Clinicalevaluation revealed multiple proliferative and ulcerative lesions, extending until the isthmus of the fauces, erythematousareas around the teeth and multifocal gingival reabsorption. Once the clinical signs and lesions were observed, samples werecollected for histopathological examination and sent to the Laboratory of Animal Pathology (LAP) of Faculty of Agronomyand Veterinary Medicine of the University of Passo Fundo (FAVM-UPF). Histologically, both fragments presented lymphoplasmacytic infiltration, with large and intensely eosinophilic cytoplasm, often with granular aspect, central to lateralizedhyperchromatic nuclei, located predominantly in lamina propria and mucosa, as well as a discrete Mott cell infiltrate. Itwas also observed the presence of diffuse suppurative chronic inflammatory infiltrate, predominantly in lamina propriaand mucosa, as well as foci of edema and hemorrhage, in addition to loss of tissue architecture establishing the definitivediagnosis of...

Feline lymphoplasmacytic gingivostomatitis: clinical and anatomopathological aspects

Background: Feline lymphoplasmacytic gingivostomatitis (FLPG) is an idiopathic, multifactorial and highly challengingcondition, since the results of the available treatments are partial and transitory. A set of lesions triggered by inflammatoryreaction is observed, sometimes with ulcerations in the oral mucosa, leading to algia and discomfort. Histopathologicalexamination figures as the definitive diagnostic tool, presenting distinct cellular elements. The present study aims to reportthree cases of FLPG, firstly addressing the anatomopathological findings, as well as the therapeutic approach used andthe results obtained in each case.Cases: Case 1- Occurred in a feline Siamese male 15-year-old, weighing 3.8 kg, which was admitted at a local clinic, underthe complaint of prostration, dysphagia, and weight loss, signs that were noticed approximately 5 days before. Clinicalevaluation revealed multiple proliferative and ulcerative lesions, extending until the isthmus of the fauces, erythematousareas around the teeth and multifocal gingival reabsorption. Once the clinical signs and lesions were observed, samples werecollected for histopathological examination and sent to the Laboratory of Animal Pathology (LAP) of Faculty of Agronomyand Veterinary Medicine of the University of Passo Fundo (FAVM-UPF). Histologically, both fragments presented lymphoplasmacytic infiltration, with large and intensely eosinophilic cytoplasm, often with granular aspect, central to lateralizedhyperchromatic nuclei, located predominantly in lamina propria and mucosa, as well as a discrete Mott cell infiltrate. Itwas also observed the presence of diffuse suppurative chronic inflammatory infiltrate, predominantly in lamina propriaand mucosa, as well as foci of edema and hemorrhage, in addition to loss of tissue architecture establishing the definitivediagnosis of...(AU)

Porphyromonas gingivalis na cavidade oral de neonatos da raça Bulldog Inglês / Porphyromonas gingivalis in the oral cavity of English bulldog newborn puppies

Background: Periodontal disease (PD) is the most common disease of the oral cavity in cats and dogs, and it affects up to 80% of these animals. PD begins with the accumulation of bacteria on the surface of the teeth, and it poses a risk for the health of pets. Research on PD in dogs has focused on the identification and characterization of bacterial communities present in the oral cavity. Porphyromonas gingivalis is highly prevalent in the oral cavity. Therefore, the aim of this study was to detect P. gingivalis before and after dental eruption in 15 English bulldog newborn puppies, hoping to contribute to early guidance of oral hygiene management and prevent future PD. Materials, Methods & Results: Fifteen English bulldog newborn puppies were used in this study. Two groups (G1 and G2) were formed with eight and seven puppies, respectively. Oral swab samples were taken from the maxillary incisor region of animals from G1 and G2 10 days after birth (T10). At this moment, the clinical evaluation of the oral cavity showed healthy gums with a thin, shiny, pinkish, and firm margin, without any odor or granular appearance, and with no tooth eruption. On postnatal day 25 (T25), a subgingival sample was collected with a Gracey curette from the maxillary incisors; the oral cavity examination revealed healthy gums and presence of gingival sulcus. Bilateral subgingival samples were also collected from the maxillary canines and fourth premolars of the dams at T10 and T25. All newborn puppies were fed maternal breast milk and supplementation exclusively with commercial milk for dogs in individual bottles. The dams were fed commercial dry food. The average weight of G1 and G2 at T10 was 625.87 ± 85.26 g and 543.50 ± 92.88 g, respectively, and 100% (15/15) of the animals were negative for PG as assessed by polymerase chain reaction (PCR) on oral swab samples. [...]

Porphyromonas gingivalis na cavidade oral de neonatos da raça Bulldog Inglês / Porphyromonas gingivalis in the oral cavity of English bulldog newborn puppies

Background: Periodontal disease (PD) is the most common disease of the oral cavity in cats and dogs, and it affects up to 80% of these animals. PD begins with the accumulation of bacteria on the surface of the teeth, and it poses a risk for the health of pets. Research on PD in dogs has focused on the identification and characterization of bacterial communities present in the oral cavity. Porphyromonas gingivalis is highly prevalent in the oral cavity. Therefore, the aim of this study was to detect P. gingivalis before and after dental eruption in 15 English bulldog newborn puppies, hoping to contribute to early guidance of oral hygiene management and prevent future PD. Materials, Methods & Results: Fifteen English bulldog newborn puppies were used in this study. Two groups (G1 and G2) were formed with eight and seven puppies, respectively. Oral swab samples were taken from the maxillary incisor region of animals from G1 and G2 10 days after birth (T10). At this moment, the clinical evaluation of the oral cavity showed healthy gums with a thin, shiny, pinkish, and firm margin, without any odor or granular appearance, and with no tooth eruption. On postnatal day 25 (T25), a subgingival sample was collected with a Gracey curette from the maxillary incisors; the oral cavity examination revealed healthy gums and presence of gingival sulcus. Bilateral subgingival samples were also collected from the maxillary canines and fourth premolars of the dams at T10 and T25. All newborn puppies were fed maternal breast milk and supplementation exclusively with commercial milk for dogs in individual bottles. The dams were fed commercial dry food. The average weight of G1 and G2 at T10 was 625.87 ± 85.26 g and 543.50 ± 92.88 g, respectively, and 100% (15/15) of the animals were negative for PG as assessed by polymerase chain reaction (PCR) on oral swab samples. [...](AU)

Tratamento de um mastocitoma de alto grau na língua de um cão por meio de radioterapia e quimioterapia: relato de caso / Treatment of a canine high grade lingual mast cell tumor with radiation therapy and chemotherapy: case report

Um canino da raça Boxer, fêmea, de oito anos de idade, foi atendido com salivação, halitose e disfagia. No exame clínico, foi observada uma massa ulcerada no terço médio da língua medindo 3,5 x 4,0cm. A histopatologia e a imuno-histoquímica levaram ao diagnóstico de um mastocitoma de alto grau. O tratamento cirúrgico (glossectomia parcial) foi declinado pelo proprietário, sendo a radioterapia indicada em seu lugar. O protocolo radioterápico empregado foi 15 frações de 300cGy, realizadas cinco vezes por semana. O equipamento utilizado foi de ortovoltagem. A lesão neoplásica apresentou remissão clínica completa a partir da quarta sessão radioterápica. O único efeito colateral observado foi mucosite leve na região irradiada, que, entretanto, não levou a sintomas clínicos. A quimioterapia sistêmica consistiu de vimblastina e lomustina, alternadas a cada 14 dias, durante quatro meses. Até o momento (22 meses após o tratamento), não há evidências de recidiva local ou metástases do mastocitoma. A associação da radioterapia e da quimioterapia pode ser considerada uma alternativa terapêutica nos casos de mastocitomas irressecáveis, já que, neste caso, levou à remissão completa e duradoura de um tumor agressivo, com ótima tolerância do paciente ao tratamento e posterior qualidade de vida.(AU)

An 8 year old female boxer was presented with salivation, halitosis and dysphagia. In the clinical examination, an ulcerated mass in the middle third of the tongue was observed, measuring 3.5 x 4.0cm. Histopathology and immunohistochemistry the confirmed diagnosis of a high-grade mast cell tumor. Surgical treatment (partial glossectomy) was declined by owner, and radiotherapy was indicated. The protocol consisted of fifteen daily fractions of 300 cGy each. The equipment used was an orthovoltage unit. The tumor had complete clinical remission after the fourth session, and mild mucositis was the only side effect observed. Systemic chemotherapy was performed with vinblastine and lomustine, alternated every 14 days, during four months. There is no evidence of local recurrence or metastasis in this patient twenty-two months after treatment. The combination of radiation therapy and chemotherapy can be considered as an alternative therapy in cases of unresectable mast cell tumors. It led to complete and durable remission of an aggressive tumor, with great quality of life.(AU)

Tratamento de um mastocitoma de alto grau na língua de um cão por meio de radioterapia e quimioterapia: relato de caso / Treatment of a canine high grade lingual mast cell tumor with radiation therapy and chemotherapy: case report

Um canino da raça Boxer, fêmea, de oito anos de idade, foi atendido com salivação, halitose e disfagia. No exame clínico, foi observada uma massa ulcerada no terço médio da língua medindo 3,5 x 4,0cm. A histopatologia e a imuno-histoquímica levaram ao diagnóstico de um mastocitoma de alto grau. O tratamento cirúrgico (glossectomia parcial) foi declinado pelo proprietário, sendo a radioterapia indicada em seu lugar. O protocolo radioterápico empregado foi 15 frações de 300cGy, realizadas cinco vezes por semana. O equipamento utilizado foi de ortovoltagem. A lesão neoplásica apresentou remissão clínica completa a partir da quarta sessão radioterápica. O único efeito colateral observado foi mucosite leve na região irradiada, que, entretanto, não levou a sintomas clínicos. A quimioterapia sistêmica consistiu de vimblastina e lomustina, alternadas a cada 14 dias, durante quatro meses. Até o momento (22 meses após o tratamento), não há evidências de recidiva local ou metástases do mastocitoma. A associação da radioterapia e da quimioterapia pode ser considerada uma alternativa terapêutica nos casos de mastocitomas irressecáveis, já que, neste caso, levou à remissão completa e duradoura de um tumor agressivo, com ótima tolerância do paciente ao tratamento e posterior qualidade de vida.(AU)

An 8 year old female boxer was presented with salivation, halitosis and dysphagia. In the clinical examination, an ulcerated mass in the middle third of the tongue was observed, measuring 3.5 x 4.0cm. Histopathology and immunohistochemistry the confirmed diagnosis of a high-grade mast cell tumor. Surgical treatment (partial glossectomy) was declined by owner, and radiotherapy was indicated. The protocol consisted of fifteen daily fractions of 300 cGy each. The equipment used was an orthovoltage unit. The tumor had complete clinical remission after the fourth session, and mild mucositis was the only side effect observed. Systemic chemotherapy was performed with vinblastine and lomustine, alternated every 14 days, during four months. There is no evidence of local recurrence or metastasis in this patient twenty-two months after treatment. The combination of radiation therapy and chemotherapy can be considered as an alternative therapy in cases of unresectable mast cell tumors. It led to complete and durable remission of an aggressive tumor, with great quality of life.(AU)

c-Kit immunoexpression patterns differ in melanotic and amelanotic canine oral melanomas / Análise qualitativa quanto à diferença da imunoexpressão do gene c-Kit em melanomas melânicos e amelânicos da cavidade oral em cães

Melanomas are the most common oral malignancy in dogs. Cell proliferation and connexin expression has been shown to differ in canine melanotic and amelanotic oral melanomas. This study aimed to analyze the c-Kit protein expression in melanotic and amelanotic melanomas from canine buccal cavity. A total of 34 canine buccal melanomas (19 melanotic and 15 amelanotic).were collected. The amelanotic melanomas presented faster evolution and higher incidence of metastasis than melanotic tumors. A significantly higher number of c-Kit positive cells were observed in amelanotic neoplasms. In addition, the intensity of c-Kit immunolabeling was predominantly stronger in amelanotic melanomas. These results confirm a potential role for c-Kit in canine oral melanomas with clear differences in expression patterns between the two histological types of tumor, melanotic and amelanotic. This study highlights the importance of a detailed study of c-Kit mutations in canine oral melanomas to better understand the molecular mechanisms implicated in the development of this disease(AU)

Melanomas são as mais frequentes neoplasias malignas da cavidade bucal de cães. Sabe-se que a proliferação de células e expressão de conexina diferem em melanomas melanóticos e amelanóticos da cavidade bucal de cães. Este estudo analisou a expressão da proteína c-Kit em melanomas melanóticos e amelanóticos da cavidade bucal canina. Um total de 34 melanomas bucais caninos (19 melanóticos e 15 amelanóticos) foram coletados. Os melanomas amelanóticos apresentaram evolução mais rápida e maior incidência de metástase. Foi constatado um número significativamente maior de células positivas para c-Kit em neoplasias amelanóticas. Além disso, a intensidade de imunomarcação de c-Kit foi predominantemente mais forte em melanomas amelanóticos. Estes resultados confirmam um papel potencial para c-Kit em melanomas orais caninos, com diferenças claras em padrões de expressão entre os dois tipos histológicos de tumor, melanóticos e amelanóticos. Este trabalho destaca a importância de um estudo detalhado das mutações c-Kit em melanomas orais caninos para ser possível a melhor compreensão dos mecanismos moleculares envolvidos no desenvolvimento da doença(AU)

Clinical and mycological analysis of dog's oral cavity

The oral microbiota of humans and animals is made up of a wide variety of yeasts and bacteria, but microbiota of dogs is not totally described. Although such identification is an important step to establish the etiopathogenesis and adequate therapy for the periodontal disease The aim of this study was to evaluate and correlate oral alterations with the presence of yeasts in oral cavity of female dogs. After clinical evaluation samples from healthy and from dogs with oral diseases were obtained from three different oral sites by swabs, curettes, millimeter periodontal probes and HA membrane tip in cellulose ester. Yeast identification was performed through macroscopic and microscopic colony features and biochemical tests. Dental calculus was the most prevalent occurrence in the oral cavity of 59 females. However, the isolation of yeasts was significantly higher (p < 0.05) in animals suffering from halitosis. Eleven yeast species were identified, namely: Malassezia pachydermatis, Rhodotorula spp., Candida albicans, C. catenulata, C. famata, C. guilliermondii, C. parapsilosis, C. intermedia, Trichosporon asahii, T. mucoides and Cryptococcus albidus. It could be concluded that the yeasts are part of the microbiota from the different sites of the oral cavity of the female canines studied without causing any significant alterations except halitosis.(AU)

Alterações anatomopatológicas na cavidade oral equina / natomopathological alterations of the equine oral cavity

A saúde bucal é essencial para o bem estar dos equídeos, incluindo exames periódicos da cavidade oral para detecção, correção e manutenção das arcadas dentárias. O Brasil possui grande número de equinos, com aproximadamente sete milhões de exemplares. No entanto, o número de animais que recebe algum tipo de cuidado odontológico é bastante reduzido. Os cuidados odontológicos devem ser iniciados desde o nascimento. Importantes alterações, como a fenda palatina, falhas na oclusão, presença de dentes supranumerários e tumores podem interferir na amamentação e, posteriormente, na alimentação podendo predispor a distúrbios digestórios. Deve-se levar em conta que alterações dentárias podem repercutir em transtornos diversos, desde simples rejeição a embocaduras, perda do elemento dental, inanição e até a morte. Portanto, esta revisão tem como objetivo abordar as principais alterações encontradas na cavidade oral equina e contribuir no conhecimento para auxiliar na conduta médica mais adequada, favorecendo a saúde do animal, com qualidade de vida e desempenho satisfatório.

Oral health is essential for the well-being of equids, including the performance of periodic examinations of the oral cavity for the detection, correction and maintenance of the teeth. There is a great number of horses in Brazil, with approximately seven million animals. Dental care should be initiated at birth, when important alterations, such as cleft palate, malocclusion, supernumerary teeth and tumours, can be diagnosed. These alterations may interfere with lactation, and later with feeding, leading to digestive disorders. It should always be considered that dental disorders may cause several problems, including bit rejection, tooth losses, inanition and even death. Therefore, this review aimed at approaching the main alterations found in the oral cavity of horses and contributing for the development of the most adequate medical conduct, favoring animal health and a satisfactory performance.

Alterações anatomopatológicas na cavidade oral equina / natomopathological alterations of the equine oral cavity

A saúde bucal é essencial para o bem estar dos equídeos, incluindo exames periódicos da cavidade oral para detecção, correção e manutenção das arcadas dentárias. O Brasil possui grande número de equinos, com aproximadamente sete milhões de exemplares. No entanto, o número de animais que recebe algum tipo de cuidado odontológico é bastante reduzido. Os cuidados odontológicos devem ser iniciados desde o nascimento. Importantes alterações, como a fenda palatina, falhas na oclusão, presença de dentes supranumerários e tumores podem interferir na amamentação e, posteriormente, na alimentação podendo predispor a distúrbios digestórios. Deve-se levar em conta que alterações dentárias podem repercutir em transtornos diversos, desde simples rejeição a embocaduras, perda do elemento dental, inanição e até a morte. Portanto, esta revisão tem como objetivo abordar as principais alterações encontradas na cavidade oral equina e contribuir no conhecimento para auxiliar na conduta médica mais adequada, favorecendo a saúde do animal, com qualidade de vida e desempenho satisfatório.(AU)

Oral health is essential for the well-being of equids, including the performance of periodic examinations of the oral cavity for the detection, correction and maintenance of the teeth. There is a great number of horses in Brazil, with approximately seven million animals. Dental care should be initiated at birth, when important alterations, such as cleft palate, malocclusion, supernumerary teeth and tumours, can be diagnosed. These alterations may interfere with lactation, and later with feeding, leading to digestive disorders. It should always be considered that dental disorders may cause several problems, including bit rejection, tooth losses, inanition and even death. Therefore, this review aimed at approaching the main alterations found in the oral cavity of horses and contributing for the development of the most adequate medical conduct, favoring animal health and a satisfactory performance.(AU)

Anestesia em roedores e lagomorfos para procedimentos odontológicos / Anesthesia and analgesia for rodents and lagomorphos dental procedures / La anestesia en roedores y conejos durante procedimentos dentales

Atualmente a procura por animais exóticos vêm crescendo mundialmente e a procura por cuidados especializados vêm acompanhando esse crescimento. Coelhos e roedores apresentam semelhanças e particularidades anatômicas que, somando-se ao manejo errôneo dessas espécies, estão diretamente relacionadas ao desenvolvimento de doenças associadas à cavidade oral. Assim como em cães e gatos, o tratamento odontológico só é possível ser realizado com adequados procedimentos anestésicos e controle satisfatório da dor. Devido ao seu alto metabolismo e a dificuldade de acessar as vias aéreas, a anestesia nesses animais deve ser realizada por profissionais treinados e alguns cuidados devem ser tomados para o sucesso do procedimento.(AU)

Currently the demand for exotic animals has been growing worldwide and the demand for specialized care has been following this growth. Rabbits and rodents present anatomical similarities and peculiarities that, together with the erroneous management of these species, are directly related to the development of diseases associated with the oral cavity. As with dogs and cats, the dental treatment can only be performed with adequate anesthetic procedures and satisfactory pain control. Due to its high metabolism and difficulty in accessing the airways, anesthesia in these animals should be performed by trained professionals and some special cares should be taken for the success of the procedure.(AU)

Actualmente la demanda por animales exóticos se ha creciendo en el todomundo y la busca por atención especializada ha acompariado este crecimiento. Conejos y roedores muestran similitudes y las características anatómicas que, anadiendo a la mala gestión de estos especies, están directamente relacionados con el desarrollo de enfermidades asociadas con la cavidad oral. Al igualque los perros y los gatos, el tratamiento dental sólo puede llevarse a cabo com procedimientos anestésicos adecuados y el control satisfactorio del dolor. Debido a su alto metabolismo y la dificultad de acceso a la vía aérea, la anestesia en estos animales debe ser realizada por profesionales capacitados y algunos cuidados se debe tomar para el éxito del procedimiento.(AU)

Anestesia em roedores e lagomorfos para procedimentos odontológicos / Anesthesia and analgesia for rodents and lagomorphos dental procedures / La anestesia en roedores y conejos durante procedimentos dentales

Atualmente a procura por animais exóticos vêm crescendo mundialmente e a procura por cuidados especializados vêm acompanhando esse crescimento. Coelhos e roedores apresentam semelhanças e particularidades anatômicas que, somando-se ao manejo errôneo dessas espécies, estão diretamente relacionadas ao desenvolvimento de doenças associadas à cavidade oral. Assim como em cães e gatos, o tratamento odontológico só é possível ser realizado com adequados procedimentos anestésicos e controle satisfatório da dor. Devido ao seu alto metabolismo e a dificuldade de acessar as vias aéreas, a anestesia nesses animais deve ser realizada por profissionais treinados e alguns cuidados devem ser tomados para o sucesso do procedimento.

Currently the demand for exotic animals has been growing worldwide and the demand for specialized care has been following this growth. Rabbits and rodents present anatomical similarities and peculiarities that, together with the erroneous management of these species, are directly related to the development of diseases associated with the oral cavity. As with dogs and cats, the dental treatment can only be performed with adequate anesthetic procedures and satisfactory pain control. Due to its high metabolism and difficulty in accessing the airways, anesthesia in these animals should be performed by trained professionals and some special cares should be taken for the success of the procedure.

Actualmente la demanda por animales exóticos se ha creciendo en el todomundo y la busca por atención especializada ha acompariado este crecimiento. Conejos y roedores muestran similitudes y las características anatómicas que, anadiendo a la mala gestión de estos especies, están directamente relacionados con el desarrollo de enfermidades asociadas con la cavidad oral. Al igualque los perros y los gatos, el tratamiento dental sólo puede llevarse a cabo com procedimientos anestésicos adecuados y el control satisfactorio del dolor. Debido a su alto metabolismo y la dificultad de acceso a la vía aérea, la anestesia en estos animales debe ser realizada por profesionales capacitados y algunos cuidados se debe tomar para el éxito del procedimiento.

Tumor venéreo transmissível canino com localização primária e única em cavidade oral / Canine transmissible venereal tumor with primary and unique site in the oral cavity

O tumor venéreo transmissível (TVT) pode ser observado na cavidade oral de cães, sem a associação com lesões genitais, sendo assim caracterizado como extragenital e primário. Todavia esta forma possui uma reduzida prevalência. O trabalho objetivou a descrição de um TVT oral primário em canino. Um cão apresentava o histórico de tumor bucal. O animal foi submetido ao exame físico, realizando citologia da neoformação oral. Optou-se pela administração do sulfato de vincristina (0,75 mg/m2, a cada sete dias, com um total de seis sessões) e prednisolona (1 mg/kg, a cada 24h por sete dias seguido de redução progressiva da dose). Constatou-se um tumor na parte rostral da mandíbula e outro na hemimandíbula direita. O exame citológico diagnosticou TVT de padrão misto. Esta neoplasia não estava presente na genitália externa do animal ou em outras localizações anatômicas. Logo, caracterizou-se o TVT oral como uma forma extragenital e primária. Após a sexta sessão do sulfato de vincristina e finalizada a administração da prednisolona, houve remissão total dos tumores. Deve-se incluir o TVT como diagnóstico diferencial de outras neoformações orais de cães, pois apesar da possibilidade de semelhança macroscópica, ocorre distinção de prognóstico e tratamento.

The transmissible venereal tumor (TVT) can be observed in the oral cavity of dogs, without any association with genital lesions, and thus characterized as extragenital and primary. However, this form has a low prevalence. This present study aimed to describe an oral primary TVT in canine. One dog had a history of oral tumor. The animal was subjected to physical examination, when cytology of the oral neoformation was performed. It was chosen the administration of vincristine sulfate (0.75 mg/m2, every seven days, with a total of six sessions), and prednisolone (1 mg/kg every 24 hours, for seven days, followed by gradual reduction of the dose). It was detected a tumor in the rostral part of the jaw and another one in the right side of the mandible. Cytologic examination diagnosed TVT of mixed pattern. This tumor was not present in the external genitalia of the animal or in other anatomical locations. Thus, the TVT was characterized as an extragenital and primary form. After the sixth session of vincristine sulfate, and the completion of the administration of prednisolone, there was full remission of the tumors. The TVT must be included as a differential diagnosis of other oral neoformations in dogs, because, despite the possibility of macroscopic similarity, there is a distinction between them regarding prognosis and treatment.

Tumor venéreo transmissível canino com localização primária e única em cavidade oral / Canine transmissible venereal tumor with primary and unique site in the oral cavity

O tumor venéreo transmissível (TVT) pode ser observado na cavidade oral de cães, sem a associação com lesões genitais, sendo assim caracterizado como extragenital e primário. Todavia esta forma possui uma reduzida prevalência. O trabalho objetivou a descrição de um TVT oral primário em canino. Um cão apresentava o histórico de tumor bucal. O animal foi submetido ao exame físico, realizando citologia da neoformação oral. Optou-se pela administração do sulfato de vincristina (0,75 mg/m2, a cada sete dias, com um total de seis sessões) e prednisolona (1 mg/kg, a cada 24h por sete dias seguido de redução progressiva da dose). Constatou-se um tumor na parte rostral da mandíbula e outro na hemimandíbula direita. O exame citológico diagnosticou TVT de padrão misto. Esta neoplasia não estava presente na genitália externa do animal ou em outras localizações anatômicas. Logo, caracterizou-se o TVT oral como uma forma extragenital e primária. Após a sexta sessão do sulfato de vincristina e finalizada a administração da prednisolona, houve remissão total dos tumores. Deve-se incluir o TVT como diagnóstico diferencial de outras neoformações orais de cães, pois apesar da possibilidade de semelhança macroscópica, ocorre distinção de prognóstico e tratamento.(AU)

The transmissible venereal tumor (TVT) can be observed in the oral cavity of dogs, without any association with genital lesions, and thus characterized as extragenital and primary. However, this form has a low prevalence. This present study aimed to describe an oral primary TVT in canine. One dog had a history of oral tumor. The animal was subjected to physical examination, when cytology of the oral neoformation was performed. It was chosen the administration of vincristine sulfate (0.75 mg/m2, every seven days, with a total of six sessions), and prednisolone (1 mg/kg every 24 hours, for seven days, followed by gradual reduction of the dose). It was detected a tumor in the rostral part of the jaw and another one in the right side of the mandible. Cytologic examination diagnosed TVT of mixed pattern. This tumor was not present in the external genitalia of the animal or in other anatomical locations. Thus, the TVT was characterized as an extragenital and primary form. After the sixth session of vincristine sulfate, and the completion of the administration of prednisolone, there was full remission of the tumors. The TVT must be included as a differential diagnosis of other oral neoformations in dogs, because, despite the possibility of macroscopic similarity, there is a distinction between them regarding prognosis and treatment.(AU)

Carcinoma escamoso oral em gato jovem / Squamous Cell Carcinoma Oral in Young Feline

Background: Oral neoplasms are common in cats. Just the percentage of oral squamous cell carcinoma (SCC) accounts for about 70% of all feline oral tumors also it is considered highly invasive and malignant. There are reports that the flea collar increases five times the risk oral SCC development. In addition, smoke exposure is also considered a risk factor, and the animals were exposed to tobacco when makes it self-cleaning. SCC well differentiated is characterized histologically by numerous keratin pearls formation and clearly evident intercellular bridges with poor mitotic activity and nuclear pleomorphism. The median age of cats with oral SCC is about 11-13 years, but, cats as young as three years and as old as twenty-one years have been previously reported. However, it was not found reports of oral SCC in cats at age younger than one year old. The aim of this article is reports one case of oral SCC feline at age of three months old. Five days after surgical procedure the patient returned to the veterinary and the owner report that it returned to eating well. Case: It was exanimate a three months old male mixed breed cat presenting oral volume increased and the biopsy test was suggested. However, the owner returned 3 months later when the animal showed tumor 6 cm in diameter, dysphagia, tongue protrusion, excessive salivation, halitosis and weight loss. It was indicated a wide surgical excision of tumoral mass. The tissue was submitted to histopathology. Discussion: The historical, macroscopic characteristics and predisponents factors may aid in carcinoma diagnosis, however, the cytologic or histological examination of tissue confirms this diagnosis. Therefore, the microscopic evaluation revealed a malignant neoplastic proliferation of stratified squamous epithelial cells desmosomal junctions evident, few foci keratin pearl formation and presence of mononuclear inflammatory reaction perifocal.(...)