Polycystic kidney disease in rough toothed dolphins (Steno bredanensis) found in the Paraná coast, southern Brazil

Background: Renal cystic diseases (RCD) are characterized by cystic structures on renal parenchyma associated withobstructive lesions, membranous disruptions, and/or growth disturbances. The polycystic kidney disease (PKD) showsspecific pathological characteristics, related to mutations on PKD1 and/or PKD2 chromosome locus on humans. In Persiancats and bull terriers the condition is like the human “adult-onset” PKD, while in Perendale sheep the “childhood”-like isdescribed. In cetaceans, RCD are reported, however the characterization of PKD is scarcely described. This report aimsto describe two cases of PKD and one of RCD in stranded Steno bredanensis, and to discuss the disease associated factors.Cases: Four rough-toothed-dolphins were found stranded in the Paraná coast, southern Brazil between 2016 to 2018,through the Santos Basin Beach Monitoring Project (PMP-BS), one of the systematic monitoring programs required byBrazilian Institute of Environment and Renewable Natural Resources (IBAMA) for the environmental licensing processof oil production and transport by Petrobras in the presalt province. In three animals histological sampling was performed.One of them (animal 3) was found alive, presenting altered buoyancy with lateralization to the right and signs of pneumonia. The blood analysis showed anemia and leukocytosis. The animal showed poor clinical prognosis, and even withsupportive treatment, come to death four days after the rescue. Routine autopsies were performed on all animals. Animals1 and 2 presented macroscopically enlarged kidneys containing disseminated cystic...

Polycystic kidney disease in rough toothed dolphins (Steno bredanensis) found in the Paraná coast, southern Brazil

Background: Renal cystic diseases (RCD) are characterized by cystic structures on renal parenchyma associated withobstructive lesions, membranous disruptions, and/or growth disturbances. The polycystic kidney disease (PKD) showsspecific pathological characteristics, related to mutations on PKD1 and/or PKD2 chromosome locus on humans. In Persiancats and bull terriers the condition is like the human “adult-onset” PKD, while in Perendale sheep the “childhood”-like isdescribed. In cetaceans, RCD are reported, however the characterization of PKD is scarcely described. This report aimsto describe two cases of PKD and one of RCD in stranded Steno bredanensis, and to discuss the disease associated factors.Cases: Four rough-toothed-dolphins were found stranded in the Paraná coast, southern Brazil between 2016 to 2018,through the Santos Basin Beach Monitoring Project (PMP-BS), one of the systematic monitoring programs required byBrazilian Institute of Environment and Renewable Natural Resources (IBAMA) for the environmental licensing processof oil production and transport by Petrobras in the presalt province. In three animals histological sampling was performed.One of them (animal 3) was found alive, presenting altered buoyancy with lateralization to the right and signs of pneumonia. The blood analysis showed anemia and leukocytosis. The animal showed poor clinical prognosis, and even withsupportive treatment, come to death four days after the rescue. Routine autopsies were performed on all animals. Animals1 and 2 presented macroscopically enlarged kidneys containing disseminated cystic...(AU)

Pulmonary Aspergillis in the dolphin (Pontoporia blainvillei)

Fungal infections that affect marine mammals, like most fungal infections, can be secondary to environmental stress or other infectious diseases. This article describes a case of pulmonary infection by Aspergillus spp. in a specimen of Pontoporia blainvillei found dead near the town of San Clemente de Tuyu and near the bay of Samborombón, BuenosAires, Argentina. The lung was collapsed with necrotic foci, fragments were collected, fixed in 10% formalin and submitted to histopathological examination. Microscopically, a marked change of the pulmonary architecture was observed, with total alveolar collapse, extensive necrotic areas, where septal hyphae were observed weakly, when stained with H-E and clearly evidenced with Grocott staining. Since the potential causes of immunosuppression were not evident, the authors consider it probable that infection by Aspergillus spp. was established in the lungs that presented a primary, possibly bacterial pneumonia, as a result of some degree of immunosuppression.(AU)

Pulmonary Aspergillis in the dolphin (Pontoporia blainvillei)

Fungal infections that affect marine mammals, like most fungal infections, can be secondary to environmental stress or other infectious diseases. This article describes a case of pulmonary infection by Aspergillus spp. in a specimen of Pontoporia blainvillei found dead near the town of San Clemente de Tuyu and near the bay of Samborombón, BuenosAires, Argentina. The lung was collapsed with necrotic foci, fragments were collected, fixed in 10% formalin and submitted to histopathological examination. Microscopically, a marked change of the pulmonary architecture was observed, with total alveolar collapse, extensive necrotic areas, where septal hyphae were observed weakly, when stained with H-E and clearly evidenced with Grocott staining. Since the potential causes of immunosuppression were not evident, the authors consider it probable that infection by Aspergillus spp. was established in the lungs that presented a primary, possibly bacterial pneumonia, as a result of some degree of immunosuppression.