Use of masitinib mesylate as an adjuvant treatment of metastatic canine mast cell tumor / Utilização do mesilato de masitinibe no tratamento adjuvante do mastocitoma canino metastático

Background: The proliferative disorders of mast cells include, in addition to mast cell tumor, systemic mastocytosis and myeloid leukemia of mast cells. Surgery is the treatment of choice for tumors in the skin, in regions which allow wide excision but adjuvant treatments should be performed in selected patients. However, the use of adjuvant chemotherapy remains empirical, due to the absence of controlled studies. Despite the relevance of the use of tyrosine kinase inhibitors for the treatment of mast cell tumors, studies with these drugs have focused primarily on neoadjuvant scenery. Case: A 13-year-old male Poodle dog, weighing 4.6 kg, was presented with bilateral increase in inguinal lymph nodes and a vesicular cutaneous lesion, in the inguinal region, 75 days after surgery for the removal of a scrotum grade II mast cell tumor. Patient was admitted for surgery and the tissues removed were sent for pathological examination that allowed the diagnosis of grade II mast cell tumor and metastasis in all inguinal lymph nodes. The immunohistochemical study for CD117 revealed an aberrant expression of KIT receptor (KIT II), while the PCR for mutations in exon 11 of c-KIT gene revealed internal tandem duplications. The patient underwent a session of chemotherapy with lomustine, however it had serious side effects that resulted in discontinuation of treatment, opting for utilization...(AU)

Use of masitinib mesylate as an adjuvant treatment of metastatic canine mast cell tumor / Utilização do mesilato de masitinibe no tratamento adjuvante do mastocitoma canino metastático

Background: The proliferative disorders of mast cells include, in addition to mast cell tumor, systemic mastocytosis and myeloid leukemia of mast cells. Surgery is the treatment of choice for tumors in the skin, in regions which allow wide excision but adjuvant treatments should be performed in selected patients. However, the use of adjuvant chemotherapy remains empirical, due to the absence of controlled studies. Despite the relevance of the use of tyrosine kinase inhibitors for the treatment of mast cell tumors, studies with these drugs have focused primarily on neoadjuvant scenery. Case: A 13-year-old male Poodle dog, weighing 4.6 kg, was presented with bilateral increase in inguinal lymph nodes and a vesicular cutaneous lesion, in the inguinal region, 75 days after surgery for the removal of a scrotum grade II mast cell tumor. Patient was admitted for surgery and the tissues removed were sent for pathological examination that allowed the diagnosis of grade II mast cell tumor and metastasis in all inguinal lymph nodes. The immunohistochemical study for CD117 revealed an aberrant expression of KIT receptor (KIT II), while the PCR for mutations in exon 11 of c-KIT gene revealed internal tandem duplications. The patient underwent a session of chemotherapy with lomustine, however it had serious side effects that resulted in discontinuation of treatment, opting for utilization...

Estudo retrospectivo dos casos de mastocitoma canino atendidos no Hospital Veterinário da UNIMAR no período de 2009 à dezembro de 2012 / Retrospective study of canine mast cell tumor in Unimar Veterinary Hospital in the period of January 2009 to December 2012 / Estudio retrospectivo de los casos tratados de mastocitoma canino em Hospital Veterinario Unimar el periodo enero 2009 a diciembre de 2012

Foram analisados os prontuários dos casos atendidos no Hospital Veterinário da Universidade de Marília diagnosticados pelo setor de Patologia Veterinária no período de janeiro de 2009 a dezembro de 2012. Foram diagnosticados 22 casos de cães com mastocitoma. Destes animais, 14 eram machos e oito eram fêmeas, com idade variando de três a 13 anos. Segundo a classificação histológica, um animal foi diagnosticado grau 1, seis animais eram grau 2, oito eram grau 3 e em sete animais não foi possível a graduação. Quatro animais passaram por intervenção cirúrgica, quatro fizeram quimioterapia, sete realizaram cirurgia seguida por quimioterapia. A intervenção cirúrgica seguida de tratamento quimioterápico, em casos de prognóstico favorável, proporciona maior sobrevida. A citologia permite o diagnóstico do mastocitoma, porém a histopatologia faz-se imperativa para a determinação do grau histológico e delineamento do tratamento.(AU)

From January 2009 to December 2012, were analyzed the cases medical records seen at the Veterinary Hospital of the University of Marilia that were diagnosed by the Department of Veterinary Pathology. Were 22 cases of dogs with mast cell tumors diagnosed. Of these animais, 14 were males and eight females, with varying from three to 13 years. According to histological classification, one animal was diagnosed grade 1, six animais were grade 2, eight were grade 3 and seven pets not been possible graduation. Four animais had surgical intervention, four received chemotherapy, and seven had surgical intervention followed by chemotherapy. The surgery followed by chemotherapy in cases of favorable prognosis, provides long-term survival. Cytological allows the mast cell tumor diagnose, but the histopathology it is imperative for the determination of the histological grade and treatment.(AU)

Se analizaron los registros de los casos atendidos en el Hospital Veterinario de la Universidad de Marília diagnosticado por el sector de Patología Veterinaria desde enero del 2009 hasta diciembre del 2012. Se diagnosticaron 22 casos de canes con mastocitoma. De estos animales, 14 eran machos y ocho hembras, entre tres a 13 anos. De acuerdo con la clasificación histológica, un animal fue diagnosticado con grado 1, seis animales fueron de grado 2, ocho fueron de grado 3 y en siete animales no fue posible determinar o grado de clasificación. Cuatro animales fueron sometidos a intervención quirúrgica, cuatro recibieron quimioterapía, siete fueron sometidos a cirugía seguida de quimioterapía. La intervención quirúrgica seguida de quimioterapia en casos de pronóstico favorable, proporciona una mayor sobrevida. La citología permite el diagnóstico del mastocitoma, pero la patología es fundamental para determinar el grado histológico y el diseño del tratamiento.(AU)

Estudo retrospectivo dos casos de mastocitoma canino atendidos no Hospital Veterinário da UNIMAR no período de 2009 à dezembro de 2012 / Retrospective study of canine mast cell tumor in Unimar Veterinary Hospital in the period of January 2009 to December 2012 / Estudio retrospectivo de los casos tratados de mastocitoma canino em Hospital Veterinario Unimar el periodo enero 2009 a diciembre de 2012

Foram analisados os prontuários dos casos atendidos no Hospital Veterinário da Universidade de Marília diagnosticados pelo setor de Patologia Veterinária no período de janeiro de 2009 a dezembro de 2012. Foram diagnosticados 22 casos de cães com mastocitoma. Destes animais, 14 eram machos e oito eram fêmeas, com idade variando de três a 13 anos. Segundo a classificação histológica, um animal foi diagnosticado grau 1, seis animais eram grau 2, oito eram grau 3 e em sete animais não foi possível a graduação. Quatro animais passaram por intervenção cirúrgica, quatro fizeram quimioterapia, sete realizaram cirurgia seguida por quimioterapia. A intervenção cirúrgica seguida de tratamento quimioterápico, em casos de prognóstico favorável, proporciona maior sobrevida. A citologia permite o diagnóstico do mastocitoma, porém a histopatologia faz-se imperativa para a determinação do grau histológico e delineamento do tratamento.

From January 2009 to December 2012, were analyzed the cases medical records seen at the Veterinary Hospital of the University of Marilia that were diagnosed by the Department of Veterinary Pathology. Were 22 cases of dogs with mast cell tumors diagnosed. Of these animais, 14 were males and eight females, with varying from three to 13 years. According to histological classification, one animal was diagnosed grade 1, six animais were grade 2, eight were grade 3 and seven pets not been possible graduation. Four animais had surgical intervention, four received chemotherapy, and seven had surgical intervention followed by chemotherapy. The surgery followed by chemotherapy in cases of favorable prognosis, provides long-term survival. Cytological allows the mast cell tumor diagnose, but the histopathology it is imperative for the determination of the histological grade and treatment.

Se analizaron los registros de los casos atendidos en el Hospital Veterinario de la Universidad de Marília diagnosticado por el sector de Patología Veterinaria desde enero del 2009 hasta diciembre del 2012. Se diagnosticaron 22 casos de canes con mastocitoma. De estos animales, 14 eran machos y ocho hembras, entre tres a 13 anos. De acuerdo con la clasificación histológica, un animal fue diagnosticado con grado 1, seis animales fueron de grado 2, ocho fueron de grado 3 y en siete animales no fue posible determinar o grado de clasificación. Cuatro animales fueron sometidos a intervención quirúrgica, cuatro recibieron quimioterapía, siete fueron sometidos a cirugía seguida de quimioterapía. La intervención quirúrgica seguida de quimioterapia en casos de pronóstico favorable, proporciona una mayor sobrevida. La citología permite el diagnóstico del mastocitoma, pero la patología es fundamental para determinar el grado histológico y el diseño del tratamiento.

Retalho de avanço toracocervical dorsal em cão com mastocitoma / Advancement flap thoracocervical dorsal dog with mast cell tumor

O Mastocitoma canino, também conhecido como mastocitoma histiocítico ou sarcoma da célula do mastócito é a neoplasia mais comum que acomete os cães, representando até 27% dos tumores malignos desta espécie, e caracteriza-se pela proliferação dos mastócitos. O tratamento consiste na exérese tumoral com margem de segurança, seguido de protocolo quimioterápico. A cirurgia plástica reparadora está indicada para reparar o leito pós-exérese, especialmente com o uso de retalho cutâneo vascularizado. O presente relato tem como objetivo apresentar um caso de mastocitoma grau II na região cervical dorsal de um cão,que necessitou da técnica de cirúrgia plástico reparadora para correção da ferida cirúrgica remanescente.AU

The canine mast cell tumor, also known as histiocytic mastocytoma cell or mast cell sarcoma is the most common cancer that affects dogs, representing up to 27% of malignant tumors of this kind and is characterized by proliferation of mast cells. The treatment consists of tumor resection with a safety margin, followed by chemotherapy protocol. The reconstructive plastic surgery is indicated to repair the bed post-excision, especially with the use of vascularized skin flap. This paper aims to report a case of mastocytoma grade II in dorsal cervical region of a dog, which used the restorative plastic surgery technique for correction of the surgical wound.AU

Retalho de avanço toracocervical dorsal em cão com mastocitoma / Advancement flap thoracocervical dorsal dog with mast cell tumor

O Mastocitoma canino, também conhecido como mastocitoma histiocítico ou sarcoma da célula do mastócito é a neoplasia mais comum que acomete os cães, representando até 27% dos tumores malignos desta espécie, e caracteriza-se pela proliferação dos mastócitos. O tratamento consiste na exérese tumoral com margem de segurança, seguido de protocolo quimioterápico. A cirurgia plástica reparadora está indicada para reparar o leito pós-exérese, especialmente com o uso de retalho cutâneo vascularizado. O presente relato tem como objetivo apresentar um caso de mastocitoma grau II na região cervical dorsal de um cão,que necessitou da técnica de cirúrgia plástico reparadora para correção da ferida cirúrgica remanescente.

The canine mast cell tumor, also known as histiocytic mastocytoma cell or mast cell sarcoma is the most common cancer that affects dogs, representing up to 27% of malignant tumors of this kind and is characterized by proliferation of mast cells. The treatment consists of tumor resection with a safety margin, followed by chemotherapy protocol. The reconstructive plastic surgery is indicated to repair the bed post-excision, especially with the use of vascularized skin flap. This paper aims to report a case of mastocytoma grade II in dorsal cervical region of a dog, which used the restorative plastic surgery technique for correction of the surgical wound.