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1.
Braz. j. vet. pathol ; 4(1): 58-61, mar. 2011. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1398116

Resumo

A 6-year-old, female, mixed-breed dog was presented for necropsy with history of prostration and incoordination followed by circling to the right and seizures. There were no gross findings in the brain. Histologically, there were numerous neoplastic glial cells throughout the thalamus, midbrain, pons and medulla oblongata. Moderate multifocal lymphoplasmacytic perivascular cuffings were also present in the same areas. In addition, severe multifocal proliferation of glial cells was observed in the leptomeninge and white matter of the cerebellum. The neoplastic cells observed in the brain stem were negative for GFAP, while in the cerebellum the neoplastic glial cells were strongly labeled with GFAP and vimentin. Based on the histopathological findings and on the immunohistochemical results, a diagnosis of gliomatosis cerebri was made.(AU)


Assuntos
Animais , Feminino , Cães , Neuroglia/citologia , Neoplasias Neuroepiteliomatosas/diagnóstico , Cérebro/fisiopatologia , Autopsia/veterinária
2.
Braz. j. vet. pathol ; 3(2): 131-136, nov. 2010.
Artigo em Inglês | VETINDEX | ID: biblio-1469831

Resumo

Protoplasmic astrocytomas are uncommon in humans and animals. A 14-year-old, intact female German Shepherd dog presented with a history of ataxia of the pelvic limbs, left-side head torsion and hypermetric response of the right side for approximately 15 days. Neurological examination revealed the presence of cerebellar syndrome and paradoxical vestibular syndrome. Medical therapy was initiated, but neurological signs were progressive, and the owner opted for euthanasia. Gross examination showed no cerebellar lesion. Microscopic features were characterized by prominent background microcystic degeneration and the presence of spindle cells with scant cytoplasm and delicate glial fibers. The immunohistochemical assay showed positive staining for GFAP (glial fibrillar acidic protein), vimentin and S100, and negative staining for factor VIII. A definitive diagnosis of protoplasmic astrocytoma was made on the basis of the histological and immunohistochemical findings.


Assuntos
Animais , Astrocitoma/complicações , Astrocitoma/mortalidade , Astrocitoma/veterinária , Dissinergia Cerebelar Mioclônica/diagnóstico , Dissinergia Cerebelar Mioclônica/mortalidade , Dissinergia Cerebelar Mioclônica/veterinária , Microcystis/citologia , Neuroglia/citologia , Sarcoma/diagnóstico , Vimentina/biossíntese
3.
Braz. J. Vet. Pathol. ; 3(2): 131-136, nov. 2010.
Artigo em Inglês | VETINDEX | ID: vti-2530

Resumo

Protoplasmic astrocytomas are uncommon in humans and animals. A 14-year-old, intact female German Shepherd dog presented with a history of ataxia of the pelvic limbs, left-side head torsion and hypermetric response of the right side for approximately 15 days. Neurological examination revealed the presence of cerebellar syndrome and paradoxical vestibular syndrome. Medical therapy was initiated, but neurological signs were progressive, and the owner opted for euthanasia. Gross examination showed no cerebellar lesion. Microscopic features were characterized by prominent background microcystic degeneration and the presence of spindle cells with scant cytoplasm and delicate glial fibers. The immunohistochemical assay showed positive staining for GFAP (glial fibrillar acidic protein), vimentin and S100, and negative staining for factor VIII. A definitive diagnosis of protoplasmic astrocytoma was made on the basis of the histological and immunohistochemical findings.(AU)


Assuntos
Animais , Astrocitoma/complicações , Astrocitoma/mortalidade , Astrocitoma/veterinária , Dissinergia Cerebelar Mioclônica/diagnóstico , Dissinergia Cerebelar Mioclônica/mortalidade , Dissinergia Cerebelar Mioclônica/veterinária , Microcystis/citologia , Sarcoma/diagnóstico , Neuroglia/citologia , Vimentina/biossíntese
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