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1.
Ciênc. Anim. (Impr.) ; 33(1): 152-160, jan.-mar. 2023. ilus
Artigo em Português | VETINDEX | ID: biblio-1434533

Resumo

A criptococose é uma doença infecciosa sistêmica de origem fúngica, causada pelas espécies: Cryptococcus neoformans e Cryptococcus gattii. É considerada uma micose oportunista capaz de infectar mamíferos domésticos, animais silvestres e seres humanos, sendo classificada como uma doença zoonótica. Esse patógeno é encontrado principalmente em ambientes contaminados por fezes de pombos (Columba livia), que atuam como importantes fontes de infecção do fungo. De acordo com sua disseminação para os tecidos do organismo, a doença pode causar diferentes síndromes tanto em seres humanos como em animais síndrome respiratória, síndrome neurológica, síndrome ocular e síndrome cutânea. O diagnóstico pode ser realizado através da pesquisa de antígeno polissacarídeo circulante no soro ou líquor, por meio da prova de látex. Testes imunoenzimáticos (ELISA) também podem ser realizados para detecção de antígenos dessa levedura. Exame citológico, histopatológico e cultura fúngica para a identificação do agente tornam o diagnóstico da criptococose mais fácil. O tratamento é baseado no uso de antifúngicos e sua escolha é realizada através da avaliação dos sinais clínicos observados. Diante do exposto, o objetivo deste trabalho é relatar um caso de criptococose respiratória e cutânea em felino doméstico de vida livre da cidade de Sobral/CE.


Cryptococcosis is a systemic infectious disease of fungal origin caused by the species: Cryptococcus neoformans and Cryptococcus gattii. It is considered an opportunistic mycosis capable of infecting domestic mammals, wild animals, and humans, being classified as a zoonotic disease. This pathogen is mainly found mainly in environments contaminated by pigeon (Columba livia) feces, which act as important sources of fungal infection. According to its spread to the body's tissues, the disease can cause different syndromes in both humans and animals: respiratory syndrome, neurological syndrome, ocular syndrome, and cutaneous syndrome. The diagnosis can be made through the investigation of circulating polysaccharide antigen in serum or cerebrospinal fluid using the latex test. Immunoenzymatic tests (ELISA) can also be performed to detect yeast antigens. Cytological examination, histopathological examination, and fungal culture to identify the agent make the diagnosis of cryptococcosis easier. The treatment is based on the use of antifungals, and its choice is made through the evaluation of the observed clinical signs. In this context, this work aims to report a case of respiratory and cutaneous cryptococcosis in a free-range domestic cat in the city of Sobral/CE.


Assuntos
Animais , Gatos , Doenças do Gato , Zoonoses , Criptococose/veterinária , Cryptococcus neoformans/patogenicidade , Cryptococcus gattii/patogenicidade
2.
Artigo em Português | VETINDEX | ID: biblio-1451824

Resumo

Criptococose é uma micose sistêmica não contagiosa que acomete, principalmente, felinos. O agente etiológico é uma levedura do gênero Cryptococcus sp., e a sua transmissão ocorre por via aerógena, com a inalação dos esporos que se alojam, principalmente, na cavidade nasal e pulmão. A forma nasal é a mais comum em felinos e as suas manifestações clínicas incluem edema nasofacial, eritema e secreção nasal. O diagnóstico pode ser realizado por meio de cultivo micológico, citologia, histologia e reação em cadeia polimerase. Neste artigo, é apresentado o relato de caso de um felino diagnosticado com criptococose, no qual o diagnóstico de triagem foi realizado por meio de rinoscopia. No atendimento inicial, o animal apresentava hiporexia, reflexo de deglutição constante, engasgos, odor acentuado em região nasal e crepitações pulmonares com evolução de três meses. O diagnóstico foi realizado com o emprego de rinoscopia, que identificou massa interna na região da mucosa nasofaríngea, com posterior biópsia e exame anatomopatológico. Após a confirmação diagnóstica, o paciente foi medicado com itraconazol 10 mg/kg SID, por 5 meses, e teve a resolução de todos os sinais clínicos apresentados. A criptococose deve ser considerada como diagnóstico, diferencial de alterações do sistema respiratório em felinos e a rinoscopia pode ser um recurso diagnóstico importante para auxiliar na conclusão e reconhecimento da enfermidade.(AU)


Cryptococcosis is a non-contagious systemic mycosis that primarily affects felines. Its etiological agent is a yeast of the genus Cryptococcus sp., and its transmission occurs through the air, by inhalation of spores that primarily lodge in the nasal cavity and lungs. The nasal form is the most common in felines and clinical manifestations include nasofacial edema, erythema and nasal discharge. Diagnosis can be made by means of mycological culture, cytology, histology and polymerase chain reaction. This article presents a case of a feline diagnosed with cryptococcosis, in which the screening diagnosis was performed by means of rhinoscopy. In the initial care, the animal presented hyporexia, constant swallowing reflex, choking, accentuated odor in the nasal region and pulmonary crackles with evolution of three months. The diagnosis was made using rhinoscopy, which identified an internal mass in the nasopharyngeal mucosa, and subsequent biopsy and anatomopathological examination. After diagnostic confirmation, the patient was medicated with itraconazole 10 mg/kg SID for 5 months and had resolution of all clinical signs presented. Cryptococcosis should be considered as a differential diagnosis of alterations in the respiratory system in cats and rhinoscopy can be an important diagnostic tool to assist in the conclusion and recognition of this disease.(AU)


Assuntos
Animais , Gatos/microbiologia , Criptococose/diagnóstico por imagem , Cryptococcus
3.
Pesqui. vet. bras ; 43: e07169, 2023. tab, graf
Artigo em Inglês | LILACS-Express | VETINDEX | ID: biblio-1422297

Resumo

ABSTRACT: In this retrospective study, the clinical and anatomopathological findings of fungal diseases in dogs and cats in Northeastern Brazil are described. During the study period, 6,827 histopathological examinations (4,090 necropsies and 2,737 biopsies) of companion animals were reviewed, and fungal infections were diagnosed in 54 cases. Of these, 32 cases were diagnosed in cats and 22 in dogs. Sporotrichosis was the most prevalent mycosis (19/54), followed by dermatophytosis (9/54), cryptococcosis (8/54), candidiasis (7/54), and phaeohyphomycosis (4/54). Other diseases had two cases each, including aspergillosis, mucormycosis, and histoplasmosis, whereas coccidioidomycosis occurred once. Mycoses were diagnosed through microscopic lesions associated with the histomorphological characteristics of the agent, as evidenced by routine and special histochemical stains. They were occasionally confirmed by immunohistochemistry and microbiological cultivation. This retrospective study showed that despite being uncommon, fungal diseases are important causes of death in dogs and cats in the region, with cats being the most affected species and sporotrichosis being the most prevalent mycosis. Clinical signs were correlated with the portal of entry of the infection associated with localized or disseminated superficial and deep skin lesions or affecting parenchymal organs, especially in systemic infections. Microscopic lesions were mainly characterized by pyogranulomatous inflammation associated with fungal structures. In dogs, mycoses occurred mainly owing to an immunological impairment secondary to canine distemper virus co-infection.


RESUMO: Neste estudo retrospectivo, são descritos os achados clínicos e anatomopatológicos das doenças fúngicas em cães e gatos no Nordeste do Brasil. Durante o período de estudo, foram revisados 6.827 exames histopatológicos (4.090 necropsias e 2.737 biópsias) de animais de companhia e diagnosticados 54 casos de infecções fúngicas. Destes, 32 casos foram diagnosticados em gatos e 22 em cães. A esporotricose foi a micose mais prevalente (19/54), seguida pela dermatofitose (9/54), criptococose (8/54), candidíase (7/54) e feo-hifomicose (4/54). Outras doenças tiveram dois casos cada, incluindo aspergilose, mucormicose e histoplasmose, enquanto a coccidioidomicose ocorreu uma vez. As micoses foram diagnosticadas por meio das lesões microscópicas associadas às características histomorfológicas do agente, evidenciadas pelas colorações de rotina e histoquímicas especiais, e ocasionalmente confirmadas pela imuno-histoquímica e cultivo microbiológico. Esse estudo retrospectivo demonstrou que apesar de incomuns, as doenças fúngicas são importantes causas de morte em cães e gatos da região, sendo os gatos a espécie mais afetada e a esporotricose, a micose mais prevalente. Os sinais clínicos estavam correlacionados com a porta de entrada da infecção, associados a lesões cutâneas localizadas ou disseminadas superficiais e profundas ou afetando órgãos parenquimatosos, especialmente em infecções sistêmicas. As lesões microscópicas eram caracterizadas principalmente por inflamação piogranulomatosa associada a estruturas fúngicas. Nos cães, as micoses ocorreram principalmente devido ao comprometimento imunológico secundária a coinfecção pelo vírus da cinomose canina.

4.
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.561-4 jan. 2020. ilus
Artigo em Português | VETINDEX | ID: biblio-1458388

Resumo

Background: Cryptococcosis is a potentially fatal systemic mycosis that can affect several animal species. The disease is caused by the yeast species Cryptococcus neoformans and C. gattii and is usually associated with immunosuppressive diseases or debilitating factors. In Brazil, cryptococcosis in ruminants has been described in several states, but there have been only two instances of infection in sheep. Until the present, cryptococcosis caused by C. gattii has only been reported in goats. The objective of this study was to describe, for the first time, a case of nasal cryptococcosis caused by C. gattii in a sheep in the state of Bahia. Case: The disease affected a 4-year-old Santa Inês sheep, created in extensive system in the municipality of Ribeira do Pombal, Bahia, Brazil. The animal presented weight loss, with an asymmetric increase of volume in the right nasal cavity, accompanied by dyspnea and bloody nasal discharge. Samples of the tumor mass were collected for cytological analysis of yeast structures compatible with Cryptococcus spp. After cytological diagnosis, the sheep was sent to the Livestock Development Center of the Federal University of Bahia. On physical examination, there was a large and firm irregular mass, strongly adhering to the right nasal cavity and causing facial asymmetry. Surgical removal was attempted, but a marked infiltrative character of the lesion was observed, with extensive tissue destruction. Owing to the unfavorable prognosis, euthanasia was carried out followed by necropsy, in which a large irregular mass was observed that almost completely obliterated the right nasal cavity. Resorption of the right nasal bone and the dorsal and middle nasal turbinates was also observed. Fragments of the nasal lesion were collected, fixed in 10% formalin, routinely processed for histopathology, and stained with hematoxylin and eosin (HE) and Mayer’s...


Assuntos
Animais , Criptococose/diagnóstico , Criptococose/veterinária , Cryptococcus gattii/isolamento & purificação , Ovinos/microbiologia , Reação em Cadeia da Polimerase/veterinária , Rinite/veterinária
5.
Acta sci. vet. (Online) ; 48(suppl.1): Pub. 561, 21 nov. 2020. ilus
Artigo em Português | VETINDEX | ID: vti-765645

Resumo

Background: Cryptococcosis is a potentially fatal systemic mycosis that can affect several animal species. The disease is caused by the yeast species Cryptococcus neoformans and C. gattii and is usually associated with immunosuppressive diseases or debilitating factors. In Brazil, cryptococcosis in ruminants has been described in several states, but there have been only two instances of infection in sheep. Until the present, cryptococcosis caused by C. gattii has only been reported in goats. The objective of this study was to describe, for the first time, a case of nasal cryptococcosis caused by C. gattii in a sheep in the state of Bahia. Case: The disease affected a 4-year-old Santa Inês sheep, created in extensive system in the municipality of Ribeira do Pombal, Bahia, Brazil. The animal presented weight loss, with an asymmetric increase of volume in the right nasal cavity, accompanied by dyspnea and bloody nasal discharge. Samples of the tumor mass were collected for cytological analysis of yeast structures compatible with Cryptococcus spp. After cytological diagnosis, the sheep was sent to the Livestock Development Center of the Federal University of Bahia. On physical examination, there was a large and firm irregular mass, strongly adhering to the right nasal cavity and causing facial asymmetry. Surgical removal was attempted, but a marked infiltrative character of the lesion was observed, with extensive tissue destruction. Owing to the unfavorable prognosis, euthanasia was carried out followed by necropsy, in which a large irregular mass was observed that almost completely obliterated the right nasal cavity. Resorption of the right nasal bone and the dorsal and middle nasal turbinates was also observed. Fragments of the nasal lesion were collected, fixed in 10% formalin, routinely processed for histopathology, and stained with hematoxylin and eosin (HE) and Mayers...(AU)


Assuntos
Animais , Criptococose/diagnóstico , Criptococose/veterinária , Ovinos/microbiologia , Cryptococcus gattii/isolamento & purificação , Reação em Cadeia da Polimerase/veterinária , Rinite/veterinária
6.
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.537-4 jan. 2020. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1458364

Resumo

Background: Cryptococcosis is a serious fungal infection contracted by humans and animals, and the most common systemic mycosis found in cats. This disease is often contracted through inhalation of fungal propagules. The Central Nervous System (CNS) may be infected through local extension (nasal and frontal sinuses) or via hematogenous route. Similarly to CNS bacterial infection, the clinical signs of neurological dysfunction may be attributed to mass effect (gelatinous mass of fungal microorganisms and fungal granuloma formation) or to a more disseminated inflammatory response to invading microorganisms. The objective of this study is to report one case of a patient with cryptococcal granulomas in the central nervous system and one case of a patient with neurological signs associated to a cryptococcosis. Cases: Case 1. A 3-year-old male mixed breed feline was admitted to a veterinary clinic, located in Porto Alegre, RS, Southern Brazil. The patient presented unsourced behavioral changes, vestibular ataxia and dysphagia caused by inability of coordination. The following tests were performed: complete blood count test, biochemical analysis, computed tomography scan (CT scan), fluid analysis, radiography and toxoplasmosis test. The following medicine were administrated for treatment: fluconazole, dexamethasone, mannitol, phenobarbital and levetiracetam. Fluid therapy was also part of the treatment. Immediately after death, the cat was submitted for necropsy, and a fungal granulomatous meningoencephalomyelitis was diagnosed. Cryptococcus sp. was identified as the causal agent through pathological findings, fungal culture and PCR analysis. Case 2. One year later, another feline was admitted to the same clinic (a 2-year-old female mixed breed) presenting hypersalivation, tremors and excessive vocalization. The patient had contact with the deceased feline. The following tests were performed: complete blood count...


Assuntos
Animais , Gatos , Criptococose/terapia , Criptococose/veterinária , Cryptococcus/isolamento & purificação , Sistema Nervoso Central/microbiologia , Glucocorticoides/uso terapêutico , Prednisolona/uso terapêutico
7.
Acta sci. vet. (Online) ; 48(suppl.1): Pub. 537, Oct. 10, 2020. ilus
Artigo em Inglês | VETINDEX | ID: vti-765363

Resumo

Background: Cryptococcosis is a serious fungal infection contracted by humans and animals, and the most common systemic mycosis found in cats. This disease is often contracted through inhalation of fungal propagules. The Central Nervous System (CNS) may be infected through local extension (nasal and frontal sinuses) or via hematogenous route. Similarly to CNS bacterial infection, the clinical signs of neurological dysfunction may be attributed to mass effect (gelatinous mass of fungal microorganisms and fungal granuloma formation) or to a more disseminated inflammatory response to invading microorganisms. The objective of this study is to report one case of a patient with cryptococcal granulomas in the central nervous system and one case of a patient with neurological signs associated to a cryptococcosis. Cases: Case 1. A 3-year-old male mixed breed feline was admitted to a veterinary clinic, located in Porto Alegre, RS, Southern Brazil. The patient presented unsourced behavioral changes, vestibular ataxia and dysphagia caused by inability of coordination. The following tests were performed: complete blood count test, biochemical analysis, computed tomography scan (CT scan), fluid analysis, radiography and toxoplasmosis test. The following medicine were administrated for treatment: fluconazole, dexamethasone, mannitol, phenobarbital and levetiracetam. Fluid therapy was also part of the treatment. Immediately after death, the cat was submitted for necropsy, and a fungal granulomatous meningoencephalomyelitis was diagnosed. Cryptococcus sp. was identified as the causal agent through pathological findings, fungal culture and PCR analysis. Case 2. One year later, another feline was admitted to the same clinic (a 2-year-old female mixed breed) presenting hypersalivation, tremors and excessive vocalization. The patient had contact with the deceased feline. The following tests were performed: complete blood count...(AU)


Assuntos
Animais , Gatos , Criptococose/terapia , Criptococose/veterinária , Cryptococcus/isolamento & purificação , Sistema Nervoso Central/microbiologia , Glucocorticoides/uso terapêutico , Prednisolona/uso terapêutico
8.
Acta sci. vet. (Impr.) ; 47(suppl.1): Pub.427-2019. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1458191

Resumo

Background: Cryptococcosis is a mycosis that primarily affects domestic cats and is caused by fungi of the genus Cryptococcus, resulting in cutaneous, ocular, respiratory, and neurological manifestations. Diagnosis is based on the microscopicevaluation of the lesions and isolation of the causative agent. The aim of this study was to describe a case of feline cryptococcosis diagnosed by cytology and treated at the Veterinary Hospital of the State University of Santa Cruz (HV-UESC).Case: A 5-year-old uncastrated male cat was taken to the HV-UESC small animal clinic, owing to a gradual increase inthe volume of the nasal plane spanning over a year, accompanied by respiratory distress. Upon physical examination, theanimal was found to have regular nutritional status, dehydration, hypocorous mucosae, and enlarged popliteal lymph nodes.In addition, multifocal areas of ulceration on the body as well as increased volume in the nasal plane (clown nose) wereobserved. Peripheral blood samples were collected for complete blood count and biochemical analysis. Due to clinicalsuspicion of fungal lesions, fine needle aspiration of the nasal lesion was performed and cytological slides were sent tothe HV-UESC histopathology laboratory. Probable diagnoses included rhinosporidiosis, cryptococcosis, and histoplasmosis. The animal was subjected to thoracic radiography in the imaging division of the HV-UESC. Blood counts revealedthrombocytopenia (130,000/mm3) and biochemical tests presented hypoproteinemia (3.2 g/dL), with hypoalbuminemia(1.52 g/dL); however, chest radiography did not show pulmonary alterations. Results of cytological analysis indicatedpyogranulomatous inflammation associated with intracellular organisms, demonstrating a pathogen morphology similarto that of Cryptococcus spp. Before the diagnosis, itraconazole1 5 mg/kg (1 capsule, twice a day for 30 days) and fipronil2(1 ampoule 0.5 mL, on the back) were prescribed...


Assuntos
Animais , Gatos , Criptococose/diagnóstico , Criptococose/patologia , Criptococose/veterinária , Biópsia por Agulha Fina/veterinária
9.
Acta sci. vet. (Online) ; 47(suppl.1): Pub. 427, Oct. 9, 2019. ilus
Artigo em Inglês | VETINDEX | ID: vti-25730

Resumo

Background: Cryptococcosis is a mycosis that primarily affects domestic cats and is caused by fungi of the genus Cryptococcus, resulting in cutaneous, ocular, respiratory, and neurological manifestations. Diagnosis is based on the microscopicevaluation of the lesions and isolation of the causative agent. The aim of this study was to describe a case of feline cryptococcosis diagnosed by cytology and treated at the Veterinary Hospital of the State University of Santa Cruz (HV-UESC).Case: A 5-year-old uncastrated male cat was taken to the HV-UESC small animal clinic, owing to a gradual increase inthe volume of the nasal plane spanning over a year, accompanied by respiratory distress. Upon physical examination, theanimal was found to have regular nutritional status, dehydration, hypocorous mucosae, and enlarged popliteal lymph nodes.In addition, multifocal areas of ulceration on the body as well as increased volume in the nasal plane (clown nose) wereobserved. Peripheral blood samples were collected for complete blood count and biochemical analysis. Due to clinicalsuspicion of fungal lesions, fine needle aspiration of the nasal lesion was performed and cytological slides were sent tothe HV-UESC histopathology laboratory. Probable diagnoses included rhinosporidiosis, cryptococcosis, and histoplasmosis. The animal was subjected to thoracic radiography in the imaging division of the HV-UESC. Blood counts revealedthrombocytopenia (130,000/mm3) and biochemical tests presented hypoproteinemia (3.2 g/dL), with hypoalbuminemia(1.52 g/dL); however, chest radiography did not show pulmonary alterations. Results of cytological analysis indicatedpyogranulomatous inflammation associated with intracellular organisms, demonstrating a pathogen morphology similarto that of Cryptococcus spp. Before the diagnosis, itraconazole1 5 mg/kg (1 capsule, twice a day for 30 days) and fipronil2(1 ampoule 0.5 mL, on the back) were prescribed...(AU)


Assuntos
Animais , Gatos , Criptococose/diagnóstico , Criptococose/patologia , Criptococose/veterinária , Biópsia por Agulha Fina/veterinária
10.
R. cient. eletr. Med. Vet. ; 30jan. 2018. ilus
Artigo em Português | VETINDEX | ID: vti-738099

Resumo

A criptococose é uma doença infecciosa fúngica causada por uma levedura, da espécie Cryptococcus neoformans. Acomete diferentes espécies de animais e também o homem. O presente trabalho tem como por objetivo relatar um caso de criptococose em uma gata atendida na Clínica Veterinária da UNIFAI, com sinais clínicos de dispneia, espirros, secreção nasal bilateral, deformidade nasal com aumento de volume no plano nasal e úlceras no focinho. Foi realizado exame citológico onde foi observado processo inflamatório com presença de macrófagos e neutrófilos, além de estruturas leveduriformes com paredes espessas de formato redondo a oval caracterizando-se como cryptococcus neofarmans. No exame radiográfico foi observado aumento de volume em região de focinho sem alteração de radiopacidade indicando possível granuloma. Através da anamnese, exame físico, exame citológico, foi diagnosticado Criptococose. O tratamento indicado foi administração via oral de Itraconazol 50mg a cada 24 horas durante 60 dias.(AU)


Cryptococcosis is a fungal infectious disease caused by a yeast of the species Cryptococcus neoformans. It is the most common systemic mycosis in cats. The present study has the objective to report a case of cryptococcosis in a cat treated at the Veterinary Clinic of UNIFAI, with clinical signs of dyspnea, sneezing, secretion in the nostrils, nasal deformity with increased, volume and ulcers on the muzzle. Was performed the cytology examination where an inflammatory process was observed with presence of macrophages and neutrophils, as well as leveduriform structures with thick walls of round to oval shape, characterized as cryptococcus neofarmans. In the radiographic examination, a volume increase was observed in the region of muzzle without alteration of radiopacity indicating possible granuloma. Through the anamnesis, physical examination, cytological examination, Cryptococcosis was diagnosed. The indicated treatment was oral administration of Itraconazole 50mg every 24 hours for 60 days.


Assuntos
Animais , Gatos , Criptococose/diagnóstico , Criptococose/tratamento farmacológico , Criptococose/veterinária , Cryptococcus neoformans , Micoses/veterinária
11.
Artigo em Português | VETINDEX | ID: biblio-1494280

Resumo

A criptococose é uma doença infecciosa fúngica causada por uma levedura, da espécie Cryptococcus neoformans. Acomete diferentes espécies de animais e também o homem. O presente trabalho tem como por objetivo relatar um caso de criptococose em uma gata atendida na Clínica Veterinária da UNIFAI, com sinais clínicos de dispneia, espirros, secreção nasal bilateral, deformidade nasal com aumento de volume no plano nasal e úlceras no focinho. Foi realizado exame citológico onde foi observado processo inflamatório com presença de macrófagos e neutrófilos, além de estruturas leveduriformes com paredes espessas de formato redondo a oval caracterizando-se como cryptococcus neofarmans. No exame radiográfico foi observado aumento de volume em região de focinho sem alteração de radiopacidade indicando possível granuloma. Através da anamnese, exame físico, exame citológico, foi diagnosticado Criptococose. O tratamento indicado foi administração via oral de Itraconazol 50mg a cada 24 horas durante 60 dias.


Cryptococcosis is a fungal infectious disease caused by a yeast of the species Cryptococcus neoformans. It is the most common systemic mycosis in cats. The present study has the objective to report a case of cryptococcosis in a cat treated at the Veterinary Clinic of UNIFAI, with clinical signs of dyspnea, sneezing, secretion in the nostrils, nasal deformity with increased, volume and ulcers on the muzzle. Was performed the cytology examination where an inflammatory process was observed with presence of macrophages and neutrophils, as well as leveduriform structures with thick walls of round to oval shape, characterized as cryptococcus neofarmans. In the radiographic examination, a volume increase was observed in the region of muzzle without alteration of radiopacity indicating possible granuloma. Through the anamnesis, physical examination, cytological examination, Cryptococcosis was diagnosed. The indicated treatment was oral administration of Itraconazole 50mg every 24 hours for 60 days.


Assuntos
Animais , Gatos , Criptococose/diagnóstico , Criptococose/tratamento farmacológico , Criptococose/veterinária , Cryptococcus neoformans , Micoses/veterinária
12.
Artigo em Português | VETINDEX | ID: biblio-1488998

Resumo

A criptococose é uma micose de natureza sistêmica oportunista, considerada uma zoonose causada pelo complexo Cryptococcus neoformans que compreende dois agentes etiológicos, o C. neoformans e o C. gattii, capazes de acometer aves, homens, animais domésticos e silvestres. A infecção ocorre por inalação dos esporos do agente que é frequentemente isolado em excretas de pombos (Columba livia), considerados os reservatórios naturais do fungo. As alterações são encontradas em diversos sistemas do organismo. A criptococose é uma das micoses de mais fácil diagnóstico por apresentar marcado tropismo neurológico, abundância de elementos fúngicos no líquor e nas lesões. Para o tratamento em animais e humanos, as drogas selecionadas são diferenciadas para que não haja a seleção de estirpes resistentes.


Cryptococcosis is an opportunist systemic mycosis considered as zoonosis caused by the complex Cryptococcus neoformans that comprises two etiologic agents, C. neoformans and C. gattii. Both of them can attack birds, humans, domestic animals and wild ones. The infection is produced by spores inhalation. These spores are often isolated from pigeon (Columba livia) faeces. These birds are considered as the natural fungus reservoir. The lesions of this disease can be found in several organ systems and it is one of the mycosis with prompt diagnosis because the infectious agent presents a marked neurological tropism, plenty of fungy elements in the CSF and in the lesions. The treatment of animals and humans must be performed with selected different drugs to prevent the selection of resistant strains.


Assuntos
Animais , Aves/anormalidades , Criptococose/classificação , Criptococose/história , Criptococose/veterinária , Medicina Veterinária/tendências
13.
R. Educ. contin. Med. Vet. Zoot. ; 15(1): 24-29, 2017. ilus
Artigo em Português | VETINDEX | ID: vti-722667

Resumo

A criptococose é uma micose de natureza sistêmica oportunista, considerada uma zoonose causada pelo complexo Cryptococcus neoformans que compreende dois agentes etiológicos, o C. neoformans e o C. gattii, capazes de acometer aves, homens, animais domésticos e silvestres. A infecção ocorre por inalação dos esporos do agente que é frequentemente isolado em excretas de pombos (Columba livia), considerados os reservatórios naturais do fungo. As alterações são encontradas em diversos sistemas do organismo. A criptococose é uma das micoses de mais fácil diagnóstico por apresentar marcado tropismo neurológico, abundância de elementos fúngicos no líquor e nas lesões. Para o tratamento em animais e humanos, as drogas selecionadas são diferenciadas para que não haja a seleção de estirpes resistentes.(AU)


Cryptococcosis is an opportunist systemic mycosis considered as zoonosis caused by the complex Cryptococcus neoformans that comprises two etiologic agents, C. neoformans and C. gattii. Both of them can attack birds, humans, domestic animals and wild ones. The infection is produced by spores inhalation. These spores are often isolated from pigeon (Columba livia) faeces. These birds are considered as the natural fungus reservoir. The lesions of this disease can be found in several organ systems and it is one of the mycosis with prompt diagnosis because the infectious agent presents a marked neurological tropism, plenty of fungy elements in the CSF and in the lesions. The treatment of animals and humans must be performed with selected different drugs to prevent the selection of resistant strains.(AU)


Assuntos
Animais , Aves/anormalidades , Criptococose/classificação , Criptococose/história , Criptococose/veterinária , Medicina Veterinária/tendências
14.
R. bras. Ci. Vet. ; 24(3): 128-131, jul.-set. 2017. ilus
Artigo em Português | VETINDEX | ID: vti-16942

Resumo

A criptococose é uma micose sistêmica que em cães frequentemente está envolvida com lesões nos sistemas respiratório e nervoso central. O acometimento do sistema gastrointestinal por este fungo é considerada rara. O objetivo deste estudo é relatar um caso de criptococose intestinal em um cão, macho, da raça Boxer, de quatro anos, com histórico de êmese e diarreia sanguinolenta há cinco dias. Ao exame físico foi constatado dor abdominal e estrutura firme em região mesogástrica. Após realização de exame ultrassonográfico sugestivo de intussuscepção, realizou-se a celiotomia exploratória, e foi visualizada uma lesão nodular de 5 cm na parede do jejuno, retirada por enterectomia. O fragmento intestinal contendo a lesão foi encaminhado para análise histopatológica. Na macroscopia, a massa apresentava aspecto gelatinoso aos cortes, com superfície de corte compacta e tonalidade creme. No exame histopatológico, observou-se acentuada quantidade de estruturas leveduriformes, redondas ou ovoides, circundada por espessa cápsula, e discreto e difuso processo inflamatório mononuclear. A coloração pelo ácido periódico de Schiff (PAS) ajudou a confirmar a infecção pelo fungo do gênero Cryptococcus. Não foi possível dar continuidade ao caso, uma vez que o proprietário não retornou mais ao atendimento. Sugere-se que a porta de entrada da criptococose neste estudo, tenha sido através da ingestão da levedura desidratada, ou pela entrada do agente na extensa ulceração em jejuno, já que o mesmo pode ser encontrado em intestino delgado de cães saudáveis e de cães com enteropatia crônica. Conclui-se que, apesar da criptococose intestinal em cães ser considerada rara, recomenda-se a inclusão nos diagnósticos diferenciais de lesões que acometem os segmentos intestinais sem o envolvimento clínico de demais sistemas.(AU)


Cryptococcosis is a systemic mycosis and is often associated with lesions in the respiratory and central nervous systems in dogs. However, the involvement of the gastrointestinal system in this fungal infection is rare. This study reports a case of intestinal cryptococcosis in a 4-year-old male Boxer dog with a history of emesis and bloody diarrhea for five days. His physical examination revealed abdominal pain and a firm structure in the mesogastric region. After an ultrasound examination suggested intussusception, exploratory celiotomy was performed, and a 5 cm mass was visualized on the wall of the jejunum, which was subsequently removed by an enterectomy and sent for histopathological analysis. Macroscopically, the mass presented a gelatinous aspect, with a compact cut surface and cream shade. On histopathological examination, multiple leveduriform structures, round or ovoid, surrounded by a thick capsule, and discrete, diffuse mononuclear inflammatory processes were observed. Schiffs periodic acid staining confirmed the infection with a fungus of the genus Cryptococcus. It was not possible to continue the investigation because the owner did not return to the service. It is suggested that the entry point of cryptococcosis was through the ingestion of dehydrated yeast or through extensive jejunal ulceration, as it can be found in the small intestine of both healthy dogs and those with chronic enteropathy. Therefore, although intestinal cryptococcosis in dogs is rare, it is recommended to include it as a differential diagnosis for gastrointestinal lesions without the clinical involvement of other systems.(AU)


Assuntos
Animais , Masculino , Adulto Jovem , Cães , Criptococose/diagnóstico por imagem , Criptococose/veterinária , Intestinos/patologia , Diagnóstico Diferencial
15.
Braz. j. vet. pathol ; 9(3): 98-102, nov. 2016. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1469963

Resumo

A case of granulomatous leptomeningitis caused by Cryptococcus neoformans is described in a 2-year-old mixed-breed, female goat which presented acute neurological signs including ataxia, nystagmus, bilateral blindness, opisthotonus, hyperesthesia, and spastic paresis of forelimbs. Granulomatous inflammation was detected in the pia arachnoid covering the frontal, parietal and occipital lobes of the telencephalon; cerebellum, thalamus, mesencephalon, pons, medulla, and cervical and thoracolumbar segments of the spinal cord. Yeast-like organisms with morphology compatible with Cryptococcus spp. were observed. A 350 base pair sequence was amplified from DNA extracted from the formalin fixed paraffin embedded (FFPE) tissue. The amplified sequence matched 100% Cryptococcus neoformans. It is suggested that cryptococcal meningitis should be included in the differential diagnosis list of goat diseases with neurological signs such as ataxia, opisthotonus, nystagmus, hyperesthesia and spastic paresis.


Assuntos
Feminino , Animais , Cabras , Cryptococcus neoformans , Meningite Criptocócica/veterinária , Doenças das Cabras , Doenças do Sistema Nervoso Central/veterinária
16.
Braz. J. Vet. Pathol. ; 9(3): 98-102, nov. 2016. ilus
Artigo em Inglês | VETINDEX | ID: vti-968

Resumo

A case of granulomatous leptomeningitis caused by Cryptococcus neoformans is described in a 2-year-old mixed-breed, female goat which presented acute neurological signs including ataxia, nystagmus, bilateral blindness, opisthotonus, hyperesthesia, and spastic paresis of forelimbs. Granulomatous inflammation was detected in the pia arachnoid covering the frontal, parietal and occipital lobes of the telencephalon; cerebellum, thalamus, mesencephalon, pons, medulla, and cervical and thoracolumbar segments of the spinal cord. Yeast-like organisms with morphology compatible with Cryptococcus spp. were observed. A 350 base pair sequence was amplified from DNA extracted from the formalin fixed paraffin embedded (FFPE) tissue. The amplified sequence matched 100% Cryptococcus neoformans. It is suggested that cryptococcal meningitis should be included in the differential diagnosis list of goat diseases with neurological signs such as ataxia, opisthotonus, nystagmus, hyperesthesia and spastic paresis.(AU)


Assuntos
Animais , Feminino , Cabras , Cryptococcus neoformans , Meningite Criptocócica/veterinária , Doenças do Sistema Nervoso Central/veterinária , Doenças das Cabras
17.
Artigo em Português | LILACS-Express | VETINDEX | ID: biblio-1462358

Resumo

ABSTRACT Cryptococcosis is primarily a pulmonary mycosis, being acquired by inhalation of infective fungal propagules found in the environment. One of the main etiological agents of cryptococcosis is the yeast Cryptococcus neoformans , which has worldwide distribution and whose naturalhabitat is the feces of birds. The aim of this study was to investigate the occurrence of Cryptococcus spp. in excreta ofColumba livia (domestic pigeon) found in the outer area of the building of Hospital Universitário Dr. Miguel Riet Correa Junior, a reference center for the treatment of Acquired Immunodeficiency Syndrome in southern state of Rio Grande do Sul, Brazil. During a period of ten months, a total of 40 samples of dried excreta was collected from the site's academic area and hospital. To the excreta, were added saline solution with chloramphenicol, homogenized in a vortex, cultivated in Niger seed agar and incubated at 25°C with daily observations up to seven days. The identification of the microorganism was performed by phenotypical and biochemical tests. From the 40 samples processed and analyzed, 13 (32.5%) were positive for the isolation ofCryptococcus spp., with the quantity of yeasts ranging from 20.000 to 3.000.000 CFU/g of feces. Isolation of the opportunistic fungusCryptococcus spp. at a university hospital is relevant in public health for demonstrating the exposure of individuals who frequent this site to infectant propagules.


RESUMO A criptococose é uma micose primariamente pulmonar, sendo adquirida por meio de inalação de propágulos fúngicos infectantes encontrados no ambiente. Um dos principais agentes etiológicos da criptococose é a espécie Cryptococcus neoformans , que apresenta distribuição mundial. O objetivo desse trabalho foi pesquisar a ocorrência de Cryptococcus spp. em excretas de Columba livia (pombos domésticos) encontradas na área externa do prédio do Hospital Universitário Dr. Miguel Riet Correa Junior, centro de referência para o tratamento da Síndrome da Imunodeficiência Adquirida na região sul do estado do Rio Grande do Sul, Brasil. Durante um período de dez meses, foi coletado um total de 40 amostras de excretas secas da área acadêmica e da área hospitalar do Hospital Universitário. As excretas foram adicionadas de solução salina com cloranfenicol, homogeneizados em vórtex, semeados em ágar Níger e incubados a 25ºC com observações diárias até sete dias. A identificação do micro-organismo foi realizada por provas fenotípicas e bioquímicas. Das 40 amostras processadas e analisadas, 13 (32,5%) foram positivas para o isolamento de Cryptococcus spp., variando de 20.000 a 3.000.000 UFC/g de fezes. O isolamento desse fungo em um ambiente hospitalar é relevante em saúde pública, pois evidencia a exposição dos indivíduos que frequentam esse local a propágulos infectantes.

18.
Artigo em Português | VETINDEX | ID: vti-743030

Resumo

ABSTRACT Cryptococcosis is primarily a pulmonary mycosis, being acquired by inhalation of infective fungal propagules found in the environment. One of the main etiological agents of cryptococcosis is the yeast Cryptococcus neoformans , which has worldwide distribution and whose naturalhabitat is the feces of birds. The aim of this study was to investigate the occurrence of Cryptococcus spp. in excreta ofColumba livia (domestic pigeon) found in the outer area of the building of Hospital Universitário Dr. Miguel Riet Correa Junior, a reference center for the treatment of Acquired Immunodeficiency Syndrome in southern state of Rio Grande do Sul, Brazil. During a period of ten months, a total of 40 samples of dried excreta was collected from the site's academic area and hospital. To the excreta, were added saline solution with chloramphenicol, homogenized in a vortex, cultivated in Niger seed agar and incubated at 25°C with daily observations up to seven days. The identification of the microorganism was performed by phenotypical and biochemical tests. From the 40 samples processed and analyzed, 13 (32.5%) were positive for the isolation ofCryptococcus spp., with the quantity of yeasts ranging from 20.000 to 3.000.000 CFU/g of feces. Isolation of the opportunistic fungusCryptococcus spp. at a university hospital is relevant in public health for demonstrating the exposure of individuals who frequent this site to infectant propagules.


RESUMO A criptococose é uma micose primariamente pulmonar, sendo adquirida por meio de inalação de propágulos fúngicos infectantes encontrados no ambiente. Um dos principais agentes etiológicos da criptococose é a espécie Cryptococcus neoformans , que apresenta distribuição mundial. O objetivo desse trabalho foi pesquisar a ocorrência de Cryptococcus spp. em excretas de Columba livia (pombos domésticos) encontradas na área externa do prédio do Hospital Universitário Dr. Miguel Riet Correa Junior, centro de referência para o tratamento da Síndrome da Imunodeficiência Adquirida na região sul do estado do Rio Grande do Sul, Brasil. Durante um período de dez meses, foi coletado um total de 40 amostras de excretas secas da área acadêmica e da área hospitalar do Hospital Universitário. As excretas foram adicionadas de solução salina com cloranfenicol, homogeneizados em vórtex, semeados em ágar Níger e incubados a 25ºC com observações diárias até sete dias. A identificação do micro-organismo foi realizada por provas fenotípicas e bioquímicas. Das 40 amostras processadas e analisadas, 13 (32,5%) foram positivas para o isolamento de Cryptococcus spp., variando de 20.000 a 3.000.000 UFC/g de fezes. O isolamento desse fungo em um ambiente hospitalar é relevante em saúde pública, pois evidencia a exposição dos indivíduos que frequentam esse local a propágulos infectantes.

19.
Arq. Inst. Biol ; 82: 1-4, 2015.
Artigo em Português | LILACS, VETINDEX | ID: biblio-1026511

Resumo

A criptococose é uma micose primariamente pulmonar, sendo adquirida por meio de inalação de propágulos fúngicos infectantes encontrados no ambiente. Um dos principais agentes etiológicos da criptococose é a espécie Cryptococcus neoformans , que apresenta distribuição mundial. O objetivo desse trabalho foi pesquisar a ocorrência de Cryptococcus spp. em excretas de Columba livia (pombos domésticos) encontradas na área externa do prédio do Hospital Universitário Dr. Miguel Riet Correa Junior, centro de referência para o tratamento da Síndrome da Imunodeficiência Adquirida na região sul do estado do Rio Grande do Sul, Brasil. Durante um período de dez meses, foi coletado um total de 40 amostras de excretas secas da área acadêmica e da área hospitalar do Hospital Universitário. As excretas foram adicionadas de solução salina com cloranfenicol, homogeneizados em vórtex, semeados em ágar Níger e incubados a 25ºC com observações diárias até sete dias. A identificação do micro-organismo foi realizada por provas fenotípicas e bioquímicas. Das 40 amostras processadas e analisadas, 13 (32,5%) foram positivas para o isolamento de Cryptococcus spp., variando de 20.000 a 3.000.000 UFC/g de fezes. O isolamento desse fungo em um ambiente hospitalar é relevante em saúde pública, pois evidencia a exposição dos indivíduos que frequentam esse local a propágulos infectantes.(AU)


Cryptococcosis is primarily a pulmonary mycosis, being acquired by inhalation of infective fungal propagules found in the environment. One of the main etiological agents of cryptococcosis is the yeast Cryptococcus neoformans , which has worldwide distribution and whose natural habitat is the feces of birds. The aim of this study was to investigate the occurrence of Cryptococcus spp. in excreta of Columba livia (domestic pigeon) found in the outer area of the building of Hospital Universitário Dr. Miguel Riet Correa Junior, a reference center for the treatment of Acquired Immunodeficiency Syndrome in southern state of Rio Grande do Sul, Brazil. During a period of ten months, a total of 40 samples of dried excreta was collected from the site's academic area and hospital. To the excreta, were added saline solution with chloramphenicol, homogenized in a vortex, cultivated in Niger seed agar and incubated at 25°C with daily observations up to seven days. The identification of the microorganism was performed by phenotypical and biochemical tests. From the 40 samples processed and analyzed, 13 (32.5%) were positive for the isolation of Cryptococcus spp., with the quantity of yeasts ranging from 20.000 to 3.000.000 CFU/g of feces. Isolation of the opportunistic fungus Cryptococcus spp. at a university hospital is relevant in public health for demonstrating the exposure of individuals who frequent this site to infectant propagules.(AU)


Assuntos
Animais , Columbidae , Virulência , Saúde Pública , Criptococose , Cryptococcus , Brasil
20.
Arq. Inst. Biol ; 82: 01-04, 2015.
Artigo em Português | VETINDEX | ID: biblio-1462273

Resumo

Cryptococcosis is primarily a pulmonary mycosis, being acquired by inhalation of infective fungal propagules found in the environment. One of the main etiological agents of cryptococcosis is the yeast Cryptococcus neoformans, which has worldwide distribution and whose natural habitat is the feces of birds. The aim of this study was to investigate the occurrence of Cryptococcus spp. in excreta of Columba livia (domestic pigeon) found in the outer area of the building of Hospital Universitário Dr. Miguel Riet Correa Junior, a reference center for the treatment of Acquired Immunodeficiency Syndrome in southern state of Rio Grande do Sul, Brazil. During a period of ten months, a total of 40 samples of dried excreta was collected from the sites academic area and hospital. To the excreta, were added saline solution with chloramphenicol, homogenized in a vortex, cultivated in Niger seed agar and incubated at 25C with daily observations up to seven days. The identification of the microorganism was performed by phenotypical and biochemical tests. From the 40 samples processed and analyzed, 13 (32.5%) were positive for the isolation of Cryptococcus spp., with the quantity of yeasts ranging from 20.000 to 3.000.000 CFU/g of feces. Isolation of the opportunistic fungus Cryptococcus spp. at a university hospital is relevant in public health for demonstrating the exposure of individuals who frequent this site to infectant propagules.


A criptococose é uma micose primariamente pulmonar, sendo adquirida por meio de inalação de propágulos fúngicos infectantes encontrados no ambiente. Um dos principais agentes etiológicos da criptococose é a espécie Cryptococcus neoformans, que apresenta distribuição mundial. O objetivo desse trabalho foi pesquisar a ocorrência de Cryptococcus spp. em excretas de Columba livia (pombos domésticos) encontradas na área externa do prédio do Hospital Universitário Dr. Miguel Riet Correa Junior, centro de referência para o tratamento da Síndrome da Imunodeficiência Adquirida na região sul do estado do Rio Grande do Sul, Brasil. Durante um período de dez meses, foi coletado um total de 40 amostras de excretas secas da área acadêmica e da área hospitalar do Hospital Universitário. As excretas foram adicionadas de solução salina com cloranfenicol, homogeneizados em vórtex, semeados em ágar Níger e incubados a 25ºC com observações diárias até sete dias. A identificação do micro-organismo foi realizada por provas fenotípicas e bioquímicas. Das 40 amostras processadas e analisadas, 13 (32,5%) foram positivas para o isolamento de Cryptococcus spp., variando de 20.000 a 3.000.000 UFC/g de fezes. O isolamento desse fungo em um ambiente hospitalar é relevante em saúde pública, pois evidencia a exposição dos indivíduos que frequentam esse local a propágulos infectantes.


Assuntos
Animais , Columbidae , Criptococose , Cryptococcus , Saúde Pública , Virulência , Brasil
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