Mixossarcoma esplênico em cão / Splenic myxosarcoma in a dog

Background: Myxosarcomas (MXS) are malignant mesenchymal neoplasms originated from mainly mucin producing fibroblasts than collagen. Despite malignant neoplasms, MXS is believed to have low metastase generation ability. Myxosarcomas reports in dogs are widespread, usually involving trunk and limbs subcutaneous tissue. The aim of this report is to describe clinical, pathological, and immunohistochemistry aspects of a rare case of splenic myxosarcoma in a dog.Case: A 10-year-old, intact male Basset Hound, weiging 25 kg, showing signals such apathy, dark soft-stooled stools, progressive thinning, and increasing abdominal enlargement, perceived three months ago was brought to clinical consultation. Physical examination showed extremely pale oral and ocular mucosas, in addition to mild dehydration (6%), 35.4°C rectal temperature, and a very bulging abdomen, with no fluids or gases, evidence at abdominal percussion. A complete blood count (CBC) revealed neutrophilic leukocytosis and anemia. Patient´s abdominal cavity ultrasound examination showed an heterogeneous mass, occupying large part of cavity, and apparently from spleen origin. A spleenic multilobulated mass measuring 25 x 12 x 20 cm was obtained after exploratory laparotomy. The mass showed predominantly soft consistency with some firm areas, and no visible mesentery or other abdominal organs adhesions. Mass and spleen histopathological examination were routinely processed for histological analysis with haematoxylin and eosin and alcian blue staining. In addition, fragments of the neoplasm were submitted to immunohistochemistry (IHC) which confirmed myxosarcoma diagnosis. The owner returned to hospital two months after, complaining for apathy, prostration, anorexia, and abdominal pain. A new ultrasound examination were suggestive of liver and kidneys neoplasms. The tutor opted for patient´s euthanasia. However, dog´s necropsy was not authorized...

Mixossarcoma esplênico em cão / Splenic myxosarcoma in a dog

Background: Myxosarcomas (MXS) are malignant mesenchymal neoplasms originated from mainly mucin producing fibroblasts than collagen. Despite malignant neoplasms, MXS is believed to have low metastase generation ability. Myxosarcomas reports in dogs are widespread, usually involving trunk and limbs subcutaneous tissue. The aim of this report is to describe clinical, pathological, and immunohistochemistry aspects of a rare case of splenic myxosarcoma in a dog.Case: A 10-year-old, intact male Basset Hound, weiging 25 kg, showing signals such apathy, dark soft-stooled stools, progressive thinning, and increasing abdominal enlargement, perceived three months ago was brought to clinical consultation. Physical examination showed extremely pale oral and ocular mucosas, in addition to mild dehydration (6%), 35.4°C rectal temperature, and a very bulging abdomen, with no fluids or gases, evidence at abdominal percussion. A complete blood count (CBC) revealed neutrophilic leukocytosis and anemia. Patient´s abdominal cavity ultrasound examination showed an heterogeneous mass, occupying large part of cavity, and apparently from spleen origin. A spleenic multilobulated mass measuring 25 x 12 x 20 cm was obtained after exploratory laparotomy. The mass showed predominantly soft consistency with some firm areas, and no visible mesentery or other abdominal organs adhesions. Mass and spleen histopathological examination were routinely processed for histological analysis with haematoxylin and eosin and alcian blue staining. In addition, fragments of the neoplasm were submitted to immunohistochemistry (IHC) which confirmed myxosarcoma diagnosis. The owner returned to hospital two months after, complaining for apathy, prostration, anorexia, and abdominal pain. A new ultrasound examination were suggestive of liver and kidneys neoplasms. The tutor opted for patient´s euthanasia. However, dog´s necropsy was not authorized...(AU)

Aspectos citológicos das principais neoplasias mesenquimais tegumentares em cães (canis familiares)

O presente estudo avaliou os achados citológicos de 55 casos diagnosticados histologicamente como fibroma, hemangioma, fibrossarcoma (FSA), mixossarcoma (MXS), tumor de parede perivascular (TPP), tumor da bainha de nervo periférico (TBNP), lipossarcoma (LPS) e hemangiossarcoma (HSA) cutâneos e subcutâneos caninos, com o objetivo de estabelecer possíveis direcionamentos diagnósticos. A celularidade moderada ou intensa esteve presente em 16,6, 72,2 e 50,0% das amostras benignas, de sarcoma de tecidos moles (STS) e HSA, respectivamente. O predomínio de células fusiformes a ovaladas ou ovaladas foi observado em 50,0; 80,9 e 87,5% das amostras benignas, de STS e HSA, respectivamente. A associação destes dois achados em uma mesma amostra foi observada em 0,0 e 55,6% dos casos benignos e de FSA/MXS/HSA, respectivamente. Alguns achados foram observados exclusivamente em determinadas neoplasias, como a presença de células cabeças de inseto e células coroa, observadas apenas nos TPPs e TBNPs; citoplasma com vacúolos lipídicos, somente nos LPSs, e figuras angioformativas, observadas apenas nas neoplasias vasculares (hemangioma e HSA). As figuras de mitose, binucleação e multinucleação foram observadas somente nos casos malignos, enquanto a presença de vasos sanguineos foi observada em 5,5; 42,9 e 31,3% das amostras benignas, de STS e HSA, respectivamente; e a presença de nucléolos múltiplos foi observada em 5,5; 14,3 e 62,5% dos mesmos respectivos grupos. Entretanto a ausência de importantes critérios de malignidade foi observada em uma proporção significativa dos casos malignos

The present study evaluated the cytological findings of 55 cases diagnosed histologically as fibroma, hemangioma, fibrosarcoma (FSA), myxosarcoma (MXS), perivascular wall tumor (TPP), peripheral nerve sheath tumor (TBNP), liposarcoma (LPS) and hemangiosarcoma (HSA) cutaneous and subcutaneous in dogs, with the objective of establishing possible diagnostic directions. Moderate or intense cellularity was present in 16.6, 72.2 and 50.0% of benign soft tissue sarcoma (STS) and HSA samples, respectively. The predominance of predominantly fusiform to oval or oval cells was observed in 50.0; 80.9 and 87.5% of benign STS and HSA samples, respectively. The association of these two findings in the same sample was observed in 0.0 and 55.6% of benign and FSA / MXS / HSA cases, respectively. Some findings were observed exclusively in certain neoplasms, such as the presence of insect head cells and crown cells, observed only in TPPs and TBNPs; lipid cytoplasm, only in LPSs and angioformative figures, observed only in vascular neoplasms (hemangioma and HSA). Mitosis, binucleation and multinucleation figures were observed only in malignant cases, while the presence of blood vessels was observed in 5.5; 42.9 and 31.3% of the benign samples, of STS and HSA, respectively; and the presence of multiple nucleoli was observed in 5.5; 14.3 and 62.5% of the same respective groups. However, the absence of important malignancy criteria was observed in a significant proportion of malignant cases.

Dificuldades no diagnóstico do mixossarcoma de vesícula urinária em cão / Challenges in diagnosing of canine myxosarcoma bladder

Tumores envolvendo o sistema urinário representam aproximadamente 2,4% das neoplasias emcães. Estudos revelam que, embora as neoplasias possam afetar qualquer parte do sistema urinário, oenvolvimento da bexiga é incomum e a inespecificidade dos sinais pode comprometer a suspeita inicial e odiagnóstico precoce. Apesar dos avanços na ultrassonografia e na citologia, nas ultimas décadas, algumasimprecisões ainda ocorrem. Esse trabalho descreve o acompanhamento e as dificuldades no diagnóstico de ummixossarcoma vesical raro em um cão, fêmea, da raça Maltês, com 11 anos de idade apresentando hiporexia,vômito e dor abdominal. Houve limitação no diagnóstico utilizando-se a ultrassonografia, sendo o examehistopatológico fundamental para conclusão do caso

Tumors in urinary system represent approximately 2.4% of neoplasms in dogs. Searches showthat although the tumors can affect any part of the urinary system, the involvement of the urinary bladder isuncommon and non-specificity of clinical signs may compromise the initial clinical suspicion and early accuratediagnosis of canine bladder tumor. Despite ultrasonography and citology advances over the past decades,inaccuracies in the evaluation of the urinary bladder still remain. This paper describes the monitoring anddifficulties in diagnosis of myxosarcoma bladder rare in a eleven-month-old female Maltese dog who hadappetite loss, vomiting and abdominal pain. There were limitations in the diagnosis using ultrasound, and thehistopathological examination was fundamental for case completing

Dificuldades no diagnóstico do mixossarcoma de vesícula urinária em cão / Challenges in diagnosing of canine myxosarcoma bladder

Tumores envolvendo o sistema urinário representam aproximadamente 2,4% das neoplasias emcães. Estudos revelam que, embora as neoplasias possam afetar qualquer parte do sistema urinário, oenvolvimento da bexiga é incomum e a inespecificidade dos sinais pode comprometer a suspeita inicial e odiagnóstico precoce. Apesar dos avanços na ultrassonografia e na citologia, nas ultimas décadas, algumasimprecisões ainda ocorrem. Esse trabalho descreve o acompanhamento e as dificuldades no diagnóstico de ummixossarcoma vesical raro em um cão, fêmea, da raça Maltês, com 11 anos de idade apresentando hiporexia,vômito e dor abdominal. Houve limitação no diagnóstico utilizando-se a ultrassonografia, sendo o examehistopatológico fundamental para conclusão do caso(AU)

Tumors in urinary system represent approximately 2.4% of neoplasms in dogs. Searches showthat although the tumors can affect any part of the urinary system, the involvement of the urinary bladder isuncommon and non-specificity of clinical signs may compromise the initial clinical suspicion and early accuratediagnosis of canine bladder tumor. Despite ultrasonography and citology advances over the past decades,inaccuracies in the evaluation of the urinary bladder still remain. This paper describes the monitoring anddifficulties in diagnosis of myxosarcoma bladder rare in a eleven-month-old female Maltese dog who hadappetite loss, vomiting and abdominal pain. There were limitations in the diagnosis using ultrasound, and thehistopathological examination was fundamental for case completing(AU)

Cutaneous myxosarcoma in a Syrian hamster (Mesocricetus auratus) / Mixossarcoma cutâneo em um hamster Sírio

The pathological findings in a 2-years-old Syrian hamster (Mesocricetus auratus) with a cutaneous myxosarcoma are described. Grossly, there was a large cutaneous mass in the right cervical region. Microscopical evaluation revealed a myxosarcoma characterized by pleomorphic, fusiform cells loosely arranged, randomly distributed, and presenting a moderate amount of basophilic amorphous stroma. There were hemorrhagic areas within the tumor. The basophilic amorphous stroma was positive to Alcian blue confirming the presence of a mucopolysaccharide matrix. Immunohistochemically, the neoplastic cells expressed vimentin, and were negative for cytokeratin or glial fibrillary acidic protein (GFAP).

São descritos os achados anatomopatológicos de um caso de mixossarcoma cutâneo em um Hamster Sírio de 2 anos de idade. Macroscopicamente, foi evidenciada um grande massa cutânea na região cervical lateral direita. A microscopia revelou a presença de um mixossarcoma caracterizado por células fusiformes pleomórficas, frouxamente arranjadas, distribuídas aleatoriamente e, apresentando quantidade moderada de substância basofílica amorfa no estroma e áreas hemorrágicas. O estroma basofílico amorfo foi positivo na coloração Alcian blue, confirmando a presença de matriz mucopolissacarídea. Na imunoistoquímica, as células neoplásicas expressaram vimentina e foram negativas para a marcação de citoqueratina e proteína ácida fibrilar (GFAP).

Mixossarcoma em cavidade abdominal em Boxer. Relato de caso

O artigo não apresenta resumo.

Mixossarcoma em cavidade abdominal em Boxer. Relato de caso

O artigo não apresenta resumo.

Mixossarcoma em mesentério de cão

Myxosarcoma is an unusual neoplasm in the dog, most seen in the skin, and seldom in the heart and in the liver. The authors describe a case of a 5-years old mongrel dog showing abdominal distension, weakness, and decreased appetite. An exploratory celiotomy showed a massive non-encapsulated nodular tumour, adhered on the mesentery, measuring 30cm in diameter. Histopatology identified the tumour as a myxosarcoma. There is not previous record of mesenteric myxosarcoma.

Mixossarcoma cutâneo em um Hamster Sírio / Cutaneous myxosarcoma in a Syrian hamster (Mesocricetus auratus)

São descritos os achados anatomopatológicos de um caso de mixossarcoma cutâneo em um Hamster Sírio de 2 anos de idade. Macroscopicamente, foi evidenciada um grande massa cutânea na região cervical lateral direita. A microscopia revelou a presença de um caso de mixossarcoma caracterizado por células fusiformes pleomórficas, frouxamente arranjadas, distribuídas aleatoriamente e, apresentando quantidade moderada de substância basofílica amorfa no estroma e áreas hemorrágicas. O estroma basofílico amorfo foi positivo na coloração Alcian blue, confirmando a presença de matriz mucopolissacarídea. Na imunoistoquímica, as células neoplásicas expressaram vimentina e foram negativas para a marcação de citoqueratina e proteína ácida fibrilar (GFAP).

The pathological findings in a 2-years-old Syrian hamster (Mesocricetus auratus) with a cutaneous myxosarcoma are described. Grossly, there was a large cutaneous mass in the right cervical region. Microscopical evaluation revealed a myxosarcoma characterized by pleomorphic, fusiform cells loosely arranged, randomly distributed, and presenting a moderate amount of basophilic amorphous stroma. There were hemorrhagic areas within the tumor. The basophilic amorphous stroma was positive to Alcian blue confirming the presence of a mucopolysaccharide matrix. Immunohistochemically, the neoplastic cells expressed vimentin, and were negative for cytokeratin or glial fibrillary acidic protein (GFAP).

Mixossarcoma cutâneo em um Hamster Sírio / Cutaneous myxosarcoma in a Syrian hamster (Mesocricetus auratus)

São descritos os achados anatomopatológicos de um caso de mixossarcoma cutâneo em um Hamster Sírio de 2 anos de idade. Macroscopicamente, foi evidenciada um grande massa cutânea na região cervical lateral direita. A microscopia revelou a presença de um caso de mixossarcoma caracterizado por células fusiformes pleomórficas, frouxamente arranjadas, distribuídas aleatoriamente e, apresentando quantidade moderada de substância basofílica amorfa no estroma e áreas hemorrágicas. O estroma basofílico amorfo foi positivo na coloração Alcian blue, confirmando a presença de matriz mucopolissacarídea. Na imunoistoquímica, as células neoplásicas expressaram vimentina e foram negativas para a marcação de citoqueratina e proteína ácida fibrilar (GFAP).

The pathological findings in a 2-years-old Syrian hamster (Mesocricetus auratus) with a cutaneous myxosarcoma are described. Grossly, there was a large cutaneous mass in the right cervical region. Microscopical evaluation revealed a myxosarcoma characterized by pleomorphic, fusiform cells loosely arranged, randomly distributed, and presenting a moderate amount of basophilic amorphous stroma. There were hemorrhagic areas within the tumor. The basophilic amorphous stroma was positive to Alcian blue confirming the presence of a mucopolysaccharide matrix. Immunohistochemically, the neoplastic cells expressed vimentin, and were negative for cytokeratin or glial fibrillary acidic protein (GFAP).

Mixossarcoma cutâneo em um Hamster Sírio / Cutaneous myxosarcoma in a Syrian hamster (Mesocricetus auratus)

São descritos os achados anatomopatológicos de um caso de mixossarcoma cutâneo em um Hamster Sírio de 2 anos de idade. Macroscopicamente, foi evidenciada um grande massa cutânea na região cervical lateral direita. A microscopia revelou a presença de um caso de mixossarcoma caracterizado por células fusiformes pleomórficas, frouxamente arranjadas, distribuídas aleatoriamente e, apresentando quantidade moderada de substância basofílica amorfa no estroma e áreas hemorrágicas. O estroma basofílico amorfo foi positivo na coloração Alcian blue, confirmando a presença de matriz mucopolissacarídea. Na imunoistoquímica, as células neoplásicas expressaram vimentina e foram negativas para a marcação de citoqueratina e proteína ácida fibrilar (GFAP).

The pathological findings in a 2-years-old Syrian hamster (Mesocricetus auratus) with a cutaneous myxosarcoma are described. Grossly, there was a large cutaneous mass in the right cervical region. Microscopical evaluation revealed a myxosarcoma characterized by pleomorphic, fusiform cells loosely arranged, randomly distributed, and presenting a moderate amount of basophilic amorphous stroma. There were hemorrhagic areas within the tumor. The basophilic amorphous stroma was positive to Alcian blue confirming the presence of a mucopolysaccharide matrix. Immunohistochemically, the neoplastic cells expressed vimentin, and were negative for cytokeratin or glial fibrillary acidic protein (GFAP).