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1.
Acta sci. vet. (Impr.) ; 51: Pub. 1908, 2023. tab
Artigo em Português | VETINDEX | ID: biblio-1435008

Resumo

Background: The nonsteroidal anti-inflammatory drugs (NSAIDs) exert their analgesic effect through peripheral inhibition of prostaglandin synthesis and a variety of other peripheral and central mechanisms. However, NSAIDs are associated with some adverse effects, mainly related to the gastrointestinal, renal, and hepatic systems, highlighting the need for research to develop safer drugs. Therefore, the aim of this study was to evaluate the efficacy of preoperative oral administration of carprofen or grapiprant in female cats submitted to elective ovariohysterectomy on the quality of perioperative analgesia and the need for hypnotic and analgesic drugs. Materials, Methods & Results: Thirty-three adult female cats were selected, without defined breed and healthy based on physical examination, routine laboratory analyses (complete blood count, total protein, Heinz body investigation and serum quantification of alanine transaminase [ALT], aspartate transaminase [AST], gamma glutamyl transpeptidase [GGT], alkaline phosphatase [ALP], urea, frutosamine, and glucose) and negative tests for feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). After 3 days of adaptation, they were submitted to ovariohysterectomy by celiotomy and randomly allocated into 2 groups according to the preoperative drug used: GCAR [carprofen - 4 mg/kg, VO, 2 h before surgery; n = 11] and GGRA (grapiprant - 2 mg/kg IV, 2 h before surgery; n = 21]. The cats were pre-medicated with acepromazine 0.05 mg/ kg IV and later submitted to general anesthesia with propofol intravenously. Anesthesia was maintained with isoflurane in 100% oxygen. After anesthetic induction, a continuous infusion of remifentanil at a rate of 10 µg/kg/h was initiated. During the transanesthetic period, the parameters of heart rate; respiratory rate; systolic, mean, and diastolic arterial pressure using the oscillometric method; electrocardiogram; rectal temperature; partial pressure of CO2 at the end of expiration: and partial saturation of O2 in hemoglobin were continuously monitored. The evaluation of nociception was based on the changes in the aforementioned physiological parameters. The rate of remifentanil used did not change over time with the use of carprofen. However, animals that received grapiprant required a lower remifentanil dose at 20, 25, and 30 min during the procedure. The female cats that received carprofen showed an increase in mean heart rate at 30 min compared to that at 20 and 25 min. In the Grapiprant group, the heart rate at 35 min was higher only than that observed at 25 min. Discussion: The remifentanil rate did not differ between the groups, even between the times for GCAR. However, the remifentanil rate was lower from 20 min of the procedure for GGRA. This decrease may be related to a decrease in the need for anesthetics and analgesics by decreasing temperature, which causes decreases in metabolism and surgical stimulation. The increase in systolic, mean, diastolic, and heart rate arterial pressure parameters observed in both treatments after 15 min of anesthesia is related to the nociceptive stimulus resulting from traction and ligation of the ovarian pedicles and maneuvers for exteriorization of the uterus. These are considered the moments of greater surgical stimulus during ovariohysterectomy, evidenced by the greater release of cortisol and increase in physiological parameters. The results of this study show that the administration of carprofen or grapiprant was clinically similar when used preemptively for perioperative analgesia in cats submitted to elective ovariohysterectomy.


Assuntos
Animais , Feminino , Gatos , Ovariectomia/veterinária , Anti-Inflamatórios não Esteroides/administração & dosagem , Histerectomia/veterinária , Carbazóis/análise , Dinoprostona , Nociceptividade
2.
Braz. j. biol ; 83: 1-8, 2023. tab, graf, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1468849

Resumo

Although propolis has been reported for having anti-inflammatory activities, its effects on complement system has not been much studied. This research was conducted to find out the effects of Indonesian propolis on the expression levels of C3, C1r/s, Bf, MBL, and C6 in zebrafish larvae which were induced by lipopolysaccharide (LPS). Counting of macrophages migrating to yolk sac and liver histology were carried out. Larvae were divided into four groups: CON (cultured in E3 medium only), LPS (cultured in a medium containing 0.5 μg/L LPS), LPSIBU (cultured in a medium containing LPS, and then treated with 100 μg/L ibuprofen for 24 hours), and LPSPRO (cultured in a medium containing LPS, and then immersed in 14,000 μg/L propolis for 24 hours) groups. The results showed that complement gene expression in larvae from the LPSIBU and LPSPRO groups were generally lower than in larvae from the LPS group. The number of macrophage migrations to the yolk in the LPSPRO group was also lower than in the LPS group. Histological structure of liver in all groups were considered normal. This study shows that Indonesian propolis has the potential to be used as an alternative to the substitution of NSAIDs.


Embora a própolis tenha sido relatada por ter atividade anti-inflamatória, seus efeitos no sistema complemento, uma parte do sistema imunológico inato, não foram muito estudados. Esta pesquisa foi conduzida para descobrir os efeitos da própolis da Indonésia nos níveis de expressão de C3, C1r/s, Bf, MBL e C6 em larvas de peixe-zebra induzidas por lipopolissacarídeo (LPS). Foram realizadas contagens de macrófagos que migram para o saco vitelino e histologia do fígado. As larvas foram divididas em quatro grupos: CON (cultivadas apenas em meio E3), LPS (cultivadas em meio contendo 0,5 μg/L de LPS), LPSIBU (cultivadas em meio contendo LPS e, em seguida, tratadas com 100 μg/L de ibuprofeno por 24 horas) e LPSPRO (cultivado em meio contendo LPS, e então imerso em própolis 14,000 μg/L por 24 horas). Os resultados mostraram que a expressão do gene do complemento em larvas dos grupos LPSIBU e LPSPRO foi geralmente menor que em larvas do grupo LPS. O número de migrações de macrófagos para a gema no grupo LPSPRO também foi menor que no grupo LPS. A estrutura histológica do fígado em todos os grupos foi considerada normal. Este estudo mostra que a própolis indonésia tem potencial para ser utilizada como alternativa na substituição dos AINEs (anti-inflamatórios não esteroides).


Assuntos
Animais , Anti-Inflamatórios não Esteroides , Fígado/anatomia & histologia , Peixe-Zebra/genética , Peixe-Zebra/metabolismo , Própole/análise , Saco Vitelino/efeitos dos fármacos , Sistema Imunitário/efeitos dos fármacos
3.
Braz. J. Biol. ; 83: 1-8, 2023. tab, graf, ilus
Artigo em Inglês | VETINDEX | ID: vti-765426

Resumo

Although propolis has been reported for having anti-inflammatory activities, its effects on complement system has not been much studied. This research was conducted to find out the effects of Indonesian propolis on the expression levels of C3, C1r/s, Bf, MBL, and C6 in zebrafish larvae which were induced by lipopolysaccharide (LPS). Counting of macrophages migrating to yolk sac and liver histology were carried out. Larvae were divided into four groups: CON (cultured in E3 medium only), LPS (cultured in a medium containing 0.5 μg/L LPS), LPSIBU (cultured in a medium containing LPS, and then treated with 100 μg/L ibuprofen for 24 hours), and LPSPRO (cultured in a medium containing LPS, and then immersed in 14,000 μg/L propolis for 24 hours) groups. The results showed that complement gene expression in larvae from the LPSIBU and LPSPRO groups were generally lower than in larvae from the LPS group. The number of macrophage migrations to the yolk in the LPSPRO group was also lower than in the LPS group. Histological structure of liver in all groups were considered normal. This study shows that Indonesian propolis has the potential to be used as an alternative to the substitution of NSAIDs.(AU)


Embora a própolis tenha sido relatada por ter atividade anti-inflamatória, seus efeitos no sistema complemento, uma parte do sistema imunológico inato, não foram muito estudados. Esta pesquisa foi conduzida para descobrir os efeitos da própolis da Indonésia nos níveis de expressão de C3, C1r/s, Bf, MBL e C6 em larvas de peixe-zebra induzidas por lipopolissacarídeo (LPS). Foram realizadas contagens de macrófagos que migram para o saco vitelino e histologia do fígado. As larvas foram divididas em quatro grupos: CON (cultivadas apenas em meio E3), LPS (cultivadas em meio contendo 0,5 μg/L de LPS), LPSIBU (cultivadas em meio contendo LPS e, em seguida, tratadas com 100 μg/L de ibuprofeno por 24 horas) e LPSPRO (cultivado em meio contendo LPS, e então imerso em própolis 14,000 μg/L por 24 horas). Os resultados mostraram que a expressão do gene do complemento em larvas dos grupos LPSIBU e LPSPRO foi geralmente menor que em larvas do grupo LPS. O número de migrações de macrófagos para a gema no grupo LPSPRO também foi menor que no grupo LPS. A estrutura histológica do fígado em todos os grupos foi considerada normal. Este estudo mostra que a própolis indonésia tem potencial para ser utilizada como alternativa na substituição dos AINEs (anti-inflamatórios não esteroides).(AU)


Assuntos
Animais , Peixe-Zebra/genética , Peixe-Zebra/metabolismo , Saco Vitelino/efeitos dos fármacos , Fígado/anatomia & histologia , Própole/análise , Sistema Imunitário/efeitos dos fármacos , Anti-Inflamatórios não Esteroides
4.
Artigo em Português | VETINDEX | ID: biblio-1433807

Resumo

Lornoxicam é um anti-inflamatório não esteroidal (AINE) de uso exclusivamente humano, pois não existem doses estabelecidas nem indicações para o uso veterinário. Contudo, casos de intoxicação acidental em cães têm sido descritos. Neste estudo relata-se um caso de intoxicação acidental por lornoxicam em um cão atendido num hospital veterinário universitário. Trata-se de um cão, macho, da raça Shih Tzu, de aproximadamente 7 meses de idade, que havia ingerido 6 comprimidos de lornoxicam (Xepa®). Foram realizados exames de imagem e laboratoriais, sendo constatada gastrite medicamentosa e, posteriormente, quadro suspeito de peritonite. O animal foi tratado com antieméticos, protetores gástricos e antimicrobianos.(AU)


Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) for human use only, since there are no established doses or indications for veterinary use. However, cases of accidental poisoning in dogs have been described. This work aims to report a case of accidental poisoning by lornoxicam in a dog treated at an university veterinary hospital. A male Shih Tzu dog, approximately 7 months old, who had ingested six lornoxicam tablets (Xepa®). Imaging and laboratory tests were performed, and drug gastritis was found and, later, a suspected condition of peritonitis. The animal was treated with antiemetics, gastric protectors and antimicrobials.(AU)


Assuntos
Animais , Masculino , Peritonite/tratamento farmacológico , Anti-Inflamatórios não Esteroides/toxicidade , Cães , Intoxicação/diagnóstico
5.
Artigo em Português | VETINDEX | ID: biblio-1378444

Resumo

O presente trabalho avaliou os efeitos analgésicos do carprofeno associado ou não à condroitina com glicosamina no tratamento de 26 cães com osteoartrite, distribuídos nos grupos: GT ­ carprofeno (Carproflan®); GTP ­ carprofeno e glicosaminoglicanos (Carproflan® e Procart®); e GC ­ somente analgésico (dipirona). A evolução dos pacientes foi classificada na escala de claudicação no dia do primeiro atendimento e aos 7, 14 e 21 dias. No GT, 60% dos animais apresentou melhora clínica a partir do 7º dia, 30% não alterou seu escore de claudicação e 10% apresentou êmese a partir do 7º dia, com suspensão da medicação. No GTP, 60% dos animais apresentou melhora clínica a partir do 7º dia, 30% não alterou seu escore de claudicação, 5% apresentou êmese a partir do 7º dia e 5% a partir do 14º dia, com suspensão da medicação. No GC, nenhum animal apresentou melhora clínica. Conclui-se que os animais submetidos ao tratamento com carprofeno apresentaram melhora na claudicação, principalmente quando associado aos glicosaminoglicanos.(AU)


The analgesic effects of carprofen associated or not with chondroitin with glucosamine were evaluated in the treatment of 26 dogs with osteoarthritis, distributed into groups: TG ­ carprofen (Carproflan®); PTG ­ carprofen and glycosaminoglycans (Carproflan® and Procart®); and CG ­ only analgesic (dipyrone). The evolution of patients was classified on the lameness scale on the first day of care and at 7, 14 and 21 days. In the TG, 60% of the animals showed clinical improvement from the 7th day, 30% did not change their lameness score and 10% had emesis from the 7th day, with discontinuation of the medication. In the PTG, 60% of the animals showed clinical improvement from the 7th day, 30% did not change their lameness score, 5% had emesis from the 7th day and 5% from the 14th day, with discontinuation of the medication. In the CG, no animal showed clinical improvement. It was concluded that animals undergoing treatment with carprofen showed improvement in lameness, especially when associated with glycosaminoglycans.(AU)


Assuntos
Animais , Osteoartrite/veterinária , Claudicação Intermitente/diagnóstico , Medição da Dor/veterinária , Anti-Inflamatórios não Esteroides/efeitos adversos , Glicosaminoglicanos/efeitos adversos
6.
Braz. J. Vet. Res. Anim. Sci. (Online) ; 59: e176998, fev. 2022. tab, ilus
Artigo em Inglês | VETINDEX | ID: biblio-1397329

Resumo

The poultry industry suffers from various diseases or stresses. In poultry, apart from being antipyretic, acetylsalicylic acid (ASA) is widely used to cope with different issues including heat stress, and respiratory and digestive orders. This study evaluated the beneficial and toxic effects of ASA at different dose levels in broiler birds. To evaluate these toxic and beneficial effects it is necessary to examine the physical and serum biochemical parameters as well as the histopathological changes with tissue sections taken from broiler birds under experimental trial. This study was conducted on 60 one-day-old broiler chicks purchased from a local market in Faisalabad. Chicks were reared for the first 14 days under similar conditions. On the 15th day, birds were randomly divided into 4 groups (1-4) with 15 birds in each group. Group 4 was kept as control, while groups 1, 2, and 3 were treated with ASA at the dose of 300, 600, and 1200 mg/L of drinking water for 21 days. There were 3 samplings performed at 21, 28, and 35 days post-treatment. The live body weight and carcass weight were noted on each sampling. All the visceral organs were recorded for gross pathological changes. The serum samples were collected for biochemical evaluation. Histopathology of all the visceral organs was performed to observe the microscopic changes. A significant (P<0.05) increase in live body weight at a 300mg/L dose was noted after the first 2 samplings. A significant (P<0.05) increase in the relative organ weight was recorded at 1200 mg/L. The groups treated with ASA 600 and 1200 mg/L showed increased (P<0.05) AST, ALT, and creatinine levels from that of the control group. The group treated with 1200 mg/L of ASA showed increased (P<0.05) urea, serum total protein, and albumin level in all the samplings. Histopathological changes revealed swollen hepatocytes, increased sinusoidal spaces in the liver, congestion and abnormal glomerular spaces in the kidney, congestion and alveolar disruption in the lungs, and generation of villi and cellular degeneration in the intestine in a high-dose group. The study concluded that ASA at a low dose can be used for a long time in broilers and has a growth promontory role, while high-level doses cause hepatorenal toxicity.(AU)


A indústria avícola é afetada por diversas doenças ou estresses. Particularmente devido às aves serem antipiréticas. O ácido acetil salicílico (AAS) é largamente utilizado com diferentes objetivos que incluem o controle do estresse calórico, bem como a atividade respiratória e digestiva. O propósito deste estudo foi a avaliação dos efeitos benéficos e tóxicos do emprego de diferentes dosagens do AAS em frangos de corte. As variáveis analisadas foram: exame físico, parâmetros bioquímicos, bem como as alterações histopatológica em seções de tecidos colhidas das aves em um ensaio experimental. O estudo foi conduzido em 60 frangos de corte com um dia de idade adquiridos em um mercado local de Faisalabad que foram recriados nos primeiros 14 dias em idênticas condições. Então no 15º dia as aves foram distribuídas randomicamente em quatro grupos identificados pelos números 1 a 4, com 15 aves em cada grupo. O grupo 4 foi mantido como grupo controle e os grupos 1, 2 e 3 foram tratados com AAS, respectivamente, nas doses de 300, 600 e 1200 mg/L de água de bebida, durante 21 dias. Foram realizadas três amostragens nos dias 21, 28 e 35 pós-tratamento. O peso vivo corpóreo e da carcaça foi registrado em cada amostragem. Em todos os órgãos viscerais foi analisada a presença de alterações patológicas. As amostras de soro sanguíneo foram colhidas para a avaliação bioquímica. O exame histopatológico de todos os órgãos viscerais foi realizado para a observação de alterações microscópicas. A partir da segunda amostragem foi observado um aumento significante (p<0,05) no peso corpóreo na dosagem de 300mg/L. Um significante aumento no peso relativo dos órgãos foi registrado na dosagem de 1200 mg/L. Os grupos tratados com dosagens de 600 e 1200 mg/L de AAS, apresentaram aumento significante dos níveis de AST, ALT e de creatinina quando comparados ao grupo controle. O grupo tratado com 1200 mg/L de AAS apresentou um aumento significante (P,0,05) de uréia, proteína sérica total e de albumina em todas as amostragens. No grupo de alta dosagem foram observados alterações histopatológicas constituídas por aumento dos hepatócitos, aumento dos espaços sinusoidais no fígado, congestão e anormalidades nos espaços glomerulares nos rins, congestão e ruptura alveolar nos pulmões, degeneração das vilosidades e celular nos intestinos A conclusão obtida foi que em frangos de corte uma baixa dosagem do AAS pode ser utilizada por um período de longa duração, apresentando um efeito promotor do crescimento, contudo as doses elevadas determinam toxicidade hepática e renal.(AU)


Assuntos
Animais , Galinhas/fisiologia , Aspirina/administração & dosagem , Aspirina/efeitos adversos , Sorologia , Bioquímica/métodos
7.
Acta cir. bras ; 36(8): e360805, 2021. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1339014

Resumo

ABSTRACT Purpose: The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats. Methods: Forty-seven female Wistar rats were submitted to pelvic radiation and divided into eight groups: control A, mesalazine A, chondroitin A, and conjugate A, gavage of the according substance two weeks after irradiation and sacrifice three weeks after oral treatment; control C, mesalazine C, chondroitin C, and conjugate C, sacrifice six weeks after oral treatment. The rectum was submitted to histological characterization for each of the findings: inflammatory infiltrate, epithelial degeneration, mucosal necrosis, and fibrosis. Results: The inflammatory infiltrate was more intense in chondroitin A, mesalazine A, and conjugate C. The collagen deposition was less intense in chondroitin A, and mesalazine A, and more intense in control C. Conclusions: Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.


Assuntos
Animais , Feminino , Ratos , Proctite/tratamento farmacológico , Colite Ulcerativa/tratamento farmacológico , Reto , Anti-Inflamatórios não Esteroides/uso terapêutico , Administração Oral , Ratos Wistar , Mesalamina/uso terapêutico
8.
Semina ciênc. agrar ; 42(3,supl. 1): 1411-1420, 2021. tab, graf
Artigo em Inglês | VETINDEX | ID: biblio-1501934

Resumo

Sunflower to be used in ornamental floral arrangements need to be free from damage, and have longer shelf life. The aim of the present study was to evaluate the effect of acetylsalicylic acid (ASA) on the postharvest longevity of ornamental sunflower. Floral stems of the cultivar Vicent’s Choice from Sakata Seed were placed in flasks containing 350 mL of solution containing 0, 200, 400, 600, 800, or 1000 mg of ASA per liter of distilled water. Aspirin® (acetylsalicylic acid) tablets were used as the source of salicylic acid. Grades from 0 to 5 were assigned every day, according to a pre-established criteria for assessing the longevity and quality of the inflorescences. The data were subjected to analysis of variance, Tukey's test (t = 0.05%), and regression analysis using Sisvar program. Significant differences were observed in the grades from the sixth to the tenth day of treatment, but not in the total longevity. Treatment with 400 mg L-¹ of ASA improved the commercial longevity to an average of 9 days, about 4 days more than the control (0 mg L-¹). At 400 mg L-¹ dose, ASA prolongs the commercial longevity and maintains the postharvest quality of ornamental sunflower stems. However, at the maximum dose used (1000 mg L-¹), the evaluated parameters did not show any improvement over the controls.


A utilização do girassol em arranjos florais e ornamentação exige um material de qualidade, livre de danos e com alta durabilidade. O objetivo do presente estudo foi avaliar o efeito da solução conservante de ácido acetilsalicílico na longevidade pós colheita de girassol ornamental. Hastes florais da cultivar Vicent's Choice - Sakata Seed foram padronizadas e alocadas em frascos contendo 350 mL de solução composta por 0, 200, 400, 600, 800, e 1000 mg de ácido acetilsalicílico (AAS) por litro de água destilada. Utilizaram-se comprimidos do medicamento Aspirina® (Ácido acetilsalicílico) como fonte de ácido salicílico. Diariamente houve a atribuição de notas de zero a cinco de acordo com tabela pré-estabelecida para avaliação da longevidade e qualidade das inflorescências de girassol. Os dados foram submetidos a análise de variância, teste de Tukey (t= 0.05%), e análise de regressão com o auxílio do programa Sisvar. Foi possível observar diferenças significativas no critério notas a partir do sexto até o décimo dia de teste. Não houve diferenças significativas para a variável longevidade total, entretanto, quanto à longevidade comercial, o tratamento com 400 mg L-¹ se diferenciou dos demais com média de 9 dias, cerca de 4 dias a mais que a testemunha (0 mg L-¹). A utilização de solução conservante de ácido acetilsalicílico (400 mg L-¹) prolonga a longevidade comercial e a manutenção da qualidade pós-colheita de hastes florais de girassol ornamental quando comparado ao tratamento controle. A utilização da dosagem máximo (1000 mg L-¹) não promoveu aumento significativo em comparação com a testemunha para este parâmetro avaliado.


Assuntos
Aspirina/administração & dosagem , Flores , Helianthus/efeitos dos fármacos
9.
Semina Ci. agr. ; 42(3,supl. 1): 1411-1420, 2021. tab, graf
Artigo em Inglês | VETINDEX | ID: vti-765814

Resumo

Sunflower to be used in ornamental floral arrangements need to be free from damage, and have longer shelf life. The aim of the present study was to evaluate the effect of acetylsalicylic acid (ASA) on the postharvest longevity of ornamental sunflower. Floral stems of the cultivar Vicents Choice from Sakata Seed were placed in flasks containing 350 mL of solution containing 0, 200, 400, 600, 800, or 1000 mg of ASA per liter of distilled water. Aspirin® (acetylsalicylic acid) tablets were used as the source of salicylic acid. Grades from 0 to 5 were assigned every day, according to a pre-established criteria for assessing the longevity and quality of the inflorescences. The data were subjected to analysis of variance, Tukey's test (t = 0.05%), and regression analysis using Sisvar program. Significant differences were observed in the grades from the sixth to the tenth day of treatment, but not in the total longevity. Treatment with 400 mg L-¹ of ASA improved the commercial longevity to an average of 9 days, about 4 days more than the control (0 mg L-¹). At 400 mg L-¹ dose, ASA prolongs the commercial longevity and maintains the postharvest quality of ornamental sunflower stems. However, at the maximum dose used (1000 mg L-¹), the evaluated parameters did not show any improvement over the controls.(AU)


A utilização do girassol em arranjos florais e ornamentação exige um material de qualidade, livre de danos e com alta durabilidade. O objetivo do presente estudo foi avaliar o efeito da solução conservante de ácido acetilsalicílico na longevidade pós colheita de girassol ornamental. Hastes florais da cultivar Vicent's Choice - Sakata Seed foram padronizadas e alocadas em frascos contendo 350 mL de solução composta por 0, 200, 400, 600, 800, e 1000 mg de ácido acetilsalicílico (AAS) por litro de água destilada. Utilizaram-se comprimidos do medicamento Aspirina® (Ácido acetilsalicílico) como fonte de ácido salicílico. Diariamente houve a atribuição de notas de zero a cinco de acordo com tabela pré-estabelecida para avaliação da longevidade e qualidade das inflorescências de girassol. Os dados foram submetidos a análise de variância, teste de Tukey (t= 0.05%), e análise de regressão com o auxílio do programa Sisvar. Foi possível observar diferenças significativas no critério notas a partir do sexto até o décimo dia de teste. Não houve diferenças significativas para a variável longevidade total, entretanto, quanto à longevidade comercial, o tratamento com 400 mg L-¹ se diferenciou dos demais com média de 9 dias, cerca de 4 dias a mais que a testemunha (0 mg L-¹). A utilização de solução conservante de ácido acetilsalicílico (400 mg L-¹) prolonga a longevidade comercial e a manutenção da qualidade pós-colheita de hastes florais de girassol ornamental quando comparado ao tratamento controle. A utilização da dosagem máximo (1000 mg L-¹) não promoveu aumento significativo em comparação com a testemunha para este parâmetro avaliado.(AU)


Assuntos
Helianthus/efeitos dos fármacos , Aspirina/administração & dosagem , Flores
10.
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.494-4 jan. 2020. ilus, tab
Artigo em Inglês | VETINDEX | ID: biblio-1458321

Resumo

Background: Inappropriate use of drugs for veterinary patients represents a common problem at clinical practice. Nonsteroidal anti-inflammatories are one of these misused drugs and may lead to clinical status of challenging diagnosis. Adverseeffects for patients submitted to its incorrect use may include simple cases such as pharmacological gastroenteritis to severeacute renal failure or perforated gastroenteric ulcers with no pathognomonic clinical signs. The objective of this reportwas to describe a case of a perforated pyloric ulcer secondary to prolonged use of meloxicam in a cat with its clinical,laboratorial and image aspects from the moment of suspicion until the diagnosis.Case: An 8-year-old female feline was attended at the Veterinary Hospital of the Dom Bosco Catholic University, withmain complaint being a mammary nodule with recent ulceration. Tumor staging and pre-surgical blood analysis wereperformed previous to total unilateral mastectomy. Eleven days post-surgery the patient was brought for suture removal,but it was observed stupor, moderate dehydration (estimated 10%), 36.7ºC rectal temperature, heart rate at 100 beats/min,respiratory rate at 60 breaths/min, 40 mg/dL blood glucose, icterus and abdominal distension with tympany at percussion(fluid wave test was negative). Anamnesis revealed the possible use of meloxicam for 10 days. The first suspicion wassepsis, with enteric gas secondary to infection. Due to no classical signs of peritoneum effusion and possible severe entericdistension, abdominocentesis was not immediate performed. Complete blood count and serum biochemistry revealed amarked band leukocytosis associated with renal injury, supporting the first sepsis suspicion. Abdominal radiography revealedradiodensity of diffuse aspect at ventral topography but no evidence of marked...


Assuntos
Animais , Gatos , Anti-Inflamatórios não Esteroides/efeitos adversos , Mucosa Gástrica/lesões , Úlcera Gástrica/veterinária
11.
Acta sci. vet. (Online) ; 48(suppl.1): Pub. 494, Mar. 20, 2020. ilus, tab
Artigo em Inglês | VETINDEX | ID: vti-25601

Resumo

Background: Inappropriate use of drugs for veterinary patients represents a common problem at clinical practice. Nonsteroidal anti-inflammatories are one of these misused drugs and may lead to clinical status of challenging diagnosis. Adverseeffects for patients submitted to its incorrect use may include simple cases such as pharmacological gastroenteritis to severeacute renal failure or perforated gastroenteric ulcers with no pathognomonic clinical signs. The objective of this reportwas to describe a case of a perforated pyloric ulcer secondary to prolonged use of meloxicam in a cat with its clinical,laboratorial and image aspects from the moment of suspicion until the diagnosis.Case: An 8-year-old female feline was attended at the Veterinary Hospital of the Dom Bosco Catholic University, withmain complaint being a mammary nodule with recent ulceration. Tumor staging and pre-surgical blood analysis wereperformed previous to total unilateral mastectomy. Eleven days post-surgery the patient was brought for suture removal,but it was observed stupor, moderate dehydration (estimated 10%), 36.7ºC rectal temperature, heart rate at 100 beats/min,respiratory rate at 60 breaths/min, 40 mg/dL blood glucose, icterus and abdominal distension with tympany at percussion(fluid wave test was negative). Anamnesis revealed the possible use of meloxicam for 10 days. The first suspicion wassepsis, with enteric gas secondary to infection. Due to no classical signs of peritoneum effusion and possible severe entericdistension, abdominocentesis was not immediate performed. Complete blood count and serum biochemistry revealed amarked band leukocytosis associated with renal injury, supporting the first sepsis suspicion. Abdominal radiography revealedradiodensity of diffuse aspect at ventral topography but no evidence of marked...(AU)


Assuntos
Animais , Gatos , Anti-Inflamatórios não Esteroides/efeitos adversos , Mucosa Gástrica/lesões , Úlcera Gástrica/veterinária
12.
Ciênc. Anim. (Impr.) ; 30(04, Supl. 2): 239-242, 2020.
Artigo em Português | VETINDEX | ID: biblio-1472569

Resumo

Malignant mammary tumors are most prevalent neoplasms in bitches. Currently, it is known the influence of several factors and biological markers involved in tumors development, such as cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs appears as a promising adjuvant treatment. The aim of this study was to evaluate and to compare the effectiveness of piroxicam and Trocoxil® (mavacoxib) in reduce the peritumoral temperature. At random, it was selected 16 middle-aged bitches presenting mammary tumor according the routine of the Veterinary Hospital. On day 0, after clinical examination and thermography of both mammary chains, piroxicam was prescribed to group 1 (n=12) (0.3mg/kg, VO, SID, 10 days) and to group 2 (n=4) was prescribed Trocoxil® (2mg/kg, VO, single dose). After 10 days, the animals returned for further evaluation and the second thermography. The images were analyzed, tabulated and submitted to statistical analysis by the SigmaPlot® program in a simple t-test, considering p<0.05. The results indicated that Trocoxil® showed a better ability to reduce peritumoral temperature than piroxicam after 10 days of treatment (p=0.041), suggesting this drug with better efficiency in the adjuvant treatment of mammary neoplasms in bitches.


Assuntos
Feminino , Animais , Cães , Anti-Inflamatórios não Esteroides/efeitos adversos , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Neoplasias Mamárias Animais/diagnóstico , Neoplasias Mamárias Animais/tratamento farmacológico , Termografia
13.
Ci. Anim. ; 30(04, Supl. 2): 239-242, 2020.
Artigo em Português | VETINDEX | ID: vti-32094

Resumo

Malignant mammary tumors are most prevalent neoplasms in bitches. Currently, it is known the influence of several factors and biological markers involved in tumors development, such as cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs appears as a promising adjuvant treatment. The aim of this study was to evaluate and to compare the effectiveness of piroxicam and Trocoxil® (mavacoxib) in reduce the peritumoral temperature. At random, it was selected 16 middle-aged bitches presenting mammary tumor according the routine of the Veterinary Hospital. On day 0, after clinical examination and thermography of both mammary chains, piroxicam was prescribed to group 1 (n=12) (0.3mg/kg, VO, SID, 10 days) and to group 2 (n=4) was prescribed Trocoxil® (2mg/kg, VO, single dose). After 10 days, the animals returned for further evaluation and the second thermography. The images were analyzed, tabulated and submitted to statistical analysis by the SigmaPlot® program in a simple t-test, considering p<0.05. The results indicated that Trocoxil® showed a better ability to reduce peritumoral temperature than piroxicam after 10 days of treatment (p=0.041), suggesting this drug with better efficiency in the adjuvant treatment of mammary neoplasms in bitches.(AU)


Assuntos
Animais , Feminino , Cães , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Neoplasias Mamárias Animais/diagnóstico , Neoplasias Mamárias Animais/tratamento farmacológico , Anti-Inflamatórios não Esteroides/efeitos adversos , Termografia
14.
Arq. bras. med. vet. zootec. (Online) ; 71(4): 1316-1326, jul.-ago. 2019. tab, graf
Artigo em Português | LILACS, VETINDEX | ID: biblio-1038610

Resumo

O presente trabalho objetivou comparar o efeito do flunixin meglumine, cetoprofeno e meloxicam no tratamento da dor pós-operatória de ovinos submetidos à implantação de cânula ruminal e orquiectomia. Foram utilizados 32 ovinos, machos, pesando em média 35,5±3,5kg, distribuídos em três grupos: GFlu (flunixin meglumine 1,1mg/kg i.v.), GCet (cetoprofeno 3,0mg/kg i.v.) e GMel (meloxicam 0,5mg/kg i.v.). Exame clínico e coletas de sangue foram realizados no M0 (pré-avaliação), M1 (10 minutos após a pré-avaliação), M2 (início da sutura para fixação da cânula ruminal), M3 (logo após o término da cirurgia) e em duas, 12, 23, 25, 48 e 72 horas após a cirurgia (M2h, M12h, M23h, M25h, M48h e M72h), quando foram avaliados cortisol, glicose, proteína total, albumina, γ-glutamiltransferase (GGT), aspartato aminotransferase (AST), creatina quinase (CK), ureia, creatinina e hemograma. Nos M2h, M12h, M23h, M25h e M48h, foi realizada avaliação comportamental. O GFlu apresentou maior concentração de cortisol no M12h e no M48h e maior escore de dor na fístula e no testículo no M12h, quando comparado ao GMel. Os animais do GCet apresentaram menor interação com outros membros da baia no M23h. A ação analgésica do meloxicam foi maior em animais submetidos à implantação de cânula ruminal e orquiectomia, quando comparado ao flunixin meglumine e ao cetoprofeno.(AU)


This study aimed to compare the effect of flunixin meglumine, ketoprofen, and meloxicam in the treatment of postoperative pain in sheep submitted to ruminal cannulation and orchiectomy. 32 sheep were submitted to implantation of rumen cannula and orchiectomy, divided into three groups: GFlu (Flunixin meglumine 1,1mg/kg i.v.); GCet (Ketoprofen 3,0mg/kg i.v.); GMel (Meloxicam 0,5mg/kg i.v.). Clinical examination and blood samples were performed at M0 (pre-evaluation), M1 (10 minutes after pre-evaluation), M2 (beginning ruminal cannula), M3 (immediately post-surgery), and M2h, M12h, M23h, M25h, M48h and M72h (2h, 12h, 23h, 25h, 48h and 72 hours post-surgery) with the evaluation of cortisol, glucose, total protein, albumin, γ-glutamyl transferase (GGT), aspartate aminotransferase (AST), creatine kinase (CK), urea, creatinine and blood count. At M2h, M12h, M23h, M25h and M48h a behavioral evaluation was performed. The GFlu showed higher concentration of cortisol at M12h and M48h and greater pain score related with fistula and testis procedures at M12h when compared to GMel. Animals in the GCet group presented lower interaction with other animals in the same M23h paddock. The analgesia provided by Meloxicam was higher than flunixin meglumine and ketoprofen in animals submitted to placement of ruminal cannula and orchiectomy.(AU)


Assuntos
Animais , Estresse Fisiológico , Ovinos , Cateterismo/veterinária , Orquiectomia/veterinária , Anti-Inflamatórios não Esteroides/administração & dosagem , /uso terapêutico , Bem-Estar do Animal
15.
Arq. bras. med. vet. zootec. (Online) ; 71(4): 1316-1326, jul.-ago. 2019. tab, graf
Artigo em Português | VETINDEX | ID: vti-25215

Resumo

O presente trabalho objetivou comparar o efeito do flunixin meglumine, cetoprofeno e meloxicam no tratamento da dor pós-operatória de ovinos submetidos à implantação de cânula ruminal e orquiectomia. Foram utilizados 32 ovinos, machos, pesando em média 35,5±3,5kg, distribuídos em três grupos: GFlu (flunixin meglumine 1,1mg/kg i.v.), GCet (cetoprofeno 3,0mg/kg i.v.) e GMel (meloxicam 0,5mg/kg i.v.). Exame clínico e coletas de sangue foram realizados no M0 (pré-avaliação), M1 (10 minutos após a pré-avaliação), M2 (início da sutura para fixação da cânula ruminal), M3 (logo após o término da cirurgia) e em duas, 12, 23, 25, 48 e 72 horas após a cirurgia (M2h, M12h, M23h, M25h, M48h e M72h), quando foram avaliados cortisol, glicose, proteína total, albumina, γ-glutamiltransferase (GGT), aspartato aminotransferase (AST), creatina quinase (CK), ureia, creatinina e hemograma. Nos M2h, M12h, M23h, M25h e M48h, foi realizada avaliação comportamental. O GFlu apresentou maior concentração de cortisol no M12h e no M48h e maior escore de dor na fístula e no testículo no M12h, quando comparado ao GMel. Os animais do GCet apresentaram menor interação com outros membros da baia no M23h. A ação analgésica do meloxicam foi maior em animais submetidos à implantação de cânula ruminal e orquiectomia, quando comparado ao flunixin meglumine e ao cetoprofeno.(AU)


This study aimed to compare the effect of flunixin meglumine, ketoprofen, and meloxicam in the treatment of postoperative pain in sheep submitted to ruminal cannulation and orchiectomy. 32 sheep were submitted to implantation of rumen cannula and orchiectomy, divided into three groups: GFlu (Flunixin meglumine 1,1mg/kg i.v.); GCet (Ketoprofen 3,0mg/kg i.v.); GMel (Meloxicam 0,5mg/kg i.v.). Clinical examination and blood samples were performed at M0 (pre-evaluation), M1 (10 minutes after pre-evaluation), M2 (beginning ruminal cannula), M3 (immediately post-surgery), and M2h, M12h, M23h, M25h, M48h and M72h (2h, 12h, 23h, 25h, 48h and 72 hours post-surgery) with the evaluation of cortisol, glucose, total protein, albumin, γ-glutamyl transferase (GGT), aspartate aminotransferase (AST), creatine kinase (CK), urea, creatinine and blood count. At M2h, M12h, M23h, M25h and M48h a behavioral evaluation was performed. The GFlu showed higher concentration of cortisol at M12h and M48h and greater pain score related with fistula and testis procedures at M12h when compared to GMel. Animals in the GCet group presented lower interaction with other animals in the same M23h paddock. The analgesia provided by Meloxicam was higher than flunixin meglumine and ketoprofen in animals submitted to placement of ruminal cannula and orchiectomy.(AU)


Assuntos
Animais , Estresse Fisiológico , Ovinos , Cateterismo/veterinária , Orquiectomia/veterinária , Anti-Inflamatórios não Esteroides/administração & dosagem , Bem-Estar do Animal
16.
Acta cir. bras. ; 34(12): e201901201, 2019. ilus
Artigo em Inglês | VETINDEX | ID: vti-24496

Resumo

Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.(AU)


Assuntos
Animais , Masculino , Ratos , Anti-Inflamatórios não Esteroides , Compostos de Rutênio/uso terapêutico , Meloxicam , Insuficiência Renal Crônica/induzido quimicamente , Modelos Animais
17.
Acta sci. vet. (Impr.) ; 47: Pub.1663-2019. tab, graf
Artigo em Inglês | VETINDEX | ID: biblio-1458061

Resumo

Background: Acute phase proteins (APPs) are clinically useful parameters for measuring the occurrence and severity ofinflammatory responses in cattle. As large group of proteins, APPs are mainly secreted by hepatocytes whose concentrationincrease or decrease as response to tissue injury, inflammation or infection. The transition from late pregnancy to earlylactation is associated with a compromised immune status coupled with increased acute phase response. Non-steroidalanti-inflammatory drugs (NSAIDs) are used in treatment of inflammatory conditions. The main objective of the presentstudy was to analyze the effects of a preventive administration of the NSAID (ketoprofen) in post-calving dairy cows onconcentration of APPs (haptoglobin and fibrinogen) and their relationship with indicators of liver function.Materials, Methods & Results: The treatment group (n = 15) was given an intramuscular injection of ketoprofen in theconcentration of 3 mg/kg during three consecutive days after calving. The control group (n = 15) was not treated withketoprofen. Blood samples were taken from coccygeal vein, on the first day of treatment and in the first and second weekpostpartum and they were analyzed for metabolic parameters (albumin and aspartat aminotransferaze) and APPs such ashaptoglobin and fibrinogen. Compared with control, ketoprofen administration decrease the levels of haptoglobin and fibrinogen and AST activity. Increase in albumin concentration was recorded in experimental group of cows compared withcontrol. Negative correlations (P < 0.01) were found between the haptoglobin concentration and albumin concentrationand aspartate aminotransferaze activity. Discussion: As inflammatory indicator in dairy cows, it is recorded that serum concentrations of haptoglobin is increasedduring mastitis. Beside haptoglobin, fibrinogen represents one of the APPs whose serum concentration increases during response in the acute phase. During the first and second week...


Assuntos
Feminino , Animais , Gravidez , Bovinos , Anti-Inflamatórios não Esteroides , Cetoprofeno/administração & dosagem , Cetoprofeno/análise , Lactação , Metabolismo , Proteínas de Fase Aguda/análise , Fibrinogênio , Haptoglobinas , Ácidos Graxos não Esterificados
18.
Acta sci. vet. (Online) ; 47: Pub. 1663, June 9, 2019. tab, graf
Artigo em Inglês | VETINDEX | ID: vti-19705

Resumo

Background: Acute phase proteins (APPs) are clinically useful parameters for measuring the occurrence and severity ofinflammatory responses in cattle. As large group of proteins, APPs are mainly secreted by hepatocytes whose concentrationincrease or decrease as response to tissue injury, inflammation or infection. The transition from late pregnancy to earlylactation is associated with a compromised immune status coupled with increased acute phase response. Non-steroidalanti-inflammatory drugs (NSAIDs) are used in treatment of inflammatory conditions. The main objective of the presentstudy was to analyze the effects of a preventive administration of the NSAID (ketoprofen) in post-calving dairy cows onconcentration of APPs (haptoglobin and fibrinogen) and their relationship with indicators of liver function.Materials, Methods & Results: The treatment group (n = 15) was given an intramuscular injection of ketoprofen in theconcentration of 3 mg/kg during three consecutive days after calving. The control group (n = 15) was not treated withketoprofen. Blood samples were taken from coccygeal vein, on the first day of treatment and in the first and second weekpostpartum and they were analyzed for metabolic parameters (albumin and aspartat aminotransferaze) and APPs such ashaptoglobin and fibrinogen. Compared with control, ketoprofen administration decrease the levels of haptoglobin and fibrinogen and AST activity. Increase in albumin concentration was recorded in experimental group of cows compared withcontrol. Negative correlations (P < 0.01) were found between the haptoglobin concentration and albumin concentrationand aspartate aminotransferaze activity. Discussion: As inflammatory indicator in dairy cows, it is recorded that serum concentrations of haptoglobin is increasedduring mastitis. Beside haptoglobin, fibrinogen represents one of the APPs whose serum concentration increases during response in the acute phase. During the first and second week...(AU)


Assuntos
Animais , Feminino , Gravidez , Bovinos , Cetoprofeno/administração & dosagem , Cetoprofeno/análise , Proteínas de Fase Aguda/análise , Lactação , Metabolismo , Anti-Inflamatórios não Esteroides , Haptoglobinas , Fibrinogênio , Ácidos Graxos não Esterificados
19.
Ars Vet. ; 35(1): 01-06, mar. 2019. ilus
Artigo em Português | VETINDEX | ID: vti-21777

Resumo

Síndrome da lise tumoral é considerada uma emergência metabólica grave, caracterizada pela liberação de substâncias citotóxicas na circulação sanguínea, podendo acarretar acidose lática, distúrbio eletrolítico e elevado risco de morte em um período de evolução relativamente pequeno. É considerada uma condição rara em pequenos animais e pouco relatada na literatura veterinária, principalmente quando associada à presença de neoplasmas sólidos. Este relato correlaciona o uso do antiinflamatório não esteróide firocoxibe, utilizado como base terapêutica na remissão da reação inflamatória neoplásica, com o desenvolvimento abrupto da síndrome da lise tumoral, em um paciente canino, da raça Schnauzer miniatura, acometido com carcinoma mamário inflamatório em estágio inicial.(AU)


Tumor Lysis Syndrome is considered a serious metabolic emergency, characterized by the release of cytotoxic substances into the bloodstream, which can lead to lactic acidosis, electrolyte disturbance, and high risk of death in a relatively small clinical course. It is considered a rare condition in small animals, especially when associated with the presence of solid neoplasms. This report correlates the influence of the use of the non-steroidal anti-inflammatory firocoxib, used as a therapeutic base in the remission of the neoplastic inflammatory reaction, and as a consequence there was the abrupt development of the Tumor Lysis Syndrome in a canine patient of the miniature Schnauzer breed, with early inflammatory breast carcinoma.(AU)


Assuntos
Animais , Cães , Feminino , Síndrome de Lise Tumoral , Neoplasias da Mama/veterinária , Neoplasias da Mama/tratamento farmacológico , Inibidores de Ciclo-Oxigenase 2/efeitos adversos , Carcinoma/veterinária , Anti-Inflamatórios não Esteroides/efeitos adversos
20.
Ars vet ; 35(1): 01-06, mar. 2019. ilus
Artigo em Português | VETINDEX | ID: biblio-1463490

Resumo

Síndrome da lise tumoral é considerada uma emergência metabólica grave, caracterizada pela liberação de substâncias citotóxicas na circulação sanguínea, podendo acarretar acidose lática, distúrbio eletrolítico e elevado risco de morte em um período de evolução relativamente pequeno. É considerada uma condição rara em pequenos animais e pouco relatada na literatura veterinária, principalmente quando associada à presença de neoplasmas sólidos. Este relato correlaciona o uso do antiinflamatório não esteróide firocoxibe, utilizado como base terapêutica na remissão da reação inflamatória neoplásica, com o desenvolvimento abrupto da síndrome da lise tumoral, em um paciente canino, da raça Schnauzer miniatura, acometido com carcinoma mamário inflamatório em estágio inicial.


Tumor Lysis Syndrome is considered a serious metabolic emergency, characterized by the release of cytotoxic substances into the bloodstream, which can lead to lactic acidosis, electrolyte disturbance, and high risk of death in a relatively small clinical course. It is considered a rare condition in small animals, especially when associated with the presence of solid neoplasms. This report correlates the influence of the use of the non-steroidal anti-inflammatory firocoxib, used as a therapeutic base in the remission of the neoplastic inflammatory reaction, and as a consequence there was the abrupt development of the Tumor Lysis Syndrome in a canine patient of the miniature Schnauzer breed, with early inflammatory breast carcinoma.


Assuntos
Feminino , Animais , Cães , Anti-Inflamatórios não Esteroides/efeitos adversos , Carcinoma/veterinária , /efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/veterinária , Síndrome de Lise Tumoral
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