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1.
Arq. bras. med. vet. zootec. (Online) ; 75(2): 247-253, Mar.-Apr. 2023. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1434105

Resumo

We report a case of urethral obstruction due to seminal vesiculitis in a Dorper sheep, with symptoms of anuria, rectal prolapse, orchitis/epididymitis, and uroperitoneum and biochemical tests indicating severe azotemia. The animal died due to advanced azotemia, and necropsy revealed kidneys with cortical and medullary necrosis, pyelonephritis of renal calyces, hydronephrosis, ruptured and necrotic bladder, and vesicular, bulbourethral, and ampoule accessory sex glands. There was prostate hyperplasia that revealed a large amount of pus in the cross section, which was also observed bilaterally in the epididymis and right testis. Morphotintorial and biochemical analyses of bacteria obtained from microbiological culture revealed Corynebacterium sp. and Escherichia coli. Infection, hyperplasia, and abscessation of accessory sex glands caused urethral compression, resulting in an obstructive condition, similar to urolithiasis, in addition to bacteremia. Hyperplastic seminal vesiculitis, although rare, must be included among the differential diagnoses of obstructive processes in the urinary tract of sheep.


Relata-se um caso de obstrução uretral decorrente de vesiculite seminal em carneiro da raça Dorper, com quadro de anúria, prolapso retal, orquite/epididimite e uroperitôneo, com exames bioquímicos indicativos de severa azotemia. Devido ao quadro avançado de azotemia, o animal faleceu e, na necropsia, foi observado:: rins com necrose de cortical e medular, pielonefrite dos cálices renais e hidronefrose, bexiga rompida e necrosada, assim como glândulas sexuais acessórias vesiculares, bulbouretrais e ampola. Havia hiperplasia de próstata que, ao corte transversal, revelou grande quantidade de pus, que também foi observado bilateralmente no epidídimo e no testículo direito. As análises morfotintoriais e bioquímicas das bactérias obtidas a partir do cultivo microbiológico foram compatíveis com Corynebacterium sp. e Escherichia coli. A infecção, a hiperplasia e a abscedação das glândulas sexuais acessória, causaram compressão uretral, levando a um quadro obstrutivo, semelhante à urolitíase, somado à bacteremia. A vesiculite seminal hiperplásica, apesar de rara, deve ser incluída entre os diagnósticos diferenciais dos processos obstrutivos do trato urinário de carneiros.


Assuntos
Animais , Doenças dos Ovinos , Obstrução Uretral/veterinária , Doenças Urológicas/veterinária , Corynebacterium/patogenicidade , Escherichia coli/patogenicidade
2.
Acta sci. vet. (Impr.) ; 50(supl.1): 784, 2022. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1370253

Resumo

Background: Polioencephalomalacia (PEM) is a neurological disease in ruminants, which is characterized by malacia of brain gray matter. Thiamine deficiency and sulfur intoxication are the most common causes of PEM in sheep. Affected animals present signs of cerebrocortical syndrome, including amaurosis, ataxia, head pressing, mental depression, seizures, and opisthotonus. The neurological examination aims to determine the neurolocalization of the lesions and advanced imaging techniques are useful for confirming the affected area(s) in the central nervous system. The aim of this study is to describe clinical features and ante-mortem diagnosis using magnetic resonance imaging (MRI) in a sheep with PEM. Case: A 18-month-old male Dorper sheep from a flock started receiving concentrate 7 days before. According to the owner, no clinical signs of abnormality were observed on the previous morning. However, in the afternoon, the animal became selfisolated and did not follow the flock to the sheepfold. The following day, he was found in recumbency. Physical examination revealed lateral recumbency, rectal temperature 39.5ºC, 52 bpm, 120 bpm, congested mucous membranes, capillary refill time 1 s, ruminal (4/5 min) and intestinal hypomotility. The assessment of the central nervous system revealed a decreased level of consciousness, focal seizures, opisthotonus, and absence of menace response. The following differential diagnoses were listed: PEM, head trauma, focal symmetrical encephalomalacia, bacterial encephalitis, and rabies. Treatment was composed of dexamethasone [0.2 mg/kg - i.v., SID (1st-3rd day), 0.1 mg/kg, i.v., SID (4th-6th day), and 0.05 mg/kg, i.v., SID (7th-9th day)]; mannitol [1 g/kg - i.v. and diazepam 0.4 mg/kg, i.v. single dose at admission]; vitamin B1 [10 mg/kg - i.m., SID], furosemide [1 mg/kg - i.v., SID for 3 days] and sulfadoxine/trimethoprim [30 mg/kg - i.m., SID for 10 days]. After the initial treatment, the patient showed mild clinical improvement; however, the amaurosis was still present. Magnetic resonance imaging of the brain was performed on the 2nd day of hospitalization, showing a symmetrical hypersignal in the parietal and occipital cortices, in the axial and sagittal sequences weighted in T2 and FLAIR. Discussion: This study aimed to describe the clinical signs and MRI findings in a sheep with PEM. In this case, the sudden change to the feed composition probably led to ruminal dysbiosis, inhibition of thiamine-producing microorganisms and proliferation of bacteria that synthesize thiaminase. Thiamine therapy proved to be effective and capable of reverting the clinical signs. The decrease in the level of consciousness, cortical blindness, and opisthotonus are due to alterations in the parietal cortex, in the occipital cortex, and in the cerebellum, respectively, which were demonstrated by hypersignal areas in the MRI. Therefore, the neurolocalization of the lesion based on neurologic examination and the MRI findings were related. The physicochemical and cytological evaluations of the cerebrospinal fluid, and dosage of thiamine and the concentration of hydrogen sulphide in the rumen were not performed. However, the response to thiamine treatment associated with the neurologic examination and MRI findings helped in determining the diagnosis. Additionally, MRI can be used as a useful tool for the ante mortem diagnosis of PEM.


Assuntos
Animais , Masculino , Deficiência de Tiamina/veterinária , Ovinos , Encefalomalacia/veterinária , Encefalomalacia/diagnóstico por imagem , Espectroscopia de Ressonância Magnética , Necrose/veterinária , Doenças do Sistema Nervoso/veterinária
3.
Ciênc. Anim. (Impr.) ; 31(01): 146-152, 2021. ilus
Artigo em Português | VETINDEX | ID: biblio-1472691

Resumo

O gênero Aspergillus compreende espécies de fungos saprotróficos, globalmente distribuídos, sendo os Aspergillus seção Fumigati conhecidos por causarem doença em humanos e animais imunocomprometidos. Os sinais clínicos dependem do sistema acometido, podendo apresentar febre branda, cólicas intensas, pneumonias, micose de bolsa gutural, e, ocasionalmente, lesões no sistema nervoso central. O presente trabalho objetiva relatar os sinais clínicos, os achados de necropsia e a histologia de um caso de aspergilose sistêmica em um potro de oito meses de idade. O animal apresentava refluxo enterogástrico, peristaltismo aumentado, fezes pastosas, dor abdominal e desidratação intensa. O quadro clínico evoluiu para óbito e o cadáver foi encaminhado para a necropsia. Macroscopicamente, havia sufusões e equimoses na serosa do trato gastrointestinal e ulcerações na mucosa do intestino delgado. No pulmão, havia nódulos multifocais, esbranquiçados e firmes que, ao corte, apresentavam-se císticos, com revestimento interno vinhoso e friável. O coração exibia áreas esbranquiçadas multifocais no miocárdio e os rins continham nódulos avermelhados nas regiões cortical e medular. No encéfalo, havia áreas multifocais amareladas e hemorrágicas com bordos avermelhados. Microscopicamente, observaram-se áreas multifocais de necrose com infiltrado inflamatório granulomatoso no intestino, pulmão, encéfalo, miocárdio e nos rins. Hifas fúngicas intralesionais e intravasculares foram observadas no encéfalo e no pulmão. Estruturas de fenótipo compatível com Aspergillus fumigatus foram observadas na cultura fúngica. Amostras encaminhadas para virologia apresentaram-se positivas para Herpesvírus Equino (HVE) tipo 1 e 4. O diagnóstico de aspergilose sistêmica foi determinado pelo histórico clínico, imunossupressão, achados macroscópicos, histológicos, isolamento do fungo e à infecção concomitante por HVE.


The Aspergillus genus comprises globally distributed species of saprotrophic fungi, with the Aspergillus section Fumigatus known to cause diseases in humans and immunocompromised animals. Clinical signs depend on the affected system, exhibiting mild fever, severe colic, pneumonia, guttural bag mycosis and occasionally lesions in the central nervous system. The present work aims to report the clinical signs, necropsy findings and histology of a case of systemic aspergillosis in an eight-months-old foal. The animal had enterogastric reflux, increased peristalsis, pasty feces, abdominal pain and severe dehydration. The condition evolved to death and the cadaver was sent for necropsy. Macroscopically, there were suffusions and ecchymosis in the serosa of the gastrointestinal tract and ulcerations in the mucosa of the small intestines. In the lung, there were multifocal, whitish and firm nodules that were cystic when cut with a friable winey internal lining. The heart had whitish multifocal areas in the myocardium and the kidneys contained reddish nodules in the cortical and medullary regions. In the brain there were yellowish and hemorrhagic multifocal areas with reddish borders. Microscopically, multifocal areas of necrosis with granulomatous inflammatory infiltrate were observed in the intestine, lung, brain, myocardium and kidneys. Intralesional and intravascular fungal were observed in the brain and lung. Structures with phenotype compatible with Aspergillus fumigatus were observed in the fungal culture. In virology, samples were positive for equine herpesvirus (HVE) types 1 and 4. The diagnosis of systemic aspergillosis was determined due to the clinical history, immunosuppression, macroscopic and histological findings, fungal isolation and concomitant HVE infection.


Assuntos
Masculino , Animais , Aspergilose/complicações , Aspergilose/diagnóstico , Aspergilose/sangue , Aspergilose/veterinária
4.
Ci. Anim. ; 31(01): 146-152, 2021. ilus
Artigo em Português | VETINDEX | ID: vti-31946

Resumo

O gênero Aspergillus compreende espécies de fungos saprotróficos, globalmente distribuídos, sendo os Aspergillus seção Fumigati conhecidos por causarem doença em humanos e animais imunocomprometidos. Os sinais clínicos dependem do sistema acometido, podendo apresentar febre branda, cólicas intensas, pneumonias, micose de bolsa gutural, e, ocasionalmente, lesões no sistema nervoso central. O presente trabalho objetiva relatar os sinais clínicos, os achados de necropsia e a histologia de um caso de aspergilose sistêmica em um potro de oito meses de idade. O animal apresentava refluxo enterogástrico, peristaltismo aumentado, fezes pastosas, dor abdominal e desidratação intensa. O quadro clínico evoluiu para óbito e o cadáver foi encaminhado para a necropsia. Macroscopicamente, havia sufusões e equimoses na serosa do trato gastrointestinal e ulcerações na mucosa do intestino delgado. No pulmão, havia nódulos multifocais, esbranquiçados e firmes que, ao corte, apresentavam-se císticos, com revestimento interno vinhoso e friável. O coração exibia áreas esbranquiçadas multifocais no miocárdio e os rins continham nódulos avermelhados nas regiões cortical e medular. No encéfalo, havia áreas multifocais amareladas e hemorrágicas com bordos avermelhados. Microscopicamente, observaram-se áreas multifocais de necrose com infiltrado inflamatório granulomatoso no intestino, pulmão, encéfalo, miocárdio e nos rins. Hifas fúngicas intralesionais e intravasculares foram observadas no encéfalo e no pulmão. Estruturas de fenótipo compatível com Aspergillus fumigatus foram observadas na cultura fúngica. Amostras encaminhadas para virologia apresentaram-se positivas para Herpesvírus Equino (HVE) tipo 1 e 4. O diagnóstico de aspergilose sistêmica foi determinado pelo histórico clínico, imunossupressão, achados macroscópicos, histológicos, isolamento do fungo e à infecção concomitante por HVE.(AU)


The Aspergillus genus comprises globally distributed species of saprotrophic fungi, with the Aspergillus section Fumigatus known to cause diseases in humans and immunocompromised animals. Clinical signs depend on the affected system, exhibiting mild fever, severe colic, pneumonia, guttural bag mycosis and occasionally lesions in the central nervous system. The present work aims to report the clinical signs, necropsy findings and histology of a case of systemic aspergillosis in an eight-months-old foal. The animal had enterogastric reflux, increased peristalsis, pasty feces, abdominal pain and severe dehydration. The condition evolved to death and the cadaver was sent for necropsy. Macroscopically, there were suffusions and ecchymosis in the serosa of the gastrointestinal tract and ulcerations in the mucosa of the small intestines. In the lung, there were multifocal, whitish and firm nodules that were cystic when cut with a friable winey internal lining. The heart had whitish multifocal areas in the myocardium and the kidneys contained reddish nodules in the cortical and medullary regions. In the brain there were yellowish and hemorrhagic multifocal areas with reddish borders. Microscopically, multifocal areas of necrosis with granulomatous inflammatory infiltrate were observed in the intestine, lung, brain, myocardium and kidneys. Intralesional and intravascular fungal were observed in the brain and lung. Structures with phenotype compatible with Aspergillus fumigatus were observed in the fungal culture. In virology, samples were positive for equine herpesvirus (HVE) types 1 and 4. The diagnosis of systemic aspergillosis was determined due to the clinical history, immunosuppression, macroscopic and histological findings, fungal isolation and concomitant HVE infection.(AU)


Assuntos
Animais , Masculino , Aspergilose/sangue , Aspergilose/complicações , Aspergilose/diagnóstico , Aspergilose/veterinária
5.
Ci. Rural ; 50(12): e20200379, 2020. tab, ilus
Artigo em Inglês | VETINDEX | ID: vti-29594

Resumo

Hypercortisolism is a common endocrinopathy in dogs; however, in a few cases, bilateral functional adrenocortical adenomas cause spontaneous disease, and thrombotic events are considered uncommon complications. The aim of this report was to describe a case of bilateral adrenocortical adenoma in a dog with hyperadrenocorticism associated with distal aortic and iliac thrombosis, with emphasis on clinical and pathological aspects. A 15-year-old spayed female Dachshund with a previous clinical history of hyperadrenocorticism presented with acute bilateral hindlimb paraparesis. A vertebral thoracolumbar radiography was performed and did not present any evidence of intervertebral disk disease or vertebral abnormalities; however, abdominal ultrasound and vascular Doppler evaluation revealed bilateral adrenal enlargement in addition to an aortic and external iliac artery thrombus. The animal was euthanized. At necropsy, both adrenal glands were enlarged by well-demarcated neoplastic nodules in the parenchyma, and a thrombus caudal to the abdominal aorta bifurcation within the external iliac arteries that extended to the left external iliac artery was noted. Histological evaluation revealed a well-differentiated neoplastic proliferation of cortical epithelial cells, consistent with bilateral adenoma, and muscular necrosis in the pelvic limbs was also observed. Bilateral functional adrenocortical adenoma; although, very rare, should be considered as a cause of hypercortisolism, and aortic thrombosis in dogs should be considered as a possible consequence.(AU)


Hipercortisolismo é uma endocrinopatia comum em cães, no entanto, apenas em poucos casos adenomas adrenocorticais funcionais bilaterais são a causa de doença espontânea, e eventos trombóticos são considerados complicações incomuns. O objetivo deste relato foi descrever um caso de adenoma adrenocortical bilateral em um cão com hiperadrenocorticismo associado a trombose aórtica distal e ilíaca, com ênfase nos aspectos clínicos e patológicos. Um cão, Dachshund, fêmea castrada, de 15 anos, com histórico clínico prévio de hiperadrenocorticismo, apresentou paraparesia aguda dos membros posteriores. Foi realizada radiografia toracolombar vertebral, a qual não mostrou nenhuma evidência de doença do disco intervertebral ou anormalidades vertebrais; no entanto, ultrassonografia abdominal e Doppler vascular revelaram um trombo na aorta e artéria ilíaca externa, e adrenomegalia bilateral. O animal foi submetido à eutanásia. Na necropsia, ambas as adrenais estavam distendidas por nódulos neoplásicos bem delimitados no parênquima e notou-se um trombo caudalmente à bifurcação da aorta abdominal às artérias ilíacas externas, estendendo-se à ilíaca externa esquerda. Na avaliação histológica observou-se proliferação neoplásica bem diferenciada de células epiteliais corticais, consistente com adenoma bilateral; também foi observada necrose muscular nos membros pélvicos. O adenoma adrenocortical funcional bilateral, embora muito raro, deve ser considerado uma causa de hipercortisolismo, e a trombose aórtica em cães deve ser considerada uma possível consequência.(AU)


Assuntos
Animais , Cães , Doenças do Cão , Trombose/veterinária , Trombose/complicações , Adenoma Adrenocortical/veterinária , Adenoma Adrenocortical/complicações , Doenças do Sistema Endócrino/veterinária
6.
Acta sci. vet. (Online) ; 48(suppl.1): Pub. 567, 27 nov. 2020. ilus
Artigo em Português | VETINDEX | ID: vti-31274

Resumo

Background: Perinatal mortality in sheep is determined by death between 60 days of gestation and 28 days postpartum. The starvation / hypothermia complex was characterized by lambs that walked, but did not feed. Polioencephalomalacia (PEM) is a descriptive term that indicates the morphological diagnosis for necrosis with softening of the gray matter in the brain. There are no data available in the literature relating PEM to the starvation / hypoglycemia / hypothermia complex in small ruminants. Thus, the objective of this work is to report a case of polyioencephalomalacia related to the starvation / hypoglycemia / hypothermia and septicemia complex in a newborn sheep. Case: A 5-day-old sheep female mixed race (Dorper x Santa Inês), 3.0 kg, from a rural property in the Federal District, was sent to the Veterinary Pathology Laboratory of the University of Brasília, for a necropsy. Organ fragments were collected and fixed in a 10 % buffered formalin solution, routinely processed for histology and stained with Hematoxylin and Eosin (HE). Additionally, swabs from the meninges, eyeballs and navels were collected for bacteriology. The animal came from twin pregnancies and was weak since birth. With three days of life, it presented apathy, weakness, difficulty in breastfeeding, difficulty in walking, and decubitus in a self-auscultation position. After 2 days of evolution the lamb died. Macroscopically, eyeball opacity, omphalophlebitis and congested brain were observed. Microscopically in the frontal cortex, the leptomeninge was markedly thickened by a large number of neutrophils and, to a lesser extent, macrophages, lymphocytes and plasmocytes, associated with aggregates of free eosinophilic rods or in the cytoplasm of macrophages. In the underlying gray substance, the neurópilo was observed containing...(AU)


Assuntos
Animais , Feminino , Animais Recém-Nascidos , Ovinos/anormalidades , Mortalidade Perinatal , Encefalomalacia/veterinária , Necrose/veterinária , Morte Encefálica/veterinária , Doenças do Sistema Nervoso/veterinária
7.
Acta sci. vet. (Impr.) ; 48(suppl.1): Pub.567-4 jan. 2020. ilus
Artigo em Português | VETINDEX | ID: biblio-1458394

Resumo

Background: Perinatal mortality in sheep is determined by death between 60 days of gestation and 28 days postpartum. The starvation / hypothermia complex was characterized by lambs that walked, but did not feed. Polioencephalomalacia (PEM) is a descriptive term that indicates the morphological diagnosis for necrosis with softening of the gray matter in the brain. There are no data available in the literature relating PEM to the starvation / hypoglycemia / hypothermia complex in small ruminants. Thus, the objective of this work is to report a case of polyioencephalomalacia related to the starvation / hypoglycemia / hypothermia and septicemia complex in a newborn sheep. Case: A 5-day-old sheep female mixed race (Dorper x Santa Inês), 3.0 kg, from a rural property in the Federal District, was sent to the Veterinary Pathology Laboratory of the University of Brasília, for a necropsy. Organ fragments were collected and fixed in a 10 % buffered formalin solution, routinely processed for histology and stained with Hematoxylin and Eosin (HE). Additionally, swabs from the meninges, eyeballs and navels were collected for bacteriology. The animal came from twin pregnancies and was weak since birth. With three days of life, it presented apathy, weakness, difficulty in breastfeeding, difficulty in walking, and decubitus in a self-auscultation position. After 2 days of evolution the lamb died. Macroscopically, eyeball opacity, omphalophlebitis and congested brain were observed. Microscopically in the frontal cortex, the leptomeninge was markedly thickened by a large number of neutrophils and, to a lesser extent, macrophages, lymphocytes and plasmocytes, associated with aggregates of free eosinophilic rods or in the cytoplasm of macrophages. In the underlying gray substance, the neurópilo was observed containing...


Assuntos
Feminino , Animais , Animais Recém-Nascidos , Encefalomalacia/veterinária , Mortalidade Perinatal , Ovinos/anormalidades , Doenças do Sistema Nervoso/veterinária , Morte Encefálica/veterinária , Necrose/veterinária
8.
Acta cir. bras. ; 35(12): e351202, 2020. tab, graf, ilus
Artigo em Inglês | VETINDEX | ID: vti-30314

Resumo

Purpose: To investigate the therapeutic benefits of Hydroxysafflor yellow A (HSYA) on blood-brain barrier (BBB) vulnerability after traumatic brain injury (TBI) and identify its potential action of mechanisms on TBIinduced injuries. Methods: The rat TBI model was performed by using a controlled cortical impact device. The BBB permeability induced by TBI was measured through Evans Blue dye superflux and western blotting or polymerase chain reaction (PCR) for tight junctional proteins (TJPs). The post-TBI changes in oxidative stress markers, inflammatory response and neuron apoptosis in brain tissue were also tested. Results: Herein, the results showed that HSYA acutely attenuated BBB permeability via increasing the production of the TJPs, including occludin, claudin-1 and zonula occludens protein 24 h after TBI. Additionally, HSYA could suppress the secretion of proinflammatory factors, such as interleukin-1, interleukin-6, and tumor necrosis factor- (IL-1, IL-6, and TNF-), and also concurrently down-regulate the expression of inflammation-related Toll-like receptor 4/nuclear factor kappa-B (TLR4/NF-kB) protein. These HSYA challenged changes were accompanied by the decreased TBI induced oxidative stress markers and inhibited the expression of apoptosis proteins Bax, caspase-3 and caspase-9. Conclusions: Taken together, all findings suggested that HSYA (30 mg/kg) are against TBI through improving the integrity in BBB, which are associated with the antioxidant, anti-inflammation and antiapoptosis via the probable mechanism of down-regulation of the TLR4/NF-kB pathway, and its in-detail protective mechanisms are under study.(AU)


Assuntos
Animais , Ratos , Barreira Hematoencefálica/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Apoptose/efeitos dos fármacos , Lesões Encefálicas/tratamento farmacológico , Lesões Encefálicas/veterinária
9.
Acta sci. vet. (Impr.) ; 47(suppl.1): Pub.458-2019. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1458222

Resumo

Background: Anaplastic carcinoma of the mammary gland is considered a highly invasive and malignant neoplasia, whichusually leads to neoplastic thrombosis and epidermal ulceration due to invasiveness of lymphatic vessels by tumor emboli.Loss of epidermal barrier predisposes to secondary bacterial infection, mainly by commensal bacteria of the skin, andsepticemia can be observed in cases of systemic dissemination. Neoplastic emboli and septic thrombi can lead to vascularobstruction, which can predispose to infarction in multiple organs. The aim of this case report is to describe a case ofhemorrhagic stroke in a dog with anaplastic carcinoma of the mammary gland.Case: A 12-year-old, mixed breed, female spayed canine presented with mammary tumor with plaque formation, associatedwith skin ulceration which extended to the medial region of pelvic limbs. The animal also displayed neurologic clinicalsigns characterized by stupor, opisthotonos and apathy. Due to poor prognosis, the canine was euthanized and submittedto necropsy. During external examination, the animal was in a good body condition, had moderately pale mucosae, andit was noted a nodular plaque in the abdominal ventral area extending from thoracic to inguinal mammary gland. Themass was firm and white, extensively ulcerated, and extending from the thoracic to inguinal mammary gland. There wasa well circumscribed area of infarction in the spleen and kidney. In the cerebral cortex it was observed an extensive areaof hemorrhage with adhered blood clot from frontal to temporal lobe. There were multiple well circumscribed, firm, andwhite areas in the myocardium. Histologically, the neoplastic proliferation was composed by epithelial cells with high pleomorphism, features of malignancy, and no delimitations, leading to the diagnosis of anaplastic carcinoma of the mammarygland. Admixed with tumor cells there were multiple areas of hemorrhage, necrosis and thrombosis...


Assuntos
Feminino , Animais , Cães , Acidente Vascular Cerebral/veterinária , Carcinoma/veterinária , Hemorragias Intracranianas/veterinária , Infarto Cerebral/veterinária , Neoplasias Mamárias Animais , Trombose Intracraniana/veterinária , Autopsia/veterinária
10.
Acta sci. vet. (Online) ; 47(suppl.1): Pub. 458, Dec. 14, 2019. ilus
Artigo em Inglês | VETINDEX | ID: vti-25749

Resumo

Background: Anaplastic carcinoma of the mammary gland is considered a highly invasive and malignant neoplasia, whichusually leads to neoplastic thrombosis and epidermal ulceration due to invasiveness of lymphatic vessels by tumor emboli.Loss of epidermal barrier predisposes to secondary bacterial infection, mainly by commensal bacteria of the skin, andsepticemia can be observed in cases of systemic dissemination. Neoplastic emboli and septic thrombi can lead to vascularobstruction, which can predispose to infarction in multiple organs. The aim of this case report is to describe a case ofhemorrhagic stroke in a dog with anaplastic carcinoma of the mammary gland.Case: A 12-year-old, mixed breed, female spayed canine presented with mammary tumor with plaque formation, associatedwith skin ulceration which extended to the medial region of pelvic limbs. The animal also displayed neurologic clinicalsigns characterized by stupor, opisthotonos and apathy. Due to poor prognosis, the canine was euthanized and submittedto necropsy. During external examination, the animal was in a good body condition, had moderately pale mucosae, andit was noted a nodular plaque in the abdominal ventral area extending from thoracic to inguinal mammary gland. Themass was firm and white, extensively ulcerated, and extending from the thoracic to inguinal mammary gland. There wasa well circumscribed area of infarction in the spleen and kidney. In the cerebral cortex it was observed an extensive areaof hemorrhage with adhered blood clot from frontal to temporal lobe. There were multiple well circumscribed, firm, andwhite areas in the myocardium. Histologically, the neoplastic proliferation was composed by epithelial cells with high pleomorphism, features of malignancy, and no delimitations, leading to the diagnosis of anaplastic carcinoma of the mammarygland. Admixed with tumor cells there were multiple areas of hemorrhage, necrosis and thrombosis...(AU)


Assuntos
Animais , Feminino , Cães , Hemorragias Intracranianas/veterinária , Acidente Vascular Cerebral/veterinária , Carcinoma/veterinária , Neoplasias Mamárias Animais , Trombose Intracraniana/veterinária , Infarto Cerebral/veterinária , Autopsia/veterinária
11.
Ars vet ; 35(1): 16-20, mar. 2019. ilus
Artigo em Português | VETINDEX | ID: biblio-1463493

Resumo

A encefalomalácia nutricional é um distúrbio metabólico caracterizado por sinais clínicos neurológicos e sua etiologia é atribuída à hipovitaminose E. Atinge frangos jovens acarretando altos prejuízos aos criadores e agroindústrias pela sua alta morbidade e mortalidade. O objetivo do presente estudo foi relatar as alterações macroscópicas e histopatológicas de um caso de encefalomalácia nutricional. Um frango de corte com quatro semanas de vida, foi encaminhado ao Laboratório de Patologia Animal da Universidade Federal de Rondônia. Ao exame físico apresentou escore corporal 1 e sinais neurológicos como, ataxia, andar em círculos, lateralização da cabeça, prostração e hiperestesia, caracterizada por espasmos corporais iniciados após estímulos como sons altos e toque físico. Após eutanásia, realizou-se exame necroscópico e exame histopatológico. Para isto, foram coletados fragmentos de órgãos e fixados em formalina tamponada a 10%. No exame necroscópico constatou-se necrose coliquativa no encéfalo, o qual apresentou-se extremamente friável, com coloração pálida. Na análise histopatológica foram observadas alterações como vacuolização citoplasmática, degeneração de células de Purkinje e malácia focal extensa na substância cinzenta cortical e da substância branca do cerebelo. Pela história clínica e as observações necroscópicas e histopatológicas, o caso foi diagnosticado como encefalomalácia nutricional por hipovitaminose E.


Nutritional encephalomalacia is a metabolic disorder characterized by clinical neurological signs and its etiology is attributed to hypovitaminosis E. It affects young chickens causing high losses to breeders and agroindustries due to their high morbidity and mortality. The aim of the present study was to report macroscopic and histopathological changes in a case of nutritional encephalomalacia. A young chicken with four weeks of life conducted to the Animal Pathology Laboratory of Federal University of Rondônia. Physical examination showed poor body score and neurological signs, such as ataxia, circling, head lateralization, prostration and hypersensitivity, characterized by body spasms initiated after stimuli such as loud sounds and physical touch. After euthanasia, necroscopic examination was performed, organ fragments were collected and fixed in 10% buffered formalin. Necroscopic examination revealed collictive necrosis in the brain, which was extremely friable, with a pale color. In histopathological analysis, changes such as cytoplasmic vacuolization, Purkinje cell degeneration and extensive focal malacia in the cortical gray matter and white matter of the cerebellum were observed. From the clinical history and necroscopic and histopathological observations, the case was diagnosed as nutritional encephalomalacia by hypovitaminosis E.


Assuntos
Animais , Deficiência de Vitamina E/complicações , Deficiência de Vitaminas/complicações , Encefalomalacia/fisiopatologia , Encefalomalacia/veterinária , Galinhas , Cérebro/patologia , Encefalopatias Metabólicas/fisiopatologia
12.
Ars Vet. ; 35(1): 16-20, mar. 2019. ilus
Artigo em Português | VETINDEX | ID: vti-21751

Resumo

A encefalomalácia nutricional é um distúrbio metabólico caracterizado por sinais clínicos neurológicos e sua etiologia é atribuída à hipovitaminose E. Atinge frangos jovens acarretando altos prejuízos aos criadores e agroindústrias pela sua alta morbidade e mortalidade. O objetivo do presente estudo foi relatar as alterações macroscópicas e histopatológicas de um caso de encefalomalácia nutricional. Um frango de corte com quatro semanas de vida, foi encaminhado ao Laboratório de Patologia Animal da Universidade Federal de Rondônia. Ao exame físico apresentou escore corporal 1 e sinais neurológicos como, ataxia, andar em círculos, lateralização da cabeça, prostração e hiperestesia, caracterizada por espasmos corporais iniciados após estímulos como sons altos e toque físico. Após eutanásia, realizou-se exame necroscópico e exame histopatológico. Para isto, foram coletados fragmentos de órgãos e fixados em formalina tamponada a 10%. No exame necroscópico constatou-se necrose coliquativa no encéfalo, o qual apresentou-se extremamente friável, com coloração pálida. Na análise histopatológica foram observadas alterações como vacuolização citoplasmática, degeneração de células de Purkinje e malácia focal extensa na substância cinzenta cortical e da substância branca do cerebelo. Pela história clínica e as observações necroscópicas e histopatológicas, o caso foi diagnosticado como encefalomalácia nutricional por hipovitaminose E.(AU)


Nutritional encephalomalacia is a metabolic disorder characterized by clinical neurological signs and its etiology is attributed to hypovitaminosis E. It affects young chickens causing high losses to breeders and agroindustries due to their high morbidity and mortality. The aim of the present study was to report macroscopic and histopathological changes in a case of nutritional encephalomalacia. A young chicken with four weeks of life conducted to the Animal Pathology Laboratory of Federal University of Rondônia. Physical examination showed poor body score and neurological signs, such as ataxia, circling, head lateralization, prostration and hypersensitivity, characterized by body spasms initiated after stimuli such as loud sounds and physical touch. After euthanasia, necroscopic examination was performed, organ fragments were collected and fixed in 10% buffered formalin. Necroscopic examination revealed collictive necrosis in the brain, which was extremely friable, with a pale color. In histopathological analysis, changes such as cytoplasmic vacuolization, Purkinje cell degeneration and extensive focal malacia in the cortical gray matter and white matter of the cerebellum were observed. From the clinical history and necroscopic and histopathological observations, the case was diagnosed as nutritional encephalomalacia by hypovitaminosis E.(AU)


Assuntos
Animais , Encefalomalacia/veterinária , Encefalomalacia/fisiopatologia , Deficiência de Vitaminas/complicações , Deficiência de Vitamina E/complicações , Galinhas , Encefalopatias Metabólicas/fisiopatologia , Cérebro/patologia
13.
Pesqui. vet. bras ; 38(5)2018.
Artigo em Inglês | VETINDEX | ID: vti-743801

Resumo

ABSTRACT: To evaluate the outcome of acute lesions in the brains of sheep that completely clinically recover from acute polioencephalomalacia (PEM), ten sheep were used in this experiment. Eight of those sheep received varying doses of amprolium to induce PEM. Four sheep were treated intramuscularly with 40mg/kg/body weight with thiamine to allow recovery and four sheep were left untreated. Two control sheep did not receive either amprolium or thiamine and were kept along with the other eight sheep for the duration of the experiment. Except for the two drugs, the diet and water source were the same for the ten sheep. Two sheep receiving high daily doses of amprolium and one sheep receiving a lower dose had acute deaths and developed acute brain lesions consisting of neuronal laminar cortical necrosis (red neurons), edema, reactive astrocytes, swollen endothelial cells and gitter cells infiltration. Four sheep that recovered from lower doses of amprolium-induced PEM after being treated with thiamine and another one that recovered spontaneously were euthanatized six months after clinical recovery and had gross changes consisting of segmental absence of cortical tissue. Histologically these segmental cortex-deprived areas corresponded to quasi-empty spaces where only vessels and gitter cells existed. No changes were seen in the brains of the two control sheep.


RESUMO: Para avaliar a evolução das lesões agudas no cérebro de ovinos que se recuperam clinicamente de polioencefalomalacia aguda (PEM), dez ovinos foram usados neste experimento. Oito desses ovinos receberam doses variáveis de amprólio para induzir PEM. Quatro ovinos foram tratados intramuscularmente com 40mg/kg/peso corporal de tiamina para permitir a recuperação, e outros quatro ficaram sem tratamento. Dois ovinos controles não receberam amprólio nem tiamina e foram mantidos com os outros oito ovinos durante a duração do experimento. Exceto pelas duas drogas, a dieta e a fonte de água eram as mesmas para os dez ovinos. Dois ovinos que receberam doses diárias altas de amprólio, e um que recebeu doses menores, tiveram mortes agudas e desenvolveram lesões cerebrais constituídas por necrose neuronal laminar cortical (neurônios vermelhos), edema, tumefação de células endoteliais, astrócitos reativos, tumefação de células endoteliais e infiltração por células gitter. Quatro ovinos que se recuperam da PEM induzida por amprólio, após tratamento com tiamina, e outro que se recuperou espontaneamente, permaneceram clinicamente normais e foram submetidos a eutanásia seis meses após a recuperação clínica. Na necropsia, apresentavam alterações macroscópicas caracterizadas por ausência segmentar de tecido corticocerebral. Histologicamente, essas áreas privadas de tecido cortical consistiam de espaços praticamente vazios onde apenas vasos e células gitter eram vistos. Não foram encontradas alterações no encéfalo das duas ovelhas controle.

14.
Pesqui. vet. bras ; 38(5)2018.
Artigo em Português | VETINDEX | ID: vti-743816

Resumo

ABSTRACT: Twenty six cases of bovine herpetic meningoencephalitis diagnosed from 2010-2016 in Goiás state, Brazil, were studied. Affected cattle were mainly 60-day to 18-month-old. There was no association of the disease with sex and seasonality. The disease was found in all five mesoregions with a higher prevalence in southern and central state of Goiás. Clinical signs more frequently observed included blindness, incoordination, circling, excessive salivation, and ataxia. Main gross findings in the brain were congestion with swelling and flattening of gyri, softening and yellow discoloration of cerebral cortex and hemorrhagic foci. In five cases no gross changes were observed in the brain and in four cases there is no information. The main histopathological changes were in the cortex of telencephalic lobes, especially the frontal and parietal; however less prominent and less frequently found lesions occurred in the thalamus, basal nuclei, midbrain, pons, medulla oblongata, cerebellum, and hippocampus. All cases presented lymphoplasmocytic meningoencephalitis and intranuclear basophilic inclusion bodies in astrocytes, less commonly in neurons. Other frequent lesions included segmental laminar neuronal necrosis (red neurons), spongiosis, swollen vascular endothelial nuclei, gliosis (focal and diffuse), hypertrophy of astrocytes, infiltration of gitter cells, congestion, and hemorrhage. Lesions less frequently observed were Alzheimer type II astrocytes, residual lesion and neuronophagia. The most frequently affected cortical layers by neuronal necrosis and edema were external and internal granular, molecular, and pyramidal cell layers. Gyri and sulci were equally affected. Of the 26 cases, in 2 (7.69%) the DNA of BoHV-5 was amplified with samples fixed in 10% formalin and paraffin-embedded. DNA of BoHV-1 was identified in another case (3.84%) where, positive to BoHV-1, fresh samples were used.


RESUMO: Foram estudados 26 casos de meningoencefalite por herpesvírus bovino (BoHV) diagnosticados entre 2010-2016, no Estado de Goiás (GO). A doença acometeu principalmente bovinos jovens, entre 60 dias a 18 meses de idade. Não houve associação entre os casos e o sexo dos bovinos e a sazonalidade. A doença foi observada em todas as cinco Mesorregiões do Estado, com uma frequência maior nas Mesorregiões Sul e Centro. Os sinais clínicos mais frequentemente observados incluíram cegueira, incoordenação, sialorreia e ataxia. As principais alterações macroscópicas observadas incluíram congestão com tumefação e achatamento das circunvoluções, amolecimento e amarelamento do córtex telencefálico e focos de hemorragia. Em cinco encéfalos, não foram observadas alterações macroscópicas e em quatro as alterações não foram informadas. As principais alterações histológicas ocorreram no córtex telencefálico, principalmente o córtex frontal e parietal, mas em alguns casos, lesões de menor intensidade foram também observadas no tálamo, núcleos basais, mesencéfalo, ponte, bulbo, cerebelo e hipocampo. Todos os casos apresentaram meningoencefalite linfoplasmocítica e corpúsculos de inclusão intranucleares basofílicos em astrócitos e, eventualmente, em neurônios. Outras lesões frequentes incluíram necrose neuronal laminar segmentar (neurônio vermelho), espongiose, tumefação do núcleo das células endoteliais, gliose focal ou difusa, hipertrofia de astrócitos, infiltração por células gitter, congestão e hemorragia. Lesões menos comuns incluíram astrócitos Alzheimer tipo II, lesão residual e neuronofagia. A necrose neuronal e o edema (espongiose) foram mais acentuados nas camadas granular externa, molecular, de células piramidais e granular interna dos telencéfalos. Tanto os giros quanto os sulcos foram afetados igualmente. Dos 26 casos, o DNA de BoHV-5 foi amplificado em dois (7,69%) casos, enquanto que o de BoHV-1 foi identificado em um caso (3,84%). Nos casos positivos para BoHV-5 foram usadas amostras fixadas em formol a 10% e incluídas em parafina e amostras congeladas foram utilizadas no caso positivo para BoHV-1.

15.
Pesqui. vet. bras ; 38(5): 806-810, May 2018. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-955399

Resumo

To evaluate the outcome of acute lesions in the brains of sheep that completely clinically recover from acute polioencephalomalacia (PEM), ten sheep were used in this experiment. Eight of those sheep received varying doses of amprolium to induce PEM. Four sheep were treated intramuscularly with 40mg/kg/body weight with thiamine to allow recovery and four sheep were left untreated. Two control sheep did not receive either amprolium or thiamine and were kept along with the other eight sheep for the duration of the experiment. Except for the two drugs, the diet and water source were the same for the ten sheep. Two sheep receiving high daily doses of amprolium and one sheep receiving a lower dose had acute deaths and developed acute brain lesions consisting of neuronal laminar cortical necrosis (red neurons), edema, reactive astrocytes, swollen endothelial cells and gitter cells infiltration. Four sheep that recovered from lower doses of amprolium-induced PEM after being treated with thiamine and another one that recovered spontaneously were euthanatized six months after clinical recovery and had gross changes consisting of segmental absence of cortical tissue. Histologically these segmental cortex-deprived areas corresponded to quasi-empty spaces where only vessels and gitter cells existed. No changes were seen in the brains of the two control sheep.(AU)


Para avaliar a evolução das lesões agudas no cérebro de ovinos que se recuperam clinicamente de polioencefalomalacia aguda (PEM), dez ovinos foram usados neste experimento. Oito desses ovinos receberam doses variáveis de amprólio para induzir PEM. Quatro ovinos foram tratados intramuscularmente com 40mg/kg/peso corporal de tiamina para permitir a recuperação, e outros quatro ficaram sem tratamento. Dois ovinos controles não receberam amprólio nem tiamina e foram mantidos com os outros oito ovinos durante a duração do experimento. Exceto pelas duas drogas, a dieta e a fonte de água eram as mesmas para os dez ovinos. Dois ovinos que receberam doses diárias altas de amprólio, e um que recebeu doses menores, tiveram mortes agudas e desenvolveram lesões cerebrais constituídas por necrose neuronal laminar cortical (neurônios vermelhos), edema, tumefação de células endoteliais, astrócitos reativos, tumefação de células endoteliais e infiltração por células gitter. Quatro ovinos que se recuperam da PEM induzida por amprólio, após tratamento com tiamina, e outro que se recuperou espontaneamente, permaneceram clinicamente normais e foram submetidos a eutanásia seis meses após a recuperação clínica. Na necropsia, apresentavam alterações macroscópicas caracterizadas por ausência segmentar de tecido corticocerebral. Histologicamente, essas áreas privadas de tecido cortical consistiam de espaços praticamente vazios onde apenas vasos e células gitter eram vistos. Não foram encontradas alterações no encéfalo das duas ovelhas controle.(AU)


Assuntos
Animais , Cicatrização , Lesões Encefálicas/terapia , Ovinos/lesões , Amprólio
16.
Pesqui. vet. bras ; 38(5): 806-810, May 2018. tab, ilus
Artigo em Inglês | VETINDEX | ID: vti-20688

Resumo

To evaluate the outcome of acute lesions in the brains of sheep that completely clinically recover from acute polioencephalomalacia (PEM), ten sheep were used in this experiment. Eight of those sheep received varying doses of amprolium to induce PEM. Four sheep were treated intramuscularly with 40mg/kg/body weight with thiamine to allow recovery and four sheep were left untreated. Two control sheep did not receive either amprolium or thiamine and were kept along with the other eight sheep for the duration of the experiment. Except for the two drugs, the diet and water source were the same for the ten sheep. Two sheep receiving high daily doses of amprolium and one sheep receiving a lower dose had acute deaths and developed acute brain lesions consisting of neuronal laminar cortical necrosis (red neurons), edema, reactive astrocytes, swollen endothelial cells and gitter cells infiltration. Four sheep that recovered from lower doses of amprolium-induced PEM after being treated with thiamine and another one that recovered spontaneously were euthanatized six months after clinical recovery and had gross changes consisting of segmental absence of cortical tissue. Histologically these segmental cortex-deprived areas corresponded to quasi-empty spaces where only vessels and gitter cells existed. No changes were seen in the brains of the two control sheep.(AU)


Para avaliar a evolução das lesões agudas no cérebro de ovinos que se recuperam clinicamente de polioencefalomalacia aguda (PEM), dez ovinos foram usados neste experimento. Oito desses ovinos receberam doses variáveis de amprólio para induzir PEM. Quatro ovinos foram tratados intramuscularmente com 40mg/kg/peso corporal de tiamina para permitir a recuperação, e outros quatro ficaram sem tratamento. Dois ovinos controles não receberam amprólio nem tiamina e foram mantidos com os outros oito ovinos durante a duração do experimento. Exceto pelas duas drogas, a dieta e a fonte de água eram as mesmas para os dez ovinos. Dois ovinos que receberam doses diárias altas de amprólio, e um que recebeu doses menores, tiveram mortes agudas e desenvolveram lesões cerebrais constituídas por necrose neuronal laminar cortical (neurônios vermelhos), edema, tumefação de células endoteliais, astrócitos reativos, tumefação de células endoteliais e infiltração por células gitter. Quatro ovinos que se recuperam da PEM induzida por amprólio, após tratamento com tiamina, e outro que se recuperou espontaneamente, permaneceram clinicamente normais e foram submetidos a eutanásia seis meses após a recuperação clínica. Na necropsia, apresentavam alterações macroscópicas caracterizadas por ausência segmentar de tecido corticocerebral. Histologicamente, essas áreas privadas de tecido cortical consistiam de espaços praticamente vazios onde apenas vasos e células gitter eram vistos. Não foram encontradas alterações no encéfalo das duas ovelhas controle.(AU)


Assuntos
Animais , Cicatrização , Lesões Encefálicas/terapia , Ovinos/lesões , Amprólio
17.
Acta sci. vet. (Impr.) ; 46(supl): Pub.340-2018. tab, ilus
Artigo em Inglês | VETINDEX | ID: biblio-1458007

Resumo

Background: Herpetic meningoencephalitis is an infectious contagious disease worldwide distributed, most often caused by bovine alphaherpesvirus type 5 (BoHV-5), although bovine alphaherpesvirus type 1 (BoHV-1) may occasionally be the causative agent. The disease is characterized by subacute to acute clinical onset, often affecting animals submitted to stressful situations. Clinical signs are mainly neurologic due to meningoencephalitis and cortical necrosis. The involvement of the spinal cord has also been reported, however in BoHV-1 associated disease only. The aim of this report is to describe an outbreak of bovine meningoencephalomyelitis associated to BoHV-5.Case: In August 2017, nine 1-year-old calves died in a beef cattle farm with a flock of approximately 400 bovines. The animals presented neurological clinical signs characterized by excessive salivation, nasal and ocular discharges, incoordination, apathy, head tremors, head pressing, wide-based stance, recumbency followed by convulsions and paddling. According to the owner and referring veterinarian, affected animals displayed severe clinical signs with rapid progression and often leading to death in up to seven days. Four of these calves were submitted for necropsy, and gross lesions were present in the brain, characterized by mild to moderate multifocal hemorrhagic and soft areas. On cut surface, extensive areas of dark brown discoloration and malacia were observed. Histologically, lesions were characterized by extensive areas of liquefactive necrosis in the cerebral cortex grey matter, associated with inflammatory infiltrates composed of neutrophils, lymphocytes, plasma cells and foamy macrophages, as well as multifocal to coalescing areas of hemorrhage and fibrin deposition. Intranuclear eosinophilic inclusion bodies were rarely observed in neurons and astrocytes. On leptomeninges, there was diffuse inflammatory infiltrates of lymphocytes and plasma cells.[...]


Assuntos
Animais , Bovinos , Encefalite Viral/veterinária , Infecções por Herpesviridae/veterinária , Meningoencefalite/diagnóstico , Meningoencefalite/veterinária , Brasil
18.
Acta sci. vet. (Online) ; 46(supl): Pub. 340, 2018. tab, ilus
Artigo em Inglês | VETINDEX | ID: vti-735138

Resumo

Background: Herpetic meningoencephalitis is an infectious contagious disease worldwide distributed, most often caused by bovine alphaherpesvirus type 5 (BoHV-5), although bovine alphaherpesvirus type 1 (BoHV-1) may occasionally be the causative agent. The disease is characterized by subacute to acute clinical onset, often affecting animals submitted to stressful situations. Clinical signs are mainly neurologic due to meningoencephalitis and cortical necrosis. The involvement of the spinal cord has also been reported, however in BoHV-1 associated disease only. The aim of this report is to describe an outbreak of bovine meningoencephalomyelitis associated to BoHV-5.Case: In August 2017, nine 1-year-old calves died in a beef cattle farm with a flock of approximately 400 bovines. The animals presented neurological clinical signs characterized by excessive salivation, nasal and ocular discharges, incoordination, apathy, head tremors, head pressing, wide-based stance, recumbency followed by convulsions and paddling. According to the owner and referring veterinarian, affected animals displayed severe clinical signs with rapid progression and often leading to death in up to seven days. Four of these calves were submitted for necropsy, and gross lesions were present in the brain, characterized by mild to moderate multifocal hemorrhagic and soft areas. On cut surface, extensive areas of dark brown discoloration and malacia were observed. Histologically, lesions were characterized by extensive areas of liquefactive necrosis in the cerebral cortex grey matter, associated with inflammatory infiltrates composed of neutrophils, lymphocytes, plasma cells and foamy macrophages, as well as multifocal to coalescing areas of hemorrhage and fibrin deposition. Intranuclear eosinophilic inclusion bodies were rarely observed in neurons and astrocytes. On leptomeninges, there was diffuse inflammatory infiltrates of lymphocytes and plasma cells.[...](AU)


Assuntos
Animais , Bovinos , Meningoencefalite/diagnóstico , Meningoencefalite/veterinária , Herpesvirus Bovino 5 , Infecções por Herpesviridae/veterinária , Encefalite Viral/veterinária , Brasil
19.
Pesqui. vet. bras ; 38(5): 902-912, May 2018. tab, graf, ilus
Artigo em Português | VETINDEX | ID: vti-19533

Resumo

Foram estudados 26 casos de meningoencefalite por herpesvírus bovino (BoHV) diagnosticados entre 2010-2016, no Estado de Goiás (GO). A doença acometeu principalmente bovinos jovens, entre 60 dias a 18 meses de idade. Não houve associação entre os casos e o sexo dos bovinos e a sazonalidade. A doença foi observada em todas as cinco Mesorregiões do Estado, com uma frequência maior nas Mesorregiões Sul e Centro. Os sinais clínicos mais frequentemente observados incluíram cegueira, incoordenação, sialorreia e ataxia. As principais alterações macroscópicas observadas incluíram congestão com tumefação e achatamento das circunvoluções, amolecimento e amarelamento do córtex telencefálico e focos de hemorragia. Em cinco encéfalos, não foram observadas alterações macroscópicas e em quatro as alterações não foram informadas. As principais alterações histológicas ocorreram no córtex telencefálico, principalmente o córtex frontal e parietal, mas em alguns casos, lesões de menor intensidade foram também observadas no tálamo, núcleos basais, mesencéfalo, ponte, bulbo, cerebelo e hipocampo. Todos os casos apresentaram meningoencefalite linfoplasmocítica e corpúsculos de inclusão intranucleares basofílicos em astrócitos e, eventualmente, em neurônios. Outras lesões frequentes incluíram necrose neuronal laminar segmentar (neurônio vermelho), espongiose, tumefação do núcleo das células endoteliais, gliose focal ou difusa, hipertrofia de astrócitos, infiltração por células gitter, congestão e hemorragia. Lesões menos comuns incluíram astrócitos Alzheimer tipo II, lesão residual e neuronofagia. A necrose neuronal e o edema (espongiose) foram mais acentuados nas camadas granular externa, molecular, de células piramidais e granular interna dos telencéfalos. Tanto os giros quanto os sulcos foram afetados igualmente. Dos 26 casos, o DNA de BoHV-5 foi amplificado em dois (7,69%) casos, enquanto que o de BoHV-1 foi identificado em um caso (3,84%)...(AU)


Twenty six cases of bovine herpetic meningoencephalitis diagnosed from 2010-2016 in Goiás state, Brazil, were studied. Affected cattle were mainly 60-day to 18-month-old. There was no association of the disease with sex and seasonality. The disease was found in all five mesoregions with a higher prevalence in southern and central state of Goiás. Clinical signs more frequently observed included blindness, incoordination, circling, excessive salivation, and ataxia. Main gross findings in the brain were congestion with swelling and flattening of gyri, softening and yellow discoloration of cerebral cortex and hemorrhagic foci. In five cases no gross changes were observed in the brain and in four cases there is no information. The main histopathological changes were in the cortex of telencephalic lobes, especially the frontal and parietal; however less prominent and less frequently found lesions occurred in the thalamus, basal nuclei, midbrain, pons, medulla oblongata, cerebellum, and hippocampus. All cases presented lymphoplasmocytic meningoencephalitis and intranuclear basophilic inclusion bodies in astrocytes, less commonly in neurons. Other frequent lesions included segmental laminar neuronal necrosis (red neurons), spongiosis, swollen vascular endothelial nuclei, gliosis (focal and diffuse), hypertrophy of astrocytes, infiltration of gitter cells, congestion, and hemorrhage. Lesions less frequently observed were Alzheimer type II astrocytes, residual lesion and neuronophagia. The most frequently affected cortical layers by neuronal necrosis and edema were external and internal granular, molecular, and pyramidal cell layers. Gyri and sulci were equally affected. Of the 26 cases, in 2 (7.69%) the DNA of BoHV-5 was amplified with samples fixed in 10% formalin and paraffin-embedded. DNA of BoHV-1 was identified in another case (3.84%) where, positive to BoHV-1, fresh samples were used.(AU)


Assuntos
Animais , Bovinos , Bovinos/anormalidades , Bovinos/lesões , Encefalite por Herpes Simples/veterinária , Encefalite por Herpes Simples/epidemiologia , Noxas , Brasil
20.
Acta sci. vet. (Impr.) ; 45(suppl.1): Pub.238-2017. ilus
Artigo em Português | VETINDEX | ID: biblio-1457783

Resumo

Background: The presence of macroscopic concretions in the urinary system is called urolithiasis. In horses the occurrence is rare. The calculi are generally large and unique spicule concretions, composed of calcium carbonate crystals. Less commonly, the concretions are of mixed crystals of calcium carbonate and of calcium phosphate. The aim of the this work was to report a case of obstructive urethrolithiasis in a horse.Case: A 1-year-and-5-month-old, undefined breed, uncastrated male presented tenesmus, strangury, and dysuria. The horse died seven days after the onset of clinical signs and was referred for necropsy. At necropsy, samples were collected from organs of the abdominal cavity, thoracic cavity, central nervous system and integumentary system. The fragments were fixed in 10% formaldehyde, cleaved, routinely processed for histology and stained with hematoxylin and eosin. A urinary calculus collected during necropsy was sent for chemical analysis. In the abdominal cavity, a large quantity of citrus liquid of uremic odor was observed. Deposition of fibrin filaments in the peritoneum was observed, as well as in diaphragm and abdominal organs. Serosa of the small and large intestine was red with evidence of the capillaries. Kidneys presented multiple slightly protrusive white areas with a maximum diameter of 3 mm. When cutting, these areas were limited to the cortical region. There was rupture of the urinary bladder, diffuse loss of the mucosa with capillary exposure and evidence, as well as the deposition of fibrin and crude blood clots. The opening of the penile urethra presented a urolith of approximately 3.5 x 3 cm in size, with a rough and porous surface, light brown and of a stony consistency. Necrosis of the mucosa and hemorrhage were also observed in the urethra....


Assuntos
Animais , Cavalos , Doenças Urológicas , Estruvita , Obstrução Uretral/veterinária
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