Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
Mais filtros

Tipo de documento
Intervalo de ano de publicação
1.
J. Venom. Anim. Toxins incl. Trop. Dis. ; 20: 1-6, 2014. graf, ilus
Artigo em Inglês | VETINDEX | ID: vti-10977

Resumo

Hump-nosed viper bites are frequent in southern India and Sri Lanka. However, the published literature on this snakebite is limited and its venom composition is not well characterized. In this case, we report a patient with thrombotic thrombocytopenic purpura-like syndrome following envenoming which, to the best of our knowledge, has not been reported in the literature before. A 55-year-old woman from southern Sri Lanka presented to the local hospital 12 hours after a hump-nosed viper (Hypnale hypnale) bite. Five days later, she developed a syndrome that was characteristic of thrombotic thrombocytopenic purpura with fever, thrombocytopenia, microangiopathic hemolysis, renal impairment and neurological dysfunction in the form of confusion and coma. Her clinical syndrome and relevant laboratory parameters improved after she was treated with therapeutic plasma exchange. We compared our observations on this patient with the current literature and concluded that thrombotic thrombocytopenic purpura is a theoretically plausible yet unreported manifestation of hump-nosed viper bite up to this moment. This study also provides an important message for clinicians to look out for this complication in hump-nosed viper bites since timely treatment can be lifesaving.(AU)


Assuntos
Animais , Venenos de Víboras/análise , Mordeduras de Serpentes/complicações , Púrpura Trombocitopênica Trombótica , Toxicophis pugnax/análise
2.
J. venom. anim. toxins incl. trop. dis ; 20: 1-6, 04/02/2014. graf, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1484581

Resumo

Hump-nosed viper bites are frequent in southern India and Sri Lanka. However, the published literature on this snakebite is limited and its venom composition is not well characterized. In this case, we report a patient with thrombotic thrombocytopenic purpura-like syndrome following envenoming which, to the best of our knowledge, has not been reported in the literature before. A 55-year-old woman from southern Sri Lanka presented to the local hospital 12 hours after a hump-nosed viper (Hypnale hypnale) bite. Five days later, she developed a syndrome that was characteristic of thrombotic thrombocytopenic purpura with fever, thrombocytopenia, microangiopathic hemolysis, renal impairment and neurological dysfunction in the form of confusion and coma. Her clinical syndrome and relevant laboratory parameters improved after she was treated with therapeutic plasma exchange. We compared our observations on this patient with the current literature and concluded that thrombotic thrombocytopenic purpura is a theoretically plausible yet unreported manifestation of hump-nosed viper bite up to this moment. This study also provides an important message for clinicians to look out for this complication in hump-nosed viper bites since timely treatment can be lifesaving.


Assuntos
Animais , Mordeduras de Serpentes/complicações , Púrpura Trombocitopênica Trombótica , Venenos de Víboras/análise , Toxicophis pugnax/análise
3.
Artigo em Inglês | VETINDEX | ID: vti-443074

Resumo

Many toxins from scorpion venoms cause neurotransmitters release by activating the autonomic system. The aim of the present work was to determine osmotic fragility of red blood cells (RBCs) and serum biochemical changes produced by the venom of Odonthobuthus doriae (O. doriae), a dangerous species of scorpion in Iran. For this study we selected 2 groups, each one containing 10 New Zealand white rabbits weighing 2 ± 0.2 kg. In vivo and in vitro osmotic fragilities as well as packed cell volume (PCV) were determined. Serum was separated and used for determination of glucose, blood urea nitrogen (BUN), creatinine, uric acid (UA), triglycerides, cholesterol, aspartate aminotransferase (AST, EC 2.6.1.1), and alanine aminotransferase (ALT, EC 2.6.1.2). Results indicate that Odonthobuthus doriae venom (0.5 mg/kg, IV) causes a significant increase (p 0.05) of serum glucose, UA, PCV, ALT, and AST. Increase was also observed in BUN, but it was not statistically significant. On the other hand a significant decrease (p 0.05) was observed in triglycerides and cholesterol levels. Increased in vivo osmotic fragility of RBCs was significant too, but in vitro osmotic fragility did not show a significant change. These results support the hypothesis that the biochemical variation caused by scorpion venom can be due to an autonomic storm and release of catecholamines.

4.
J. venom. anim. toxins incl. trop. dis ; 12(1): 67-77, 2006. tab, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: lil-423835

Resumo

Many toxins from scorpion venoms cause neurotransmitters release by activating the autonomic system. The aim of the present work was to determine osmotic fragility of red blood cells (RBCs) and serum biochemical changes produced by the venom of Odonthobuthus doriae (O. doriae), a dangerous species of scorpion in Iran. For this study we selected 2 groups, each one containing 10 New Zealand white rabbits weighing 2 ± 0.2 kg. In vivo and in vitro osmotic fragilities as well as packed cell volume (PCV) were determined. Serum was separated and used for determination of glucose, blood urea nitrogen (BUN), creatinine, uric acid (UA), triglycerides, cholesterol, aspartate aminotransferase (AST, EC 2.6.1.1), and alanine aminotransferase (ALT, EC 2.6.1.2). Results indicate that Odonthobuthus doriae venom (0.5 mg/kg, IV) causes a significant increase (p<0.05) of serum glucose, UA, PCV, ALT, and AST. Increase was also observed in BUN, but it was not statistically significant. On the other hand a significant decrease (p<0.05) was observed in triglycerides and cholesterol levels. Increased in vivo osmotic fragility of RBCs was significant too, but in vitro osmotic fragility did not show a significant change. These results support the hypothesis that the biochemical variation caused by scorpion venom can be due to an autonomic storm and release of catecholamines.(AU)


Assuntos
Animais , Coelhos , Venenos de Escorpião/análise , Fenômenos Bioquímicos , Nitrogênio da Ureia Sanguínea , Técnicas In Vitro , Glucose , Fragilidade Osmótica , Intoxicação
5.
MEDVEP. Rev. cient. Med. Vet. ; 9(28): 13-23, jan.-mar. 2011. ilus
Artigo em Português | VETINDEX | ID: vti-1612

Resumo

Objetivou-se avaliar os sinais clínicos e cardiovascularesde cães após inoculação experimentaldo veneno do escorpião-amarelo, Tityus serrulatus. Doze cães adultos foram distribuídos em doisgrupos: controle (GI), animais inoculados com 0,5mL de placebo (PBS) por via subcutânea na facemedial da coxa esquerda; e envenenado (GII), animais inoculados com veneno liofi lizado de Tityusserrulatus(250μg/kg) diluído em PBS. Os animais foram examinados até 72h após o envenenamento,sendo aferidos parâmetros clínicos gerais e cardiovasculares por meio de eletrocardiogramas (ECG),ecocardiogramas (ECO), mensurações de pressão arterial sistólica (PAS) e radiografi as torácicas. Oscães envenenados(GII) manifestaram intensa dor no local de aplicação, sem lesões, até 11h após, comlambidas no local da administração do veneno, claudicação, suspensão do membro, difi culdade aodeitar, vocalização, letargia além das reações sistêmicas como, dor abdominal, vômitos, espirros, rinorréiae sialorréia. Não houve alterações de temperatura retal, das freqüências respiratória e cardíaca,nem à auscultação das áreas cardíaca e pulmonar.Um cão apresentou reação alérgica com edemana face e congestão de mucosas. A PAS média dos cães elevou-se entre 30 min e 12 horas após a inoculaçãodo veneno, comparando-se aos cães do GI. Não foram encontradas alterações deECG, ECO enas radiografi as torácicas. O efeito neurotóxico do veneno de T. serrulatus, promotor de liberação deneurotransmissores, foi elucidado pela reação adrenérgica de vasoconstrição, levando à hipertensão.A alta dose de veneno escorpiônico administrada aos animais maximizou o efeito doloroso local erevelou a resistência do cão frente à ausência de alterações cardiopulmonares(AU)


In order to observe the clinical effects of scorpion sting, 12 healthy mongrel male dogs were distributedin two groups, with six animals each: group I (control group) and group II (venom group).The lyophilized yellow scorpion (Tityus serrulatus) venom (250μg/kg) diluted in 0,5ml phosphatebuffered saline (PBS) was given to group II by subcutaneous injection, in the left forearm, medial face. Group I received only 0,5ml of PBS, by subcutaneous injection, in the left forearm, medial face. Both groupsunderwent clinical examination, with systemic cardiovascular parameters (including electrocardiogram, echocardiogramevaluation of arterial blood pressure and chest X-rays). After envenomation, until 11h, dogs from groupII showed several behavioral changes, such as the manifestation of intense local pain, sneezing, intense salivation,vomiting and abdominal pain.It was no observed alterations in the rectal temperature, cardiac and respiratory frequencyneither alterations after cardiac and pulmonary auscultation. One dog presented allergic reaction with faceedema and mucosa congest.In all animals from group II, the systolic blood pressure increased between 30min and12h when compared with group I (control). In both groups, no major change was observed in echocardiographyand in electrocardiography, except for slight sinus arrhythmia. The neurotoxic effect of T. serrulatusvenom, whichliberatesneurotransmissores, was elicited byadrenergic reaction of vasoconstrictioncausing hypertension. Thehigh dose of scorpion venom administrated to dogs maximized local pain and showed the dog resistance from theabsence of cardiopulmonary alterations(AU)


Assuntos
Animais , Cães , Venenos de Escorpião/efeitos adversos , Venenos de Escorpião , Cães , Sistema Cardiovascular
6.
Artigo em Português | VETINDEX | ID: biblio-1485401

Resumo

Objetivou-se avaliar os sinais clínicos e cardiovascularesde cães após inoculação experimentaldo veneno do escorpião-amarelo, Tityus serrulatus. Doze cães adultos foram distribuídos em doisgrupos: controle (GI), animais inoculados com 0,5mL de placebo (PBS) por via subcutânea na facemedial da coxa esquerda; e envenenado (GII), animais inoculados com veneno liofi lizado de Tityusserrulatus(250μg/kg) diluído em PBS. Os animais foram examinados até 72h após o envenenamento,sendo aferidos parâmetros clínicos gerais e cardiovasculares por meio de eletrocardiogramas (ECG),ecocardiogramas (ECO), mensurações de pressão arterial sistólica (PAS) e radiografi as torácicas. Oscães envenenados(GII) manifestaram intensa dor no local de aplicação, sem lesões, até 11h após, comlambidas no local da administração do veneno, claudicação, suspensão do membro, difi culdade aodeitar, vocalização, letargia além das reações sistêmicas como, dor abdominal, vômitos, espirros, rinorréiae sialorréia. Não houve alterações de temperatura retal, das freqüências respiratória e cardíaca,nem à auscultação das áreas cardíaca e pulmonar.Um cão apresentou reação alérgica com edemana face e congestão de mucosas. A PAS média dos cães elevou-se entre 30 min e 12 horas após a inoculaçãodo veneno, comparando-se aos cães do GI. Não foram encontradas alterações deECG, ECO enas radiografi as torácicas. O efeito neurotóxico do veneno de T. serrulatus, promotor de liberação deneurotransmissores, foi elucidado pela reação adrenérgica de vasoconstrição, levando à hipertensão.A alta dose de veneno escorpiônico administrada aos animais maximizou o efeito doloroso local erevelou a resistência do cão frente à ausência de alterações cardiopulmonares


In order to observe the clinical effects of scorpion sting, 12 healthy mongrel male dogs were distributedin two groups, with six animals each: group I (control group) and group II (venom group).The lyophilized yellow scorpion (Tityus serrulatus) venom (250μg/kg) diluted in 0,5ml phosphatebuffered saline (PBS) was given to group II by subcutaneous injection, in the left forearm, medial face. Group I received only 0,5ml of PBS, by subcutaneous injection, in the left forearm, medial face. Both groupsunderwent clinical examination, with systemic cardiovascular parameters (including electrocardiogram, echocardiogramevaluation of arterial blood pressure and chest X-rays). After envenomation, until 11h, dogs from groupII showed several behavioral changes, such as the manifestation of intense local pain, sneezing, intense salivation,vomiting and abdominal pain.It was no observed alterations in the rectal temperature, cardiac and respiratory frequencyneither alterations after cardiac and pulmonary auscultation. One dog presented allergic reaction with faceedema and mucosa congest.In all animals from group II, the systolic blood pressure increased between 30min and12h when compared with group I (control). In both groups, no major change was observed in echocardiographyand in electrocardiography, except for slight sinus arrhythmia. The neurotoxic effect of T. serrulatusvenom, whichliberatesneurotransmissores, was elicited byadrenergic reaction of vasoconstrictioncausing hypertension. Thehigh dose of scorpion venom administrated to dogs maximized local pain and showed the dog resistance from theabsence of cardiopulmonary alterations


Assuntos
Animais , Cães , Cães , Sistema Cardiovascular , Venenos de Escorpião , Venenos de Escorpião/efeitos adversos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA