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Purpose: To conduct a systematic literature review with meta-analysis to identify whether antibiotic prophylaxis after removal of the indwelling urinary catheter reduces posterior infections. Methods: A systematic literature review was conducted in the databases PubMed, Embase, Cochrane, Google Scholar, and Latin American and Caribbean Health Sciences Literature, using the keywords "antibiotics" AND "prostatectomy" AND "urinary catheter." Results: Three articles were identified having the scope of our review, with 1,040 patients, which were subjected to our meta-analysis revealing a marginally significant decrease in the risk of urinary infection after indwelling urinary catheter removal (odds ratio-OR = 0.51; 95% confidence interval-95%CI 0.27-0.98; p = 0.04; I2 = 0%). No difference was found regarding the presence of bacteriuria (OR = 0.39; 95%CI 0.12-1.24; p = 0.11; I2 = 73%). Conclusions: In our meta-analysis, there was a significant decrease in urinary tract infection with antibiotic prophylaxis after indwelling urinary catheter removal following radical prostatectomy.

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The potential of Alhagi maurorum (Boiss.) aqueous extract (AME), used in traditional medicine for treatment or prevention of urolithiasis, to dissolve calcium oxalate stones in vitro was evaluated. In order to determine the litholytic potential of the extract, Calcium oxalate urinary stones were incubated during 12 weeks under continuous shaking in the presence of AME, Rowanix or NaCl 9 g/mL solution were used as controls. After the incubation period, the residual weight of the treated calculi was determined and the rate of dissolution was calculated. The medium pH variation was measured and changes in the calcium oxalate crystals at the stone surface were assessed using a scanning electron microscope (SEM). The results showed a significant dissolution effect for the extract on the kidney calculi during the experimentation period. At the end of the experiment, the percentages of calculi weight decrease were 41.23, 4.97 and 55.67% for the extract, NaCl solution and Rowanix, respectively. Gas Chromatography analysis revealed mainly the presence of the following phyto-compounds: Cyclopropenone, 2,3-diphenyl; 1-Nonadecanol; methyl-alpha-D-mannopyranoside; cis-9-Hexadecenal. These compounds unarguably play crucial roles in the health care system especially in cancer treatment and many other diseases including urolithiasis. The urinary stone dissolution, independent of medium pH, could be attributed to formation of complexes between the phytochemical compounds in the extract and the calculi.

Foi avaliado o potencial do extrato aquoso (AME) de Alhagi maurorum (Boiss.), usado na medicina tradicional para tratamento ou prevenção de urolitíase, para dissolver cálculos de oxalato de cálcio in vitro. Para determinar o potencial litolítico do extrato, cálculos urinários de oxalato de cálcio foram incubados durante 12 semanas sob agitação contínua na presença de AME, Rowanix ou solução de NaCl 9 g/mL foram usados ​​como controles. Após o período de incubação, o peso residual dos cálculos tratados foi determinado e a taxa de dissolução foi calculada. A variação do pH médio foi medida e as alterações nos cristais de oxalato de cálcio na superfície da pedra foram avaliadas usando um microscópio eletrônico de varredura (MEV). Os resultados mostraram um efeito de dissolução significativo para o extrato sobre os cálculos renais durante o período de experimentação. Ao final do experimento, os percentuais de diminuição do peso dos cálculos foram de 41,23, 4,97 e 55,67% para o extrato, solução de NaCl e Rowanix, respectivamente. A análise por cromatografia gasosa revelou principalmente a presença dos seguintes fitocompostos: Ciclopropenona, 2,3-difenil; 1-Nonadecanol; metil-alfa-D-manopiranosídeo; cis-9-hexadecenal. Esses compostos indiscutivelmente desempenham papéis cruciais no sistema de saúde, especialmente no tratamento do câncer e de muitas outras doenças, incluindo urolitíase. A dissolução do cálculo urinário, independente do pH médio, pode ser atribuída à formação de complexos entre os compostos fitoquímicos do extrato e os cálculos.

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In recent years, avian medicine has advanced in the recognition of kidney diseases, but little is known about the morphology and renal morphometry of the common ostrich Struthio camelus Linnaeus, 1758. This study aimed to describe the morphometry and location of kidneys in the common ostrich. Twenty-six cadavers, aged one to seven days, which died of natural causes on a farm in the municipality of Magé, state of Rio de Janeiro, Brazil, were donated to the Department of Animal and Human Anatomy at the Universidade Federal Rural do Rio de Janeiro (UFRRJ). The specimens were identified, sexed, and fixed in a 10% aqueous solution of formaldehyde. The kidneys and renal divisions were measured using a precision digital caliper. The kidneys of S. camelus are elongated, and lobular, and have three renal divisions (cranial, middle, and caudal). The average length of the right kidney was 6.69 ± 0.83 cm, and the left kidney was 6.87 ± 0.81 cm. The body length correlated positively and significantly with the lengths of the right kidney (r = 0.8273, p = 0.0017) and left kidney (r = 0.8534, p = 0.0008) in females. The renal cranial limit was observed at the eighth lumbar vertebra (L8) in 22 kidneys (42.3%), and the caudal limit, at the eighth sacrocaudal vertebra (Sc8) in 11 kidneys (21.2%), and the second caudal vertebra (C2) in 11 kidneys (21.2%). The morphometric dimensions and skeletopy of the ostrich kidney contribute to the field of comparative avian anatomy and assist in the interpretation of imaging techniques.(AU)

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Background: Urethropreputial fistulas are communicative conduits between the urethra, prepuce, and environment whose origin deviates the urinary flow from its physiological path. The condition has a multifactorial cause and is considered uncommon in dogs. By the scarce occurrence of this malformation, as well as the scarcity of case reports on the subject, the present work aims to report a case of congenital urethropreputial fistula in a mixed breed dog and the surgical procedures performed to correct this genitourinary abnormality. In addition, it seeks to cross information available in the literature with the changes found during the case attendance. Case: An approximately 1-year-old male canine, mixed breed, was attended at the Veterinary Hospital of the Federal Rural University of Pernambuco (HOVET - UFRPE) with a complaint of dysuria, where the urinary flow occurred by dripping through an orifice caudal to the external urethral ostium. According to the tutor, the animal presented the condition since its adoption at 2 months old. The general physical examination did not show any changes in the physiological parameters. The mucous membranes were normal in color, the capillary refill time was 2 s, there was no pain or discomfort on superficial and deep palpation of the abdomen, and the heart and respiratory rates were within the range considered normal for the species. The specific examination found the existence of a fistula on the ventral aspect of the foreskin, whose resolution required a surgical intervention that consisted of obliteration of the fistula communication channel by suturing the defect using an absorbable suture thread. However, this was not effective in solving the problem of the animal, which returned to the hospital complaining of ischuria, leading to the need for 2 other surgical procedures: A scrotal urethrostomy, whose result was also inadequate due to the displacement of the urethral catheter given the postoperative conditions and the animal's temperament, and, to guarantee the proper functioning of the lower urinary tract, avoiding recurrences, a new urethrostomy dorsal to the first, in the perineal region, was performed. The animal did not present episodes of urinary retention after the third procedure and had a significant improvement in the condition in which it was before the initial treatment. Discussion: Urogenital anomalies are rare in dogs and can be acquired or congenital. With an etiology still not fully elucidated, the variety of fistula presentations indicates that the condition probably has multifactorial causes. The affection may be confused with hypospadias. However, in this case, the external urethral ostium is out of its anatomical location, and several other abnormalities are present, like cryptorchidism, intersexuality, and penile underdevelopment. The his-tory obtained through the anamnesis, associated with the absence of traumatic episodes in the region and other associated congenital alterations, leads to the understanding that it is a urethral fistula not associated with hypospadias and has a congenital origin. The failure of the first surgical intervention provides relevant data in search of the probable causes of fistula formation. The impossibility of urethral catheterization associated with ischuria consequent to the obliteration of the defect is indicative that the urethral path was blind-ended or with a significant reduction of the lumen, and the resulting increase in pressure can be considered a factor for the formation of the fistula.

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Clinical History: A 6-year-old spayed female Samoyed dog was presented to the Dermatology Service at Auburn University Veterinary Teaching Hospital (AUVTH) for a 6-month history of non-pruritic alopecia on the hips and back, with the skin turning black in those areas (Figures 1 and 2). The animal had a prior history of hypothyroidism (controlled at the time of evaluation) and a urinary tract infection. The dog was on levothyroxine, Interceptor plus, Nexgard, fish oil, and Royal Canin Veterinary Diet Adult Urinary SO Dry Dog Food. There was no travel history outside the Southern United States. This animal was cohoused with another healthy dog. Bloodwork was unremarkable and testing for Cushing's disease was negative. Skin scrapes, cytology, and dermatophyte and bacterial cultures were negative.(AU)

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The Caatinga biome is unique to Brazil, with unfavorable environmental characteristics for the survival of Leptospira spp. However, recent studies have shown high positivity at PCR (polymerase chain reaction) in small ruminants. There are no Leptospira spp. studies based on sample calculation in pigs in the Caatinga. The aim of this study was to assess the importance of pigs in the spread of leptospirosis in the Caatinga biome. Overall, 200 biological samples (urine, blood, vaginal fluid, and tissues of reproductive and urinary tracts) were collected from 40 slaughtered sows, and MAT (microscopic agglutination test) and PCR tests were carried out to detect anti-Leptospira spp. antibodies and the agent's DNA, respectively. The serological analysis showed a positivity rate of 5% (2/40), and the PCR identified Leptospira spp. DNA in 62.5% (25/40) of the animals. Only 2.5% (1/40) of the animals were positive for both techniques. The detected serogroups were Australis (50%) and Bataviae (50%), with antibody titers of 25 and 50. Leptospira spp. DNA was detected in 40% (16/40) of the reproductive tract samples, 32.5% (13/40) of the urinary tract, 32.5% (13/40) of the vaginal fluid and 30% (12/40) of the urine. There was no agreement (Kappa <0) between PCR samples from the genital tract vs. urinary tract or serological results. Genetic sequencing of one urine and one urinary tract tissue sample revealed 99% identity with L. borgpetersenii. The results indicate that leptospirosis is a concern in pigs in the context of Caatinga, with a high prevalence of infection detected by different diagnostic methods. The molecular analysis revealed a considerable proportion of infected animals. The findings emphasize the importance of a multifaceted approach in the diagnosis of leptospirosis in pigs, with a focus on the use of genital tract samples for the diagnosis of leptospirosis in this animal species, providing valuable insights for the control and prevention of this disease in both animals and the zoonotic context. Finally, the detection of leptospires in the genital tract indicates a possibility of male-female transmission in the venereal context.

O bioma Caatinga é único no Brasil, com características ambientais desfavoráveis à sobrevivência de Leptospira spp. Porém, estudos recentes demonstraram alta positividade na PCR (reação em cadeia da polimerase) em pequenos ruminantes. Não existem estudos para a infecção por Leptospira spp. baseados em cálculo amostral em suínos na Caatinga. O objetivo deste estudo foi avaliar a importância dos suínos na disseminação da leptospirose no bioma Caatinga. Foram coletadas 200 amostras biológicas (urina, sangue, fluido vaginal e tecidos do trato reprodutivo e urinário) de 40 porcas abatidas e realizados testes SAM (teste de soroaglutinação microscópica) e PCR para detecção de anticorpos anti-Leptospira spp. e DNA do agente, respectivamente. A análise sorológica mostrou taxa de positividade de 5% (2/40) e a PCR identificou o DNA de Leptospira spp. em 62,5% (25/40) dos animais. Apenas 2,5% (1/40) dos animais foram positivos para ambas as técnicas. Os sorogrupos detectados foram Australis (50%) e Bataviae (50%), com títulos de anticorpos de 25 e 50. O DNA de Leptospira spp. foi detectado em 40% (16/40) das amostras do trato reprodutivo, 32,5% (13/40) do trato urinário, 32,5% (13/40) do fluido vaginal e 30% (12/40) de urina. Não houve concordância (Kappa <0) entre amostras de PCR do trato genital vs. trato urinário ou resultados sorológicos. O sequenciamento genético de uma amostra de urina e de uma amostra de tecido do trato urinário revelou 99% de identidade com L. borgpetersenii. Os resultados obtidos indicam que a leptospirose representa uma preocupação em suínos no contexto da Caatinga, com alta prevalência de infecção detectada por diferentes métodos diagnósticos, bem como análises moleculares revelaram proporção considerável de animais infectados. Os resultados enfatizam a importância de uma abordagem multifacetada no diagnóstico da leptospirose em suínos, com foco no uso de amostras do trato genital para o diagnóstico da leptospirose nesta espécie animal, fornecendo informações valiosas para o controle e prevenção desta doença em animais e no contexto zoonótico. Por fim, a detecção de leptospiras no trato genital indica possibilidade de transmissão macho-fêmea no contexto venéreo.

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Gomphrena celosioides, popularly known as perpétua, perpétua brava, bachelor´s button and prostate globe amarahth, is used for the treatment of urinary tract disorders, kidney stones, for skin diseases, infectious diseases, gastrointestinal and respiratory conditions. Rich in phenolic acids and flavonoids, this plant has therefore a potential for use in cancer prevention. Given the above, the present research aimed to evaluate the carcinogenic effect of the ethanolic extract of G. celosioides (EEGc) in an alternative model of Drosophila melanogaster and the genotoxic and antigenotoxic effects in Swiss mice. The larval survival test and the detection of epithelial tumor clones were performed in D. melanogaster. The tested EEGc concentrations were 0.96, 1.92, 3.85 and 7.70 mg/mL. In Swiss mice, the genotoxicity and antigenotoxicity of doses of 100, 1,000 and 2,000 mg/Kg were evaluated. The results showed that EEGc at a concentration of 7.70 mg/mL reduced (p<0.05) larval survival. However, EEGc was not carcinogenic, and the lowest concentration (0.96 mg/mL) prevented (p<0.05) the basal occurrence of epithelial tumors. In mice, EEGc at the highest dose (2,000mg/Kg) increased the frequency of genomic lesions (p<0.05). Yet, none of the doses caused chromosomal lesions (p>0.05). When associated with cyclophosphamide, EEGc was antigenotoxic (p<0.05). The percentages of reduction of genomic damage ranged from 33.39 to 63.23% and of chromosomal damage from 20.00 to 77.19%. In view of the above, it is suggested that EEGc is not carcinogenic, has an antigenotoxic effect and chemopreventive properties.

Gomphrena celosioides, conhecida popularmente por perpétua, perpétua brava, bachelor´s button e prostate globe amarahth, é utilizada na medicina popular para o tratamento de distúrbios do trato urinário e pedra nos rins e para doenças de pele, infecciosas, gastrointestinais e respiratórias. Essa planta é rica em ácidos fenólicos e flavonóides e, portanto, tem potencial para uso na prevenção de câncer. Frente ao exposto, a presente pesquisa teve por objetivo avaliar o efeito carcinogênico do extrato etanólico de G. celosioides (EEGc) em modelo alternativo de Drosophila melanogaster e os efeitos genotóxicos e antigenotóxicos em camundongos Swiss. Em D. melanogaster foi realizado o teste de sobrevivência larval e para a detecção de clones de tumores epiteliais. As concentrações testadas do EEGc foram de 0,96, 1,92, 3,85 e 7,70 mg/mL. Em camundongos Swiss avaliou-se a genotoxicidade e antigenotoxicidade das doses de 100, 1.000 e 2.000 mg/Kg. Os resultados demonstraram que o EEGc na concentração de 7,70 mg/mL reduziu (p<0,05) a sobrevivência larval. No entanto, o EEGc não é carcinogênico e a menor concentração (0,96 mg/mL) preveniu (p<0,05) a ocorrência basal de tumores epiteliais. Nos camundongos o EEGc na maior dose (2.000mg/Kg) aumentou a frequência de lesões genômicas (p<0,05). Porém, nenhuma das doses causou lesões cromossômicas (p>0,05). Quando associado à ciclofosfamida o EEGc foi antigenotóxico (p<0,05). As porcentagens de redução de danos genômicos variaram de 33,39 a 63,23% e de danos cromossômicos de 20,00 a 77,19%. Frente ao exposto, sugere-se que o EEGc não é carcinogênico, tem efeito antigenotóxico e propriedade quimiopreventiva.

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Retrospective studies that address the diseases in the feline species are scarce. Herein, we presented the cause of death or euthanasia of cats from January 2020 to December 2021, during the first and second years of the SARS-CoV-2 pandemic. The data were obtained from necropsies performed by the Federal Rural University of Rio de Janeiro and the Federal University of Mato Grosso. A total of 96 feline necropsies were performed. In 87 cases (90.6%), we established the reason for death, while in nine cases (9.4%), the diagnoses were inconclusive. We established the diagnostic groups: infectious and parasitic (37.5%), neoplasm (14.5%), malformation (7.3%), lower urinary tract disease (7.3%), degenerative (6.2%), traumas (6.2%), other causes (8.4%) and iatrogenic (3.1%). The most common cat diseases in Mato Grosso and Rio de Janeiro were infectious. The most common inflammatory lesions were bacterial and viral pneumonia. Alphaherpesvirus (FeHV), Mycoplasma sp., and Pseudomonas sp. were the main detected agents.

Estudos retrospectivos que abordam doenças em felinos domésticos são escassos. Apresentamos aqui a causa da morte ou razões para eutanásia de gatos domésticos entre janeiro de 2020 e dezembro de 2021, durante o primeiro e segundo ano da pandemia de SARS-CoV-2. Os dados foram obtidos em necropsias realizadas pela Universidade Federal Rural do Rio de Janeiro e Universidade Federal de Mato Grosso. Foram realizadas 96 necropsias de felinos. Em 87 casos (90,6%) foi estabelecido a causa da morte e em nove casos (9,4%) os diagnósticos foram inconclusivos. Estabelecemos os grupos diagnósticos: infecciosos e parasitários (37,5%), neoplasias (14,5%), malformações (7,3%), doenças do trato urinário inferior (7,3%), degenerativas (6,2%), traumas (6,2%), outras causas (8,4%) e iatrogênicas (3,1%). As doenças mais frequentes em gatos do Mato Grosso e Rio de Janeiro foram as infecciosas. As lesões inflamatórias mais frequentes foram as pneumonias bacterianas e virais. Os principais agentes detectados foram Alphaherpesvirus (FeHV), Mycoplasma sp. e Pseudomonas sp.

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The present study was conducted to isolate and characterize bacteria from water and soil sample taken from the Lahore Canal at different sites i.e. Mall Road, Mohlanwal and Khera site. Isolated bacterial strains were identified on the basis of morphological and biochemical tests. Identification was confirmed by culturing bacteria on selective media. Antibiotic resistance test was also performed to observe the resistance of bacteria against different antibiotics. Blood agar test was performed for identification of different pathogenic bacteria. The result revealed that water and soil samples of Lahore Canal Lahore from different sites were contaminated with Escherichia coli, Salmonella sp., Vibrio sp., Bacillus spp., Enterococcus sp. and Staphylococcus spp. Due to presence of these pathogens, this water is not suitable for any domestic and irrigation use. Study also revealed that water of the Lahore Canal is harmful for human health as it is contaminated with bacteria that can cause severe disease e.g., Escherichia coli can cause gastroenteritis, Bacillus spp. can cause nausea and vomiting, Enterococcus may infect urinary tract, Salmonella sp. is responsible for Bacteremia, Staphylococcus spp. can cause mild fever and Vibrio sp. can be the reason of cholera. Thus it is rendered unfit for any kind of human use even other than drinking like swimming, bathing, washing etc., until and unless some remedial measures are employed to eradicate pathogenic microorganisms by WASA and LWMS according to standards of WHO. Similarly, it is quite harmful, when and where ever it is used for irrigation without proper treatment.

O presente estudo foi realizado para isolar e caracterizar bactérias de amostras de água e solo retiradas do Canal Lahore, em Lahore, em diferentes locais, ou seja, Mall Road, Mohlanwal e Khera. As cepas bacterianas isoladas foram identificadas com base em testes morfológicos e bioquímicos. A identificação foi confirmada por cultura de bactérias em testes de meios seletivos. O teste de resistência aos antibióticos também foi realizado para observar a resistência das bactérias a diferentes antibióticos. Foi realizado o teste de ágar sangue para identificar diferentes bactérias patogênicas. O resultado revelou que amostras de água e solo do Canal Lahore, Lahore, de diferentes localidades estavam contaminadas com Escherichia coli, Salmonella sp., Vibrio sp., Bacillus spp., Enterococcus sp. e Staphylococcus spp. Por causa da presença desses patógenos, essa água não é adequada para qualquer uso doméstico e de irrigação. O estudo revelou que a água do Canal Lahore é prejudicial à saúde humana, pois está contaminada com bactérias que podem causar doenças graves, por exemplo: Escherichia coli pode ocasionar gastroenterite; Bacillus spp. pode causar náuseas e vômitos; Enterococcus sp. pode infectar o trato urinário; Salmonella sp. é responsável pela bacteremia; Staphylococcus spp. pode causar febre leve; e Vibrio sp. pode ser a razão da cólera. Assim, torna-se imprópria para uso humano, como natação, banho, lavagem etc., até que algumas medidas corretivas sejam empregadas para erradicar microrganismos patogênicos por WASA e LWMS de acordo com os padrões da OMS. Da mesma forma, é bastante prejudicial, quando usada para irrigação sem tratamento adequado.

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A 2-year-old English bulldog presented history of recurrent lower urinary tract disease, refractory to treatment. The Complete Blood Count revealed lymphopenia, hyperproteinemia, and hyperglobulinemia, while urinalysis indicated leukocyturia and bacteriuria. On the abdominal ultrasound, the bladder had a focal wall thickening in its cranial portion, as well as irregular echogenicity and internal margins. A bladder surgical biopsy was performed, indicating the presence of follicular cystitis. Clinical signs disappeared after treatment with a combination of amoxicillin and clavulanic acid, NSAIDs, supplementation with cranberry extract associated with cat's claw (Uncaria tomentosa). Clinical follow-up 12 months after surgery showed remission at all clinical signs. Follicular cystitis in dogs was reported only once worldwide, this case report is the first in Brazil; thus, it may be considered in the differential diagnosis for patients with refractory and recurrent lower urinary tract disease.

Um Bulldog Inglês de 2 anos apresentou história clínica de doença recorrente do trato urinário inferior, refratária ao tratamento. O hemograma revelou uma discreta linfopenia, hiperproteinemia e hiperglobulinemia. Já a urinálise apontou leucocitúria e bacteriúria. Na ultrassonografia, a bexiga apresentava espessamento focal da parede da bexiga em porção cranial, ecogênica e margens internas irregulares. A biópsia cirúrgica da bexiga foi compatível com cistite folicular. Os sinais clínicos desapareceram após o tratamento com uma combinação de amoxicilina - ácido clavulânico, AINEs, suplementação alimentar de extrato de cranberry associado a unha de gato (fitoterápico da planta Uncaria tomentosa). O acompanhamento, 12 meses após a cirurgia, confirmou que o cão estava livre de sinais clínicos. A cistite folicular foi relatada apenas em 1 cão no mundo, sendo esse considerado o primeiro relato no Brasil. Essa enfermidade deve ser considerada um diferencial para pacientes com doença refratária do trato urinário inferior de longa data.

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The aims of this study were to search for the presence of bacterial and fungal growth in urine samples from cats with urethral obstruction, to identify the causative infectious agents, and to compare select clinical-laboratory parameters with urine culture results after urethral catheterization. Twenty-eight male cats were enrolled in this prospective study. Urethral catheterization was performed aseptically, and the catheter was maintained for 24-48 hours with a sterile closed collection system. No antibiotics were used during this period. The first urine sample was obtained at the time of presentation, and the second, 24-48 hours after catheter removal, both by cystocentesis. Two cats (7.1%) presented a positive bacterial urine culture on the first sample. The frequency of positive urine cultures in the second sample was 52.4% (11/21 cats). One third of bacterial pathogens were Gram-positive, one third were Gram-negative, and one third were mixed isolates. Fungal cultures were all negative. There was significant association of positive urine culture results with pyuria (P=0.0128). A high frequency of positive urine cultures after urinary catheter removal was observed, despite respecting the standards of care for urethral catheters. Still, these results should be interpreted with caution, since intermittent bladder flushing was performed disconnecting the collecting system, which may have represented a critical point for bacterial contamination. It is emphasized that urine cultures should be considered as follow up in cats with urethral obstruction, after urethral catheter removal.

Os objetivos deste estudo foram pesquisar a presença de crescimento bacteriano e fúngico em amostras de urina de gatos com obstrução uretral, identificar os agentes infecciosos causadores e comparar parâmetros clínico-laboratoriais selecionados com os resultados da urocultura após a cateterização uretral. Vinte e oito gatos machos foram incluídos neste estudo prospectivo. A sondagem uretral foi realizada de forma asséptica, e o cateter foi mantido por 24-48 horas, com um sistema de coleta fechado e estéril. Não foram utilizados antibióticos durante esse período. A primeira amostra de urina foi obtida no momento da admissão do felino, e a segunda 24-48 horas após a retirada do cateter, ambas por cistocentese. Dois gatos (7,1%) apresentaram urocultura bacteriana positiva na primeira amostra de urina. A frequência de culturas de urina positivas na segunda amostra foi de 52,4% (11/21 gatos). Um terço das bactérias isoladas eram Gram-positivas, um terço eram Gram-negativas e um terço eram infecções mistas. As culturas fúngicas foram todas negativas. Houve associação significativa das uroculturas positivas com presença de piúria (P=0,0128). Observou-se alta frequência de uroculturas positivas após a retirada do cateter urinário, apesar de se respeitarem as diretrizes de cuidados com os cateteres uretrais. Ainda assim, esses resultados devem ser interpretados com cautela, pois a lavagem vesical intermitente foi realizada desconectando o sistema coletor, o que pode ter representado um ponto crítico para contaminação bacteriana. Ressalta-se que as uroculturas devem ser consideradas como acompanhamento em gatos com obstrução uretral, após a retirada do cateter uretral.

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Background: Ectopic ureter is a congenital abnormality that may be bilateral or unilateral and affects mainly young animals of both sexes, in which the ureter does not drain naturally into the trigone of the bladder. This is due to the abnormal differentiation of the mesonephric and metanephric ducts in the embryonic stage. The most common clinical signs are incontinence and urinary infection. This case report describes the surgical technique of ureteroneocystostomy (UNC), as well as the postoperative therapeutic approach in a case of bilateral extramural ectopic ureter in a bitch Pitbull. Case: A 10-month-old bitch Pitbull, weighing 31 kg, with a 6-month history of pollakiuria, urinary incontinence and recur-rent urinary infection was diagnosed with an extramural ectopic ureter by means of excretory urography. Preoperative tests included complete blood count, biochemical parameters (ALT, albumin, urea, creatinine, calcium, phosphorus), urinalysis, urine culture and antibiogram, urinary protein creatinine (UPC) ratio and abdominal ultrasound. After completing the complement tests, the patient was subjected to surgery to correct the anatomical course of her ureters, using the ureteroneocystostomy technique. The patient received general inhalation anesthesia, a median celiotomy was performed from the xiphoid cartilage to the pubis, and the ureters were identified. Both ureters were found to be inserted in the urethra, so their distal portion was tied off with 3-0 polydioxanone suture. After this, a cystotomy was performed to implant the ureters in the region of the vesical trigone by suturing them into the bladder mucosa with 5-0 polydioxanone suture in a simple interrupted pattern. This procedure was initially performed on the left ureter, which was dilated, followed by the right ureter, which was normal. Cystorraphy was performed using two suture patterns, a simple continuous pattern and a Cushing pattern with 3-0 polydioxanone suture. Cheilorrhaphy was performed using nylon suture in a sultan pattern, the subcutaneous tissue was closed in a simple continuous pattern using 3-0 polydioxanone suture and the skin in a wolf pattern using 3-0 nylon suture. The patient remained hospitalized for 48 h postoperatively, presenting good evolution of healing. Signs of urinary incontinence persisted for a week after surgical intervention, thereafter gradually returning to normality. Two months after the surgical procedure, the patient under-went a new excretory cystourethrography, which showed bladder fullness and normal topographical anatomy of the ureters. Discussion: Ureteral ectopy is the most frequent cause of urinary incontinence in puppies, especially females. Although the history and clinical signs of a patient lead to suspicion of ectopic ureter, imaging tests are indispensable for diagnostic confirmation. In the patient of this case report, an excretory urography was essential to locate the urethral termination and insertion, thus allowing the urethral ectopy to be classified as extramural. The surgical technique selected here was uretero-neocystostomy, which allowed the proper insertion of the ureters into the urinary bladder in anatomical topography, followed by a satisfactory response in urinary continence and bladder fullness, despite urinary incontinence in the postoperative period. Factors such as early diagnosis, functional viability of the urinary tract, application of the appropriate surgical technique and strict postoperative management were essential for the therapeutic success of the ectopic ureter surgery. It was concluded that the ureteroneocystostomy technique with transverse transection for the correction of extramural ectopic ureter was a satisfactory procedure, proving to be feasible and adequate for restoring normal urinary flow.

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This study aims to analyze the effects of multimodal environmental modification (MEMO) of cats with recurrence of lower urinary tract signs (LUTS). Treatment of FLUTD included pharmacological treatment, dietary management, and multimodal environmental modification approaches. Twenty client-owned indoor-housed cats with recurrence of lower urinary tract signs had been covered in this observation. Diagnosis of lower urinary tract was made primarily based on the cat's clinical signs, results of laboratory parameters, urinalysis and ultrasonographic examination. Cats were divided into two groups as cefovecin (8 mg/kg sc, single time use) + meloxicam (0.1mg/kg q24h, 3 days) + dry food including l-tryptophan and milk protein hydrolysate to dissolve struvite stones (Group 1) and cefovecin + meloxicam + dry food including l-tryptophan and milk protein hydrolysate to dissolve struvite stones + multimodal environmental modification (Group 2). Clinical and urinary parameters are scored as 0, 1, 2, 3 or 4 points on initial, third, seventh days. Scores of clinical parameters were significantly different between (p<0.05) group 2 and group 1 on the third and seventh days and scores of urinary parameters are significantly different between (p<0.05) group 2 than group 1 on the seventh day. Clients who were contacted after 1 year reported that they did not see any clinical signs of urinary tract diseases.

Este estudo tem como objetivo avaliar os efeitos da modificação ambiental multimodal (MEMO) em gatos com recorrência de sinais do trato urinário inferior (LUTS). O tratamento da FLUTD incluiu tratamento farmacológico, controle dietético e abordagens de modificação ambiental multimodal. Vinte gatos de propriedade de clientes, alojados em ambientes fechados, com recorrência de sinais do trato urinário inferior foram incluídos nessa observação. O diagnóstico do trato urinário inferior foi feito principalmente com base nos sinais clínicos do gato, nos resultados dos parâmetros laboratoriais, na urinálise e no exame ultrassonográfico. Os gatos foram divididos em dois grupos: cefovecina (8 mg/kg sc, uso único) + meloxicam (0,1mg/kg q24h, 3 dias) + ração seca incluindo l-triptofano e hidrolisado de proteína do leite para dissolver cálculos de estruvita (Grupo 1) e cefovecina + meloxicam + ração seca incluindo l-triptofano e hidrolisado de proteína do leite para dissolver cálculos de estruvita + modificação ambiental multimodal (Grupo 2). Os parâmetros clínicos e urinários foram pontuados como 0, 1, 2, 3 ou 4 pontos no primeiro, terceiro e sétimo dias. As pontuações dos parâmetros clínicos foram significativamente diferentes entre (p<0,05) o grupo 2 e o grupo 1 no terceiro e sétimo dias, e as pontuações dos parâmetros urinários foram significativamente diferentes entre (p<0,05) o grupo 2 e o grupo 1 no sétimo dia. Os clientes que foram contatados após um ano relataram que não observaram nenhum sinal clínico de doenças do trato urinário.

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Background: The urinary tract is composed by kidneys, urinary bladder and urethra. The kidneys produce urine that achieve urinary bladder by ureters. These have the origin in the renal pelvis, run through the retroperitoneum, end up at the dorsolateral superficies of the urinary bladder, and empty at the trigone. Ureters abnormalities are the rarest congenital defects in the canine urinary tract and ureteroceles are cystic dilatations of the distal segment of the ureter that could be associated to partial or complete urinary obstructions and could lead to megaureter and hydronephrosis. So, the aim of the present study was to describe a case of megaureter by intramural ureteral ectopia in a bitch. Case: A 1-year-old-and-8-month bitch Akita, weighing 18 kg, was referred to the Uniube Veterinary Hospital with vaginal secretion, prostration, hypodipsia, hyporexia and pyrexia related by the tutor. On physical examination, an increase in vulva volume and a vaginal discharge were observed. Nevertheless, others physical exams, blood count and biochemical tests were considered to be within normal parameters. Urinalysis showed cloudy aspect, proteinuria, occult blood, erythrocytes, pyuria, leucocytes, and discreet presence of bacteria. Abdominal ultrasonography revealed a megaureter with right uterocele and excretory urography showed absence of glomerular filtration by right kidney. The patient was submitted to surgery for right kidney and ureter exeresis. Histopathology evaluation showed intense dilation of the ureter and severe multifocal renal fibrosis. The surgery was well succeeded, and the patient recovered completely. Discussion: Once megaureter are associated with congenital abnormalities like ectopic ureter and ureterocele, it is usually diagnosed in young patients with medium age of 10 months, which is below the age of the patient in this case report. Additionally, in the patient here reported, the unilateral alteration could explain the absence of kidney fail symptoms. In more than 90% of the cases, the ureteral ectopia was associated with multiple anomalies in the urinary tract, as was observed in this patient, that presented besides ectopic ureter, ureterocele, megaureter and renal dystrophy. All these morphological alterations made impossible the complete urine elimination, which predispose to urinary tract infection, that was observed in this report. According to literature, urinary tract anomalies are associated with infection in 64 to 85% and 50% of the cases also present hydronephrosis and hydroureter. It was also described that ureteral ectopia is diagnosed by visualization of hydroureter in abdominal ultrasonography. The findings present in this report differs a little, once the right kidney was atrophic possibly by malformation or even so by a chronic renal lesion due to the difficulty in urine flow. The excretory urography showed no filtration in the right kidney, indicating non-functionality that was confirmed by histopathology, in which was observed small glomerulus and large amount of connective tissue deposition. In cases of unilateral megaureter with ipsilateral kidney commitment, there is indication of nephroureterectomy, that was performed in the patient of the present report. As far as we know, this is the first report of megaureter, ureterocele and ectopia ureteral together in the same patient. In conclusion, the procedure was secure, efficient and promote a better quality of life for the patient and prevent the recurrence of urinary tract infections.

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A equinocultura consiste numa importante atividade do agronegócio brasileiro, movimentando bilhões ao ano e gerando empregos diretos e indiretos. Considerada a raça equina mais numerosa do país, a criação de Mangalarga Marchador se concentra, em especial, no estado de Minas Gerais. Deste modo, este estudo teve como objetivo explorar o cenário clínico-reprodutivo da raça Mangalarga Marchador no Norte de Minas Gerais a fim de compreender o perfil da criação nesta mesorregião. Para isso, foi realizada a aplicação de questionário online, o qual foi preenchido mediante aceite prévio do Termo de Consentimento Livre e Esclarecido. A amostra foi composta por 52 criadores e os resultados obtidos foram submetidos à análise de frequência pelo teste qui-quadrado. Dentre os dados obtidos, 38% dos criadores relataram o lazer como finalidade de criação (p=0,53). Com relação ao método de acasalamento, 40% informaram a utilização da monta dirigida. Contudo, a maioria (58%; p<0,01) realiza a inseminação artificial, sendo que destes, 62% utilizam o sêmen fresco (p<0,01). Além disso, 51,92% relataram a realização da transferência de embriões (p=0,78). Com relação às enfermidades reprodutivas, o aborto, em fêmeas, e a hérnia inguinal, em machos, foram mais prevalentes com 39,13% (p<0,01) e 83,33% (p<0,01), respectivamente. Foi constatada ainda prevalência da assistência técnica por médico veterinário (86,53%; p<0,01) com periodicidade, em sua maioria, mensal (16,55%; p<0,01). Portanto, é possível inferir que a região do Norte do estado requer melhorias no manejo sanitário-reprodutivo voltado à raça Mangalarga Marchador para que a eficiência reprodutiva desejada seja alcançada.

Equinoculture is an important activity of Brazilian agribusiness, moving billions a year and generating direct and indirect jobs. Considered the most numerous equine breed in the country, Mangalarg Marchador breeding is concentrated, especially, in the Minas Gerais state. Therefore, this study aimed to explore the clinical and reproductive scenario of the Mangalarga Marchador breed in the Northern Minas Gerais region to understand the breeding profile in this mesoregion. For this purpose, an online questionnaire was applied, which was completed upon prior acceptance of the Free and Informed Consent Form. The sample consisted of 52 breeders and the results obtained were subjected to frequency analysis by chi-square test. Among the data obtained, 38% of breeders reported leisure as the breeding purpose (p=0.53). Regarding the mating method, 40% reported the use of controlled cover. However, the majority (58%; p<0,01) performs artificial insemination, of which 62% use semen fresh (p<0.01). In addition, 51.92% reported the practice of embryo transfer (p=0,78). Regarding reproductive diseases, abortion, in females, and inguinal hernia, in males, were more prevalent with, 39.13% (p<0.01) and 83.33% (p<0.01), respectively. There was also remarkable technical assistance by veterinarians (86.53%; p<0.01) with monthly periodicity (16.55%; p<0.01). Therefore, it is possible to infer that the northern region of Minas Gerais requires improvements in sanitary-reproductive management applied to the Mangalarga Marchador breed to achieve the desired reproductive efficiency.

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This study aimed to characterize the reproductive biology of Hyphessobrycon heterorhabdus, and its response to environmental variations in the Eastern Amazon streams. We sampled specimens every two months, between March 2019 and January 2020. The population was evaluated for sex ratio, reproductive activity, growth pattern, condition factor, size at the first sexual maturation, spawning type, and fecundity. We analyzed 180 specimens, which showed a sex ratio of 1.6 males for each female across the whole period, with 2.3 males for each female during the period of greatest reproductive activity. The peak of reproductive activity coincided with higher precipitation periods and was partially predicted by factors such as water temperature, stream discharge, dissolved oxygen, substrate complexity, and electrical conductivity. The length where 50% and 100% of population to reach sexual maturity was 18.0 and 22.0 mm for males and 19.7 and 27.0 mm for females. The oocyte diameters showed a bimodal frequency, with at least two batches of oocytes. The average fecundity of 197 oocytes. The results indicate that this species presents an opportunistic strategy, and the tactics that make up this strategy depend on variations in both the physical structure of the habitat and physicochemical aspects of the water.(AU)

Este estudo teve como objetivo caracterizar a biologia reprodutiva de Hyphessobrycon heterorhabdus e sua resposta às variações ambientais em riachos da Amazônia Oriental. Os espécimes foram amostrados bimestralmente, entre março de 2019 e janeiro de 2020. A população foi avaliada quanto à razão sexual, atividade reprodutiva, padrão de crescimento, fator de condição, tamanho na primeira maturação sexual, tipo de desova e fecundidade. Foram analisados 180 exemplares, que apresentaram proporção sexual de 1,6 machos para cada fêmea durante todo o período, com 2,3 machos para cada fêmea no período de maior atividade reprodutiva. O pico da atividade reprodutiva coincidiu com períodos de maior precipitação sendo parcialmente predito por fatores como temperatura da água, vazão, oxigênio dissolvido, complexidade do substrato e condutividade elétrica. O comprimento onde 50% e 100% da população atingiram a maturidade sexual foi de 18,0 e 22,0 mm para os machos e 19,7 e 27,0 mm para fêmeas. Os diâmetros dos oócitos apresentaram frequência bimodal, com pelo menos dois lotes. A fecundidade média da espécie foi de 197 oócitos. Os resultados indicam que a espécie possui uma estratégia oportunista, onde as táticas que compõem esta estratégia dependem tanto de variações na estrutura física do habitat quanto de aspectos físico-químicos da água.(AU)

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Background: Diagnostic imaging is an integral part of the examination of patients with urinary tract pathologies and many imaging modalities are available. Owing to easy accessibility and low cost, radiography used together with ultrasonography as one of the first-step imaging methods in order to visualize the urinary system. Contrast-enhanced radiographic examination of the upper urinary system "intravenous urography" (IVU) can be performed with bolus injection, abdominal compression (with bolus injection) and infusion techniques. The aim of present study was to evaluate the urograms obtained in cats with urinary system complaints, compare the application of the IVU techniques and urogram quality, and interpret their diagnostic efficacy. Materials, Methods & Results: A total of 30 cats (of different age, breed, sex and weight) with urinary system complaint brought to Selcuk University Veterinary Faculty and Balikesir University Veterinary Faculty Surgery Clinics were included in the study. The cats were randomly divided into 3 groups with 10 cats in each group. In these groups, IVU was performed with bolus (Group 1), infusion (Group 2) and abdominal compression with bolus injection (Group 3) techniques. Non-ionic monomeric contrast agent iohexol3 (300 mg I/mL, GE Healthcare) at a dose of 800 mg I/kg was administered as an IV bolus injection in the Bolus group; iohexol at a dose of 1200 mg I/kg was diluted in an equal volume of 0.9% NaCl solution and the prepared solution was administered as an IV infusion through the catheter within 10 min in the Infusion group; iohexol at a dose of 800 mg I/kg was administered through the catheter after an elastic compression band was placed around the caudal abdomen to provide compression on the ureters in the bolus injection with abdominal compression group. The contrast agent (iohexol) injection was well tolerated by all cats. None of the cats developed anaphylactoid reactions or anesthesia-related complication. Changes observed in the heart and respiration rates and body temperature during the procedure did not show a statistically significant difference between the groups (P > 0.05). The renal and ureteral opacity scores and groups were compared, there was a significant difference was observed (P < 0.05). Urograms with "1 point" and "2 points" in kidney opacity scores were in the bolus injection group; urograms with "3 points" and "4 points" showed a statistically significant increase in the infusion and abdominal compression groups (P < 0.05). Urograms with "2 points" and "3 points" in ureteral opacity scores did not show a statistically significant difference (P > 0.05). Discussion: Currently, radiological IVU can still be used as a feasible, economical and valuable diagnostic tool with appropriate techniques, contrast agents and dose selection. For this purpose, patient preparation before IVU is very important to increase the interpretation ability of the urograms obtained. Sedation or anesthesia is not required to obtain better urograms. The bolus injection technique would be preferable for evaluating the anatomical position of the kidneys and observing the renal parenchyma. Urograms up to 20 min after the injection in the ventrodorsal (VD) position would be sufficient for proper observation of the nephrography phase. The infusion technique would be preferable for evaluating the collecting system. Urograms up to 20 min following the completion of the infusion in the VD position would be sufficient for proper observation of the pyelography phase and ureters. Urograms should be obtained in the VD and lateral positions for ureteral evaluation. Urograms taken after 5 or 40 min would be sufficient, depending on the ureteral part to be examined.

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Purpose: To evaluate the effects of deep resection of endometriosis in the posterior pelvic region on urodynamic parameters. Methods: A prospective observational study conducted with female patients diagnosed with deep pelvic endometriosis before and after endometriosis resection surgery. Clinical history, image exams, the Female Lower Urinary Tract Symptoms questionnaire, urodynamic examination, cystometry, and voiding study were evaluated. Results: Patients aged 30-39 years old, operative duration of 132.5 minutes, and 2.7 days of hospital stay. Uroflowmetry and cystometry showed tendency for an increase after the surgery in the flow duration, time to maximum flow, and first voiding desire and decreased residual volume and maximum cystometric capacity. Opening, maximum urinary flow, and maximum flow pressure decreased at T1, and the closing parameters increased, although statistically non significant. The variables decreased at T1 in the urodynamic, except for detrusor overactivity. Although we observed a reasonable number of low bladder compliance and abnormal bladder sensation, the results were maintained at T1. General scores for filling and incontinence showed a significant decrease after surgery. Conclusions: A significant response in the patient's perception of urinary function was demonstrated after surgery. It is observed that the surgical procedure did not affect the uroflowmetric and cystometric characteristics of the evaluated patients.

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Estudos recentes vêm demonstrando a eficácia de produtos naturais como agentes terapêuticos anti-tumorais, avaliando-se o mecanismo de ação frente a diferentes células neoplásicas na medicina humana e veterinária. Dentre eles, a cúrcuma, conhecida como açafrão, destaca-se por suas propriedades anti-inflamatórias, anti-proliferativas e pró-apoptóticas. A curcumina é o principal composto ativo da cúrcuma e possui efeito antiproliferativo e pró apoptótico satisfatório, já descrito em diferentes linhagens neoplásicas. Sua eficácia, quando associada a diversos quimioterápicos, tem sido avaliada na busca de aumentar seus efeitos e biodisponibilidade. No trato urinário, a bexiga é o órgão mais acometido por neoplasias, sendo 80% destas malignas, incluindo o carcinoma urotelial canino (CUB), que corresponde a cerca de 2% de todos os tumores malignos do trato urinário inferior e superior. Comumente apresentada como uma neoplasia invasiva de alto grau, localizada na região do trígono e metastática. Seu tratamento inclui excisão cirúrgica, quimioterapia, emprego de inibidores de cicloxigenase (COX), radioterapia, ou a combinação desses. Entretanto, a intervenção cirúrgica muitas vezes é inviabilizada pela localização da lesão. Além disso, estudos recentes demonstraram que esta neoplasia possui semelhança com CUB humano em diferentes aspectos, servindo como um modelo natural na busca de novas estratégias terapêuticas e diagnósticas. Abordamos a respeito do uso de curcumina na terapêutica do carcinoma de bexiga, buscando estimular o desenvolvimento de mais pesquisas acerca dessa temática.

Recent studies have demonstrated differences in the prevention of natural products as antitumor therapeutic agents, evaluating the mechanism of action against neoplastic cells in human and veterinary medicine. Among them, turmeric, known as turmeric, stands out for its anti-inflammatory, anti-proliferative and pro-apoptotic properties. Curcumin is the main active compound of turmeric and has a useful antiproliferative and proapoptotic effect, already described in different neoplastic strains. In the urinary tract, the bladder is the organ most affected by neoplasms, 80% of which are malignant, including canine urothelial carcinoma (CUB), which corresponds to about 2% of all malignant tumors of the lower and upper urinary tract. Comment presented as a high-grade invasive neoplasm, located in the trigone and metastatic region. Their treatment is excision by machines, COX cyclooxygenase inhibitors, radiation therapy, or most of them. However, the location is often made impossible by the lesion. In addition, modern and recent studies seek that this similar neoplasm has different characteristics, as a human UB model therapeutic strategy. We discussed the use of curcumin in the therapy of bladder carcinoma, seeking to stimulate the development of more research on this topic.

Estudios recientes han demostrado diferencias en la prevención de productos naturales como agentes terapéuticos antitumorales, evaluando el mecanismo de acción frente a células neoplásicas en medicina humana y veterinaria. Entre ellas, la cúrcuma, conocida como cúrcuma, destaca por sus propiedades antiinflamatorias, antiproliferativas y proapoptóticas. La curcumina es el principal compuesto activo de la cúrcuma y tiene un útil efecto antiproliferativo y proapoptótico, ya descrito en diferentes cepas neoplásicas. En el tracto urinario, la vejiga es el órgano más afectado por neoplasias, el 80% de las cuales son malignas, entre ellas el carcinoma urotelial canino (CUB), que corresponde a cerca del 2% de todos los tumores malignos del tracto urinario inferior y superior. Comentario presentado como neoplasia invasiva de alto grado, localizada en trígono y región metastásica. Su tratamiento es la escisión por máquinas, inhibidores de la ciclooxigenasa COX, radioterapia, o la mayoría de ellos. Sin embargo, la localización a menudo se ve imposibilitada por la lesión. Además, estudios modernos y recientes buscan que esta neoplasia similar tenga características diferentes, como estrategias terapéuticas modelo de UB humana. Discutimos el uso de la curcumina en la terapia del carcinoma de vejiga, buscando estimular el desarrollo de más investigaciones sobre este tema.

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Detrusor hypocontractility (DH) is a disease without a gold standard treatment in traditional medicine. Therefore, there is a need to develop innovative therapies. The present report presents the case of a patient with DH who was transplanted with 2 x 106 adipose tissue-derived mesenchymal stem cells twice and achieved significant improvements in their quality of life. The results showed that cell therapy reduced the voiding residue from 1,800 mL to 800 mL, the maximum cystometric capacity from 800 to 550 mL, and bladder compliance from 77 to 36.6 mL/cmH2O. Cell therapy also increased the maximum flow from 3 to 11 mL/s, the detrusor pressure from 08 to 35 cmH2O, the urine volume from 267 to 524 mL and the bladder contractility index (BCI) value from 23 to 90. The International Continence on Incontinence Questionnaire - Short Form score decreased from 17 to 8. Given the above, it is inferred that the transplantation of adipose tissue-derived mesenchymal stem cells is an innovative and efficient therapeutic strategy for DH treatment and improves the quality of life of patients affected by this disease.

A Hipocontratilidade Detrusora (HD) é uma doença sem um tratamento padrão-ouro na medicina tradicional. Logo, há a necessidade de desenvolvimento de terapias inovadoras. O presente relato apresenta um caso de paciente com HD transplantado duas vezes com 2 x 106 células-tronco mesenquimais derivadas do tecido adiposo que obteve melhoras significativas em sua qualidade de vida. Os resultados demonstraram que a terapia celular reduziu o resíduo miccional de 1.800mL para 800mL; a Capacidade Cistométrica Máxima de 800 para 550mL; a complacência de 77 para 36,6mL/cmH2O. A terapia celular também aumentou o fluxo máximo de 3 para 11mL/s; a pressão detrusora de 08 para 35cmH2O; o volume urinado de 267 para 524mL e o índice de contratilidade vesical (BCI) de 23 para 90. O score do International Continence on Incontinence Questionare - Short Form passou de 17 para 8. Diante do exposto, infere-se que o transplante de células-tronco mesenquimais derivadas do tecido adiposo é uma estratégia terapêutica inovadora e eficiente para o tratamento da HD e para melhoria da qualidade de vida de pacientes acometidos por essa doença.